Laurent Poirel

Summary

Country: France

Publications

  1. pmc Genetic environment and expression of the extended-spectrum beta-lactamase blaPER-1 gene in gram-negative bacteria
    Laurent Poirel
    Service de Bacteriologie Virologie, Hopital de Bicetre, Universite Paris XI, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre cedex, France
    Antimicrob Agents Chemother 49:1708-13. 2005
  2. pmc Integron-encoded GES-type extended-spectrum beta-lactamase with increased activity toward aztreonam in Pseudomonas aeruginosa
    Laurent Poirel
    Service de Bacteriologie Virologie, Hopital de Bicetre, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre cedex, France
    Antimicrob Agents Chemother 49:3593-7. 2005
  3. ncbi Genetic support of extended-spectrum beta-lactamases
    L Poirel
    Service de Bacteriologie Virologie, Hopital de Bicetre, South Paris Medical School, University Paris XI, Le Kremlin Bicetre, France
    Clin Microbiol Infect 14:75-81. 2008
  4. pmc Expanded-spectrum beta-lactamase and plasmid-mediated quinolone resistance
    Laurent Poirel
    Emerg Infect Dis 13:803-5. 2007
  5. pmc Plasmid-Mediated Quinolone Resistance; Interactions between Human, Animal, and Environmental Ecologies
    Laurent Poirel
    INSERM U914 Emerging Resistance to Antibiotics, Service de Bacteriologie Virologie, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, Université Paris XI K Bicêtre, France
    Front Microbiol 3:24. 2012
  6. doi Characterization of an extended-spectrum class A β-lactamase from a novel enterobacterial species taxonomically related to Rahnella spp./Ewingella spp
    Marie Frédérique Lartigue
    INSERM U914 Emerging Resistance to Antibiotics, Faculté de Médecine et Université Paris Sud, 94275 K Bicêtre, France
    J Antimicrob Chemother 68:1733-6. 2013
  7. doi OXA-48-like carbapenemases: the phantom menace
    Laurent Poirel
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Faculté de Médecine et Université Paris Sud, 94275 K Bicêtre, France
    J Antimicrob Chemother 67:1597-606. 2012
  8. pmc Wild coastline birds as reservoirs of broad-spectrum-β-lactamase-producing Enterobacteriaceae in Miami Beach, Florida
    Laurent Poirel
    Service de Bacteriologie Virologie, INSERM U914, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculté de Médecine et Université Paris Sud, K Bicêtre, France
    Antimicrob Agents Chemother 56:2756-8. 2012
  9. doi Emergence of NDM-1-producing Klebsiella pneumoniae in Morocco
    Laurent Poirel
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, K Bicêtre, France
    J Antimicrob Chemother 66:2781-3. 2011
  10. ncbi Carbapenemases: molecular diversity and clinical consequences
    Laurent Poirel
    Universite Paris XI, Service de Bacteriologie Virologie, Hopital de Bicetre, Assistance Punblique Hôpitaux de Paris, Faculte de Medecine Paris Sud, 94275 K Bicêtre, France
    Future Microbiol 2:501-12. 2007

Detail Information

Publications169 found, 100 shown here

  1. pmc Genetic environment and expression of the extended-spectrum beta-lactamase blaPER-1 gene in gram-negative bacteria
    Laurent Poirel
    Service de Bacteriologie Virologie, Hopital de Bicetre, Universite Paris XI, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre cedex, France
    Antimicrob Agents Chemother 49:1708-13. 2005
    ..baumannii isolates. In both cases, expression of the bla(PER-1) gene was driven by promoter sequences located in ISPa12...
  2. pmc Integron-encoded GES-type extended-spectrum beta-lactamase with increased activity toward aztreonam in Pseudomonas aeruginosa
    Laurent Poirel
    Service de Bacteriologie Virologie, Hopital de Bicetre, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre cedex, France
    Antimicrob Agents Chemother 49:3593-7. 2005
    ..The bla(GES-9) gene was located inside a class 1 integron structure containing two copies of a novel insertion sequence belonging to the IS1111 family...
  3. ncbi Genetic support of extended-spectrum beta-lactamases
    L Poirel
    Service de Bacteriologie Virologie, Hopital de Bicetre, South Paris Medical School, University Paris XI, Le Kremlin Bicetre, France
    Clin Microbiol Infect 14:75-81. 2008
    ..This diversity of genetic vehicles at the origin of these mobilisation/acquisition processes enhances the spread of ESBLs...
  4. pmc Expanded-spectrum beta-lactamase and plasmid-mediated quinolone resistance
    Laurent Poirel
    Emerg Infect Dis 13:803-5. 2007
  5. pmc Plasmid-Mediated Quinolone Resistance; Interactions between Human, Animal, and Environmental Ecologies
    Laurent Poirel
    INSERM U914 Emerging Resistance to Antibiotics, Service de Bacteriologie Virologie, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, Université Paris XI K Bicêtre, France
    Front Microbiol 3:24. 2012
    ..Altogether, the recent observations suggest that the aquatic environment might constitute the original source of PMQR genes, that would secondly spread among animal or human isolates...
