Remy Sadoul

Summary

Country: France

Publications

  1. pmc Autophagy discriminates between Alix and ESCRTs
    Anne Petiot
    INSERM U836 and Université Joseph Fourier, Grenoble Institute of Neurosciences GIN, Grenoble, France
    Autophagy 5:106-7. 2009
  2. doi request reprint Alix is involved in caspase 9 activation during calcium-induced apoptosis
    Flavie Strappazzon
    INSERM U836, Grenoble, France
    Biochem Biophys Res Commun 397:64-9. 2010
  3. pmc Emerging role of neuronal exosomes in the central nervous system
    Mathilde Chivet
    U836, Equipe 2, Neurodégénérescence et Plasticité, INSERM Grenoble, France
    Front Physiol 3:145. 2012
  4. ncbi request reprint Do Alix and ALG-2 really control endosomes for better or for worse?
    Remy Sadoul
    Neurodégénérescence et Plasticité, E0108, INSERM Université Joseph Fourier, Grenoble, France
    Biol Cell 98:69-77. 2006
  5. doi request reprint Alix differs from ESCRT proteins in the control of autophagy
    Anne Petiot
    INSERM U836, Grenoble Institute of Neuroscience, F 38042 Grenoble, France
    Biochem Biophys Res Commun 375:63-8. 2008
  6. pmc Alix and ALG-2 are involved in tumor necrosis factor receptor 1-induced cell death
    Anne Laure Mahul-Mellier
    INSERM, U836, Equipe 2, Neurodégénérescence et Plasticité, Grenoble F 38042, France
    J Biol Chem 283:34954-65. 2008
  7. doi request reprint Alix and ALG-2 make a link between endosomes and neuronal death
    Anne Laure Mahul-Mellier
    INSERM, U836, Equipe 2, Neurodégénérescence et Plasticité, Grenoble, F 38042, France
    Biochem Soc Trans 37:200-3. 2009
  8. doi request reprint Release of exosomes from differentiated neurons and its regulation by synaptic glutamatergic activity
    Gaelle Lachenal
    INSERM, U836, Equipe 2, Neurodégénérescence et Plasticité, Grenoble, France
    Mol Cell Neurosci 46:409-18. 2011
  9. pmc Charged multivesicular body protein 2B (CHMP2B) of the endosomal sorting complex required for transport-III (ESCRT-III) polymerizes into helical structures deforming the plasma membrane
    Gilles Bodon
    INSERM, U836, Equipe 2, Neurodégénérescence et Plasticité, Grenoble F 38042, France
    J Biol Chem 286:40276-86. 2011
  10. doi request reprint Exosomes as a novel way of interneuronal communication
    Mathilde Chivet
    INSERM, U836, Equipe 2, Neurodégénérescence et Plasticité, Grenoble, France
    Biochem Soc Trans 41:241-4. 2013

Collaborators

  • S Fraboulet
  • Laurent Fagni
  • Alexandre Bouron
  • Winfried Weissenhorn
  • Yohann Coute
  • Beatrice Blot
  • Anne Petiot
  • Karin Pernet-Gallay
  • Mathilde Chivet
  • Christine Chatellard-Causse
  • Flavie Strappazzon
  • Yves Goldberg
  • Gilles Bodon
  • Agnès Belly
  • Jean Marc Verna
  • Sakina Torch
  • Anne Laure Mahul-Mellier
  • Romain Chassefeyre
  • Fiona Hemming
  • Vincent Mercier
  • Gaelle Lachenal
  • Olivier Destaing
  • Christophe Lamaze
  • Yasmina Saoudi
  • Cédric M Blouin
  • Marine H Laporte
  • Christine Chatellard
  • Corinne Albiges-Rizo
  • Marine Laporte
  • Federica Bertaso
  • Nathalie Bouquier
  • Adrian M Isaacs
  • Jose Martínez-Hernández
  • Anny Devoy
  • Charlotte Javalet
  • Karine Laulagnier
  • Fiona J Hemming
  • Grégory Effantin
  • David Lutje Hulsik
  • Guy Schoehn
  • Georg Haase
  • Nicolas Martinelli
  • Chantal Thibert
  • David Béal
  • Kimberley Freeman
  • Loriane Kuhn
  • Jerome Garin

