Michel Rigoulet

Summary

Country: France

Publications

  1. doi request reprint Electron competition process in respiratory chain: regulatory mechanisms and physiological functions
    Michel Rigoulet
    Universite Bordeaux 2, 1 rue Camille Saint Saens, 33077 Bordeaux Cedex, France
    Biochim Biophys Acta 1797:671-7. 2010
  2. ncbi request reprint Flux-force relationships in intact cells: a helpful tool for understanding the mechanism of oxidative phosphorylation alterations?
    M Rigoulet
    Institut de Biochimie et Génétique Cellulaires du C N R S, Universite de Bordeaux, Bordeaux, France
    Biochim Biophys Acta 1365:117-24. 1998
  3. doi request reprint Mitochondrial ROS generation and its regulation: mechanisms involved in H(2)O(2) signaling
    Michel Rigoulet
    Universite Bordeaux 2, and Institute of Biochemistry and Genetics of the Cell IBGC du CNRS, Bordeaux, France
    Antioxid Redox Signal 14:459-68. 2011
  4. ncbi request reprint Organization and regulation of the cytosolic NADH metabolism in the yeast Saccharomyces cerevisiae
    Michel Rigoulet
    Institut de Biochimie et Génétique Cellulaires, Université Victor Segalen CNRS, Bordeaux Cedex, France
    Mol Cell Biochem 256:73-81. 2004
  5. ncbi request reprint Growth yield homeostasis in respiring yeast is due to a strict mitochondrial content adjustment
    Anne Devin
    Institute of Biochemistry and Genetics of the Cell, CNRS Unité Mixte de Recherche 5095 Université Bordeaux 2, 1 rue Camille Saint Saens, 33077 Bordeaux Cedex, France
    J Biol Chem 281:26779-84. 2006
  6. ncbi request reprint Site specific alterations of adipose tissue mitochondria in 3'-azido-3'-deoxythymidine (AZT)-treated rats: an early stage in lipodystrophy?
    Catherine Deveaud
    Institut de Biochimie et de Génétique Cellulaires, UMR 5095 CNRS Université Victor Segalen, 1 rue Camille Saint Saens, 33077 Bordeaux Cedex, France
    Biochem Pharmacol 70:90-101. 2005
  7. doi request reprint Kinetic activation of yeast mitochondrial D-lactate dehydrogenase by carboxylic acids
    Arnaud Mourier
    Universite Bordeaux 2, Bordeaux Cedex, France
    Biochim Biophys Acta 1777:1283-8. 2008
  8. pmc Reactive oxygen species-mediated regulation of mitochondrial biogenesis in the yeast Saccharomyces cerevisiae
    Cyrille Chevtzoff
    Institute of Biochemistry and Genetics of the Cell, CNRS UMR 5095, 1 rue Camille Saint Saens, 33077 Bordeaux Cedex, France
    J Biol Chem 285:1733-42. 2010
  9. ncbi request reprint Competition of electrons to enter the respiratory chain: a new regulatory mechanism of oxidative metabolism in Saccharomyces cerevisiae
    Odile Bunoust
    Institut de Biochimie et Genetique Cellulaires du CNRS, Victor Segalen University of Bordeaux, 1 rue Camille Saint Saens, 33 077 Bordeaux cedex, France
    J Biol Chem 280:3407-13. 2005
  10. doi request reprint Mitochondrial energetic metabolism-some general principles
    Jean Pierre Mazat
    CNRS UMR5095, Institute of Biochemistry and Genetics of the Cell, 1 rue Camille Saint Saens, 33077 Bordeaux Cedex, France
    IUBMB Life 65:171-9. 2013

Collaborators

  • Louis Casteilla
  • Anne Galinier
  • Benoit Pinson
  • Catherine Deveaud
  • N Camougrand
  • Veronique Nogueira
  • Christer Larsson
  • Johan M Thevelein
  • Malgorzata Rak
  • Marie Paule Gonthier
  • Sylvie Caspar-Bauguil
  • Stephen Manon
  • Christine Schwimmer
  • Luc Penicaud
  • X M Leverve
  • Anne Devin
  • Nicole Avéret
  • Edgar D Yoboue