  6. doi Characterization of an extended-spectrum class A β-lactamase from a novel enterobacterial species taxonomically related to Rahnella spp./Ewingella spp
    Marie Frédérique Lartigue
    INSERM U914 Emerging Resistance to Antibiotics, Faculté de Médecine et Université Paris Sud, 94275 K Bicêtre, France
    J Antimicrob Chemother 68:1733-6. 2013
    ..To characterize the naturally occurring β-lactamase gene identified from a clinical isolate belonging to a novel enterobacterial species that is closely related to Rahnella spp. and Ewingella spp...
  7. doi OXA-48-like carbapenemases: the phantom menace
    Laurent Poirel
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Faculté de Médecine et Université Paris Sud, 94275 K Bicêtre, France
    J Antimicrob Chemother 67:1597-606. 2012
    ..Adequate screening and detection methods are therefore required to prevent and control their dissemination...
  8. pmc Wild coastline birds as reservoirs of broad-spectrum-β-lactamase-producing Enterobacteriaceae in Miami Beach, Florida
    Laurent Poirel
    Service de Bacteriologie Virologie, INSERM U914, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculté de Médecine et Université Paris Sud, K Bicêtre, France
    Antimicrob Agents Chemother 56:2756-8. 2012
    ..The most commonly identified resistance determinants were CMY-2 and CTX-M-15. Those wild birds might be therefore considered vehicles for wide dissemination of multidrug-resistant Enterobacteriaceae in the United States...
  9. doi Emergence of NDM-1-producing Klebsiella pneumoniae in Morocco
    Laurent Poirel
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, K Bicêtre, France
    J Antimicrob Chemother 66:2781-3. 2011
    ..To analyse the mechanisms responsible for multidrug resistance in three carbapenem-resistant Klebsiella pneumoniae isolates recovered from two hospitalized patients and an outpatient from the same hospital in Rabat, Morocco...
  10. ncbi Carbapenemases: molecular diversity and clinical consequences
    Laurent Poirel
    Universite Paris XI, Service de Bacteriologie Virologie, Hopital de Bicetre, Assistance Punblique Hôpitaux de Paris, Faculte de Medecine Paris Sud, 94275 K Bicêtre, France
    Future Microbiol 2:501-12. 2007
    ..Finally, the class D carbapenemases are being increasingly reported, mostly in Acinetobacter baumannii, and they compromise the efficacy of imipenem and meropenem significantly...
  11. doi Multiplex PCR for detection of acquired carbapenemase genes
    Laurent Poirel
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, Universite Paris XI, 94275 K Bicêtre, France
    Diagn Microbiol Infect Dis 70:119-23. 2011
    ..We reported here a rapid and reliable technique for screening all clinically relevant carbapenemase genes...
  12. pmc OXA-163, an OXA-48-related class D β-lactamase with extended activity toward expanded-spectrum cephalosporins
    Laurent Poirel
    Service de Bacteriologie Virologie, Hopital de Bicetre, 78 rue du General Leclerc, Le Kremlin Bicêtre 94275, France
    Antimicrob Agents Chemother 55:2546-51. 2011
    ..This study identified the first class D β-lactamase compromising both extended-spectrum cephalosporin and carbapenem activities...
  13. doi Genetic basis of antibiotic resistance in pathogenic Acinetobacter species
    Laurent Poirel
    Service de Bacteriologie Virologie, Hopital de Bicetre, South Paris Medical School, University Paris XI, INSERM U914, 94275 K Bicêtre, France
    IUBMB Life 63:1061-7. 2011
    ..The role of novel genetic elements, such as resistance islands, in concentrating antibiotic resistance genes in A. baumannii requires detailed investigation in the near future...
  14. pmc Prevalence and genetic analysis of plasmid-mediated quinolone resistance determinants QnrA and QnrS in Enterobacteriaceae isolates from a French university hospital
    Laurent Poirel
    Service de Bacteriologie Virologie, Hopital de Bicetre, Faculte de Medecine Paris Sud, Universite Paris XI, 94275 Le Kremlin Bicetre cedex, France
    Antimicrob Agents Chemother 50:3992-7. 2006
    ..This is the first study identifying the QnrS resistance determinant in Europe and indicating that this determinant might also be widespread...
  15. doi Plasmid-mediated quinolone resistance determinants among enterobacterial isolates from outpatients in Brazil
    Luciene A R Minarini
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Universite Paris XI, 78, rue du General Leclerc, 94275 K Bicêtre, France
    J Antimicrob Chemother 62:474-8. 2008
    ....