Detail Information

Publications14

  1. pmc Autophagy discriminates between Alix and ESCRTs
    Anne Petiot
    INSERM U836 and Université Joseph Fourier, Grenoble Institute of Neurosciences GIN, Grenoble, France
    Autophagy 5:106-7. 2009
    ..ESCRT protein activity therefore needs Alix for viral budding and cytokinesis but not for autophagy. The function of ESCRT can thus be clearly be disconnected from that of Alix...
  2. doi request reprint Alix is involved in caspase 9 activation during calcium-induced apoptosis
    Flavie Strappazzon
    INSERM U836, Grenoble, France
    Biochem Biophys Res Commun 397:64-9. 2010
    ..Altogether, our findings identify, for the first time, Alix as a crucial mediator of Ca(2+) induced caspase 9 activation...
  3. pmc Emerging role of neuronal exosomes in the central nervous system
    Mathilde Chivet
    U836, Equipe 2, Neurodégénérescence et Plasticité, INSERM Grenoble, France
    Front Physiol 3:145. 2012
    ..They might also allow spreading across the nervous system of pathological proteins like PrPsc, APP fragments, phosphorylated Tau, or Alpha-synuclein...
  4. ncbi request reprint Do Alix and ALG-2 really control endosomes for better or for worse?
    Remy Sadoul
    Neurodégénérescence et Plasticité, E0108, INSERM Université Joseph Fourier, Grenoble, France
    Biol Cell 98:69-77. 2006
    ..In this review I develop the hypothesis that the normal function of Alix in the endolysosomal system may be deviated by ALG-2 towards a destructive role during active cell death...
  5. doi request reprint Alix differs from ESCRT proteins in the control of autophagy
    Anne Petiot
    INSERM U836, Grenoble Institute of Neuroscience, F 38042 Grenoble, France
    Biochem Biophys Res Commun 375:63-8. 2008
    ..Furthermore, they reinforce the conclusion of other studies demonstrating that the role of Alix is different from that of classical ESCRT proteins...
  6. pmc Alix and ALG-2 are involved in tumor necrosis factor receptor 1-induced cell death
    Anne Laure Mahul-Mellier
    INSERM, U836, Equipe 2, Neurodégénérescence et Plasticité, Grenoble F 38042, France
    J Biol Chem 283:34954-65. 2008
    ..Taken together, these results highlight Alix and ALG-2 as new actors of the TNF-R1 pathway...
  7. doi request reprint Alix and ALG-2 make a link between endosomes and neuronal death
    Anne Laure Mahul-Mellier
    INSERM, U836, Equipe 2, Neurodégénérescence et Plasticité, Grenoble, F 38042, France
    Biochem Soc Trans 37:200-3. 2009
    ....
  8. doi request reprint Release of exosomes from differentiated neurons and its regulation by synaptic glutamatergic activity
    Gaelle Lachenal
    INSERM, U836, Equipe 2, Neurodégénérescence et Plasticité, Grenoble, France
    Mol Cell Neurosci 46:409-18. 2011
    ..Thus, our study paves the way towards the demonstration that exosomes take part in the physiology of the normal and pathological nervous system...
  9. pmc Charged multivesicular body protein 2B (CHMP2B) of the endosomal sorting complex required for transport-III (ESCRT-III) polymerizes into helical structures deforming the plasma membrane
    Gilles Bodon
    INSERM, U836, Equipe 2, Neurodégénérescence et Plasticité, Grenoble F 38042, France
    J Biol Chem 286:40276-86. 2011
    ..Thus, our observation that CHMP2B polymerization scaffolds membranes in vivo represents a first step toward demonstrating its structural role during outward membrane deformation...
  10. doi request reprint Exosomes as a novel way of interneuronal communication
    Mathilde Chivet
    INSERM, U836, Equipe 2, Neurodégénérescence et Plasticité, Grenoble, France
    Biochem Soc Trans 41:241-4. 2013
    ....
  11. ncbi request reprint Expression of Alix protein during early avian development
    Sandrine Fraboulet
    Laboratoire Neurodégénérescence et Plasticité, INSERM UJF EMI 0108, Hopital A Michallon, CHU, BP 217, 38043 Grenoble Cedex 9, France
    Gene Expr Patterns 3:139-42. 2003
    ..This first demonstration of Alix modulation during development suggests a role for the protein in early phases of motoneuron and muscle growth and differentiation...
  12. pmc Regulation of postsynaptic function by the dementia-related ESCRT-III subunit CHMP2B
    Romain Chassefeyre
    Institut National de la Sante et de la Recherche Medicale INSERM, Unite 836, F 38042 Grenoble, France, Université Grenoble Alpes, Grenoble Institut des Neurosciences GIN, F 38042 Grenoble, France
    J Neurosci 35:3155-73. 2015
    ..We propose that synaptic ESCRT-III filaments may function as a novel element of the submembrane cytoskeleton of spines. ..
  13. pmc ALG-2 interacting protein-X (Alix) is essential for clathrin-independent endocytosis and signaling
    Vincent Mercier
    Institut National de la Sante et de la Recherche Medicale INSERM, Unité 1216, F 38042 Grenoble, France
    Sci Rep 6:26986. 2016
    ..In addition to characterizing a new function for Alix, our results highlight Alix ko cells as a unique tool to unravel the biological consequences of CIE. ..
  14. pmc CHMP2B mutants linked to frontotemporal dementia impair maturation of dendritic spines
    Agnès Belly
    INSERM, Research Centre U836, F 38042 Grenoble, France
    J Cell Sci 123:2943-54. 2010
    ..Thus, CHMP2B is required for spine growth. Taken together, these results demonstrate that a mutant ESCRT-III subunit linked to a human neurodegenerative disease can disrupt the normal pattern of spine development...