Maria Christina Zennaro

Summary

Country: France

Publications

  1. doi request reprint Mineralocorticoid receptors in the metabolic syndrome
    Maria Christina Zennaro
    INSERM, U970, Paris Cardiovascular Research Center PARCC, 75015 Paris, France
    Trends Endocrinol Metab 20:444-51. 2009
  2. doi request reprint SFE/SFHTA/AFCE consensus on primary aldosteronism, part 5: Genetic diagnosis of primary aldosteronism
    Maria Christina Zennaro
    INSERM, U970, Paris Cardiovascular Research Center PARCC, 56, rue Leblanc, 75015 Paris, France Université Paris Descartes, Sorbonne Paris Cité, Paris, France Service de Génétique, Hopital Europeen Georges Pompidou, Assistance Publique Hopitaux de Paris, Paris, France Electronic address
    Ann Endocrinol (Paris) 77:214-9. 2016
  3. doi request reprint Inherited forms of mineralocorticoid hypertension
    Maria Christina Zennaro
    INSERM, UMRS_970, Paris Cardiovascular Research Center, Paris, France University Paris Descartes, Sorbonne Paris Cité, Paris, France Assistance Publique Hôpitaux de Paris, Hopital Europeen Georges Pompidou, Service de Genetique, Paris, France Electronic address
    Best Pract Res Clin Endocrinol Metab 29:633-45. 2015
  4. doi request reprint An update on novel mechanisms of primary aldosteronism
    Maria Christina Zennaro
    INSERMUMRS_970, Paris Cardiovascular Research Center PARCC, 56, rue Leblanc, 75015 Paris, FranceUniversity Paris DescartesSorbonne Paris Cité, Paris, FranceAssistance Publique Hôpitaux de ParisHôpital Européen Georges Pompidou, Service de Genetique, Paris, France INSERMUMRS_970, Paris Cardiovascular Research Center PARCC, 56, rue Leblanc, 75015 Paris, FranceUniversity Paris DescartesSorbonne Paris Cité, Paris, FranceAssistance Publique Hôpitaux de ParisHôpital Européen Georges Pompidou, Service de Genetique, Paris, France INSERMUMRS_970, Paris Cardiovascular Research Center PARCC, 56, rue Leblanc, 75015 Paris, FranceUniversity Paris DescartesSorbonne Paris Cité, Paris, FranceAssistance Publique Hôpitaux de ParisHôpital Européen Georges Pompidou, Service de Genetique, Paris, France
    J Endocrinol 224:R63-77. 2015
  5. pmc A network perspective on metabolic inconsistency
    Nikolaus Sonnenschein
    School of Engineering and Science, Jacobs University Bremen, Campus Ring 1, 28759 Bremen, Germany
    BMC Syst Biol 6:41. 2012
  6. doi request reprint Aldosterone resistance: structural and functional considerations and new perspectives
    Maria Christina Zennaro
    INSERM U970, Paris Cardiovascular Research Center, Paris, France
    Mol Cell Endocrinol 350:206-15. 2012
  7. doi request reprint Aldosterone-producing adenoma formation in the adrenal cortex involves expression of stem/progenitor cell markers
    Sheerazed Boulkroun
    Institut National de la Santé et de la Recherche Médicale Unité 970, PARCC, 56 rue Leblanc, 75015 Paris, France
    Endocrinology 152:4753-63. 2011
  8. doi request reprint KCNJ5 mutations in aldosterone producing adenoma and relationship with adrenal cortex remodeling
    Sheerazed Boulkroun
    Institut National de la Sante et de la Recherche Medicale INSERM, U970, Paris Cardiovascular Research Center, Paris, France Université Paris Descartes, Sorbonne Paris Cité, Paris, France
    Mol Cell Endocrinol 371:221-7. 2013
  9. doi request reprint Genetics of mineralocorticoid excess: an update for clinicians
    Maria Christina Zennaro
    INSERM, UMRS_970, Paris Cardiovascular Research Center, 56 rue Leblanc, 75015 Paris, France
    Eur J Endocrinol 169:R15-25. 2013
  10. doi request reprint Cardiovascular effects of aldosterone: insight from adult carriers of mineralocorticoid receptor mutations
    Brigitte Escoubet
    Assistance Publique Hopitaux de Paris, Hopital Bichat Claude Bernard, Paris, France
    Circ Cardiovasc Genet 6:381-90. 2013

Collaborators

Detail Information

Publications29

  1. doi request reprint Mineralocorticoid receptors in the metabolic syndrome
    Maria Christina Zennaro
    INSERM, U970, Paris Cardiovascular Research Center PARCC, 75015 Paris, France
    Trends Endocrinol Metab 20:444-51. 2009
    ....
