Fabio Garofolo

Summary

Publications

  1. doi request reprint Impact of methylation of acyl glucuronide metabolites on incurred sample reanalysis evaluation: ramiprilat case study
    Cynthia Côté
    Algorithme Pharma Inc, 575 Armand Frappier, Laval, Quebec, Canada
    Bioanalysis 3:951-65. 2011
  2. doi request reprint US FDA/EMA harmonization of their bioanalytical guidance/guideline and activities of the Global Bioanalytical Consortium
    Fabio Garofolo
    Algorithme Pharma Inc, Laval Montreal, QC, Canada
    Bioanalysis 4:231-6. 2012
  3. doi request reprint Conference report: Discussion on harmonization and globalization of bioanalytical guidances at the 19th International Reid Bioanalytical Forum
    Fabio Garofolo
    Algorithme Pharma, 575 Boulevard Armand Frappier, Laval, Montreal, Canada
    Bioanalysis 3:2717-20. 2011
  4. doi request reprint 2011 White paper on recent issues in bioanalysis and regulatory findings from audits and inspections
    Fabio Garofolo
    Algorithme Pharma Inc, Laval Montreal Quebec, H7V 4B3, Canada
    Bioanalysis 3:2081-96. 2011
  5. doi request reprint Conference report: the 1st conference in Asia-pacific on recent issues in bioanalysis
    Isabelle Dumont
    Algorithme Pharma Inc, 575 Armand Frappier Blvd, Laval Montreal Quebec, H7V 4B3, Canada
    Bioanalysis 3:723-31. 2011
  6. doi request reprint Selection of HILIC columns to handle matrix effect due to phospholipids
    Jean Nicholas Mess
    Algorithme Pharma Inc, Laval, Quebec, H7V 4B3, Canada
    Bioanalysis 1:57-62. 2009
  7. doi request reprint The 2nd Calibration and Validation Group workshop on recent issues in good laboratory practice bioanalysis
    Natasha Savoie
    Algorithme Pharma Inc, Laval Montreal, QC, Canada
    Bioanalysis 1:19-30. 2009
  8. doi request reprint Impact of organic solvent additive on the integrity of plasma samples in bioanalysis by LC-MS/MS
    Catherine Dicaire
    Algorithme Pharma, Inc, 575 Armand Frappier, Laval, QC, Canada
    Bioanalysis 5:2359-70. 2013
  9. doi request reprint Impact of oxcarbazepine sulfate metabolite on incurred sample reanalysis and quantification of oxcarbazepine
    Catherine Dicaire
    Algorithme Pharma Inc, 575 Armand Frappier, Laval, Quebec, Canada
    Bioanalysis 3:973-82. 2011
  10. doi request reprint Use of polarity switching for the simultaneous bioanalysis of analytes with three orders of magnitude difference in concentration by LC-MS/MS
    Mélanie Bergeron
    Algorithme Pharma Inc, 575 Armand Frappier, Laval, QC H7V 4B3, Canada
    Bioanalysis 5:1911-8. 2013

