Philippe Van de Perre
- Growth effects of exclusive breastfeeding promotion by peer counsellors in sub-Saharan Africa: the cluster-randomised PROMISE EBF trialIngunn Marie Stadskleiv Engebretsen
Centre for International Health, Department of Global Public Health and Primary Care, University of Bergen, PO Box 7804, 5020 Bergen, Norway
BMC Public Health 14:633. 2014....
- Sacroiliitis secondary to catheter-related bacteremia due to Mycobacterium abscessus (sensu stricto)Chrisléne Laurens
Centre Hospitalier Régional Universitaire CHRU de Montpellier, Département de Bactériologie Virologie, Montpellier, France
Ann Clin Microbiol Antimicrob 13:9. 2014..abscessus isolates. ..
- Vaccine efficacy: winning a battle (not war) against malariaPhilippe Van de Perre
Laboratories of Bacteriology and Virology, University Hospital of Montpellier, 34395 Montpellier Cedex 5, France
Lancet 364:1380-3. 2004
- Herpes simplex virus and HIV-1: deciphering viral synergyPhilippe Van de Perre
EA 4205 Transmission, Pathogenèse et Prévention de l Infection par le VIH, Université Montpellier 1 and Laboratories of Bacteriology and Virology, CHU Montpellier, Montpellier, France
Lancet Infect Dis 8:490-7. 2008..Strategies to control HSV2 and other herpesviruses deserve urgent attention and should become part of the HIV-1 prevention and care package...
- CD4+ T cells spontaneously producing human immunodeficiency virus type I in breast milk from women with or without antiretroviral drugsDiane Valea
Laboratoire Virologie, Centre Muraz, Bobo Dioulasso, Burkina Faso
Retrovirology 8:34. 2011..This latter viral reservoir remains, however, to be fully explored. CD4+ T cell-associated virus production in breast milk was therefore investigated...
- Long-term virological, immunological and mortality outcomes in a cohort of HIV-infected female sex workers treated with highly active antiretroviral therapy in AfricaCharlotte Huet
London School of Hygiene and Tropical Medicine LSHTM, London, UK
BMC Public Health 11:700. 2011....
- Genital warts and infection with human immunodeficiency virus in high-risk women in Burkina Faso: a longitudinal studyAndrea J Low
London School of Hygiene and Tropical Medicine, London, UK
BMC Infect Dis 11:20. 2011..We examined risk factors for genital warts in a cohort of high-risk women in Burkina Faso, in order to further describe their epidemiology...
- Viral load and physical status of human papillomavirus (HPV) 18 in cervical samples from female sex workers infected with HPV 18 in Burkina FasoAudrey Damay
Department of Virology and Pathology, Montpellier University Hospital, Montpellier, France
J Med Virol 81:1786-91. 2009..02). Both HPV 18 DNA and integrated DNA loads might represent markers of cervical lesions. Prospective evaluations are needed to establish the value of these parameters to predict high-grade lesion or lesion progression...
- Multicytokine detection improves latent tuberculosis diagnosis in health care workersPierre Alain Rubbo
Montpellier 1 University, Montpellier, France
J Clin Microbiol 50:1711-7. 2012..The performance of these biomarkers and their use in combination with TST and/or QFT, as well as the cost-effectiveness of such a diagnostic strategy, should be evaluated in further larger clinical trials...
- Viral load and genomic integration of HPV 16 in cervical samples from HIV-1-infected and uninfected women in Burkina FasoMarie Noelle Didelot Rousseau
Department of Virology, Montpellier University Hospital, Montpellier, France
J Med Virol 79:766-70. 2007..05; 95% confidence interval (CI), 1.11-328.3, P = 0.03), but not with HIV-1 or other high-risk HPV types (HR-HPV). Integrated HPV 16 DNA load may be considered as a useful marker of high-grade cervical lesions in HPV 16-infected women...
- Human milk-derived B cells: a highly activated switched memory cell population primed to secrete antibodiesEdouard Tuaillon
Unité de Recherche EA 4205, Universite Montpellier 1, and Laboratoire de Virologie, Centre Hospitalier Universitaire de Montpellier, Montpellier, France
J Immunol 182:7155-62. 2009..Breast milk B cells display a phenotype strikingly different from blood, are primed to secrete Abs, and have a mucosal homing profile similar to B cells located in gut-associated lymphoid tissue...
- The potential impact of CD4+ T cell activation and enhanced Th1/Th2 cytokine ratio on HIV-1 secretion in the lungs of individuals with advanced AIDS and active pulmonary infectionPierre Alain Rubbo
INSERM U1058, CHRU, Montpellier 1 University, Montpellier, France
Clin Immunol 139:142-54. 2011..In conclusion, the capacity of activated CD4(+) T cells to produce HIV-1 is driven by both the level and quality of cellular activation in the lung...