  2. doi request reprint SFE/SFHTA/AFCE consensus on primary aldosteronism, part 5: Genetic diagnosis of primary aldosteronism
    Maria Christina Zennaro
    INSERM, U970, Paris Cardiovascular Research Center PARCC, 56, rue Leblanc, 75015 Paris, France Université Paris Descartes, Sorbonne Paris Cité, Paris, France Service de Génétique, Hopital Europeen Georges Pompidou, Assistance Publique Hopitaux de Paris, Paris, France Electronic address
    Ann Endocrinol (Paris) 77:214-9. 2016
    ..In rare cases, PA may be associated with complex neurologic disorder involving epileptic seizures and cerebral palsy (Primary Aldosteronism, Seizures, and Neurologic Abnormalities [PASNA]) due to de novo germline CACNA1D mutations. ..
  3. doi request reprint Inherited forms of mineralocorticoid hypertension
    Maria Christina Zennaro
    INSERM, UMRS_970, Paris Cardiovascular Research Center, Paris, France University Paris Descartes, Sorbonne Paris Cité, Paris, France Assistance Publique Hôpitaux de Paris, Hopital Europeen Georges Pompidou, Service de Genetique, Paris, France Electronic address
    Best Pract Res Clin Endocrinol Metab 29:633-45. 2015
    ..In this review we describe the different forms of inherited mineralocorticoid hypertension, providing an overview of their clinical and biochemical features, their underlying genetic defects and specific therapeutic options. ..
  4. doi request reprint An update on novel mechanisms of primary aldosteronism
    Maria Christina Zennaro
    INSERMUMRS_970, Paris Cardiovascular Research Center PARCC, 56, rue Leblanc, 75015 Paris, FranceUniversity Paris DescartesSorbonne Paris Cité, Paris, FranceAssistance Publique Hôpitaux de ParisHôpital Européen Georges Pompidou, Service de Genetique, Paris, France INSERMUMRS_970, Paris Cardiovascular Research Center PARCC, 56, rue Leblanc, 75015 Paris, FranceUniversity Paris DescartesSorbonne Paris Cité, Paris, FranceAssistance Publique Hôpitaux de ParisHôpital Européen Georges Pompidou, Service de Genetique, Paris, France INSERMUMRS_970, Paris Cardiovascular Research Center PARCC, 56, rue Leblanc, 75015 Paris, FranceUniversity Paris DescartesSorbonne Paris Cité, Paris, FranceAssistance Publique Hôpitaux de ParisHôpital Européen Georges Pompidou, Service de Genetique, Paris, France
    J Endocrinol 224:R63-77. 2015
    ..We also address some of the foreseeable consequences that genetic knowledge may contribute to improve diagnosis and patient care. ..
  5. pmc A network perspective on metabolic inconsistency
    Nikolaus Sonnenschein
    School of Engineering and Science, Jacobs University Bremen, Campus Ring 1, 28759 Bremen, Germany
    BMC Syst Biol 6:41. 2012
    ..A network-driven interpretation of gene expression data has the potential of suggesting novel classifiers for pathological cellular states and of contributing to a general theoretical understanding of gene regulation...