  16. pmc Functional characterization of IS1999, an IS4 family element involved in mobilization and expression of beta-lactam resistance genes
    Daniel Aubert
    Service de Bacteriologie Virologie, Hopital de Bicetre, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre cedex, France
    J Bacteriol 188:6506-14. 2006
    ..This reduced transposition frequency of IS1999.2-based elements may result from a lower transcription of the transposase gene, as revealed by reverse transcription-PCR analyses...
  17. pmc Emergence of oxacillinase-mediated resistance to imipenem in Klebsiella pneumoniae
    Laurent Poirel
    Service de Bacteriologie Virologie, Universite Paris XI, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, 94275 Le Kremlin Bicetre, France
    Antimicrob Agents Chemother 48:15-22. 2004
    ..36 kDa. Thus, the high-level resistance to beta-lactams of this clinical isolate resulted from peculiar beta-lactamases and modification of outer membrane proteins...
  18. ncbi Extension of the hydrolysis spectrum of AmpC beta-lactamase of Escherichia coli due to amino acid insertion in the H-10 helix
    Hedi Mammeri
    Service de Bacteriologie Virologie, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, Universite Paris Sud, 94275 K Bicêtre, France
    J Antimicrob Chemother 60:490-4. 2007
    ..To characterize the naturally occurring expanded-spectrum beta-lactamase from an Escherichia coli clinical isolate and to compare it with a wild-type beta-lactamase...
  19. pmc Genetic and biochemical characterization of a chromosome-encoded carbapenem-hydrolyzing ambler class D beta-lactamase from Shewanella algae
    Claire Héritier
    Service de Bacteriologie Virologie, Universite Paris XI, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, 94275 Le Kremlin Bicetre, France
    Antimicrob Agents Chemother 48:1670-5. 2004
    ..algae KB-1. Very similar oxacillinases were found in other S. algae isolates...
  20. pmc BEL-1, a novel clavulanic acid-inhibited extended-spectrum beta-lactamase, and the class 1 integron In120 in Pseudomonas aeruginosa
    Laurent Poirel
    Service de Bacteriologie Virologie, Hopital de Bicetre, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre cedex, France
    Antimicrob Agents Chemother 49:3743-8. 2005
    ..In addition, this integron was bracketed by Tn1404 transposon sequences at its right end and by P. aeruginosa-specific sequences at its left end...
  21. doi Metallo-beta-lactamase-producing Pseudomonas aeruginosa isolates in Tunisia
    Wejdene Mansour
    Service de Bacteriologie Virologie, INSERM U914, Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculté de Médecine et Université Paris Paris Sud, 94275 K Bicêtre, France
    Diagn Microbiol Infect Dis 64:458-61. 2009
    ..This carbapenemase was very likely chromosomally located and as a form of a gene cassette in a class 1 integron. This is the 1st report of spread of VIM-2 producers in Tunisia...
  22. doi Dissemination of OXA-23-producing and carbapenem-resistant Acinetobacter baumannii in a University Hospital in Tunisia
    Wejdene Mansour
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculté de Médecine et Université Paris Paris Sud, Bicetre, France
    Microb Drug Resist 14:289-92. 2008
    ..This study further highlights the worldwide emergence of OXA-23-producing A. baumannii isolates...
  23. pmc Novel ambler class A carbapenem-hydrolyzing beta-lactamase from a Pseudomonas fluorescens isolate from the Seine River, Paris, France
    Delphine Girlich
    Service de Bacteriologie Virologie, Hopital de Bicetre, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre cedex, France
    Antimicrob Agents Chemother 54:328-32. 2010
    ..The bla(BIC-1) gene was chromosomally located and was also identified in two other P. fluorescens strains isolated from the Seine River 3 months later...
  24. pmc VIM-19, a metallo-beta-lactamase with increased carbapenemase activity from Escherichia coli and Klebsiella pneumoniae
    José Manuel Rodríguez-Martínez
    Service de Bacteriologie Virologie, Hopital de Bicetre, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre cedex, France
    Antimicrob Agents Chemother 54:471-6. 2010
    ..This study indicates that MBLs with enhanced activity toward carbapenems may be obtained as a result of very few amino acid substitutions...
  25. pmc TEM-121, a novel complex mutant of TEM-type beta-lactamase from Enterobacter aerogenes
    Laurent Poirel
    Service de Bacteriologie Virologie, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, Universite Paris XI, Le Kremlin Bicetre, France
    Antimicrob Agents Chemother 48:4528-31. 2004
    ..Thus, TEM-121 is a novel complex mutant TEM beta-lactamase (CMT-4) combining the kinetic properties of an ESBL and an inhibitor-resistant TEM enzyme...
  26. ncbi Vibrionaceae as a possible source of Qnr-like quinolone resistance determinants
    Laurent Poirel
    Service de Bacteriologie Virologie, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, 94275 K Bicêtre Cedex, France
    J Antimicrob Chemother 56:1118-21. 2005
    ..To gain insight into the functionality of qnr-like genes of several bacterial species of Vibrionaceae that may encode quinolone resistance determinants...
