Didier Letourneur

Summary

Affiliation: UFR SMBH
Country: France

Publications

  1. ncbi Heparin and non-heparin-like dextrans differentially modulate endothelial cell proliferation: in vitro evaluation with soluble and crosslinked polysaccharide matrices
    Didier Letourneur
    INVIMAT, X Bichat Medical School, 75018 Paris, France
    J Biomed Mater Res 60:94-100. 2002
  2. ncbi A chemically modified dextran inhibits smooth muscle cell growth in vitro and intimal in stent hyperplasia in vivo
    Jean François Deux
    INSERM ERIT M 204, X Bichat Medical School, Bat INSERM 13, 46 rue Henri Huchard, 75877 Paris Cedex 18, France
    J Vasc Surg 35:973-81. 2002
  3. ncbi Films of dextran-graft-polybutylmethacrylate to enhance endothelialization of materials
    Sidi Mohamed Derkaoui
    INSERM, U698, Bio ingénierie de Polymères Cardiovasculaires, CHU X Bichat, Université Paris Cité Paris Diderot, 75018 Paris, France
    Acta Biomater 6:3506-13. 2010
  4. doi Influence of polysaccharide composition on the biocompatibility of pullulan/dextran-based hydrogels
    Aicha Abed
    INSERM, U 698, CHU Xavier Bichat, Bât Inserm, 46 rue Henri Huchard, 75018 Paris, France
    J Biomed Mater Res A 96:535-42. 2011
  5. ncbi A new macromolecular paramagnetic MR contrast agent binds to activated human platelets
    Frederic Chaubet
    INSERM, U698, Cardiovascular Bio engineering, CHU X Bichat, University Paris 7, Paris, France
    Contrast Media Mol Imaging 2:178-88. 2007
  6. ncbi Low molecular weight fucoidan increases VEGF165-induced endothelial cell migration by enhancing VEGF165 binding to VEGFR-2 and NRP1
    Andrew C Lake
    INSERM, U 698, Bioengineering Department, X Bichat Hospital, 75018 Paris, France
    J Biol Chem 281:37844-52. 2006
  7. ncbi Heparin-like polymers modulate proinflammatory cytokine production by lipopolysaccharide-stimulated human monocytes
    Sylvie Anastase-Ravion
    LRM, Institut Galilee, University Paris 13, 93430 Villetaneuse, France
    J Biomed Mater Res 60:375-83. 2002
  8. doi A biocompatible polysaccharide hydrogel-embedded polypropylene mesh for enhanced tissue integration in rats
    Aicha Abed
    INSERM U 698, CHU Xavier Bichat, Bât Inserm, Paris, France
    Tissue Eng Part A 14:519-27. 2008
  9. ncbi Aortic aneurysms in a rat model: in vivo MR imaging of endovascular cell therapy
    Jean François Deux
    INSERM U 698, Bioengineering Department, University Paris 7 University Paris 13, X Bichat Hospital, Paris, France
    Radiology 246:185-92. 2008
  10. ncbi Inhibition of MMP-2 gene expression with small interfering RNA in rabbit vascular smooth muscle cells
    Hanna Hlawaty
    Institut National de la Santé et de la Recherche Médicale U698, Universite Paris 7, F75018 Paris, France
    Am J Physiol Heart Circ Physiol 293:H3593-601. 2007