Collaborators

Detail Information

Publications33

  1. doi request reprint Impact of methylation of acyl glucuronide metabolites on incurred sample reanalysis evaluation: ramiprilat case study
    Cynthia Côté
    Algorithme Pharma Inc, 575 Armand Frappier, Laval, Quebec, Canada
    Bioanalysis 3:951-65. 2011
    ..Reanalysis of incurred samples showed that the bioanalytical method for the quantification of ramipril and ramiprilat was generating irreproducible results for ramiprilat...
  2. doi request reprint US FDA/EMA harmonization of their bioanalytical guidance/guideline and activities of the Global Bioanalytical Consortium
    Fabio Garofolo
    Algorithme Pharma Inc, Laval Montreal, QC, Canada
    Bioanalysis 4:231-6. 2012
    ..The final presentation was by Fabio Garofolo on the progress of the Global Bioanalytical Consortium harmonization teams for small and large molecules...
  3. doi request reprint Conference report: Discussion on harmonization and globalization of bioanalytical guidances at the 19th International Reid Bioanalytical Forum
    Fabio Garofolo
    Algorithme Pharma, 575 Boulevard Armand Frappier, Laval, Montreal, Canada
    Bioanalysis 3:2717-20. 2011
    ..Indeed, this meeting is well-known for its numerous networking opportunities during the 3-day conference and for an ethos of debate on practical solutions to problems encountered in bioanalytical science...
  4. doi request reprint 2011 White paper on recent issues in bioanalysis and regulatory findings from audits and inspections
    Fabio Garofolo
    Algorithme Pharma Inc, Laval Montreal Quebec, H7V 4B3, Canada
    Bioanalysis 3:2081-96. 2011
    ..This 2011 White Paper is based on the conclusions from this workshop, and aims to provide a practical reference guide on those topics...
  5. doi request reprint Conference report: the 1st conference in Asia-pacific on recent issues in bioanalysis
    Isabelle Dumont
    Algorithme Pharma Inc, 575 Armand Frappier Blvd, Laval Montreal Quebec, H7V 4B3, Canada
    Bioanalysis 3:723-31. 2011
    ..All discussions were focused on high-quality, better compliance to regulations and scientific excellence...
  6. doi request reprint Selection of HILIC columns to handle matrix effect due to phospholipids
    Jean Nicholas Mess
    Algorithme Pharma Inc, Laval, Quebec, H7V 4B3, Canada
    Bioanalysis 1:57-62. 2009
    ..While the behavior of phospholipids has been documented under reversed-phase chromatography, there is a lack of information concerning the selectivity of hydrophilic interaction chromatography (HILIC) towards phospholipids...
  7. doi request reprint The 2nd Calibration and Validation Group workshop on recent issues in good laboratory practice bioanalysis
    Natasha Savoie
    Algorithme Pharma Inc, Laval Montreal, QC, Canada
    Bioanalysis 1:19-30. 2009
    ..5-day workshop for contract research organizations and pharmaceutical companies involved in providing bioanalytical data for bioavailability, bioequivalence, pharmacokinetic and comparability studies...
  8. doi request reprint Impact of organic solvent additive on the integrity of plasma samples in bioanalysis by LC-MS/MS
    Catherine Dicaire
    Algorithme Pharma, Inc, 575 Armand Frappier, Laval, QC, Canada
    Bioanalysis 5:2359-70. 2013
    ..Matrix effects are one of the major drawbacks of ESI-MS/MS. It is majorly caused by lipids in plasma, which can be overcome by using different extraction techniques...
  9. doi request reprint Impact of oxcarbazepine sulfate metabolite on incurred sample reanalysis and quantification of oxcarbazepine
    Catherine Dicaire
    Algorithme Pharma Inc, 575 Armand Frappier, Laval, Quebec, Canada
    Bioanalysis 3:973-82. 2011
    ..In the case of acceptable ISR evaluation, there were no precise recommendations for further testing when sporadic values were obtained...
  10. doi request reprint Use of polarity switching for the simultaneous bioanalysis of analytes with three orders of magnitude difference in concentration by LC-MS/MS
    Mélanie Bergeron
    Algorithme Pharma Inc, 575 Armand Frappier, Laval, QC H7V 4B3, Canada
    Bioanalysis 5:1911-8. 2013
    ..The challenge of quantifying two compounds in a single assay with drastic dynamic ranges is to obtain linearity without source or detector saturation at the mass spectrometer...
  11. doi request reprint 2010 white paper on recent issues in regulated bioanalysis & global harmonization of bioanalytical guidance
    Natasha Savoie
    Algorithme Pharma Inc, 575 Armand Frappier Blvd, Laval Montreal, Quebec, Canada
    Bioanalysis 2:1945-60. 2010
