Gilles Gasser

Summary

Publications

  1. doi Towards cancer cell-specific phototoxic organometallic rhenium(I) complexes
    Anna Leonidova
    Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Dalton Trans 43:4287-94. 2014
  2. doi The potential of organometallic complexes in medicinal chemistry
    Gilles Gasser
    Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Curr Opin Chem Biol 16:84-91. 2012
  3. doi Synthesis, characterisation and bioimaging of a fluorescent rhenium-containing PNA bioconjugate
    Gilles Gasser
    Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Dalton Trans 41:2304-13. 2012
  4. doi Preparation, 99mTc-labeling and biodistribution studies of a PNA oligomer containing a new ligand derivative of 2,2'-dipicolylamine
    Gilles Gasser
    Forschungszentrum Dresden Rossendorf, Institute of Radiopharmacy, PF 510119, D 01314 Dresden, Germany
    J Inorg Biochem 104:1133-40. 2010
  5. doi [(η(6)-Praziquantel)Cr(CO)3] derivatives with remarkable in vitro anti-schistosomal activity
    Malay Patra
    Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Chemistry 19:2232-5. 2013
  6. doi In vitro metabolic profile and in vivo antischistosomal activity studies of (η(6)-praziquantel)Cr(CO)3 derivatives
    Malay Patra
    Institute of Inorganic Chemistry and Institute of Molecular Cancer Research, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    J Med Chem 56:9192-8. 2013
  7. doi DNA intercalating Ru(II) polypyridyl complexes as effective photosensitizers in photodynamic therapy
    Cristina Mari
    Department of Chemistry, University of Zurich, Winterthurerstrasse 190, CH 8057 Zürich Switzerland, WWW www gassergroup com
    Chemistry 20:14421-36. 2014
  8. doi DMSO-Mediated Ligand Dissociation: Renaissance for Biological Activity of N-Heterocyclic-[Ru(η(6) -arene)Cl2 ] Drug Candidates
    Malay Patra
    Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich Switzerland
    Chemistry 19:14768-72. 2013
  9. doi Induction of Cytotoxicity through Photorelease of Aminoferrocene
    Anna Leonidova
    Department of Chemistry, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Inorg Chem 54:9740-8. 2015
  10. pmc Di-heterometalation of thiol-functionalized peptide nucleic acids
    Tanmaya Joshi
    Institute of Inorganic Chemistry, University of Zurich, Zurich, Switzerland
    Artif DNA PNA XNA 4:11-8. 2013

Collaborators

  • Ingo Ott
  • Roger Alberto
  • Carsten Schultz
  • Thomas L Mindt
  • Daniel Haussinger
  • Vera Luginbuehl
  • Tim Maisch
  • Gunnar Jeschke
  • Bernhard Spingler
  • Matthew H Todd
  • Robin B Gasser
  • Vanessa Pierroz
  • Malay Patra
  • Stefano Ferrari
  • Riccardo Rubbiani
  • Anna Leonidova
  • Tanmaya Joshi
  • Cristina Mari
  • Philipp Anstaett
  • Jeannine Hess
  • Jennifer Keiser
  • Katrin Ingram
  • Anu Naik
  • Olivier Blacque
  • Leone Spiccia
  • Igor Pavlovic
  • Sebastian Imstepf
  • Philipp M Antoni
  • Angelo Frei
  • Julia Schur
  • Rafael C Camuña
  • Thomas Fox
  • Laurent Bigler
  • Sebastian Hauke
  • Divyeshsinh T Thakor
  • Henning J Jessen
  • Jessica R Vargas
  • Colin J McKinlay
  • Michael Felber
  • Paul A Wender
  • Pilar Ruiz-Sánchez
  • Jose M Mateos
  • Ina Albert
  • Susmita Gupta
  • Pornkanok Munikorn
  • Patchanita Thamyongkit
  • Urs Ziegler
  • Luca Salassa
  • Thomas N Zehnder
  • Sandro Konatschnig
  • Luciano Oehninger
  • Koushik Venkatesan
  • Ariane Felgenträger
  • Jakob Heier
  • Solmaz Tubafard
  • Lea Gemperle
  • Andreas Bauman
  • Sandra Morard
  • Christiane A Fischer
  • Murray N Robertson
  • Marcel Kaiser