Collaborators

  • Delphine Machy
  • Eric Lancelot
  • Jean Pierre Laissy
  • C Corot
  • Benjamin Richard
  • Gisela D'Angelo
  • Aurélie San Juan
  • Jean François Deux
  • Aicha Abed
  • Laurent J Feldman
  • Liliane Louedec
  • Catherine Le Visage
  • Anne Meddahi-Pellé
  • Frederic Chaubet
  • Sidi Mohamed Derkaoui
  • Isabelle Bataille
  • Hanna Hlawaty
  • Sylvie Anastase-Ravion
  • Aude Autissier
  • Marie Paule Jacob
  • Sylvia Colliec-Jouault
  • Patrick Portes
  • Nabila Assoul
  • Jean Baptiste Michel
  • Dominique Henin
  • Noélie Brunehilde Thébaud
  • Andrew C Lake
  • Karim Senni
  • Marc Chaouat
  • Fabien Hyafil
  • Frank P Boudghene
  • Jean Guezennec
  • Charles Edouard Luyt
  • Claire Parisel
  • Nicole Haeffner-Cavaillon
  • Catherine Blondin
  • Maguette Ba
  • Patrice Flaud
  • Amélie Labbé
  • Thierry Avramoglou
  • Virginie Gueguen
  • Agung Purnama
  • Christel Barbaud
  • Eric Allaire
  • Florence Gazeau
  • Jiangping Dai
  • Jean Noel Pons
  • Jacky Roger
  • Philippe Meric
  • Charlotte Rivière
  • Bruno Deval
  • Brigitte Gillet
  • Charaf Zahir
  • Ziad Touat
  • Ramin Bazeli
  • Reine Bareille
  • Erwann Guenin
  • Jean Michel Serfaty
  • Roger Vranckx
  • Pascale Even
  • Emmanuelle Canet-Soulas
  • Martine Jandrot-Perrus
  • Vladimir A Izumrudov
  • Gregory Ducrocq
  • Dorothée Pierron
  • Isabelle Bertholon
  • Hasan Alsaid
  • Laurence Bordenave
  • Laure Bachelet
  • Mikael Mazighi
  • Farida Gueniche
  • Didier Tchetche
  • Alexandrine Foucault-Bertaud
  • Damien Lavigne
  • Mélanie Di Benedetto
  • Sylvie Igondjo-Tchen
  • Roger Vassy
  • Florence Fioretti
  • Gaston Godeau
  • Gérard Y Perret
  • Sylvie Chillon
  • Patrick Durand
  • Homa Adle-Biassette
  • John J Castellot
  • Mary Osborne-Pellegrin
  • Eric Perrier
  • Valérie André
  • Liliane Gattegno
  • Line Saffar
  • Herve Prats