  • Odile Bunoust
  • Arnaud Mourier
  • Cyrille Chevtzoff
  • Laurent Dejean
  • Audrey Carriere
  • Bertrand Beauvoit
  • Noureddine Hammad
  • Pascal Baret
  • Jean Pierre Mazat
  • Emmanuel Suraniti
  • Salvador Uribe-Carvajal
  • Abdelmajid Noubhani
  • Caroline Romestaing
  • Rodrigo Diaz-Ruiz
  • Manuel Gutiérrez-Aguilar
  • Pascaline Clerc
  • Julie Vallortigara
  • Yvette Fernandez
  • Mónica Rosas-Lemus
  • Hugo Aguilaniu
  • Lena Gustafsson
  • Marie Lise Jobin
  • Eric Rosenfeld
  • Laurent Kaiser
  • Alexis Mougeolle
  • Bernard Guerin
  • Inga Lill Pahlman
  • Christian Lefebvre d'Hellencourt
  • Margit Heiske
  • Stéphane Ransac
  • Serge P Bottari
  • Stephane Arbault
  • Venkata Suresh Vajrala
  • Bertrand Goudeau
  • Neso Sojic
  • Muriel Priault
  • Axelle Septembre-Malaterre
  • Eric Augier
  • Corinne Blancard
  • Bertrand Daignan-Fornier
  • Beatriz Monge Bonini
  • Dominique Letexier
  • Roland Favier
  • Vincent Rouleau
  • Isabelle Ollivier
  • Benjamin Rey
  • Marie Astrid Piquet
  • Maud Belouze
  • Daniela Araiza
  • Marianne Dautresme
  • Brigitte Sibille
  • Stephane Servais
  • Claude Duchamp
  • Salvador Uribe
  • Eric Fontaine
  • Victoriano Pérez-Vázquez
  • Roland H Wenger
  • Maria Carmen Carmona
  • Thomas Nystrom
  • Ana Paula Alonso
  • Samira Boubekeur
  • Jean Michel Salmon

Detail Information

Publications35

  1. doi request reprint Electron competition process in respiratory chain: regulatory mechanisms and physiological functions
    Michel Rigoulet
    Universite Bordeaux 2, 1 rue Camille Saint Saens, 33077 Bordeaux Cedex, France
    Biochim Biophys Acta 1797:671-7. 2010
    ..Indeed, the more reduced pool would be associated to the electron right of way for the external dehydrogenases whereas the less reduced pool would be associated to the electron right of way for the internal dehydrogenases...
  2. ncbi request reprint Flux-force relationships in intact cells: a helpful tool for understanding the mechanism of oxidative phosphorylation alterations?
    M Rigoulet
    Institut de Biochimie et Génétique Cellulaires du C N R S, Universite de Bordeaux, Bordeaux, France
    Biochim Biophys Acta 1365:117-24. 1998
    ....
  3. doi request reprint Mitochondrial ROS generation and its regulation: mechanisms involved in H(2)O(2) signaling
    Michel Rigoulet
    Universite Bordeaux 2, and Institute of Biochemistry and Genetics of the Cell IBGC du CNRS, Bordeaux, France
    Antioxid Redox Signal 14:459-68. 2011
    ..The consequences of ROS signaling on crucial biologic processes such as cell proliferation and differentiation are discussed...
  4. ncbi request reprint Organization and regulation of the cytosolic NADH metabolism in the yeast Saccharomyces cerevisiae
    Michel Rigoulet
    Institut de Biochimie et Génétique Cellulaires, Université Victor Segalen CNRS, Bordeaux Cedex, France
    Mol Cell Biochem 256:73-81. 2004
    ..The cell physiological consequences of such an organized and regulated network are discussed...
  5. ncbi request reprint Growth yield homeostasis in respiring yeast is due to a strict mitochondrial content adjustment
    Anne Devin
    Institute of Biochemistry and Genetics of the Cell, CNRS Unité Mixte de Recherche 5095 Université Bordeaux 2, 1 rue Camille Saint Saens, 33077 Bordeaux Cedex, France
    J Biol Chem 281:26779-84. 2006
    ..Any process leading to a defect in this adjustment allows an energy waste and consequently an energy yield decrease...
