Genomes and Genes
- High occurence of DRB1 11 in chronic lymphocytic leukaemia familiesIoannis Theodorou
Laboratoire Central d Immunologie Cellulaire Hôpital Pitié Salpêtrière, INSERM U550 Génétique Humaine des Maladies Infectieuses, Hopital Necker Enfants Malades, Paris, France
Br J Haematol 119:713-5. 2002..009). A similar trend was also observed in a second series of nine French families (P = 0.002). Larger studies are needed to determine whether non-inherited paternal or maternal DRB1 antigens play a role in familial CLL development...
- Genome-wide association study identifies variants associated with progression of liver fibrosis from HCV infectionEtienne Patin
Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Necker Medical School, INSERM Unité 980, Paris, France
Gastroenterology 143:1244-52.e1-12. 2012..Only a fraction of patients with chronic HCV infection develop liver fibrosis, a process that might also be affected by genetic factors. We performed a 2-stage GWA study of liver fibrosis progression related to HCV infection...
- Impact of IL28B, APOH and ITPA Polymorphisms on Efficacy and Safety of TVR- or BOC-Based Triple Therapy in Treatment-Experienced HCV-1 Patients with Compensated Cirrhosis from the ANRS CO20-CUPIC StudyFrédégonde About
Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale INSERM U1163, Paris, France
PLoS ONE 10:e0145105. 2015..We explored the role of IL28B, APOH and ITPA SNPs on the outcomes of triple therapy including telaprevir or boceprevir in patients with compensated cirrhosis chronically infected with HCV-1...
- A new 3p25 locus is associated with liver fibrosis progression in human immunodeficiency virus/hepatitis C virus-coinfected patientsDamien Ulveling
Equipe Genomique, Bioinformatique et Applications EA4627, Chaire de Bioinformatique, Conservatoire National des Arts et Metiers, Paris, France
Hepatology 64:1462-1472. 2016..The second signal, obtained with rs11790131 (P = 9.3 × 10-9 ) on chromosome region 9p22, was not replicated...
- Combined linkage and association studies show that HLA class II variants control levels of antibodies against Epstein-Barr virus antigensVincent Pedergnana
Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Sante et de la Recherche Medicale, Paris, France University Paris Descartes, Sorbonne Paris Cité, Imagine Institute, Paris, France
PLoS ONE 9:e102501. 2014..02). In summary, this study shows that HLA class II variants influenced anti-EBNA-1 IgG titers in a European population. It further shows the role of the same variants in the risk of HL...
- Analysis of IL28B variants in an Egyptian population defines the 20 kilobases minimal region involved in spontaneous clearance of hepatitis C virusVincent Pedergnana
Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale U980, Paris, France
PLoS ONE 7:e38578. 2012..HCV clearance in Egypt was associated with a region of IL28B smaller than that identified in European populations, and involved the non-synonymous IL28B SNP, rs8103142...
- FAS promoter polymorphisms correlate with activity grade in hepatitis C patientsDorian McIlroy
Laboratoire d Immunologie Cellulaire et Tissulaire bService de Gastroentérologie, Hopital Pitie Salpetriere, Paris, France
Eur J Gastroenterol Hepatol 17:1081-8. 2005..Hepatocytes are susceptible to FAS-mediated apoptosis. The impact of polymorphisms in the FAS gene on histopathological features of HCV infection was therefore investigated...
- Genomewide association study of a rapid progression cohort identifies new susceptibility alleles for AIDS (ANRS Genomewide Association Study 03)Sigrid Le Clerc
Conservatoire National des Arts et Metiers, Paris, France
J Infect Dis 200:1194-201. 2009..The discovery of genetic factors that predispose individuals to rapid progression to AIDS should also reveal new insights into the molecular etiology of the pathology...
- Deleterious genetic influence of CX3CR1 genotypes on HIV-1 disease progressionSophie Faure
INSERM U543, Hopital Salpetriere, Paris, France
J Acquir Immune Defic Syndr 32:335-7. 2003..These results may explain the conflicting results published on the impact of CX3CR1 polymorphism in seroconverters...
- Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02)Sophie Limou
Conservatoire National des Arts et Metiers, Universite Paris 7, Paris, France
J Infect Dis 199:419-26. 2009..The present study, the first GWAS of HIV-1 nonprogressors, underscores the potential for some HLA genes to control disease progression soon after infection...
- CCR5Delta32 protein expression and stability are critical for resistance to human immunodeficiency virus type 1 in vivoLokesh Agrawal
Indiana University School of Medicine, Department of Microbiology and Immunology, 635 Barnhill Drive, Room 420, Indianapolis, IN 46202, USA
J Virol 81:8041-9. 2007..The results also suggest that other cellular or virally induced factors may be involved in the stability of CCR5Delta32 protein...
- Identification of the CCR5-Delta32 HIV resistance allele and new mutations of the CCR5 gene in different Tunisian populationsAsma Jlizi
Laboratoire de Genetique, Immunologie et Pathologies Humaines, Faculte des Sciences de Tunis, Universite Tunis El Manar, Tunis, Tunisie
Hum Immunol 68:993-1000. 2007..The frequency of the CCR5-Delta32 variant was significantly different between the two groups, leading us to conclude that this mutation might confer protection against HIV infection in Tunisian populations...
- A triple-mutated allele of granzyme B incapable of inducing apoptosisDorian McIlroy
Laboratoire d Immunologie Cellulaire et Tissulaire, Institut National de la Sante et de la Recherche Medicale U543, Faculté de Médecine Pitié Salpêtrière, 75013 Paris, France
Proc Natl Acad Sci U S A 100:2562-7. 2003....