Detail Information

Publications29

  1. doi Towards cancer cell-specific phototoxic organometallic rhenium(I) complexes
    Anna Leonidova
    Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Dalton Trans 43:4287-94. 2014
    ..In particular, Re-Bombesin was found to be at least 20-fold more toxic after light irradiation. DNA photo-cleavage studies demonstrated that all compounds damaged DNA via singlet oxygen and, to a minor extent, superoxide production...
  2. doi The potential of organometallic complexes in medicinal chemistry
    Gilles Gasser
    Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Curr Opin Chem Biol 16:84-91. 2012
    ..Furthermore, using specific examples, we illustrate how these particular properties can be put to good use in medicinal chemistry. The examples we present have an emphasis on, but are not restricted to, anti-cancer activity...
  3. doi Synthesis, characterisation and bioimaging of a fluorescent rhenium-containing PNA bioconjugate
    Gilles Gasser
    Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Dalton Trans 41:2304-13. 2012
    ..Furthermore, Re-PNA could be detected in living cells using fluorescent microscopy...
  4. doi Preparation, 99mTc-labeling and biodistribution studies of a PNA oligomer containing a new ligand derivative of 2,2'-dipicolylamine
    Gilles Gasser
    Forschungszentrum Dresden Rossendorf, Institute of Radiopharmacy, PF 510119, D 01314 Dresden, Germany
    J Inorg Biochem 104:1133-40. 2010
    ..26 ± 0.1 SUV, 1h p.i.) and modest accumulation in the kidneys (5.45 ± 0.45 SUV, 1h p.i.). There was no significant activity in the thyroid and the stomach, demonstrating a high in vivo stability of the (99m)Tc-labeled Dpa-PNA conjugate...
  5. doi [(η(6)-Praziquantel)Cr(CO)3] derivatives with remarkable in vitro anti-schistosomal activity
    Malay Patra
    Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Chemistry 19:2232-5. 2013
    ..Both derivatives show a high in vitro activity against Schistosoma mansoni, a parasitic trematode, and only a minor cytotoxic effect on selected mammalian cell lines...
  6. doi In vitro metabolic profile and in vivo antischistosomal activity studies of (η(6)-praziquantel)Cr(CO)3 derivatives
    Malay Patra
    Institute of Inorganic Chemistry and Institute of Molecular Cancer Research, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    J Med Chem 56:9192-8. 2013
    ..The in vivo activity of 1 and 2 was then studied in mice harboring a chronic S. mansoni infection. A single dose of 1 and 2 (400 mg/kg) resulted in low worm burden reductions of 24% and 29% (p > 0.05). ..
  7. doi DNA intercalating Ru(II) polypyridyl complexes as effective photosensitizers in photodynamic therapy
    Cristina Mari
    Department of Chemistry, University of Zurich, Winterthurerstrasse 190, CH 8057 Zürich Switzerland, WWW www gassergroup com
    Chemistry 20:14421-36. 2014
    ..As anticipated, the preferential nuclear accumulation of 1 and 2 and their very high DNA binding affinity resulted in very efficient DNA photocleavage, suggesting a DNA-based mode of phototoxic action. ..
  8. doi DMSO-Mediated Ligand Dissociation: Renaissance for Biological Activity of N-Heterocyclic-[Ru(η(6) -arene)Cl2 ] Drug Candidates
    Malay Patra
    Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich Switzerland
    Chemistry 19:14768-72. 2013
    ..It is therefore highly important for researchers to study the stability in DMSO before reporting on the biological activity of such complexes. ..
  9. doi Induction of Cytotoxicity through Photorelease of Aminoferrocene
    Anna Leonidova
    Department of Chemistry, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Inorg Chem 54:9740-8. 2015
    ..Together with the absence of phototoxicity on the nonmalignant hTERT-immortalized retinal pigment epithelial (hTERT RPE-1) cell line, these results indicate catalytic generation of ROS as possible mode of action...
