Pierre Ronco

Summary

Country: France

Publications

  1. doi request reprint Membranous nephropathy: A fairy tale for immunopathologists, nephrologists and patients
    Pierre Ronco
    Sorbonne Universités, UPMC Univ Paris 06, Paris F 75005, France INSERM, UMR_S 1155, Paris F 75020, France AP HP, Hopital Tenon, Department of Nephrology and Dialysis, Paris F 75020, France Electronic address
    Mol Immunol 68:57-62. 2015
  2. doi request reprint Pathophysiological advances in membranous nephropathy: time for a shift in patient's care
    Pierre Ronco
    Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1155, Paris, France INSERM, UMR_S 1155, Paris, France AP HP, Department of Nephrology and Dialysis, Hopital Tenon, Paris, France Electronic address
    Lancet 385:1983-92. 2015
  3. ncbi request reprint [Anti-CD 10 maternal-fetal allo-immunisation]
    Pierre Ronco
    Unité INSERM UMR S 702, UPMC Universite Paris 6, Assistance Publique Hopitaux de Paris, Hopital Tenon, Paris
    Bull Acad Natl Med 196:1613-22; discussion 1622-3. 2012
  4. doi request reprint Ig-related renal disease in lymphoplasmacytic disorders: an update
    Pierre Ronco
    Assistance Publique Hopitaux de Paris, Hopital Tenon, Service de Néphrologie et Dialyses, Paris, France
    Semin Nephrol 30:557-69. 2010
  5. doi request reprint [Idiopathic and secondary membranous nephropathies]
    Pierre Ronco
    UPMC Universite Paris 6, Tenon Hospital, INSERM UMR_S702, 75970 Paris Cedex 20, France
    Presse Med 41:290-7. 2012
  6. doi request reprint [Kidney diseases: new issues]
    Pierre Ronco
    Inserm UMRS702, Tenon Hospital, UPMC Universite Paris 6, 75970 Paris Cedex 20, France
    Presse Med 41:240-6. 2012
  7. doi request reprint Genetic inhibition of discoidin domain receptor 1 protects mice against crescentic glomerulonephritis
    Monique Kerroch
    INSERM UMR S 702, Service de Néphrologie et Dialyses, Hopital Tenon, Assistance Publique Hopitaux de Paris, Université Pierre et Marie Curie UPMC, Paris 6 University, 75020 Paris, France
    FASEB J 26:4079-91. 2012
  8. pmc Tubulointerstitial nephropathies in HIV-infected patients over the past 15 years: a clinico-pathological study
    Mohamad Zaidan
    Assistance Publique Hopitaux de Paris, Department of Nephrology and Dialysis, Tenon Hospital, Paris, France
    Clin J Am Soc Nephrol 8:930-8. 2013
  9. doi request reprint Thrombospondin-1 plays a profibrotic and pro-inflammatory role during ureteric obstruction
    Naïke Bigé
    INSERM Unit 702, Paris, France
    Kidney Int 81:1226-38. 2012
  10. doi request reprint [Renal biopsy practice: results of a French study and recommendations]
    Guillaume Bollée
    UMR970, INSERM, Universite Paris Descartes, Paris, France
    Nephrol Ther 8:168-76. 2012

Detail Information

Publications79

  1. doi request reprint Membranous nephropathy: A fairy tale for immunopathologists, nephrologists and patients
    Pierre Ronco
    Sorbonne Universités, UPMC Univ Paris 06, Paris F 75005, France INSERM, UMR_S 1155, Paris F 75020, France AP HP, Hopital Tenon, Department of Nephrology and Dialysis, Paris F 75020, France Electronic address
    Mol Immunol 68:57-62. 2015
    ..We hope that they will convince them that bedside research performed with intellectual curiosity and a bit of chance can lead to significant progress in clinical medicine. ..
  2. doi request reprint Pathophysiological advances in membranous nephropathy: time for a shift in patient's care
    Pierre Ronco
    Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1155, Paris, France INSERM, UMR_S 1155, Paris, France AP HP, Department of Nephrology and Dialysis, Hopital Tenon, Paris, France Electronic address
    Lancet 385:1983-92. 2015
    ..These tests already have a major effect on diagnosis and monitoring of treatment, including after transplantation. ..
  3. ncbi request reprint [Anti-CD 10 maternal-fetal allo-immunisation]
    Pierre Ronco
    Unité INSERM UMR S 702, UPMC Universite Paris 6, Assistance Publique Hopitaux de Paris, Hopital Tenon, Paris
    Bull Acad Natl Med 196:1613-22; discussion 1622-3. 2012
    ..This will require identification of the pathogenic epitopes born by the antigen...