  6. ncbi request reprint Site specific alterations of adipose tissue mitochondria in 3'-azido-3'-deoxythymidine (AZT)-treated rats: an early stage in lipodystrophy?
    Catherine Deveaud
    Institut de Biochimie et de Génétique Cellulaires, UMR 5095 CNRS Université Victor Segalen, 1 rue Camille Saint Saens, 33077 Bordeaux Cedex, France
    Biochem Pharmacol 70:90-101. 2005
    ..Moreover, the decrease in mitochondrial oxidative capacity of inguinal adipocyte consecutive to AZT treatment is not primarily due to an oxidative stress per se, but rather to a depletion of the mtDNA content per cell...
  7. doi request reprint Kinetic activation of yeast mitochondrial D-lactate dehydrogenase by carboxylic acids
    Arnaud Mourier
    Universite Bordeaux 2, Bordeaux Cedex, France
    Biochim Biophys Acta 1777:1283-8. 2008
    ..It is non-competitive, hyperbolic and its dimension is directly related to the number of carboxylic groups on the activator. The physiological meaning of such a regulation is discussed...
  8. pmc Reactive oxygen species-mediated regulation of mitochondrial biogenesis in the yeast Saccharomyces cerevisiae
    Cyrille Chevtzoff
    Institute of Biochemistry and Genetics of the Cell, CNRS UMR 5095, 1 rue Camille Saint Saens, 33077 Bordeaux Cedex, France
    J Biol Chem 285:1733-42. 2010
    ..It is the first time that a redox sensitivity of the transcription factors involved in yeast mitochondrial biogenesis is shown. Such a process could be seen as a mitochondria quality control process...
  9. ncbi request reprint Competition of electrons to enter the respiratory chain: a new regulatory mechanism of oxidative metabolism in Saccharomyces cerevisiae
    Odile Bunoust
    Institut de Biochimie et Genetique Cellulaires du CNRS, Victor Segalen University of Bordeaux, 1 rue Camille Saint Saens, 33 077 Bordeaux cedex, France
    J Biol Chem 280:3407-13. 2005
    ..This suggests a very specific competition for electron entrance into the respiratory chain, which may be caused by the supramolecular organization of the respiratory chain. The physiological consequences of such regulation are discussed...
  10. doi request reprint Mitochondrial energetic metabolism-some general principles
    Jean Pierre Mazat
    CNRS UMR5095, Institute of Biochemistry and Genetics of the Cell, 1 rue Camille Saint Saens, 33077 Bordeaux Cedex, France
    IUBMB Life 65:171-9. 2013
    ..In this review, we will present some of the processes that allow a modular coupling between ATP synthesis and redox state. Furthermore, we will present some theoretical approaches of this highly integrated system...
  11. pmc cAMP-induced mitochondrial compartment biogenesis: role of glutathione redox state
    Edgar D Yoboue
    CNRS, Institut de Biochimie et Génétique Cellulaires, UMR 5095, F 33000 Bordeaux, France
    J Biol Chem 287:14569-78. 2012
    ..This is the first time that control of mitochondrial biogenesis through glutathione redox state has been shown...
  12. pmc The trehalose pathway regulates mitochondrial respiratory chain content through hexokinase 2 and cAMP in Saccharomyces cerevisiae
    Abdelmajid Noubhani
    CNRS, UMR5095 Institut de Biochimie et Génétique Cellulaire, 33077 Bordeaux Cedex, France
    J Biol Chem 284:27229-34. 2009
    ..This is the first time that a pathway involved in sugar storage, i.e. trehalose, is shown to regulate the mitochondrial enzymatic content...
