Genomes and Genes
- A short synthetic peptide inhibits signal transduction, migration and angiogenesis mediated by Tie2 receptorRoselyne Tournaire
Institute of Signalling, Developmental Biology and Cancer, CNRS UMR 6543, Centre Antoine Lacassagne, 33 Avenue de Valombrose, 06189 Nice cedex, France
EMBO Rep 5:262-7. 2004..It also represents a potent tool to dissect the molecular mechanisms involved in the Tie2 pathway...
- Identification of a peptide blocking vascular endothelial growth factor (VEGF)-mediated angiogenesisR Binétruy-Tournaire
Universite Paris XIII, UFR Leonard de Vinci, UPRES 2360, Ciblage Fonctionnel des Tumeurs Solides, 74 rue Marcel Cachin, 93017 Bobigny Cedex, France
EMBO J 19:1525-33. 2000..Taken together, these data demonstrate that ATWLPPR is an effective antagonist of VEGF binding, and suggest that this peptide may be a potent inhibitor of tumor angiogenesis and metastasis...
- The angiopoietin-2 gene of endothelial cells is up-regulated in hypoxia by a HIF binding site located in its first intron and by the central factors GATA-2 and Ets-1Marie Pierre Simon
Institute of Signaling, Developmental Biology and Cancer Research, CNRS UMR 6543, University of Nice, Centre A Lacassagne, Nice, France
J Cell Physiol 217:809-18. 2008..In conclusion, our study provides new elements in favor of HIF involvement in Ang-2 hypoxic regulation and identifies Ets-1 and particularly GATA-2 as central factors in endothelial specific Ang-2 expression...