  27. pmc Spread of OXA-48-encoding plasmid in Turkey and beyond
    Amélie Carrër
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, K Bicêtre, France
    Antimicrob Agents Chemother 54:1369-73. 2010
    ..That gene was located within either transposon Tn1999 or transposon Tn1999.2, which was always inserted within the same gene. This work highlights the current plasmid-mediated dissemination of the OXA-48 carbapenemase worldwide...
  28. ncbi Nosocomial spread of Pseudomonas aeruginosa isolates expressing the metallo-beta-lactamase VIM-2 in a hematology unit of a French hospital
    Cecile Aubron
    Service de Bacteriologie Virologie, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, 94275 Le Kremlin Bicetre cedex, France
    Microb Drug Resist 11:254-9. 2005
    ..aeruginosa isolates all harboring an approximately 45-kb plasmid with bla (VIM-2)-positive class 1 integrons varying in structures. This study identified a hidden reservoir of carbapenemase producers...
  29. pmc Naturally occurring extended-spectrum cephalosporinases in Escherichia coli
    Hedi Mammeri
    Service de Bacteriologie Virologie, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, Universite Paris Sud, 94275 Le Kremlin Bicetre, France
    Antimicrob Agents Chemother 50:2573-6. 2006
    ....
  30. pmc Extended-spectrum cephalosporinase in Acinetobacter baumannii
    José Manuel Rodríguez-Martínez
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Assistance Publique Hôpital de Paris, Faculté deMédecine and Université Paris Sud, France
    Antimicrob Agents Chemother 54:3484-8. 2010
    ..Site-directed mutagenesis confirmed the role of both substitutions in its ESAC property...
  31. ncbi A nosocomial outbreak of Acinetobacter baumannii isolates expressing the carbapenem-hydrolysing oxacillinase OXA-58
    Claire Héritier
    Service de Bacteriologie Virologie, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, Universite Paris XI, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre cedex, France
    J Antimicrob Chemother 55:115-8. 2005
    ..The aim of this study was to analyse the spread of the bla(OXA-58) gene as a source of carbapenem resistance in Acinetobacter baumannii in the burns unit of a university hospital in Toulouse in 2003-2004...
  32. pmc Association of plasmid-mediated quinolone resistance with extended-spectrum beta-lactamase VEB-1
    Laurent Poirel
    Service de Bacteriologie Virologie, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, Universite Paris XI, Le Kremlin Bicetre, France
    Antimicrob Agents Chemother 49:3091-4. 2005
    ..Bicêtre, France, and in 11 out of 23 bla(VEB-1)-positive enterobacterial isolates from Bangkok, Thailand. This result may explain in part the association between quinolone and extended-spectrum beta-lactam resistance...
  33. pmc Acinetobacter radioresistens as a silent source of carbapenem resistance for Acinetobacter spp
    Laurent Poirel
    Service de Bacteriologie Virologie, INSERM U914, Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Universite Paris XI, Le Kremlin Bicetre, France
    Antimicrob Agents Chemother 52:1252-6. 2008
    ..Therefore, A. radioresistens, a commensal bacterial species which is identified on the skin of hospitalized and healthy patients (a property shared with A. baumannii), was identified as the source of the bla OXA-23 gene...
  34. pmc Characterization of the naturally occurring oxacillinase of Acinetobacter baumannii
    Claire Héritier
    Service de Bacteriologie Virologie, Hopital de Bicetre, Le Kremlin Bicetre, France
    Antimicrob Agents Chemother 49:4174-9. 2005
    ..By PCR and sequencing bla(OXA-69)-like genes were identified in all A. baumannii strains tested (n = 12), suggesting that this oxacillinase is naturally occurring in that species...
  35. ncbi Multiplex PCR for detection of plasmid-mediated quinolone resistance qnr genes in ESBL-producing enterobacterial isolates
    Vincent Cattoir
    Service de Bacteriologie Virologie, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, Universite Paris XI, 78, rue du General Leclerc, 94275 K Bicêtre, France
    J Antimicrob Chemother 60:394-7. 2007
    ..To develop a rapid and reliable single-tube-based PCR technique for detecting simultaneously the plasmid-mediated quinolone resistance qnrA, qnrB and qnrS genes...
  36. doi Predominance of CTX-M-type extended-spectrum beta-lactamase genes among enterobacterial isolates from outpatients in Brazil
    Luciene A R Minarini
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculté de Médecine et Université Paris Sud, K Bicêtre, France
    Diagn Microbiol Infect Dis 65:202-6. 2009
    ..Eleven isolates (4.2%) harbored a bla(CTX-M-2) gene, 3 isolates bla(CTX-M-9), 2 isolates bla(CTX-M-8), and 6 isolates bla(SHV-5). Two novel bla(CTX-M-2) variants, namely, bla(CTX-M-74) and bla(CTX-M-75), were identified...