  4. doi request reprint Ig-related renal disease in lymphoplasmacytic disorders: an update
    Pierre Ronco
    Assistance Publique Hopitaux de Paris, Hopital Tenon, Service de Néphrologie et Dialyses, Paris, France
    Semin Nephrol 30:557-69. 2010
    ..In the past 10 years, considerable advances have occurred in chemotherapy regimens with the advent of new classes of drugs, which already result in markedly improved renal and vital survival...
  5. doi request reprint [Idiopathic and secondary membranous nephropathies]
    Pierre Ronco
    UPMC Universite Paris 6, Tenon Hospital, INSERM UMR_S702, 75970 Paris Cedex 20, France
    Presse Med 41:290-7. 2012
    ..The newly identified antigen-antibody systems should be considered as molecular signatures challenging the uniform histological definition and having a major impact on patient care in a near future...
  6. doi request reprint [Kidney diseases: new issues]
    Pierre Ronco
    Inserm UMRS702, Tenon Hospital, UPMC Universite Paris 6, 75970 Paris Cedex 20, France
    Presse Med 41:240-6. 2012
    ..Careful therapeutic education of patients is required to successfully implement established guidelines, appropriate diets and new therapeutic strategies...
  7. doi request reprint Genetic inhibition of discoidin domain receptor 1 protects mice against crescentic glomerulonephritis
    Monique Kerroch
    INSERM UMR S 702, Service de Néphrologie et Dialyses, Hopital Tenon, Assistance Publique Hopitaux de Paris, Université Pierre et Marie Curie UPMC, Paris 6 University, 75020 Paris, France
    FASEB J 26:4079-91. 2012
    ..These results prompt further interest in DDR1 blockade strategies, especially in the treatment of glomerulonephritis...
  8. pmc Tubulointerstitial nephropathies in HIV-infected patients over the past 15 years: a clinico-pathological study
    Mohamad Zaidan
    Assistance Publique Hopitaux de Paris, Department of Nephrology and Dialysis, Tenon Hospital, Paris, France
    Clin J Am Soc Nephrol 8:930-8. 2013
    ..This study analyzed the characteristics of HIV-infected patients and biopsy-proven tubulointerstitial nephropathies to define disease patterns and therapeutic implications...
  9. doi request reprint Thrombospondin-1 plays a profibrotic and pro-inflammatory role during ureteric obstruction
    Naïke Bigé
    INSERM Unit 702, Paris, France
    Kidney Int 81:1226-38. 2012
    ..Thus, TSP-1 is an important profibrotic and inflammatory mediator of renal disease. Blockade of its action may be a treatment against the development of chronic kidney disease...
  10. doi request reprint [Renal biopsy practice: results of a French study and recommendations]
    Guillaume Bollée
    UMR970, INSERM, Universite Paris Descartes, Paris, France
    Nephrol Ther 8:168-76. 2012
    ..Our working group, appointed by the scientific commission of the Société de néphrologie in France, aimed to depict the main aspects of the practice of RB in adults in France, before establishing some guidelines...
  11. doi request reprint Patterns of noncryoglobulinemic glomerulonephritis with monoclonal Ig deposits: correlation with IgG subclass and response to rituximab
    Elsa Guiard
    Department Nephrology, Hopital Europeen Georges Pompidou, Paris, France
    Clin J Am Soc Nephrol 6:1609-16. 2011
    ..The aim of this study was to describe the distribution of the different pathologic subtypes of IgG-associated glomerulopathy and to evaluate the IgG isotype involved in these diseases...
  12. doi request reprint Asymmetric dimethylarginine (ADMA) induces chronic kidney disease through a mechanism involving collagen and TGF-β1 synthesis
    Fabrice Mihout
    INSERM Unit 702, Paris, F 75020, France
    J Pathol 223:37-45. 2011
    ....
  13. ncbi request reprint COL4A1 mutations and hereditary angiopathy, nephropathy, aneurysms, and muscle cramps
    Emmanuelle Plaisier
    INSERM Unité 702, Universite Pierre et Marie Curie, Paris 6, Unités Mixtes de Recherche Scientifique 702, Assistance Publique Hopitaux de Paris, Hopital Tenon, France
    N Engl J Med 357:2687-95. 2007
    ..However, the causative genes for a number of hereditary multicystic kidney diseases, myopathies with cramps, and heritable intracranial aneurysms remain unknown...
  14. pmc Renal arterial resistive index is associated with severe histological changes and poor renal outcome during chronic kidney disease
    Naïke Bigé
    Department of Nephrology, AP HP, Hopital Tenon, 4 rue de la Chine, Paris, F 75020, France
    BMC Nephrol 13:139. 2012
    ....
  15. pmc Tissue transglutaminase contributes to interstitial renal fibrosis by favoring accumulation of fibrillar collagen through TGF-beta activation and cell infiltration
    Nasim Shweke
    INSERM UMR, Paris, France
    Am J Pathol 173:631-42. 2008
    ..Our results suggest that inhibition of TG2 may provide a new and important therapeutic target against the progression of renal fibrosis...