- Subclinical mastitis occurs frequently in association with dramatic changes in inflammatory/anti-inflammatory breast milk componentsEdouard Tuaillon
UMR Inserm U1058, EFS, Universite Montpellier 1, Montpellier, France
Pediatr Res . 2016..Mechanisms driving the emergence of SCM and changes in immunological content of human milk during SCM remains to be explored. In this study, the breast milk environment was to describe during SCM...
- Pivotal role of HIV and EBV replication in the long-term persistence of monoclonal gammopathy in patients on antiretroviral therapyDavid Eric Ouedraogo
Institut National de la Santé et de la Recherche Médicale U1058, Universite Montpellier 1, Montpellier, France
Blood 122:3030-3. 2013..Poor control of HIV replication and detectable EBV replication in plasma were both associated with long-term MG persistence in patients on ART. In the case of viral control, MG associated with HIV infection is usually transient. ..
- Increased Epstein-Barr virus in breast milk occurs with subclinical mastitis and HIV sheddingArmen Sanosyan
aUMR 1058, INSERM, Etablissement Français du Sang, Universite de Montpellier, Montpellier, France bCentre for International Health, University of Bergen, Bergen, Norway cDepartment of Paediatrics and Child health, University Teaching Hospital, School of Medicine, University of Zambia, Lusaka, Zambia dCHU Montpellier, Montpellier, France
Medicine (Baltimore) 95:e4005. 2016..SCM and decreased IL-8 responses are associated with an increased EBV shedding in breast milk which may in turn facilitate HIV replication in the mammary gland. ..
- Comparison of EBV DNA viral load in whole blood, plasma, B-cells and B-cell culture supernatantDavid Eric Ouedraogo
INSERM U1058, University of Montpellier 1, Montpellier, France Montpellier Hospital Centre, Institute of Biotherapies Research, Laboratory of Human Rare Circulating Cells, Montpellier, France Montpellier Hospital Centre, Department of Bacteriology and Virology, Paris, France
J Med Virol 86:851-6. 2014..Quantitation of EBV DNA in plasma and B-cell culture supernatant may be of interest to assess EBV reactivation dynamics and response to treatment as well as to decipher EBV host-pathogen interactions in various clinical scenarios...
- Compartment-specific HIV-1 resting T-cell reservoirsGael Petitjean
Research Unit 145 UMR 145, Institute for Research and Development IRD, and University of Montpellier 1, Montpellier, France
AIDS 20:1338-40. 2006
- Diversity of HIV-1 RNA and DNA in breast milk from HIV-1-infected mothersPierre Becquart
Research Unit 145, UMR 145, Institute for Research and Development, University of Montpellier 1, Montpellier University Hospital, Montpellier, France
Virology 363:256-60. 2007..In contrast, RNA variants detected from milk of the two breasts were mixed in 3 out of 4 mothers. This study suggests that each mammary gland is subjected to microenvironmental pressure that may differ from the contralateral breast...
- High IFN-γ Release and Impaired Capacity of Multi-Cytokine Secretion in IGRA Supernatants Are Associated with Active TuberculosisSéverine Carrère-Kremer
UMR1058 INSERM University Montpellier EFS, Montpellier, France
PLoS ONE 11:e0162137. 2016..In this way, testing cytokine profile in IGRA supernatants would be helpful to improve ATB screening strategy including immunologic tests. ..
- Lopinavir/Ritonavir versus Lamivudine peri-exposure prophylaxis to prevent HIV-1 transmission by breastfeeding: the PROMISE-PEP trial Protocol ANRS 12174Nicolas Nagot
INSERM U 1058 and CHU, Montpellier, France
BMC Infect Dis 12:246. 2012....
- Comparison of serum HBsAg quantitation by four immunoassays, and relationships of HBsAg level with HBV replication and HBV genotypesEdouard Tuaillon
Universite de Montpellier 1, INSERM Unité 1058, Montpellier, France
PLoS ONE 7:e32143. 2012..The HBsAg levels obtained by different immunoassays now need comparing and the relationships between levels of HBsAg and HBV DNA alongside HBsAg and genotype must be evaluated...
- HIV-1 co-infection prevalence in two cohorts of early HIV-1 seroconverters in FranceValerie Courgnaud
Department of Infectious Diseases, Laboratory of Virology, Montpellier University Hospital, Montpellier, France
AIDS 21:1055-6. 2007..Our results strongly suggest that HIV-1 co-infection remains a rare phenomenon in HIV-1 seroconverters infected in France between 1986 and 2004...
- ZIKA virus efficiently replicates in human retinal pigment epithelium and disturbs its permeabilitySara Salinas
UMR 1058 INSERM Université de Montpellier Etablissement Français du Sang Pathogenesis and Control of Chronic Infections, INSERM, Montpellier, France
J Virol . 2016..Recently, the Flavivirus Zika virus (ZIKV) has rapidly spread in the Americas and in the Caribbean islands.…...