  37. doi Plasmid-mediated quinolone resistance in Aeromonas allosaccharophila recovered from a Swiss lake
    Renata Cristina Picão
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculté de Médecine et Université Paris Sud, K Bicêtre, France
    J Antimicrob Chemother 62:948-50. 2008
    ..To search for plasmid-mediated qnr genes among waterborne environmental Aeromonas spp. recovered from Switzerland...
  38. ncbi Cloning and functional characterization of the ambler class C beta-lactamase of Yersinia ruckeri
    Hedi Mammeri
    Service de Bacteriologie Virologie, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, Le Kremlin Bicetre, France
    FEMS Microbiol Lett 257:57-62. 2006
    ..This work provides further evidence that fish-pathogenic gram-negative rod species may constitute a reservoir of antibiotic resistance genes...
  39. pmc AmpC beta-lactamase in an Escherichia coli clinical isolate confers resistance to expanded-spectrum cephalosporins
    Hedi Mammeri
    Service de Bacteriologie Virologie, Hopital de Bicetre, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre cedex, France
    Antimicrob Agents Chemother 48:4050-3. 2004
    ..This enzyme, exhibiting 14 amino acid substitutions compared to a reference AmpC cephalosporinase of E. coli, hydrolyzed ceftazidime and cefepime significantly...
  40. pmc BEL-2, an extended-spectrum beta-lactamase with increased activity toward expanded-spectrum cephalosporins in Pseudomonas aeruginosa
    Laurent Poirel
    Service de Bacteriologie Virologie, Hopital de Bicetre, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre cedex, France
    Antimicrob Agents Chemother 54:533-5. 2010
    ..The bla(BEL-2) gene was identified from a P. aeruginosa isolate clonally related to another bla(BEL-1)-positive isolate...
  41. pmc Carbapenem-hydrolyzing GES-5-encoding gene on different plasmid types recovered from a bacterial community in a sewage treatment plant
    Delphine Girlich
    Service de Bacteriologie Virologie, INSERM U914, Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, Le Kremlin Bicetre, France
    Appl Environ Microbiol 78:1292-5. 2012
    ..These plasmids have different backbones, belong to different incompatibility groups, and could replicate in both Pseudomonas aeruginosa and Escherichia coli...
  42. pmc Identification of the novel narrow-spectrum beta-lactamase SCO-1 in Acinetobacter spp. from Argentina
    Laurent Poirel
    Service de Bacteriologie Virologie, Hopital de Bicetre, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre cedex, France
    Antimicrob Agents Chemother 51:2179-84. 2007
    ..40% with the enzymes TEM, SHV, and CTX-M. A gene encoding a putative resolvase was identified downstream of the bla(SCO-1) gene, but its precise way of acquisition remains to be determined...
  43. pmc Regional occurrence of plasmid-mediated carbapenem-hydrolyzing oxacillinase OXA-58 in Acinetobacter spp. in Europe
    Sophie Marque
    Service de Bacteriologie Virologie, Hopital de Bicetre, Le Kremlin Bicetre, France
    J Clin Microbiol 43:4885-8. 2005
    ..clinical isolates from southern Europe, the Balkans, and central Turkey. It may contribute significantly to the emergence of carbapenem resistance in Acinetobacter spp., at least in this part of the world...
  44. pmc Extended-spectrum cephalosporinases in Pseudomonas aeruginosa
    José Manuel Rodríguez-Martínez
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Assistance Publique Hopitaux de Paris, Faculté de Médecine and Université Paris Sud, Hopital de Bicetre, 94275 K Bicêtre, France
    Antimicrob Agents Chemother 53:1766-71. 2009
    ..This report identified a novel resistance mechanism that may contribute to imipenem resistance in P. aeruginosa...
  45. pmc Plasmid-mediated quinolone resistance pump QepA2 in an Escherichia coli isolate from France
    Vincent Cattoir
    INSERM U914 Emerging Resistance to Antibiotics, Service de Bacteriologie Virologie, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Universite Paris Sud, K Bicêtre, France
    Antimicrob Agents Chemother 52:3801-4. 2008
    ..8%) that produced the putative pump QepA2 was identified. This qepA2 gene was located onto a 90-kb mobilizable plasmid that conferred reduced susceptibility to hydrophilic fluoroquinolones...
  46. pmc Novel Ambler class A beta-lactamase LAP-1 and its association with the plasmid-mediated quinolone resistance determinant QnrS1
    Laurent Poirel
    Service de Bacteriologie Virologie, Hopital de Bicetre, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre cedex, and Faculté de Médecine Paris Sud, Universite Paris Sud, K Bicêtre, France
    Antimicrob Agents Chemother 51:631-7. 2007
    ..cloacae isolates from France and Vietnam. These genes were plasmid located and associated with similar insertion sequences but were not associated with sul1-type class 1 integrons, as opposed to the qnrA genes...