  13. ncbi request reprint cAMP-induced modulation of the growth yield of Saccharomyces cerevisiae during respiratory and respiro-fermentative metabolism
    Laurent Dejean
    Institut de Biochimie et Genetique Cellulaires du CNRS, Universite Victor Segalen Bordeaux 2, 1 rue Camille Saint Saens, 33077 Cedex, Bordeaux, France
    Biochim Biophys Acta 1554:159-69. 2002
    ..It is concluded that overactivation of the cAMP/PKA pathway leads to uncoupling between biomass synthesis and catabolism, under conditions where an optimal growth rate is sustained by either a fermentative or a respiratory metabolism...
  14. doi request reprint Active proton leak in mitochondria: a new way to regulate substrate oxidation
    Arnaud Mourier
    Universite Bordeaux 2, 1 rue Camille Saint Saens, 33077 Bordeaux Cedex, France
    Biochim Biophys Acta 1797:255-61. 2010
    ..We propose to name this new mechanism "active proton leak." Such a mechanism could allow a wide modulation of substrate oxidation in response to cellular redox constraints...
  15. ncbi request reprint The yeast cAMP protein kinase Tpk3p is involved in the regulation of mitochondrial enzymatic content during growth
    Cyrille Chevtzoff
    IBGC du CNRS Université Victor Segalen, 1 rue Camille Saint Saens, 33077 Bordeaux Cedex, France
    Biochim Biophys Acta 1706:117-25. 2005
    ..Our study points to an important decrease in the cytochrome c content in the Deltatpk3 mitochondria, which leads to a decrease in the slipping process at the level of cytochrome-c-oxidase...
  16. ncbi request reprint Increasing mitochondrial substrate-level phosphorylation can rescue respiratory growth of an ATP synthase-deficient yeast
    Christine Schwimmer
    Institut de Biochimie et Génétique Cellulaires CNRS Université Victor Ségalen Bordeaux2, 1 rue Camille St Saëns, 33077 Bordeaux Cedex, France
    J Biol Chem 280:30751-9. 2005
    ..This unexpected result might be of interest for the development of therapeutic solutions in pathologies associated with defects in the oxidative phosphorylation system...
  17. doi request reprint Mitochondrial oxidative phosphorylation is regulated by fructose 1,6-bisphosphate. A possible role in Crabtree effect induction?
    Rodrigo Diaz-Ruiz
    Universite Victor Segalen Bordeaux 2, 1 rue Camille Saint Saens, 33077 Bordeaux Cedex, France
    J Biol Chem 283:26948-55. 2008
    ..From these results and taking into account that F16bP is able to accumulate in the cell cytoplasm, we propose that F16bP regulates oxidative phosphorylation and thus participates in the establishment of the Crabtree effect...
  18. ncbi request reprint Regional differences in oxidative capacity of rat white adipose tissue are linked to the mitochondrial content of mature adipocytes
    Catherine Deveaud
    Institut de Biochimie et de Génétique Cellulaires, UMR 5095 CNRS Université Victor Segalen, 1 rue Camille Saint Saens, 33077 Bordeaux Cedex, France
    Mol Cell Biochem 267:157-66. 2004
    ..Therefore, white adipose tissue appears as a heterogeneous organ with marked variation in mitochondrial content depending on its anatomical location...
  19. ncbi request reprint Profound effects of the general anesthetic etomidate on oxidative phosphorylation without effects on their yield
    Anne Devin
    Institut de Biochimie et Genetique Cellulaires du CNRS, Université de BordeauxII, 1 rue Camille Saint Saens, 33077, Bordeaux Cedex, France
    J Bioenerg Biomembr 38:137-42. 2006
    ..In conclusion, the main effect of Etomidate is to decrease the oxidative phosphorylation rate without changing yield. The H(+) leak which appears under non-phosphorylating conditions becomes negligible in physiological conditions...
  20. ncbi request reprint Activation of Ras cascade increases the mitochondrial enzyme content of respiratory competent yeast
    Laurent Dejean
    Institut de Biochimie et Génétique Cellulaires, UMR 5095 CNRS Université Victor Segalen, 1 rue Camille Saint Saens, Bordeaux Cedex 33077, France
    Biochem Biophys Res Commun 293:1383-8. 2002
    ..It is concluded that the Ras/cAMP/protein kinase A pathway is part of the regulatory circuit controlling biogenesis of the oxidative phosphorylation complexes in yeast cells...