  10. pmc Di-heterometalation of thiol-functionalized peptide nucleic acids
    Tanmaya Joshi
    Institute of Inorganic Chemistry, University of Zurich, Zurich, Switzerland
    Artif DNA PNA XNA 4:11-8. 2013
    ....
  11. doi A bis(dipyridophenazine)(2-(2-pyridyl)pyrimidine-4-carboxylic acid)ruthenium(II) complex with anticancer action upon photodeprotection
    Tanmaya Joshi
    Department of Chemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zürich Switzerland http www gassergroup com
    Angew Chem Int Ed Engl 53:2960-3. 2014
    ..This is the first substitutionally inert cytotoxic metal complex to be used as a light-triggered prodrug candidate...
  12. doi Metal-containing peptide nucleic acid conjugates
    Gilles Gasser
    Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, CH 8057, Zurich, Switzerland
    Dalton Trans 40:7061-76. 2011
    ....
  13. doi Two-photon uncageable enzyme inhibitors bearing targeting vectors
    Philipp Anstaett
    Department of Chemistry, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Photochem Photobiol Sci 14:1821-5. 2015
    ..The enzyme inhibition potential of the cyclooxygenase-2 inhibitors could be regained upon two-photon excitation with tissue-transparent near-IR light at 800 nm. ..
  14. doi Synthesis, characterization, and biological evaluation of new Ru(II) polypyridyl photosensitizers for photodynamic therapy
    Angelo Frei
    Department of Chemistry, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    J Med Chem 57:7280-92. 2014
    ..Both complexes showed significant aPDT activity (420 nm, 8 J/cm(2)) against Gram-(+) (S. aureus; >6 log10 CFU reduction) and, for 2, also against Gram-(-) E. coli (>4 log10 CFU reduction)...
  15. doi Anticancer profile of a series of gold(III) (2-phenyl)pyridine complexes
    Riccardo Rubbiani
    Department of Chemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zürich Switzerland http www gassergroup com
    ChemMedChem 9:2781-90. 2014
    ..Interestingly, 4 induced a significant increase in intracellular levels of reactive oxygen species, which led to late apoptotic events and cytocidal effects...
  16. doi Bis(dipyridophenazine)(2-(2'-pyridyl)pyrimidine-4-carboxylic acid)ruthenium(II) hexafluorophosphate: a lesson in stubbornness
    Tanmaya Joshi
    Department of Chemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zürich Switzerland http www gassergroup com
    ChemMedChem 9:1419-27. 2014
    ..The results of this important structure-activity relationship strongly support our initial hypothesis that accumulation in mitochondria is crucial for 1 to exert its cytotoxic action. ..
  17. doi Novel, mercury-free synthetic pathway for trifluoromethylthio-substituted metallocenes
    Jeannine Hess
    Department of Chemistry and Institute of Molecular Cancer Research, University of Zurich, Winterthurerstrasse190, CH 8057 Zurich, Switzerland
    Inorg Chem 53:3662-7. 2014
    ..All organometallic compounds were found either to be nontoxic or to have a moderate toxicity toward the cell lines used in this study. ..
  18. doi Molecular and cellular characterization of the biological effects of ruthenium(II) complexes incorporating 2-pyridyl-2-pyrimidine-4-carboxylic acid
    Vanessa Pierroz
    Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    J Am Chem Soc 134:20376-87. 2012
    ..It was demonstrated that the mitochondrial membrane potential in HeLa was impaired by 3 as early as 2 h after its introduction and even more with increasing time...
  19. doi Ferrocenyl derivatives of the anthelmintic praziquantel: design, synthesis, and biological evaluation
    Malay Patra
    Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    J Med Chem 55:8790-8. 2012