  16. doi request reprint [Anti-CD10 fetomaternal alloimmunisation]
    Pierre Ronco
    Unité INSERM UMR S 702, UPMC Universite Paris 6, Assistance Publique Hopitaux de Paris, Hopital Tenon, Paris, France
    Med Sci (Paris) 25:64-8. 2009
    ....
  17. doi request reprint Complete remission of monoclonal gammopathy with ocular and periorbital crystal storing histiocytosis and Fanconi syndrome
    Alyette Duquesne
    AP HP, Hopital Tenon, Department of Nephrology, Paris, F 75020 France
    Hum Pathol 44:927-33. 2013
    ..After 18 months follow-up, she is in complete hematological, ophthalmological, and renal remission...
  18. ncbi request reprint [Hereditary angiopathy with nephropathy, aneurysms and muscle cramps (HANAC): a new basement membrane-disease associated with mutations of the COL4A1 gene]
    Pierre Ronco
    Néphrologie et Dialyses, Unité INSERM UMR S 702, UPMC, Hopital Tenon, Paris
    Bull Acad Natl Med 192:971-84; discussion 984-6. 2008
    ..We discuss phenotype-genotype correlations and the implications of the HANAC syndrome for the diagnosis of autosomal dominant hematuria, cystic kidney disease, intracranial aneurysms, and muscle cramps...
  19. doi request reprint Tubular nuclear accumulation of Snail and epithelial phenotypic changes in human myeloma cast nephropathy
    Alexandre Hertig
    AP HP, Hopital Tenon, Urgences Néphrologiques and Transplantation Rénale, F 75020 Paris, France
    Hum Pathol 42:1142-8. 2011
    ..The epithelial-mesenchymal transition pathway could, therefore, be involved in the rapid renal fibrogenesis observed in this setting...
  20. doi request reprint Evidence of follicular T-cell implication in a case of IgG4-related systemic disease with interstitial nephritis
    Mohamad Zaidan
    Service de Néphrologie et Dialyses, AP HP, Hopital Tenon, Paris, France
    Nephrol Dial Transplant 26:2047-50. 2011
    ....
  21. doi request reprint [IgG4-related disease and renal and urological involvement]
    Mohamad Zaidan
    Service de Néphrologie et Dialyses, Hopital Tenon, Assistance Publique des Hopitaux de Paris, 4, rue de la Chine, 75020 Paris, France
    Nephrol Ther 8:499-507. 2012
    ..Our literature review provides nephrologists, urologists and pathologists with key elements that will help in the early diagnosis and proper management of this new and emerging disorder...
  22. doi request reprint Notch3 is essential for regulation of the renal vascular tone
    Nada Boulos
    INSERM UMR702, Paris, France
    Hypertension 57:1176-82. 2011
    ..A deficiency in the expression of Notch3 could have important physiopathological consequences in the adaptation of the cardiac and renal function to chronic increase of blood pressure...
  23. doi request reprint Novel COL4A1 mutations associated with HANAC syndrome: a role for the triple helical CB3[IV] domain
    Emmanuelle Plaisier
    AP HP, Department of Nephrology, Tenon Hospital, INSERM U702, UMRS702, Universite Pierre et Marie Curie Paris 6, Paris, France
    Am J Med Genet A 152:2550-5. 2010
    ....
  24. pmc Allo-immune membranous nephropathy and recombinant aryl sulfatase replacement therapy: a need for tolerance induction therapy
    Hanna Debiec
    Institut National de la Sante et de la Recherche Medicale, Unité Mixte de Recherche_S 702, Paris, France
    J Am Soc Nephrol 25:675-80. 2014
    ..Considering the critical requirement for ERT in patients with such enzyme deficiencies, immune tolerance induction should be advocated in the patients with allo-immune MN. ..
  25. ncbi request reprint D-Penicillamine-induced ANCA-associated crescentic glomerulonephritis in Wilson disease
    Frank Bienaime
    Department of Nephrology and Dialysis, Tenon Hospital, APHP, Paris, France
    Am J Kidney Dis 50:821-5. 2007
    ..The presentation and rapidly progressive and potentially severe outcome of this complication dramatically contrast with those of membranous and minimal change glomerulopathy, also induced by the sulfhydryl compound...
  26. doi request reprint LG3 fragment of endorepellin is a possible biomarker of severity in IgA nephropathy
    Brigitte Surin
    INSERM, UMR S 702, Paris, France
    Proteomics 13:142-52. 2013
    ..Therefore, we suggest that the LG3 fragment of endorepellin could be associated with IgAN severity and might be related to pathogenesis of IgAN...
  27. pmc Recurrent membranous nephropathy in an allograft caused by IgG3κ targeting the PLA2 receptor
    Hanna Debiec
    Institut National de la Santé et de la Recherche Médicale UMR_S 702, Paris, France
    J Am Soc Nephrol 23:1949-54. 2012
    ..In summary, this case of recurrent membranous nephropathy in a graft suggests that circulating monoclonal anti-PLA2R IgG3κ caused the disease and activated complement by the classic pathway...