  6. doi request reprint Aldosterone resistance: structural and functional considerations and new perspectives
    Maria Christina Zennaro
    INSERM U970, Paris Cardiovascular Research Center, Paris, France
    Mol Cell Endocrinol 350:206-15. 2012
    ..We will also discuss genotype-phenotype correlations and new clinical and genetic entities that may prove relevant for patient's care in neonates with renal salt losing syndromes and/or failure to thrive...
  7. doi request reprint Aldosterone-producing adenoma formation in the adrenal cortex involves expression of stem/progenitor cell markers
    Sheerazed Boulkroun
    Institut National de la Santé et de la Recherche Médicale Unité 970, PARCC, 56 rue Leblanc, 75015 Paris, France
    Endocrinology 152:4753-63. 2011
    ..Our data suggest that both APA and adjacent ZG present characteristics of stem/precursor cells; the reexpression of genes involved in fetal adrenal development could underlie excessive ZG cell proliferation and APA formation...
  8. doi request reprint KCNJ5 mutations in aldosterone producing adenoma and relationship with adrenal cortex remodeling
    Sheerazed Boulkroun
    Institut National de la Sante et de la Recherche Medicale INSERM, U970, Paris Cardiovascular Research Center, Paris, France Université Paris Descartes, Sorbonne Paris Cité, Paris, France
    Mol Cell Endocrinol 371:221-7. 2013
    ..The cell composition of APA was not significantly different between groups. These results indicate that KCNJ5 mutations are not correlated with adrenal cortex remodeling in APA...
  9. doi request reprint Genetics of mineralocorticoid excess: an update for clinicians
    Maria Christina Zennaro
    INSERM, UMRS_970, Paris Cardiovascular Research Center, 56 rue Leblanc, 75015 Paris, France
    Eur J Endocrinol 169:R15-25. 2013
    ..Finally, we outline the cardiovascular, renal, and metabolic consequences of mineralocorticoid excess beyond blood pressure regulation...
  10. doi request reprint Cardiovascular effects of aldosterone: insight from adult carriers of mineralocorticoid receptor mutations
    Brigitte Escoubet
    Assistance Publique Hopitaux de Paris, Hopital Bichat Claude Bernard, Paris, France
    Circ Cardiovasc Genet 6:381-90. 2013
    ..We aimed to assess the cardiovascular outcomes in adults carrying NR3C2 mutations...
  11. doi request reprint SFE/SFHTA/AFCE primary aldosteronism consensus: Introduction and handbook
    Laurence Amar
    Universite Paris Descartes, Sorbonne Paris Cité, Assistance Publique Hopitaux de Paris, Hopital Europeen Georges Pompidou, Unité d hypertension artérielle, 75098 Paris cedex 15, France
    Ann Endocrinol (Paris) 77:179-86. 2016
    ..If PA is non-lateralized or the patient refuses surgery, spironolactone is administered as first-line treatment, replaced by amiloride, eplerenone or calcium-channel blockers if insufficiently effective or poorly tolerated. ..
  12. pmc Different Somatic Mutations in Multinodular Adrenals With Aldosterone-Producing Adenoma
    Fábio Luiz Fernandes-Rosa
    From the INSERM, UMRS_970, Paris Cardiovascular Research Center, Paris, France F L F R, I G D, L A, T M, S B, M C Z Université Paris Descartes, Sorbonne Paris Cité, Paris, France F L F R, I G D, L A, T M, S B, M C Z Service de Génétique F L F R, M C Z, Unité Hypertension artérielle L A, and Service d Anatomie Pathologique T M, Assistance Publique Hopitaux de Paris, Hopital Europeen Georges Pompidou, Paris, France and Division of Endocrinology, G V Sonny Montgomery VA Medical Center and University of Mississippi Medical Center, Jackson, MS C E G S
    Hypertension 66:1014-22. 2015
    ..In conclusion, different mutations are found in different aldosterone-producing nodules from the same adrenal, suggesting that somatic mutations are independent events triggered by mechanisms that remain to be identified...