  47. pmc Emergence of plasmid-mediated quinolone resistance in Escherichia coli in Europe
    Hedi Mammeri
    Service de Bacteriologie Virologie, Hopital de Bicetre, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre cedex, France
    Antimicrob Agents Chemother 49:71-6. 2005
    ..This is the first report of plasmid-mediated quinolone resistance in Europe associated with an unknown level of plasmid-mediated multidrug resistance in Enterobacteriaceae...
  48. doi Screening and deciphering antibiotic resistance in Acinetobacter baumannii: a state of the art
    Rémy A Bonnin
    INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Faculté de Médecine et Université Paris Sud, K Bicêtre, France
    Expert Rev Anti Infect Ther 11:571-83. 2013
    ..The implementation of early detection and identification of multidrug-resistant A. baumannii is crucial to control their spread...
  49. pmc Resistance to cefepime and cefpirome due to a 4-amino-acid deletion in the chromosome-encoded AmpC beta-lactamase of a Serratia marcescens clinical isolate
    Hedi Mammeri
    Service de Bacteriologie Virologie, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, Universite Paris XI, 94275 Le Kremlin Bicetre, France
    Antimicrob Agents Chemother 48:716-20. 2004
    ..This work underlined that resistance to the latest expanded-spectrum cephalosporins may be mediated by structurally modified AmpC-type beta-lactamases...
  50. pmc In vivo selection of a chromosomally encoded beta-lactamase variant conferring ceftazidime resistance in Klebsiella oxytoca
    Hedi Mammeri
    Service de Bacteriologie Virologie, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, Universite Paris XI, 94275 Le Kremlin Bicetre, France
    Antimicrob Agents Chemother 47:3739-42. 2003
    ..This is the first report of in vivo selection of a K. oxytoca isolate that produced a chromosomally encoded beta-lactamase conferring resistance to ceftazidime...
  51. ncbi Prevalence of qnr genes in Salmonella in France
    Vincent Cattoir
    Service de Bacteriologie Virologie, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, Universite Paris XI, K Bicêtre, France
    J Antimicrob Chemother 59:751-4. 2007
    ..To detect the qnrA, qnrB and qnrS genes among Salmonella isolates received at the French National Reference Centre for Salmonella in Paris, France...
  52. pmc CTX-M expression and selection of ertapenem resistance in Klebsiella pneumoniae and Escherichia coli
    Delphine Girlich
    Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculté de Médecine et Université Paris Sud, K Bicêtre, France
    Antimicrob Agents Chemother 53:832-4. 2009
    ..Frequencies of mutants with decreased susceptibilities to ertapenem were similar for all beta-lactamases expressed...
  53. ncbi Plasmid-mediated quinolone resistance in Australia
    José Manuel Rodríguez-Martínez
    Service de Bacteriologie Virologie, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, Universite Paris XI, K Bicêtre, France
    Microb Drug Resist 12:99-102. 2006
    ..However, the gene cassettes of the sul1-type integrons were different. This study identified the first plasmid-mediated quinolone resistance determinant in Enterobacteriaceae in Australia...
  54. pmc Carbapenem-resistant Acinetobacter baumannii isolates from Tunisia producing the OXA-58-like carbapenem-hydrolyzing oxacillinase OXA-97
    Laurent Poirel
    Service de Bacteriologie Virologie, INSERM U914, Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculté de Médecine et Université Paris Paris Sud, K Bicêtre 94275, France
    Antimicrob Agents Chemother 52:1613-7. 2008
    ..In addition, the novel ISAba8 element (which is of the IS21 family) was identified. This is the first report of the nosocomial spread of carbapenemase producers in A. baumannii isolates in Africa...
  55. pmc Contribution of acquired carbapenem-hydrolyzing oxacillinases to carbapenem resistance in Acinetobacter baumannii
    Claire Héritier
    Service de Bacteriologie Virologie, Hopital de Bicetre, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre, France
    Antimicrob Agents Chemother 49:3198-202. 2005
    ..baumannii, and overexpression of efflux pump AdeABC may also contribute to higher levels of resistance to beta-lactams, including carbapenems...
  56. pmc Naturally occurring Class A ss-lactamases from the Burkholderia cepacia complex
    Laurent Poirel
    Service de Bacteriologie Virologie, Hopital de Bicetre, Le Kremlin Bicetre Cedex, France
    Antimicrob Agents Chemother 53:876-82. 2009
    ..cenocepacia were identified from other Burkholderia species. The corresponding ss-lactamase genes might be used as genetic tools for accurate Burkholderia species identification...
  57. ncbi Emergence of plasmid-mediated resistance to quinolones in Enterobacteriaceae
    Patrice Nordmann
    Service de Bacteriologie Virologie, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, Universite Paris Sud, 78 rue du General Leclerc, 94275, K Bicêtre, France
    J Antimicrob Chemother 56:463-9. 2005
    ..Further analysis of the role (if any) of quinolones for enhancing this gene transfer may be conducted. This could prevent the spread, if still possible, of this novel antibiotic resistance mechanism...