  28. doi request reprint Acute renal failure with lambda light chain-derived crystals in a patient with IgD myeloma
    Cécile Toly-Ndour
    Institut National de la Sante et de la Recherche Medicale, UMR S 938, système immunitaire et maladies conformationnelles, Hopital St Antoine, Paris, France
    Nephrol Dial Transplant 26:3057-9. 2011
    ..The light chain variable domain had a normal overall primary structure but included 11 somatic mutations, 3 of which likely increased the surface hydrophobicity, as observed in previously reported kappa-type crystals...
  29. doi request reprint Immunoglobulin deposition disease with a membranous pattern and a circulating monoclonal immunoglobulin G with charge-dependent aggregation properties
    Sophie de Seigneux
    AP HP, Hopital Tenon, Service de Néphrologie et Dialyses, Paris, France
    Am J Kidney Dis 56:117-21. 2010
    ..Although binding to podocyte antigens is a well-recognized determinant of subepithelial immunoglobulin deposition, proneness to aggregation as described in this case also might be nephritogenic...
  30. doi request reprint [Kidney and HIV infection]
    Emmanuelle Plaisier
    Hopital Tenon, Service de Néphrologie et Dialyses, 75970 Paris, France
    Presse Med 41:267-75. 2012
    ..Proximal renal tubular toxicity must be further evaluated in the presence of eGFR decrease and/or hypophosphatemia under tenofovir therapy...
  31. pmc MMP9 limits apoptosis and stimulates branching morphogenesis during kidney development
    Catherine Arnould
    Université Pierre et Marie Curie University of Paris 06, Paris, France
    J Am Soc Nephrol 20:2171-80. 2009
    ....
  32. doi request reprint Monoclonal immunoglobulin light and heavy chain deposition diseases: molecular models of common renal diseases
    Pierre Ronco
    UPMC Univ Paris 06, Hopital Tenon, Service de Néphrologie et Dialyses, Paris, France
    Contrib Nephrol 169:221-31. 2011
    ....
  33. pmc HANAC Syndrome Col4a1 Mutation Causes Neonate Glomerular Hyperpermeability and Adult Glomerulocystic Kidney Disease
    Zhiyong Chen
    Institut National de la Sante et de la Recherche Medicale, Unité Mixte de Recherche UMR S 1155, Paris, France
    J Am Soc Nephrol 27:1042-54. 2016
    ....
  34. pmc Pseudo-Peritoneal Carcinomatosis Presentation of a Crystal-Storing Histiocytosis With an Unmutated Monoclonal κ Light Chain
    Aude Aline-Fardin
    From the AP HP AA F, BF, Hopital Saint Antoine, Department of Pathology, Paris CNRS UMR 7276 Université de Limoges SB, MCV, Hôpital Universitaire Dupuytren AP HP DB, Hopital Tenon, Department of Pathology, Paris Université Pierre et Marie Curie Paris 6 DB, Paris Centre hospitalier de Troyes SB, Service D Hématologie AP HP MM, Hopital Saint Antoine, Service d Hématologie Clinique et Thérapie Cellulaire, Paris Université Pierre and Marie Curie MM, Paris INSERM MM, UMRS, U938, Paris AP HP PR, JJB, Hopital Tenon, Department of Nephrology and Dialysis, Paris Sorbonne Universités PR, JJB, UPMC Univ Paris 06, UMR_S 1155 INSERM PR, JJB, UMR_S 1155, Paris INSERM PA, UMRS 938, Hopital Saint Antoine, Paris Université Pierre et Marie Curie Paris6 PA, Hopital Saint Antoine, Paris INSERM LG, Children's Memorial Hospital
    Medicine (Baltimore) 94:e1247. 2015
    ..CSH may present as pseudo-peritoneal carcinomatosis and relate to a monoclonal κ LC encoded by an unmutated gene. Bortezomib-based therapy proved efficacious in this case. ..
  35. doi request reprint Acute metabolic acidosis in a GLUT2-deficient patient with Fanconi-Bickel syndrome: new pathophysiology insights
    Fabrice Mihout
    Department of Nephrology and Dialysis, AP HP, Tenon Hospital, Paris, France
    Nephrol Dial Transplant 29:iv113-6. 2014
    ..These profound alterations of the transport systems most likely contributed to proximal tubule alterations and profound bicarbonate loss. ..
  36. doi request reprint HIV-associated kidney glomerular diseases: changes with time and HAART
    Francois Xavier Lescure
    Department of Infectious and Tropical Diseases, Tenon Hospital, AP HP, Paris, France
    Nephrol Dial Transplant 27:2349-55. 2012
    ..Our objective was to assess the change in distribution of the glomerular diseases in HIV patients...