  13. pmc Mineralocorticoid receptor mutations and a severe recessive pseudohypoaldosteronism type 1
    Edwige Ludiwyne Hubert
    INSERM, U970, Paris Cardiovascular Research Center PARCC, 56, rue Leblanc, 75015 Paris, France
    J Am Soc Nephrol 22:1997-2003. 2011
    ..This might prove relevant for patient's care in neonatal salt losing disorders and may affect renal salt handling and blood pressure in the general population...
  14. doi request reprint Functional histopathological markers of aldosterone producing adenoma and somatic KCNJ5 mutations
    Fábio Luiz Fernandes-Rosa
    INSERM, UMRS_970, Paris Cardiovascular Research Center, Paris, France University Paris Descartes, Sorbonne Paris Cité, Paris, France Assistance Publique Hôpitaux de Paris, Hopital Europeen Georges Pompidou, Service de Genetique, Paris, France
    Mol Cell Endocrinol 408:220-6. 2015
    ..This was highly specific for KCNJ5 mutations, indicating that GIRK4 immunohistochemistry might be used for initial screening of the somatic mutation status...
  15. doi request reprint Prevalence, clinical, and molecular correlates of KCNJ5 mutations in primary aldosteronism
    Sheerazed Boulkroun
    Institut National de la Sante et de la Recherche Medicale, Unité Mixte de Recherche Scientifique 970, Paris Cardiovascular Research Center, Paris, France
    Hypertension 59:592-8. 2012
    ..KCNJ5 mutation carriers are more likely to be females; younger age and higher aldosterone levels at diagnosis suggest that KCNJ5 mutations may be associated with a more florid phenotype of primary aldosteronism...
  16. doi request reprint Mineralocorticoid receptor mutations differentially affect individual gene expression profiles in pseudohypoaldosteronism type 1
    Fabio L Fernandes-Rosa
    Department of Puericulture and Pediatrics, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto 14040 900, Brazil
    J Clin Endocrinol Metab 96:E519-27. 2011
    ..Type 1 pseudohypoaldosteronism (PHA1), a primary form of mineralocorticoid resistance, is due to inactivating mutations of the NR3C2 gene, coding for the mineralocorticoid receptor (MR)...
  17. pmc CACNA1H Mutations Are Associated With Different Forms of Primary Aldosteronism
    Georgios Daniil
    INSERM, UMRS_970, Paris Cardiovascular Research Center, Paris, France Université Paris Descartes, Sorbonne Paris Cité, Paris, France
    EBioMedicine 13:225-236. 2016
    ....
  18. pmc Overweight Is a Major Contributor to Atherosclerosis in Systemic Lupus Erythematosus Patients at Apparent Low Risk for Cardiovascular Disease: A Cross-Sectional Controlled Study
    Karim Sacre
    From the Département de Médecine Interne, Hopital Bichat, Universite Paris Diderot, PRES Sorbonne Paris Cité, Assistance Publique Hopitaux de Paris, Paris, France KS, M PC, TP INSERM U1149, Paris, France KS, TP Département Hospitalo Universitaire FIRE Fibrosis, Inflammation and Remodelling in Renal and Respiratory Diseases, Paris, France KS, TP Département de Physiologie, Hopital Bichat, Universite Paris Diderot, PRES Sorbonne Paris Cité, Assistance Publique Hopitaux de Paris, INSERM U1138, Paris, France BE INSERM UMRS970, Paris Cardiovascular Research Center, Paris, France Université Paris Descartes, Sorbonne Paris Cité, Paris, France Assistance Publique Hôpitaux de Paris, Hopital Europeen Georges Pompidou, Département de génétique, Paris, France M CZ and Département d Anesthésie Réanimation, Hôpitaux Universitaires Saint Louis Lariboisière, 2 UMR S 942, INSERM, 3 Université Paris Diderot
    Medicine (Baltimore) 94:e2177. 2015
    ..In multivariate analysis, only the association with overweight remained significant (OR [95% CI]: 4.13 [1.02-16.75]; P = 0.047). Overweight is a major contributor to atherosclerosis in SLE patients at apparent low risk for CVD...