  58. pmc Extended-spectrum beta-lactamase CTX-M-1 in Escherichia coli isolates from healthy poultry in France
    Delphine Girlich
    Service de Bacteriologie Virologie, Hopital de Bicetre, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre cedex, France
    Appl Environ Microbiol 73:4681-5. 2007
    ..Eleven of those strains were not clonally related and had a bla(CTX-M-1) gene located on transferable plasmids of different sizes and structures...
  59. pmc Chromosome-encoded ambler class D beta-lactamase of Shewanella oneidensis as a progenitor of carbapenem-hydrolyzing oxacillinase
    Laurent Poirel
    Service de Bacteriologie Virologie, Universite Paris XI, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, 94275 Le Kremlin Bicetre, France
    Antimicrob Agents Chemother 48:348-51. 2004
    ..This work suggests that Shewanella spp. may produce the progenitor of oxacillinases compromising the efficacy of imipenem in clinically relevant gram-negative pathogens...
  60. pmc Carbapenemase-producing Enterobacteriaceae, U.S. rivers
    Cecile Aubron
    University Paris XI, Paris, France
    Emerg Infect Dis 11:260-4. 2005
    ..beta-Lactamase IMI-2 is the first inducible and plasmid-encoded carbapenemase. Identification of clonally related E. asburiae isolates from distant rivers indicates an environmental and enterobacterial reservoir for carbapenemase genes...
  61. pmc Association of the emerging carbapenemase NDM-1 with a bleomycin resistance protein in Enterobacteriaceae and Acinetobacter baumannii
    Laurent Dortet
    Service de Bacteriologie Virologie, INSERM U914, Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, K Bicêtre, France
    Antimicrob Agents Chemother 56:1693-7. 2012
    ..This study suggests that the emerging carbapenemase NDM-1 is selected by bleomycin-like molecules, and that BRP(MBL) producers (and consequently NDM producers) are better suited to various environments...
  62. pmc Extended-spectrum beta-lactamases of the CTX-M type now in Switzerland
    Marie Frédérique Lartigue
    Service de Bacteriologie Virologie, Hopital de Bicetre, 78 rue du General Leclerc, Bicetre, France
    Antimicrob Agents Chemother 51:2855-60. 2007
    ..The plasmid-located bla(CTX-M) genes were associated with either ISEcp1 or ISCR1 insertion sequences. This study is the first published report of CTX-M-type beta-lactamases in Switzerland...
  63. ncbi A nosocomial outbreak of Pseudomonas aeruginosa isolates expressing the extended-spectrum beta-lactamase GES-2 in South Africa
    Laurent Poirel
    Service de Bacteriologie Virologie, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, 94275 Le Kremlin Bicetre, France
    J Antimicrob Chemother 49:561-5. 2002
    ..aeruginosa expressing the GES-2 beta-lactamase...
  64. doi Detection of the carbapenemase GIM-1 in Enterobacter cloacae in Germany
    Axel Hamprecht
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculté de Médecine et Université Paris Sud, Kremlin Bicetre, France
    J Antimicrob Chemother 68:558-61. 2013
    ..To characterize the mechanisms involved in reduced susceptibility to carbapenems in two Enterobacter cloacae clinical isolates...
  65. pmc Spread of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in Istanbul, Turkey
    Amélie Carrër
    Service de Bacteriologie Virologie, INSERM U914, Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, Le Kremlin Bicetre, France
    Antimicrob Agents Chemother 52:2950-4. 2008
    ....
  66. pmc NDM-4 metallo-β-lactamase with increased carbapenemase activity from Escherichia coli
    Patrice Nordmann
    Service de Bacteriologie Virologie, INSERM U914, Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculté de Médecine et Université Paris Sud, Kremlin Bicetre, France
    Antimicrob Agents Chemother 56:2184-6. 2012
    ..This amino acid substitution was not located in the known active sites of NDM-1, indicating that remote amino acid substitutions might also play a role in the extended activity of this MBL...
  67. pmc Genetic features of blaNDM-1-positive Enterobacteriaceae
    Laurent Poirel
    Service de Bacteriologie Virologie, Hopital de Bicetre, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre cedex, France
    Antimicrob Agents Chemother 55:5403-7. 2011
    ..The bla(NDM-1) plasmids coharbored a variety of resistance determinants, including β-lactamase genes, quinolone resistance genes, and 16S RNA methylase genes...
  68. pmc Integron mobilization unit as a source of mobility of antibiotic resistance genes
    Laurent Poirel
    Service de Bactériologie Virologie Hygiène, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, 78 Rue de Général Leclerc, 94275 Le Kremlin Bicetre cedex, France
    Antimicrob Agents Chemother 53:2492-8. 2009
    ..This is the first identification of MITE-type structures as a source of gene mobilization, implicating here a clinically relevant antibiotic resistance gene...