  37. ncbi request reprint Role of truncating mutations in MME gene in fetomaternal alloimmunisation and antenatal glomerulopathies
    Hanna Debiec
    INSERM Unit 489, Tenon Hospital AP HP and University of Paris 6, Paris, France
    Lancet 364:1252-9. 2004
    ..We aimed to investigate whether the disease could affect other families, to search for mutations in the metallomembrane endopeptidase (MME) gene for NEP, and to analyse the outcome of the antenatal renal insult...
  38. ncbi request reprint [Strategies to reverse fibrotic lesions of the kidney]
    Jean Jacques Boffa
    Service néphrologie et dialyses, Hopital Tenon, AP HP, Paris
    Presse Med 36:1857-64. 2007
    ..Renal regeneration may be promoted by modulation of hypoxia-inducible factor-1 (HIF-1) and vascular endothelial growth factor (VEGF)...
  39. pmc MMP9 and SCF protect from apoptosis in acute kidney injury
    Soraya Bengatta
    UPMC University of Paris 06, Paris, France
    J Am Soc Nephrol 20:787-97. 2009
    ..In conclusion, these data show that MMP9 protects the S3 segment of the proximal tubule and the I-CD from apoptosis in AKI, most likely by releasing sSCF...
  40. doi request reprint Matrix metalloproteinases and matrix receptors in progression and reversal of kidney disease: therapeutic perspectives
    Pierre Ronco
    INSERM, UMR S 702, AP HP, Hopital Tenon, Department of Nephrology, Paris, France
    Kidney Int 74:873-8. 2008
    ..These therapies together with pharmacological agents controlling MMP activity, given in appropriate windows of the course of kidney diseases may represent a useful adjunct to blockers of the renin-angiotensin system...
  41. ncbi request reprint Polyclonal IgG4 hypergammaglobulinemia associated with plasmacytic lymphadenopathy, anemia and nephropathy
    Emmanuelle Boulanger
    Department of Clinical Immunology, Hopital Saint Louis, AP HP, Paris, France
    Ann Hematol 85:833-40. 2006
    ..The increased IgG4 production was found to be mediated by soluble factor(s), most probably secreted by activated T cells, which did not require the signal transducer and activator of transcription 6 signaling pathway...
  42. ncbi request reprint Sulfated HNK-1 epitope in developing and mature kidney: a new marker for thin ascending loop of Henle and tubular injury in acute tubular necrosis
    Yves Allory
    Institut National de la Santé et de la Recherche Médicale U702 INSERM, Paris, France
    J Histochem Cytochem 54:575-84. 2006
    ..These data suggest that molecules carrying the sulfated HNK-1 carbohydrate epitope may play an important role in critical stages of renal development and in the physiology of thin ascending loop of Henle...
  43. ncbi request reprint Fetomaternal alloimmunization with antenatal glomerulopathies
    Hanna Debiec
    INSERM U 702, Pierre et Marie Curie University Paris, UMRS, AP HP Tenon Hospital, Paris, France
    Ann N Y Acad Sci 1110:559-66. 2007
    ..The identification of these B cell epitopes is useful for diagnostic tests and may lead to future development of new therapeutic approaches based on peptide-specific immune intervention...
  44. ncbi request reprint Molecular pathomechanisms of membranous nephropathy: from Heymann nephritis to alloimmunization
    Pierre Ronco
    INSERM Unit 489, Tenon Hôpital Assistance Publique, Hopitaux de Paris, 4 rue de la Chine, 75020 Paris, France
    J Am Soc Nephrol 16:1205-13. 2005
    ..Other types of alloimmunization should be investigated in MN but also in other renal and nonrenal diseases, particularly those that affect the pediatric age...
  45. doi request reprint INF2 mutations in Charcot-Marie-Tooth disease with glomerulopathy
    Olivia Boyer
    INSERM Unité 983, Service de Nephrologie Pediatrique, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, Paris, France
    N Engl J Med 365:2377-88. 2011
    ..We therefore hypothesized that INF2 may be responsible for cases of Charcot-Marie-Tooth neuropathy associated with FSGS...
  46. pmc Progression and regression in renal vascular and glomerular fibrosis
    Christos Chatziantoniou
    INSERM U489, Tenon Hospital, Paris, France
    Int J Exp Pathol 85:1-11. 2004
    ..In this review, we will focus on the mechanisms of the hypertension-associated fibrosis and the few recent studies that gave promising results for a therapeutic intervention...
  47. doi request reprint Early-childhood membranous nephropathy due to cationic bovine serum albumin
    Hanna Debiec
    INSERM, Unite Mixte de Recherche Scientifique 702, Universite Pierre et Marie Curie, Paris 6, Assistance Publique Hopitaux de Paris, Tenon Hospital, Paris, France
    N Engl J Med 364:2101-10. 2011
    ..The nature of antigens involved in other idiopathic and secondary membranous nephropathies remains unclear...