Detail Information

Publications22

  1. ncbi Heparin and non-heparin-like dextrans differentially modulate endothelial cell proliferation: in vitro evaluation with soluble and crosslinked polysaccharide matrices
    Didier Letourneur
    INVIMAT, X Bichat Medical School, 75018 Paris, France
    J Biomed Mater Res 60:94-100. 2002
    ..From the obtained results, we propose that the synthetic non-heparin-like dextran may be of interest as a coating for the endothelialization of cardiovascular biomaterials...
  2. ncbi A chemically modified dextran inhibits smooth muscle cell growth in vitro and intimal in stent hyperplasia in vivo
    Jean François Deux
    INSERM ERIT M 204, X Bichat Medical School, Bat INSERM 13, 46 rue Henri Huchard, 75877 Paris Cedex 18, France
    J Vasc Surg 35:973-81. 2002
    ..We have investigated the capacity of a water-soluble nonanticoagulant functionalized dextran (E9) in inhibition of SMC growth in vitro and in vivo...
  3. ncbi Films of dextran-graft-polybutylmethacrylate to enhance endothelialization of materials
    Sidi Mohamed Derkaoui
    INSERM, U698, Bio ingénierie de Polymères Cardiovasculaires, CHU X Bichat, Université Paris Cité Paris Diderot, 75018 Paris, France
    Acta Biomater 6:3506-13. 2010
    ..Therefore, a potential benefit of this approach is the availability of surfaces with tunable properties for the endothelialization of materials...
  4. doi Influence of polysaccharide composition on the biocompatibility of pullulan/dextran-based hydrogels
    Aicha Abed
    INSERM, U 698, CHU Xavier Bichat, Bât Inserm, 46 rue Henri Huchard, 75018 Paris, France
    J Biomed Mater Res A 96:535-42. 2011
    ..This in vitro and in vivo data can be used in the design of hydrogels appropriate for tissue engineering applications...
  5. ncbi A new macromolecular paramagnetic MR contrast agent binds to activated human platelets
    Frederic Chaubet
    INSERM, U698, Cardiovascular Bio engineering, CHU X Bichat, University Paris 7, Paris, France
    Contrast Media Mol Imaging 2:178-88. 2007
    ....
  6. ncbi Low molecular weight fucoidan increases VEGF165-induced endothelial cell migration by enhancing VEGF165 binding to VEGFR-2 and NRP1
    Andrew C Lake
    INSERM, U 698, Bioengineering Department, X Bichat Hospital, 75018 Paris, France
    J Biol Chem 281:37844-52. 2006
    ..These findings suggested an efficient mechanism of action of LMWF by promoting VEGF(165) binding to VEGFR-2 and NRP1 on ECs that could help in stimulating therapeutic revascularization...
  7. ncbi Heparin-like polymers modulate proinflammatory cytokine production by lipopolysaccharide-stimulated human monocytes
    Sylvie Anastase-Ravion
    LRM, Institut Galilee, University Paris 13, 93430 Villetaneuse, France
    J Biomed Mater Res 60:375-83. 2002
    ..Indeed, such polysaccharides, by regulating monocyte activation, could contribute to the improved biocompatibility of implants...
  8. doi A biocompatible polysaccharide hydrogel-embedded polypropylene mesh for enhanced tissue integration in rats
    Aicha Abed
    INSERM U 698, CHU Xavier Bichat, Bât Inserm, Paris, France
    Tissue Eng Part A 14:519-27. 2008
    ..Thus, this new synthetic biocompatible HM with suitable properties for tissue repair appears to be a promising material for clinical applications...
  9. ncbi Aortic aneurysms in a rat model: in vivo MR imaging of endovascular cell therapy
    Jean François Deux
    INSERM U 698, Bioengineering Department, University Paris 7 University Paris 13, X Bichat Hospital, Paris, France
    Radiology 246:185-92. 2008
    ..To prospectively evaluate in rats whether magnetic cell labeling can be used to noninvasively assess the technical success of endovascular cell therapy for abdominal aortic aneurysms (AAAs)...
  10. ncbi Inhibition of MMP-2 gene expression with small interfering RNA in rabbit vascular smooth muscle cells
    Hanna Hlawaty
    Institut National de la Santé et de la Recherche Médicale U698, Universite Paris 7, F75018 Paris, France
    Am J Physiol Heart Circ Physiol 293:H3593-601. 2007
    ....
  11. ncbi Tubular cationized pullulan hydrogels as local reservoirs for plasmid DNA
    Aurélie San Juan
    INSERM, U698, Bio ingénierie Cardiovasculaire, Universite Paris 7, Paris, F 75018, Institut Galilee, Universite Paris 13, Villetaneuse, F 93430, France
    J Biomed Mater Res A 83:819-27. 2007
    ..Hence, cationized pullulan hydrogels can be designed as tubular structures with high affinity for plasmid DNA, which may provide new biomaterials to enhance the efficiency of local arterial gene transfer strategies...
  12. ncbi Quaternized poly(4-vinylpyridine)s as model gene delivery polycations: structure-function study by modification of side chain hydrophobicity and degree of alkylation
    Aurélie San Juan
    INSERM, U698, Department of Bioengineering, X Bichat Hospital, University Paris 7, Paris, F 75018, France