  21. doi request reprint The role of mitochondrial biogenesis and ROS in the control of energy supply in proliferating cells
    Edgar D Yoboue
    Universite Bordeaux, IBGC, UMR 5095, Bordeaux, France Institut de Biochimie et Génétique Cellulaires, CNRS UMR 5095, Bordeaux, France
    Biochim Biophys Acta 1837:1093-8. 2014
    ..Moreover, the glutathione redox state is shown as being an intermediate in the regulation of mitochondrial biogenesis. This article is part of a Special Issue entitled: 18th European Bioenergetic Conference. ..
  22. ncbi request reprint Mechanisms of mitochondrial response to variations in energy demand in eukaryotic cells
    Anne Devin
    IBGC du CNRS, UMR 5095, Universite Victor Segalen Bordeaux 2, 1 rue Camille Saint Saens, 33077 Bordeaux Cedex, France
    Am J Physiol Cell Physiol 292:C52-8. 2007
    ..We discuss the energetic advantages of these mechanisms...
  23. doi request reprint The Crabtree and Warburg effects: Do metabolite-induced regulations participate in their induction?
    Noureddine Hammad
    Universite Bordeaux, IBGC, UMR 5095, Bordeaux, France Institut de Biochimie et Génétique Cellulaires, CNRS UMR 5095, Bordeaux, France
    Biochim Biophys Acta 1857:1139-46. 2016
    ..This article is part of a Special Issue entitled 'EBEC 2016: 19th European Bioenergetics Conference, Riva del Garda, Italy, July 2-6, 2016', edited by Prof. Paolo Bernardi. ..
  24. doi request reprint Proton pumping complex I increases growth yield in Candida utilis
    Nicole Avéret
    Institute of Biochemistry and Genetics of the Cell, CNRS UMR 5095, 1 rue Camille Saint Saens, 33077 Bordeaux Cedex, France Université de Bordeaux, 1 rue Camille Saint Saens, 33077 Bordeaux Cedex, France
    Biochim Biophys Acta 1847:1320-6. 2015
    ..Such a complex regulation in C. utilis allows an increase in growth yield when cytosolic NADH is not plentiful but still favors the cytosolic NADH re-oxidation at high NADH, favoring biomass generation metabolic pathways. ..
  25. doi request reprint Monitoring metabolic responses of single mitochondria within poly(dimethylsiloxane) wells: study of their endogenous reduced nicotinamide adenine dinucleotide evolution
    Emmanuel Suraniti
    University Bordeaux, ISM, UMR5255, F 33400 Talence, France
    Anal Chem 85:5146-52. 2013
    ..In addition, we showed that mitochondrial ability to generate high levels of NADH, that is its metabolic performance, is not correlated either to the initial energetic state or to the respective size of each mitochondrion...
  26. doi request reprint Dietary polyphenols preconditioning protects 3T3-L1 preadipocytes from mitochondrial alterations induced by oxidative stress
    Pascal Baret
    Groupe d Etude sur l Inflammation Chronique et l Obésité EA 4516, Universite de la Reunion, 15 Avenue Rene Cassin, BP 7151, 97715 Saint Denis Messag Cedex 9, France
    Int J Biochem Cell Biol 45:167-74. 2013
    ..This article is part of a Directed Issue entitled: Bioenergetic dysfunction, adaptation and therapy...
  27. ncbi request reprint Asymmetric inheritance of oxidatively damaged proteins during cytokinesis
    Hugo Aguilaniu
    Department of Cell and Molecular Biology Microbiology, Goteborg University, Goteborg, Sweden
    Science 299:1751-3. 2003
    ..These findings suggest that a genetically determined, Sir2p-dependent asymmetric inheritance of oxidatively damaged proteins may contribute to free-radical defense and the fitness of newborn cells...