  48. pmc Rituximab treatment for membranous nephropathy: a French clinical and serological retrospective study of 28 patients
    Pierre Antoine Michel
    Service de Néphrologie et Dialyses, Hopital Tenon, Assistance Publique Hopitaux de Paris, France
    Nephron Extra 1:251-61. 2011
    ..Antibodies became negative in all 5 responsive patients with available follow-up sera. In this retrospective study, a high rate of remission was achieved 12 months after treatment...
  49. pmc Arterial remodeling associates with CKD progression
    Marie Briet
    Department of Pharmacology and Institut National de la Santé et de la Recherche Médicale U970 PARCC, Hopital Europeen Georges Pompidou, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, 20, rue Leblanc, 75015 Paris, France
    J Am Soc Nephrol 22:967-74. 2011
    ..In conclusion, maladaptive remodeling of the carotid artery and increased pulse pressure independently associate with faster decline of renal function and progression to ESRD...
  50. ncbi request reprint Mechanisms of disease: Alloimmunization in renal diseases
    Pierre Ronco
    INSERM Unit 702, University Pierre and Marie Curie, Tenon Hospital, Paris, France
    Nat Clin Pract Nephrol 2:388-97. 2006
    ....
  51. doi request reprint A case of phospholipase A₂ receptor-positive membranous nephropathy preceding sarcoid-associated granulomatous tubulointerstitial nephritis
    Masa Knehtl
    Department of Nephrology, Hopital Tenon, Paris, France
    Am J Kidney Dis 57:140-3. 2011
    ..We discuss the relationship between membranous nephropathy and sarcoidosis based on the close appearance of the 2 diseases and the detection of phospholipase A₂ receptor in glomerular immune deposits...
  52. doi request reprint The SAM domain of ANKS6 has different interacting partners and mutations can induce different cystic phenotypes
    Zeineb Bakey
    1 Sorbonne Universités, UPMC Univ Paris 06, UMR_S1155, Paris, France 2 INSERM, UMR_S1155, Hopital Tenon, Paris, France
    Kidney Int 88:299-310. 2015
    ..Thus, our data demonstrate the importance of ANKS6 for kidney structure integrity and the essential mediating role of its SAM domain in the formation of protein complexes. ..
  53. pmc Bilateral kidney infarction due to primary Al amyloidosis: a first case report
    Fabrice Mihout
    From the Department of Nephrology and Dialysis FM, LJ, PR, EP Department of Pathology IB, Tenon Hospital, APHP, Paris, France Clinical Hematology Unit VL and Department of Cardiac Surgery SV, La Pitie Salpetriere Hospital, APHP, F 75013 Paris, France
    Medicine (Baltimore) 94:e777. 2015
    ..In addition to the very uncommon presentation, this case illustrates the tremendous progress that has occurred in the management of severe forms of AL amyloidosis. ..
  54. doi request reprint Increased risk of solid renal tumors in lithium-treated patients
    Mohamad Zaidan
    1 Department of Nephrology Transplantation, Necker Hospital, APHP, Paris Descartes University, Paris, France 2 Paris Descartes University, Sorbonne Paris Cité, Paris, France 3 INSERM U845, Centre de Recherche Croissance et Signalisation, Paris, France
    Kidney Int 86:184-90. 2014
    ..51 (95% confidence interval (CI) (1.51-21.95)) and 13.69 (95% CI (3.68-35.06)) in men and women, respectively. Thus, there is an increased risk of renal tumors in lithium-treated patients. ..
  55. ncbi request reprint Acute renal failure associated with immune restoration inflammatory syndrome
    Eric Daugas
    Department of Nephrology, Tenon Hospital, Paris, France
    Nat Clin Pract Nephrol 2:594-8; quiz 599. 2006
    ..A renal biopsy showed acute interstitial nephritis. Extensive investigations failed to detect active infection. The efficacy of HAART was attested by increased CD4+ cell counts and undetectable viral replication...
  56. ncbi request reprint Glomerular permeability is altered by loss of P0, a myelin protein expressed in glomerular epithelial cells
    Emmanuelle Plaisier
    Department of Nephrology, INSERM Unit 702, Tenon Hospital AP HP, University Pierre et Marie Curie, Paris, France
    J Am Soc Nephrol 16:3350-6. 2005
    ..These results demonstrate that P0, the major myelin protein, is also expressed during nephrogenesis and in mature kidney, mostly in podocytes. They suggest that P0 gene mutations might be involved in renal diseases...
  57. ncbi request reprint Unexpected efficacy of rituximab in multirelapsing minimal change nephrotic syndrome in the adult: first case report and pathophysiological considerations
    Helene Francois
    Department of Nephrology and Dialysis, Assistance Publique Hopitaux de Paris, AP HP, Tenon Hospital, France
    Am J Kidney Dis 49:158-61. 2007
    ..This case suggests a role of B cells in MCNS, possibly by regulating T-cell function...
