- Imaging central nervous system myelin by positron emission tomography in multiple sclerosis using [methyl-¹¹C]-2-(4'-methylaminophenyl)- 6-hydroxybenzothiazoleBruno Stankoff
INSERM, U975, Paris, France Faculty of Medicine, Pierre and Marie Curie University, Paris, France
Ann Neurol 69:673-80. 2011..Here we questioned whether the thioflavine-T derivative 2-(4'-methylaminophenyl)-6-hydroxybenzothiazole (PIB), which also binds to amyloid plaques, could serve as a myelin marker...
- The neuronal component of gray matter damage in multiple sclerosis: A [(11) C]flumazenil positron emission tomography studyLeorah Freeman
Sorbonne Universités, UPMC Univ Paris 06, UMR S 1127, and CNRS UMR 7225, and ICM, Paris, France
Ann Neurol 78:554-67. 2015..We investigated the relationship between neuronal damage and white matter (WM) lesions and evaluated the clinical relevance of this neuronal PET metric...
- Improved survival of HIV-1-infected patients with progressive multifocal leukoencephalopathy receiving early 5-drug combination antiretroviral therapyJacques Gasnault
Service de médecine interne et de maladies infectieuses, Hôpital Universitaire de Bicêtre Assistance Publique Hôpitaux de Paris, Le Kremlin Bicetre, France
PLoS ONE 6:e20967. 2011..We conducted a multicenter, open-label pilot trial evaluating the survival benefit of a five-drug cART designed to accelerate HIV replication decay and JCV-specific immune recovery...
- Imaging of CNS myelin by positron-emission tomographyBruno Stankoff
Institut National de la Sante et de la Recherche Medicale, U711, Hopital de la Salpetriere, F 75013 Paris, France
Proc Natl Acad Sci U S A 103:9304-9. 2006..Our results provide a perspective for developing a brain myelin imaging technique by positron-emission tomography...
- A novel fluorescent probe that is brain permeable and selectively binds to myelinChunying Wu
Department of Medical Chemistry and Pharmacognosy, University of Illinois at Chicago, USA, and Biologie des Interactions Neurones Glie, Hopital de la Salpetriere, Paris, France
J Histochem Cytochem 54:997-1004. 2006..These studies justified further investigation of BDB as a potential myelin-imaging probe to monitor myelin pathology in vivo...
- Promoting repair in multiple sclerosis: problems and prospectsCatherine Lubetzki
Federation de Neurologie, Hopital de la Salpetriere, Universite Pierre et Marie Curie, Paris, France
Curr Opin Neurol 18:237-44. 2005..We review recent breakthroughs in this field and discuss their putative applications to therapy...
- Biotinidase deficiency mimicking neuromyelitis optica: Initially exhibiting symptoms in adulthoodLaure Bottin
Department of Neurology, Saint Antoine University Hospital, Paris, France
Mult Scler 21:1604-7. 2015..Older children and adolescents can exhibit predominant neurological deficits including para- or tetraparesis and vision loss...
- Brain networks disconnection in early multiple sclerosis cognitive deficits: an anatomofunctional studyCéline Louapre
Universite Pierre et Marie Curie Paris 6, Centre de Recherche de l Institut du Cerveau et de la Moelle Epiniere, UMR S975, Paris, F 75013, France INSERM, U975, Paris, F 75013, France CNRS, UMR 7225, Paris, France AP HP, Hopital de la Salpetriere, Hopital Tenon, F 75020, Paris, France
Hum Brain Mapp 35:4706-17. 2014..Disconnection in the DMN and ATT networks may deprive the brain of compensatory mechanisms required to face widespread structural damage...
- Unilateral thalamic deep brain stimulation for disabling kinetic tremor in multiple sclerosisHassan Hosseini
Department of Neurology and Neurosurgery, CHU Henri Mondor, Creteil, France
Neurosurgery 70:66-9. 2012..Surgical options of multiple sclerosis (MS) tremor treatment are limited and narrowed to thalamotomy or deep brain stimulation of the thalamic nucleus ventralis intermedius. Lack of qualification protocol frequently results in poor outcome...
- Association of Caspr/paranodin with tumour suppressor schwannomin/merlin and beta1 integrin in the central nervous systemNatalia Denisenko-Nehrbass
INSERM UPMC U536, Institut du Fer a Moulin, Paris, France
J Neurochem 84:209-21. 2003..Since integrin beta1 and schwannomin do not appear to be enriched in paranodes they may be quantitatively minor partners of paranodin in these regions and/or be associated with paranodin at other locations...