    Bioconjug Chem 18:922-8. 2007
    ..The data demonstrate the advantages of partial alkylation of tertiary polyamines with medium-length alkyl agents for preparation of efficient nonviral gene delivery vectors...
  13. ncbi Human endothelial progenitor cell attachment to polysaccharide-based hydrogels: a pre-requisite for vascular tissue engineering
    Noélie Brunehilde Thébaud
    INSERM, U577, Bordeaux, F 33076 France
    J Mater Sci Mater Med 18:339-45. 2007
    ..This pullulan-based hydrogel could constitute a suitable support for vascular cell adhesion as a pre-requisite for vascular tissue engineering...
  14. ncbi Pullulan-based hydrogel for smooth muscle cell culture
    Aude Autissier
    INSERM U698, Bio ingénierie Cardiovasculaire, CHU X Bichat, Paris, F 75018, France
    J Biomed Mater Res A 82:336-42. 2007
    ..Based on these promising results, future studies will focus on the seeding of vascular cells on tubular-shaped hydrogels and the in vivo implantation of these new biomaterials...
  15. ncbi Low molecular weight fucoidan prevents neointimal hyperplasia in rabbit iliac artery in-stent restenosis model
    Jean François Deux
    ERIT M 0204 INSERM, X Bichat Hospital, University Paris VII, Paris, France
    Arterioscler Thromb Vasc Biol 22:1604-9. 2002
    ..We studied a low molecular weight (LMW) fucoidan (sulfated polysaccharide from brown seaweed) on SMC proliferation in vitro and intimal hyperplasia in vivo...
  16. ncbi The evaluation of a small-diameter polysaccharide-based arterial graft in rats
    Marc Chaouat
    INSERM, U698, Bio ingénierie Cardiovasculaire, CHU Xavier Bichat, Bât Inserm, 46 rue Henri Huchard, F 75877 Paris Cedex 18, France
    Biomaterials 27:5546-53. 2006
    ..In conclusion, we described a 2mm polysaccharide-based arterial material being investigated in vivo and demonstrating patency for up to 8 weeks post-surgery with neointima formation and absence of intimal hyperplasia...
  17. ncbi Modulation of protease nexin-1 activity by polysaccharides
    Benjamin Richard
    INSERM U698, CHU Xavier Bichat, 46 rue Henri Huchard, 75877 Paris, France
    Thromb Haemost 95:229-35. 2006
    ..The capacity of PN-1 to regulate the pericellular activity of thrombin amongst other proteases reinforces the therapeutical interest of fucoidans...
  18. ncbi Fucoidan a sulfated polysaccharide from brown algae is a potent modulator of connective tissue proteolysis
    Karim Senni
    Universite Paris Descartes, Faculte de Chirurgie Dentaire, EA2496 Réparations et Remodelages Oro faciaux, Montrouge, France
    Arch Biochem Biophys 445:56-64. 2006
    ..These results suggested that fucoidan could be used for treating some inflammatory pathologies in which uncontrolled extracellular matrix degradation takes place...
  19. ncbi Ferumoxtran-10-enhanced MRI of the hypercholesterolemic rabbit aorta: relationship between signal loss and macrophage infiltration
    Fabien Hyafil
    INSERM U698, Hopital Bichat, Assistance Publique Hopitaux de Paris, Paris, France
    Arterioscler Thromb Vasc Biol 26:176-81. 2006
    ..We evaluated the ability of ferumoxtran-10-enhanced MRI to quantify focal macrophage infiltration in the aortic wall of hypercholesterolemic rabbits...
  20. ncbi Interactions of heparin with human skin cells: binding, location, and transdermal penetration
    Claire Parisel
    INSERM ERIT M 0204, X Bichat Hospital, University Paris VII and University Paris XIII, 75877 Paris Cedex 18, France
    J Biomed Mater Res A 67:517-23. 2003
    ..Altogether, our results describe the affinity of heparin for human skin cells and suggest it may be an excellent candidate for use in the skin delivery of drugs or cosmetics and also as an active component in engineered skin...
  21. ncbi Heparin inhibits lipopolysaccharide (LPS) binding to leukocytes and LPS-induced cytokine production
    Sylvie Anastase-Ravion
    INSERM ERIT M 0204, X Bichat Hospital, Bat INSERM 13, Universities Paris VII and XIII, 46 Rue H Huchard, 75877 Paris Cedex 18, France
    J Biomed Mater Res A 66:376-84. 2003
    ..heparin inhibits the binding of LPS to cells via a CD14-independent pathway. This study suggests a potentially important therapeutic application for heparin or heparin analogs to prevent inflammation with biomaterials...
  22. ncbi Low-molecular-weight fucoidan promotes therapeutic revascularization in a rat model of critical hindlimb ischemia
    Charles Edouard Luyt
    Institut National de la Santé et de la Recherche Médicale U460, CHU X Bichat, Paris, France
    J Pharmacol Exp Ther 305:24-30. 2003
    ..001). Thus, LMW fucoidan potentiates FGF-2 activity, mobilizes SDF-1, and facilitates angiogenesis in a rat model. This natural compound could be of interest as an alternative for conventional treatment in critical ischemia...