  58. ncbi request reprint [Pathogenesis of immune glomerulonephritis]
    Jean Philippe Rougier
    Service de Nephrologie B, Hopital Tenon, 75970 Paris Cedex 20
    Rev Prat 53:1998-2004. 2003
    ..Recent significant advances in the pathophysiology of those glomerular diseases have shed considerable light on the understanding of the underlying disease even if they do not have immediate therapeutic implications...
  59. doi request reprint Onco-nephrology: glomerular diseases with cancer
    Jean François Cambier
    Nephrology and Dialysis Department, Assistance Publique Hopitaux de Paris, Tenon Hospital, Paris, France
    Clin J Am Soc Nephrol 7:1701-12. 2012
    ....
  60. ncbi request reprint Matrix metalloproteinases in kidney disease progression and repair: a case of flipping the coin
    Pierre Ronco
    INSERM Unit 702, and Universite Pierre et Marie Curie, Paris, France
    Semin Nephrol 27:352-62. 2007
    ..The major challenge with future therapeutic interventions using MMP inhibitors remains how to accomplish temporal and spatial control of their activity without flipping the coin...
  61. doi request reprint [High cardiovascular complications in systemic lupus erythematosus: physiopathology and risk management]
    Jean Jacques Boffa
    Service de Néphrologie et Dialyses, Hopital Tenon, AP HP, Paris, France
    Nephrol Ther 5:595-602. 2009
    ..Its implementation in SLE patients requires a modification of medical practices. CV risk management in SLE patients include identification of optimal targets for each traditional risk factor and SLE specific treatments...
  62. ncbi request reprint Podocyte antigens and glomerular disease
    Pierre Ronco
    INSERM Unit UMR S 702, Pierre et Marie Curie University Paris 6, AP HP Tenon Hospital, Paris, France
    Nephron Exp Nephrol 107:e41-6. 2007
    ..However, the target antigens of circulating antibodies are unknown. Current treatments for patients with MN are entirely empirical, and concept-driven therapies are dramatically lacking...
  63. doi request reprint Antigen identification in membranous nephropathy moves toward targeted monitoring and new therapy
    Pierre Ronco
    Université Pierre et Marie Curie University of Paris 06, Paris, France
    J Am Soc Nephrol 21:564-9. 2010
    ..The recent discovery of neutral endopeptidase and PLA(2)R provides new tools for monitoring human disease activity and should be of value in designing new antigen-driven therapeutic strategies...
  64. pmc Pathophysiological lessons from rare associations of immunological disorders
    Pierre Ronco
    Institut National de la Santé et de la Recherche Médicale INSERM Unité Mixte de Recherche en Santé UMR S 702, Paris, France
    Pediatr Nephrol 24:3-8. 2009
    ..The occurrence of MCD with hemopathies supports the role of T cells in the pathogenesis of proteinuria, although the characteristics of those T cells remain to be established and the glomerular permeability factor(s) identified...
  65. ncbi request reprint New insights into the pathogenesis of membranous glomerulonephritis
    Pierre Ronco
    INSERM Unit 702, Paris, France
    Curr Opin Nephrol Hypertens 15:258-63. 2006
    ..This review focuses on new pathophysiologic aspects of the disease, with special emphasis on the antigenic targets of pathogenic antibodies...
  66. doi request reprint Membranous glomerulopathy: the evolving story
    Pierre Ronco
    INSERM UMR_S 702, Paris, France
    Curr Opin Nephrol Hypertens 19:254-9. 2010
    ..This review focuses on new pathophysiologic aspects of the disease, with special emphasis on the antigenic targets of pathogenic antibodies...
  67. ncbi request reprint Immunoglobulin light (heavy)-chain deposition disease: from molecular medicine to pathophysiology-driven therapy
    Pierre Ronco
    INSERM UMR S 702, Universite Pierre et Marie Curie Paris 6, Paris, France
    Clin J Am Soc Nephrol 1:1342-50. 2006
    ....
  68. ncbi request reprint [Extra-membranous glomerulonephritis: report of a family and new physiopathological concepts]
    Hanna Debiec
    Unité INSERM 489, Hopital Tenon, 4 rue de la Chine, 75020 Paris
    Bull Acad Natl Med 187:921-32; discussion 932-4. 2003
    ..Two additional families have been identified since then. The pathophysiologic mechanisms that we have unraveled are reminiscent of Rhesus immunization and open up new avenues for therapeutic intervention...
  69. ncbi request reprint The L1 cell adhesion molecule is induced in renal cancer cells and correlates with metastasis in clear cell carcinomas
    Yves Allory
    INSERM U489, Tenon Hospital Assistance Publique Hôpitaux de Paris and Paris 6 University, 4 rue de la Chine, Paris 70520, France
    Clin Cancer Res 11:1190-7. 2005
    ..The objectives of the study were to provide a comprehensive description of L1 distribution in human kidney and to establish the prognostic relevance of L1 expression in renal cell carcinomas (RCC)...