  28. ncbi request reprint Kinetic regulation of the mitochondrial glycerol-3-phosphate dehydrogenase by the external NADH dehydrogenase in Saccharomyces cerevisiae
    Inga Lill Pahlman
    Department of Cellular and Molecular Biology Microbiology, Lundberg Laboratory, Gothenburg University, Sweden
    J Biol Chem 277:27991-5. 2002
    ..The physiological consequences of this regulation are discussed...
  29. ncbi request reprint Thyroid status is a key regulator of both flux and efficiency of oxidative phosphorylation in rat hepatocytes
    Veronique Nogueira
    Laboratoire de Bioénergétique Fondamentale et Appliquée, Universite J Fourier, Grenoble, France
    J Bioenerg Biomembr 34:55-66. 2002
    ..We conclude that energy homeostasis depends on a compromise between rate and efficiency, which is mainly regulated by thyroid hormones...
  30. ncbi request reprint Non-respiratory oxygen consumption pathways in anaerobically-grown Saccharomyces cerevisiae: evidence and partial characterization
    Eric Rosenfeld
    Laboratoire de Microbiologie et de Technologie des Fermentations, Unité Mixte de Recherches Sciences pour l OEnologie, Institut National de la Recherche Agronomique, 2 place Viala, 34060 Montpellier Cedex 1, France
    Yeast 19:1299-321. 2002
    ..Such activities are associated in vitro with a massive production of O(2) (.-) and, to a lower extent, H(2)O(2) and a likely concomitant production of H(2)O...
  31. ncbi request reprint Inhibition of preadipocyte proliferation by mitochondrial reactive oxygen species
    Audrey Carriere
    UMR 5018 CNRS UPS, IFR31, Bat L1, CHU Rangueil, 31059 Toulouse Cedex 49, France
    FEBS Lett 550:163-7. 2003
    ..Thus, mitochondrial reactive oxygen species can influence development of adipose tissue by affecting the size of the white preadipocyte pool...
  32. ncbi request reprint Mitochondrial reactive oxygen species control the transcription factor CHOP-10/GADD153 and adipocyte differentiation: a mechanism for hypoxia-dependent effect
    Audrey Carriere
    Unité Mixte de Recherche 5018 CNRS Université Paul Sabatier, IFR31, Bat L1, Complexe Hospitalier Universitaire Rangueil, 31059 Toulouse Cedex 9, France
    J Biol Chem 279:40462-9. 2004
    ..Together, these data demonstrate that mitochondrial reactive oxygen species control CHOP-10/GADD153 expression, are antiadipogenic signaling molecules, and trigger hypoxia-dependent inhibition of adipocyte differentiation...
  33. ncbi request reprint Mitochondrial adaptations to steatohepatitis induced by a methionine- and choline-deficient diet
    Caroline Romestaing
    Laboratoire de Physiologie Integrative, Cellulaire et Moléculaire, Unité Mixte de Recherches 5123 Centre National de la Recherche Scientifique, Universite Claude Bernard Lyon 1, Villeurbanne Cedex, France
    Am J Physiol Endocrinol Metab 294:E110-9. 2008
    ..We conclude that, in MCDD-fed rats, liver mitochondria exhibit an energy wastage that may contribute to limit steatosis and oxidative stress in this model of steatohepatitis...
  34. ncbi request reprint In yeast, Ca2+ and octylguanidine interact with porin (VDAC) preventing the mitochondrial permeability transition
    Manuel Gutiérrez-Aguilar
    Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, 04510 Mexico D F, Mexico
    Biochim Biophys Acta 1767:1245-51. 2007
    ..It is thus suggested that in yeast mitochondria, the voltage-dependent anion channel has a cation binding site where Ca(2+) and octylguanidine interact, conferring cation sensitivity to the yeast mitochondrial unspecific channel...
  35. ncbi request reprint Nitric oxide increases oxidative phosphorylation efficiency
    Pascaline Clerc
    INSERM, U884, F 38041, Grenoble, France
    J Bioenerg Biomembr 39:158-66. 2007
    ..We propose that NO may be a natural short-term regulator of mitochondrial physiology that increases oxidative phosphorylation efficiency in a redox-sensitive manner by decreasing the slipping in the proton pumps...