    ....
  12. doi request reprint 2009 White Paper on recent issues in regulated bioanalysis from the 3rd Calibration and Validation Group Workshop
    Natasha Savoie
    Algorithme Pharma Inc, Laval Montreal QC, Canada
    Bioanalysis 2:53-68. 2010
    ..A consensus was reached among panelists and attendees on many points regarding method validation of small molecules...
  13. doi request reprint Dried blood spot on-card derivatization: an alternative form of sample handling to overcome the instability of thiorphan in biological matrix
    Jean Nicholas Mess
    Algorithme Pharma, Laval, Quebec, Canada
    Biomed Chromatogr 26:1617-24. 2012
    ..The DBS on-card derivatization has shown to be an easy and reliable alternative form of sample collection for the quantification of thiorphan...
  14. doi request reprint Determination of naproxen using DBS: evaluation & pharmacokinetic comparison of human plasma versus human blood DBS
    Nikolay Youhnovski
    Algorithme Pharma Inc, 575 Armand Frappier, Laval, Quebec, H7V 4B3, Canada
    Bioanalysis 2:1501-13. 2010
    ..The scientific community has recently expressed interest in applying the DBS technique for quantitative determination of drugs in biological fluid...
  15. doi request reprint Pre-cut dried blood spot (PCDBS): an alternative to dried blood spot (DBS) technique to overcome hematocrit impact
    Nikolay Youhnovski
    Algorithme Pharma Inc, 575 Armand Frappier, Laval, Quebec, Canada, H7V 4B3
    Rapid Commun Mass Spectrom 25:2951-8. 2011
    ..1%) and accurate (%nominal between 95.4 and 104.4%) as the classical DBS procedure...
  16. doi request reprint Severe impact of hemolysis on stability of phenolic compounds
    Eugénie Raphaelle Bérubé
    Algorithme Pharma Inc, Laval, Montreal, Quebec, Canada
    Bioanalysis 5:1491-9. 2013
    ..The issue of morphine instability was resolved by using a reconstitution solution at a pH below the pKa of the phenol moiety. ..
  17. doi request reprint Impact of sample hemolysis on drug stability in regulated bioanalysis
    Eugénie Raphaelle Bérubé
    Algorithme Pharma Inc, Laval Montreal Quebec, H7V 4B3, Canada
    Bioanalysis 3:2097-105. 2011
    ..In this article we report two case studies where the analyte instability was a result of sample hemolysis. A description of the appropriate actions undertaken for the resolution of the issue will be discussed...
  18. doi request reprint Confirmation of no impact from different anticoagulant counter ions on bioanalytical method
    Annik Bergeron
    Algorithme Pharma Inc, 575 Armand Frappier, Laval, Quebec, H7V 4B3, Canada
    Bioanalysis 4:897-908. 2012
    ..In order to confirm that there is no impact from counter ions, matrix effect and stability evaluations were performed on bicalutamide LC-MS/MS bioanalytical methods...
  19. doi request reprint A practical approach to reduce interference due to in-source collision-induced dissociation of acylglucuronides in LC-MS/MS
    Jean Nicholas Mess
    Algorithme Pharma Inc, 575 Armand Frappier, Laval, Quebec, Canada, H7V 4B3
    Bioanalysis 3:1741-51. 2011
    ..In LC-MS/MS, glucuronide conjugated metabolites may convert back to the parent drug due to in-source collision-induced dissociation (CID)...
  20. doi request reprint An alternative solution to overcome carryover issues in bioanalysis
    Louis Philippe Morin
    Algorithme Pharma, Inc, 575 Armand Frappier, Laval, Quebec, H7V 4B3, Canada
    Bioanalysis 4:133-41. 2012
    ..This article reviews the causes of carryover and proposes an autosampler needle seat backflush as a novel solution to address the issue...
  21. doi request reprint Reliable procedures to evaluate and repair crosstalk for bioanalytical MS/MS assays
    Louis Philippe Morin
    Algorithme Pharma Inc, 575 Armand Frappier, Laval, Quebec, Canada
    Bioanalysis 3:275-83. 2011
    ..Additionally, procedures to identify, evaluate and fix possible crosstalk issues during bioanalytical assays on MS/MS instruments are proposed...
  22. doi request reprint Elimination of LC-MS/MS matrix effect due to phospholipids using specific solid-phase extraction elution conditions
    Mathieu Lahaie
    Algorithme Pharma Inc, Laval Montreal, Quebec, Canada
    Bioanalysis 2:1011-21. 2010
    ..The objective is to find elution conditions using different solid-phase extraction chemistries to reduce the amount of phospholipids in plasma extract, which is associated with matrix effect in LC-MS...
  23. doi request reprint Matrix effect elimination during LC-MS/MS bioanalytical method development
    Cynthia Côté