- Extended pre-exposure prophylaxis with lopinavir-ritonavir versus lamivudine to prevent HIV-1 transmission through breastfeeding up to 50 weeks in infants in Africa (ANRS 12174): a randomised controlled trialNicolas Nagot
INSERM U 1058, Montpellier, France Université Montpellier, Montpellier, France CHU Montpellier, Montpellier, France
Lancet 387:566-73. 2016..We aimed to compare the efficacy and safety of infant prophylaxis with the two drug regimens (lamivudine or lopinavir-ritonavir) to prevent postnatal HIV-1 transmission up to 50 weeks of breastfeeding...
- Detection of a large T-cell reservoir able to replicate HIV-1 actively in breast milkPierre Becquart
Research Unit 145 UMR 145 Institute for Research and Development IRD and University of Montpellier 1, Montpellier, France
AIDS 20:1453-5. 2006..This observation may explain the apparent paradox of a transmissible viral infection from a body fluid with a low viral concentration...
- Early infant feeding patterns and HIV-free survival: findings from the Kesho-Bora trial (Burkina Faso, Kenya, South Africa)Amandine Cournil
From the UMI 233, Institut de Recherche pour le Developpement, Universite Montpellier 1, Montpellier, France Department of Bacteriology Virology, Institut National de la Santé et de la Recherche Médicale INSERM U1058 Université Montpellier and CHRU Montpellier, Montpellier, France Department of Reproductive Health and Research, World Health Organization, Geneva, Switzerland National Institutes of Health, Bethesda, Maryland International Centre for Reproductive Health ICRH, Mombasa, Kenya International Centre for Reproductive Health, Ghent University, Ghent, Belgium Centre Muraz, Bobo Dioulasso, Burkina Faso University of KwaZulu Natal, Durban, South Africa Africa Centre for Health and Population Studies, University of KwaZulu Natal, Somkhele, South Africa and The Kesho Bora Study Group members are listed in the Appendix
Pediatr Infect Dis J 34:168-74. 2015..To investigate the association between feeding patterns and HIV-free survival in children born to HIV-infected mothers and to clarify whether antiretroviral (ARV) prophylaxis modifies the association...
- Cumulative exposure to cell-free HIV in breast milk, rather than feeding pattern per se, identifies postnatally infected infantsDorine Neveu
Département d Information Médicale et Laboratoire de Bactériologie Virologie, Universite Montpellier 1, EA 4205 and CHU Montpellier, Montpellier, France
Clin Infect Dis 52:819-25. 2011....
- Zika Virus Strains Potentially Display Different Infectious Profiles in Human Neural CellsYannick Simonin
UMR 1058, INSERM, Universite de Montpellier, Etablissement Français du Sang Pathogenesis and Control of Chronic Infections, INSERM, Montpellier, France Université de Montpellier, Montpellier, France Electronic address
EBioMedicine 12:161-169. 2016..Our results highlight the need to better characterize the physiopathology and predict neurological impairment associated with African ZIKV...
- Cytosolic RNA:DNA Duplexes Generated by Endogenous Reverse Transcriptase Activity as Autonomous Inducers of Skin Inflammation in PsoriasisJean Pierre Moles
Inserm UMR 1058, Montpellier, France
PLoS ONE 12:e0169879. 2017..These observations open a new research avenue related to endogenous retroelements for the aetiology of psoriasis and probably of other human chronic inflammatory diseases...
- Genetic diversity and population structure of Mycobacterium marinum: new insights into host and environmental specificitiesVincent Broutin
INSERM U1058 Infection by HIV and by agents with mucocutaneous tropism from pathogenesis to prevention, Montpellier, France
J Clin Microbiol 50:3627-34. 2012..It appears that only few genotypes can produce deeper infections in humans, suggesting that the immune system might play a filtering role...
- Genetic diversity and population structure of Mycobacterium tuberculosis in HIV-1-infected compared with uninfected individuals in Burkina FasoSylvain Godreuil
Laboratoire de Bacteriologie, hôpital universitaire Arnaud de Villeneuve, Montpellier, France
AIDS 21:248-50. 2007..This study suggests a lack of structure of the MTB population caused by HIV-1 infection and a similar genetic diversity of MTB in HIV-1-infected compared with uninfected individuals...
- Transfer of antibody via mother's milkPhilippe Van de Perre
Laboratory of Bacteriology and Virology, University Hospital A de Villeneuve and Mixed Research Unit 145 UMR 145, Institute for Research and Development IRD and University of Montpellier 1, Montpellier, France
Vaccine 21:3374-6. 2003..In humans, milk excreted antibodies play a major role in protecting infants from infection by pathogens having a mucosal portal of entry...