  19. doi request reprint Genetic spectrum and clinical correlates of somatic mutations in aldosterone-producing adenoma
    Fábio Luiz Fernandes-Rosa
    From the INSERM, UMRS_970, Paris Cardiovascular Research Center, Paris, France F L F R, S B, L A, T M, X J, M C Z University Paris Descartes, Sorbonne Paris Cité, Paris, France F L F R, S B, L A, T M, X J, M C Z Service de Génétique F L F R, X J, M C Z, Unité Hypertension artérielle L A, and Service d Anatomie Pathologique T M, Assistance Publique Hopitaux de Paris, Hopital Europeen Georges Pompidou, Paris, France Divisions of Internal Medicine and Hypertension, Department of Medical Sciences T A W, S M, P M and Endocrinology, Diabetes, and Metabolism, Department of Medical Sciences M M, University of Torino, Torino, Italy Medizinische Klinik und Poliklinik IV
    Hypertension 64:354-61. 2014
    ..Young women with APAs are more likely to be KCNJ5 mutation carriers; identification of specific characteristics or surrogate biomarkers of mutation status may lead to targeted treatment options. ..
  20. ncbi request reprint Different inactivating mutations of the mineralocorticoid receptor in fourteen families affected by type I pseudohypoaldosteronism
    Paola Sartorato
    Institut National de la Sante et de la Recherche Medicale, Unité 478, Faculte de Medecine Xavier Bichat, 75018 Paris, France
    J Clin Endocrinol Metab 88:2508-17. 2003
    ..Their absence in some families underscores the importance of an extensive investigation of the hMR gene and the role of precise diagnostic procedures to allow for identification of other genes potentially involved in the disease...
  21. doi request reprint Adrenal cortex remodeling and functional zona glomerulosa hyperplasia in primary aldosteronism
    Sheerazed Boulkroun
    INSERM U970, Paris Cardiovascular Research Center, Paris, France
    Hypertension 56:885-92. 2010
    ..Transcriptional phenotyping is not in favor of this being an intermediate step toward the formation of aldosterone-producing adenoma...
  22. ncbi request reprint Mineralocorticoid receptor mutations are the principal cause of renal type 1 pseudohypoaldosteronism
    Lucie Pujo
    Assistance Publique Hopitaux de Paris, Hopital Europeen Georges Pompidou, Department of Genetics, Paris, France
    Hum Mutat 28:33-40. 2007
    ..The other patients without MR mutations might have different diseases resembling to PHA1 in the neonatal period, which could be identified by extensive clinical and functional exploration...
  23. ncbi request reprint Protein inhibitor of activated signal transducer and activator of transcription 1 interacts with the N-terminal domain of mineralocorticoid receptor and represses its transcriptional activity: implication of small ubiquitin-related modifier 1 modification
    Laurent Pascual Le Tallec
    Institut National de la Sante et de la Recherche Medicale, U478, Faculte de Medecine Xavier Bichat, 16 rue Henri Huchard, 75870 Paris Cedex 18, France
    Mol Endocrinol 17:2529-42. 2003
    ..Taken together, our results identify a novel function for PIAS1 which interacts with the N-terminal domain of hMR and represses its ligand-dependent transcriptional activity, at least in part, through SUMO modifications...
  24. ncbi request reprint Aldosterone-Producing Adenoma With a Somatic KCNJ5 Mutation Revealing APC-Dependent Familial Adenomatous Polyposis
    Julien Vouillarmet
    Hospices Civils de Lyon J V, J G D, C T, Centre Hospitalier Lyon Sud, Service d endocrinologie, Diabète et Obésité, 69310 Pierre Benite, France INSERM, UMRS_970 F F R, S B, E C, M C Z, Paris Cardiovascular Research Center, 75015 Paris, France Université Paris Descartes F F R, S B, E C, M C Z, Sorbonne Paris Cité, 75006 Paris, France Assistance Publique Hôpitaux de Paris F F R, M C Z, Hopital Europeen Georges Pompidou, Service de Genetique, 75015 Paris, France Hospices Civils de Lyon P L, Hopital de la Croix Rousse, Service de cardiologie, European Society of Hypertension excellence Center, 69317 Lyon, France Université de Lyon P L, CREATIS CNRS UMR5220 Inserm U1044 INSA Lyon Université Claude Bernard Lyon 1, 69100 Lyon, New York 10032
    J Clin Endocrinol Metab 101:3874-3878. 2016
    ..Recurrent somatic mutations in KCNJ5, CACNA1D, ATP1A1, and ATP2B3 have been identified in aldosterone-producing adenomas (APAs). The question as to whether they are responsible for both nodulation and aldosterone production is not solved...