  70. doi request reprint Advances in membranous nephropathy: success stories of a long journey
    Pierre Ronco
    Inserm UMR_S702 Université Pierre et Marie Curie Assistance Publique Hôpitaux de Paris, Department of Nephrology and Dialysis, Tenon Hospital, Paris, France
    Clin Exp Pharmacol Physiol 38:460-6. 2011
    ..This suggests that food antigens may be involved in MN through charge-dependent binding to the anionic glomerular capillary wall and in situ formation of immune complexes...
  71. doi request reprint Partial fanconi syndrome induced by imatinib therapy: a novel cause of urinary phosphate loss
    Helene Francois
    AP HP, Assistance Publique Hopitaux de Paris, Department of Nephrology and Dialysis, Tenon Hospital, Paris, France
    Am J Kidney Dis 51:298-301. 2008
    ..Patients on long-term imatinib treatment should be monitored for renal failure, as well as proximal tubule dysfunction, including hypophosphatemia...
  72. ncbi request reprint Autosomal-dominant familial hematuria with retinal arteriolar tortuosity and contractures: a novel syndrome
    Emmanuelle Plaisier
    INSERM Unit 489 Departments of Neurology, and Nephrology, Tenon Hospital AP HP, Paris, France
    Kidney Int 67:2354-60. 2005
    ..Patients with thin basement membrane (BM) disease do not have extrarenal manifestations, while those with Alport syndrome often present with hearing loss, anterior lenticonus, and dot-and-fleck retinopathy...
  73. ncbi request reprint Foot gangrene in patients with end-stage renal disease: a case control study
    Mourad Boufi
    Department of Vascular Surgery and Research Unit of CNRS, UMR 7054, Tenon Hospital Assistance Publique Hôpitaux de Paris, University of Paris VI, Saint Antoine Faculty of Medicine, Paris, France
    Angiology 57:355-61. 2006
    ..6, p = 0.0023), and by impaired microcirculatory perfusion, as indicated by a lower oxygen pressure (TcPO(2)) (15.6 +/-12 mm Hg vs 26 +/-16, p = 0.07). ESRD implies a poor prognosis in patients with stage IV peripheral arterial disease...
  74. ncbi request reprint Chronic lithium nephropathy: MR imaging for diagnosis
    Maria Teresa Farres
    Department of Radiology, Hopital Tenon, Assistance Publique Hopitaux de Paris, 4 rue de la Chine, 75020 Paris, France
    Radiology 229:570-4. 2003
    ..To evaluate the appearance of lithium nephropathy at magnetic resonance (MR) imaging...
  75. ncbi request reprint Cutaneous calcification in patients with end-stage renal disease: a regulated process associated with in situ osteopontin expression
    Jacqueline Rivet
    Department of Pathology, AP HP, Saint Louis Hospital, INSERM U728, Paris, France
    Arch Dermatol 142:900-6. 2006
    ..While the pathogenesis is not well understood, it may be similar to those for medial and intimal vascular calcifications, which are actively regulated processes...
  76. pmc Proteinuria: is it all in the foot?
    Pierre Ronco
    INSERM UMR S 702, University Pierre et Marie Curie, and Department of Nephrology and Dialysis, Tenon Hospital, Paris, France
    J Clin Invest 117:2079-82. 2007
    ....
  77. doi request reprint Pathogenesis of membranous nephropathy: recent advances and future challenges
    Pierre Ronco
    INSERM UMR S 702 and Division of Nephrology, Tenon Hospital, 4 rue de Chine, Paris 75020, France pierre ronco tnn aphp fr
    Nat Rev Nephrol 8:203-13. 2012
    ..These signatures will soon have a major impact on patient care...
  78. ncbi request reprint Identification of two candidate collecting duct cell-specific cis-acting elements in the Hoxb-7 promoter region
    Emmanuelle Plaisier
    INSERM Unit 489 and University Paris VI, Paris, France
    Biochim Biophys Acta 1727:106-15. 2005
    ..CDSE-2 (-34/-13) contains sequence bears high homology with a segment of the Pax-2 promoter. CDSE-2 also conveys cell specificity but has no enhancer activity by itself...
  79. doi request reprint Renal biopsy practice in France: results of a nationwide study
    Guillaume Bollée
    Paris Descartes University, APHP, Department of Nephrology and Transplantation, Necker Enfants Malades Hospital, Paris, France
    Nephrol Dial Transplant 25:3579-85. 2010
    ..Practices vary widely among nephrologists, depending on personal experience and the availability of particular techniques. The purpose of our study was to depict the main aspects of the practice of RB in adults in France...