    Algorithme Pharma Inc, 575 Armand Frappier, Laval, QC, Canada, H7V 4B3
    Bioanalysis 1:1243-57. 2009
    ....
  24. doi request reprint Choosing the appropriate matrix to perform a scientifically meaningful lipemic plasma test in bioanalytical method validation
    Laurence Mayrand-Provencher
    Algorithme Pharma Inc, Laval, Montreal, Quebec, Canada
    Bioanalysis 6:1639-46. 2014
    ..The results obtained show that natural plasma with high triglycerides content should be used to perform a scientifically meaningful lipemic plasma test. ..
  25. doi request reprint Elimination of isobaric interference and signal-to-noise ratio enhancement using on-line mobile phase filtration in liquid chromatography/tandem mass spectrometry
    Mathieu Lahaie
    Algorithme Pharma Inc, 575 Armand Frappier, Laval, Quebec, Canada, H7V 4B3
    Rapid Commun Mass Spectrom 28:886-92. 2014
    ..In this study, a high-performance liquid chromatography (HPLC) on-line mobile phase filtration setup is described and used to remove interference to allow better detection of the analyte of interest...
  26. doi request reprint Challenges of developing a bioanalytical method for a macrolide immunosuppressant compound by LC-MS/MS
    Marie Pierre Taillon
    Algorithme Pharma Inc, Laval, Montreal, Quebec, Canada
    Bioanalysis 3:1201-15. 2011
    ..In order to resolve the matrix effect issue, the sample procedure had to be improved. The final assay showed good recovery, low matrix effect, linearity, blood stability and good precision and accuracy...
  27. doi request reprint Impact of plasma and whole-blood anticoagulant counter ion choice on drug stability and matrix effects during bioanalysis
    Mélanie Bergeron
    Algorithme Pharma Inc, 575 Armand Frappier, Laval, Quebec, H7V 4B3, Canada
    Bioanalysis 1:537-48. 2009
    ..The plasma pH may change with a different counter ion and anticoagulant; thus, it is essential to determine effects on drug stability and the matrix effect during the bioanalytical method development...
  28. doi request reprint Effect of high pH mobile phase on the sensitivity of multiple drugs by LC positive electrospray ionization MS/MS
    Jean Nicholas Mess
    Algorithme Pharma Inc, 575 Armand Frappier, Laval, Quebec, Canada
    Bioanalysis 1:1419-30. 2009
    ..In this study, the postcolumn addition approach was used to evaluate the impact of high pH modifiers on the sensitivity of 25 compounds by LC-MS/MS under positive ESI (ESI+)...
  29. doi request reprint Potentially new isobaric metabolite of fluvastatin observed by LC-MS/MS during incurred sample analysis
    Marie Pierre Taillon
    Algorithme Pharma Inc, 575 Armand Frappier Blvd, Laval Montreal, Quebec, H7V 4B3, Canada
    Bioanalysis 3:1827-35. 2011
    ..A method was developed to chromatographically separate fluvastatin from its threo isomers to support a bioequivalence study...
  30. doi request reprint Large-molecule quantification: sensitivity and selectivity head-to-head comparison of triple quadrupole with Q-TOF
    Louis Philippe Morin
    Algorithme Pharma Inc, 575 Armand Frappier, Laval, Quebec H7V 4B3, Canada
    Bioanalysis 5:1181-93. 2013
    ..This study lists the different advantages of high-resolution MS (HRMS) over standard triple quadrupole instruments and proposes basic guidelines on how to use HRMS for large-molecule quantification in a regulated environment...
  31. doi request reprint Discovery of a novel trimebutine metabolite and its impact on N-desmethyltrimebutine quantification by LC-MS/MS
    Hélène Montpetit
    Algorithme Pharma Inc, 575 Armand Frappier, Laval, QC H7V 4B3, Canada
    Bioanalysis 7:1007-15. 2015
    ..A failure in incurred sample reanalysis (ISR) for N-desmethyltrimebutine (NDMT), during the analysis of a trimebutine-containing drug GIC-1001 Phase I study, led to the discovery of a never-before reported metabolite of trimebutine...
  32. doi request reprint Application of high-resolution MS in the quantification of a therapeutic monoclonal antibody in human plasma
    Kevork Mekhssian
    Algorithme Pharma Inc, 575 Armand Frappier, Laval, Quebec, Canada, H7V 4B3
    Bioanalysis 6:1767-79. 2014
    ....
  33. doi request reprint Importance of using highly pure internal standards for successful liquid chromatography/tandem mass spectrometric bioanalytical assays
    Annik Bergeron
    Algorithme Pharma Inc, 575 Armand Frappier, Laval, Quebec, Canada, H7V 4B3
    Rapid Commun Mass Spectrom 23:1287-97. 2009
    ..Consequently, during bioanalytical method development, the purity of the IS should be scrutinized...