  25. doi request reprint [Genetic alterations in primary aldosteronism]
    Maria Christina Zennaro
    INSERM, UMRS 970, Paris centre de recherche cardiovasculaire, 56, rue Leblanc, 75015 Paris, France Université Paris Descartes, Sorbonne Paris Cité, Paris, France Assistance Publique Hôpitaux de Paris, Service de Genetique, Hopital Europeen Georges Pompidou, Paris, France
    Med Sci (Paris) 31:389-96. 2015
    ..The possible consequences that this knowledge will have on the diagnosis and management of PA will be addressed. ..
  26. doi request reprint Activation of the hypothalamic-pituitary-adrenal axis in adults with mineralocorticoid receptor haploinsufficiency
    Brian R Walker
    British Heart Foundation Centre for Cardiovascular Science B R W, R A, Queen s Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, United Kingdom Assistance Publique Hôpitaux de Paris B E, Hopital Bichat Claude Bernard, 75018 Paris, France Unité Mixte de Recherche 1138 B E, INSERM, Centre de Recherche des Cordeliers, 75006 Paris, France Université Paris Diderot B E, Sorbonne Paris Cité, 75018 Paris, France Unité Mixte de Recherche en Santé 970 M C Z, INSERM, Paris Cardiovascular Research Center, 75015 Paris, France University Paris Descartes M C Z, Sorbonne Paris Cité, 75006 Paris, France and Assistance Publique Hôpitaux de Paris M C Z, Hopital Europeen Georges Pompidou, Service de Genetique, 75015 Paris, France
    J Clin Endocrinol Metab 99:E1586-91. 2014
    ..Mineralocorticoid receptors (MRs) contribute to the negative feedback of the hypothalamic-pituitary-adrenal (HPA) axis in rodents. Studies with MR antagonists suggest a similar role in humans...
  27. pmc Increased arterial stiffness in systemic lupus erythematosus (SLE) patients at low risk for cardiovascular disease: a cross-sectional controlled study
    Karim Sacre
    Departement de Medecine Interne, Hopital Bichat, Universite Paris Diderot, PRES Sorbonne Paris Cité, Assistance Publique Hopitaux de Paris, Paris, France INSERM U1149, Paris, France Département Hospitalo Universitaire FIRE Fibrosis, Inflammation and Remodelling in Renal and Respiratory Diseases, Paris, France
    PLoS ONE 9:e94511. 2014
    ..In conclusion, arterial stiffness is increased in SLE patients despite a low risk for CVD according to Framingham score and is associated with systolic blood pressure and glucocorticoid therapy. ..
  28. ncbi request reprint Brown adipocytes are novel sites of expression and regulation of adiponectin and resistin
    Say Viengchareun
    INSERM U478, Institut Fédératif de Recherche Claude Bernard, Faculte de Medecine Xavier Bichat, 16 rue Henri Huchard, 75018, Paris, France
    FEBS Lett 532:345-50. 2002
    ....
  29. ncbi request reprint Mineralocorticoid resistance
    Maria Christina Zennaro
    Institut National de la Sante et de la Recherche Medicale, Unité 478, Faculte de Medecine, Xavier Bichat, B P 416, 16 rue H Huchard, 75870 Paris 18, France
    Trends Endocrinol Metab 15:264-70. 2004
    ..Precise clinical diagnosis and establishment of intermediate phenotypes should be helpful for identifying other genes involved in PHA1 and gaining new insight into the regulation of sodium homeostasis...