    ..It was also demonstrated using two compounds of the series as models (8A and 8B) that the complexes were stable when incubated for 24 h at 37 °C in human plasma...
  20. doi Organometallic Rhenium Complexes Divert Doxorubicin to the Mitochondria
    Sebastian Imstepf
    Department of Chemistry, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland
    Angew Chem Int Ed Engl 55:2792-5. 2016
    ..Such derivatives may enhance the therapeutic index of the aggressive parent drug and overcome drug resistance by influencing nuclear and mitochondrial homeostasis. ..
  21. doi Toward organometallic antischistosomal drug candidates
    Jeannine Hess
    Department of Chemistry, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Future Med Chem 7:821-30. 2015
    ..A ferrocenyl derivative, namely ferroquine, has even entered clinical trials as a novel antimalarial. In this short review, we report on the studies describing the use of organometallic compounds against schistosomiasis. ..
  22. doi An octadentate bifunctional chelating agent for the development of stable zirconium-89 based molecular imaging probes
    Malay Patra
    Department of Chemistry, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Chem Commun (Camb) 50:11523-5. 2014
    ..We herein report the first octadentate bifunctional chelating agent for the development of (89)Zr-labelled (bio)conjugates with improved stability. ..
  23. doi Visible-light-induced annihilation of tumor cells with platinum-porphyrin conjugates
    Anu Naik
    Department of Chemistry, University of Zurich, Winterthurerstrasse 190, CH 8057 Zürich Switzerland
    Angew Chem Int Ed Engl 53:6938-41. 2014
    ..All of these favorable characteristics imply that tetraplatinated porphyrin complexes are worthy of exploration as novel PDT anticancer agents in vivo. ..
  24. pmc Cellular delivery and photochemical release of a caged inositol-pyrophosphate induces PH-domain translocation in cellulo
    Igor Pavlovic
    Department of Chemistry, University of Zurich, Winterthurerstrasse 190, Zurich 8057, Switzerland
    Nat Commun 7:10622. 2016
    ..It is shown herein that cytoplasmic photouncaging of InsP7 leads to translocation of the PH-domain of Akt, an important signalling-node kinase involved in glucose homeostasis, from the membrane into the cytoplasm. ..
  25. doi (Metallo)porphyrins as potent phototoxic anti-cancer agents after irradiation with red light
    Philipp M Antoni
    Department of Chemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich Switzerland, Fax 41 44 635 68 03
    Chemistry 21:1179-83. 2015
    ..This finding indicates that paramagnetic compounds should be considered for photodynamic therapy (PDT). Furthermore, an additive effect of cisplatin and a zinc porphyrin, both at subtherapeutic concentrations of 0.22 μM, was observed...
  26. doi Underestimated potential of organometallic rhenium complexes as anticancer agents
    Anna Leonidova
    Department of Chemistry, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    ACS Chem Biol 9:2180-93. 2014
    ..A particular emphasis is placed on their cellular uptake and localization as well as their potential mechanism of action. ..
  27. doi Preparation of metal-containing peptide nucleic acid bioconjugates on the solid phase
    Gilles Gasser
    Institute of Inorganic Chemistry, University of Zurich, Zurich, Switzerland
    Methods Mol Biol 1050:55-72. 2014
    ..In this book chapter, we report on the recent synthetic advances towards the preparation of these "(multi-)metallic PNAs" on the solid phase...
  28. doi Organometallic compounds: an opportunity for chemical biology?
    Malay Patra
    Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Chembiochem 13:1232-52. 2012
    ..We also demonstrate that these recent discoveries are only a beginning and that many other organometallic complexes are likely to be found useful in this field of research in the near future...