  69. pmc Characterization of DIM-1, an integron-encoded metallo-beta-lactamase from a Pseudomonas stutzeri clinical isolate in the Netherlands
    Laurent Poirel
    Service de Bacteriologie Virologie, Hopital de Bicetre, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre cedex, France
    Antimicrob Agents Chemother 54:2420-4. 2010
    ..This MBL gene was embedded in a class 1 integron containing two other gene cassettes, encoding resistance to aminoglycosides and disinfectants, that was located on a 70-kb plasmid...
  70. pmc Unexpected occurrence of plasmid-mediated quinolone resistance determinants in environmental Aeromonas spp
    Vincent Cattoir
    Institut Nationale de la Santé et de la Recherche Médicale Unité 914, Le Kremlin Bicetre, France
    Emerg Infect Dis 14:231-7. 2008
    ..This identification of plasmid-mediated qnr genes outside Enterobacteriaceae underlines a possible diffusion of those resistance determinants within gram-negative rods...
  71. doi Genetic and biochemical characterisation of OXA-232, a carbapenem-hydrolysing class D β-lactamase from Enterobacteriaceae
    Anais Potron
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculté de Médecine et Université Paris Sud, K Bicêtre, France
    Int J Antimicrob Agents 41:325-9. 2013
    ..Compared with OXA-181, OXA-232 had a lower ability to hydrolyse carbapenems but conversely possessed higher hydrolytic activities against penicillins. The bla(OXA-232) gene was located on a 6.1-kb ColE-type non-conjugative plasmid...
  72. pmc Genetic features of the widespread plasmid coding for the carbapenemase OXA-48
    Laurent Poirel
    Service de Bacteriologie Virologie, INSERM U914, Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculté de Médecine et Université Paris Sud, K Bicêtre, France
    Antimicrob Agents Chemother 56:559-62. 2012
    ..Molecular epidemiology using a collection of international OXA-48 producers revealed the wide diffusion of pOXA-48a or closely related plasmids...
  73. doi A novel IncQ plasmid type harbouring a class 3 integron from Escherichia coli
    Laurent Poirel
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculté de Médecine et Université Paris Sud, K Bicêtre, France
    J Antimicrob Chemother 65:1594-8. 2010
    ..To determine the genetic structures at the origin of the mobilization of the extended-spectrum beta-lactamase (ESBL) bla(GES-1) gene in an Escherichia coli clinical isolate...
  74. pmc Beta-lactam induction of ISEcp1B-mediated mobilization of the naturally occurring bla(CTX-M) beta-lactamase gene of Kluyvera ascorbata
    Patrice Nordmann
    Service de Bacteriologie Virologie, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, INSERM U 914, and Faculté de Médecine et Université Paris Sud, Le Kremlin Bicetre, France
    FEMS Microbiol Lett 288:247-9. 2008
    ..2+/-2.7 x 10(-5)). Therefore, it is likely that neither amoxicillin/clavulanic acid nor cefquinome concentrations as found in the gut flora may enhance mobilization of the bla(CTX-M) genes in Enterobacteriaceae...
  75. pmc Diversity of beta-lactamases produced by ceftazidime-resistant Pseudomonas aeruginosa isolates causing bloodstream infections in Brazil
    Renata C Picão
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, K Bicêtre, France
    Antimicrob Agents Chemother 53:3908-13. 2009
    ..This study underlines the spread of MBL- and ESBL-producing P. aeruginosa isolates as an important source of ceftazidime resistance in Brazil...
  76. pmc Characterization of OXA-204, a carbapenem-hydrolyzing class D β-lactamase from Klebsiella pneumoniae
    Anais Potron
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculté de Médecine et Université Paris Sud, K Bicêtre, France
    Antimicrob Agents Chemother 57:633-6. 2013
    ..The bla(OXA-204) gene was located on a ca. 150-kb IncA/C-type plasmid, which also carried the bla(CMY-4) gene. The bla(OXA-204) gene was associated with an ISEcp1 element, whereas the bla(OXA-48) genes are usually associated with IS1999...
  77. pmc Tn125-related acquisition of blaNDM-like genes in Acinetobacter baumannii
    Laurent Poirel
    Service de Bacteriologie Virologie, INSERM U914, Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculté de Médecine et Université Paris Sud, K Bicêtre, France
    Antimicrob Agents Chemother 56:1087-9. 2012
    ..This transposon was also associated with the acquisition and expression of the bla(NDM-2) gene in an A. baumannii isolate in Germany. Tn125 appears to be the main vehicle for dissemination of bla(NDM) genes in that species...
  78. pmc Characterization of OXA-181, a carbapenem-hydrolyzing class D beta-lactamase from Klebsiella pneumoniae
    Anais Potron
    Service de Bactériologie Virologie Hygiène, Hopital de Bicetre, 78 Rue de Général Leclerc, 94275 Le Kremlin Bicetre cedex, France
    Antimicrob Agents Chemother 55:4896-9. 2011
    ..The bla(OXA-181) gene was located on a 7.6-kb ColE-type plasmid and was linked to the insertion sequence ISEcp1. The ISEcp1-mediated one-ended transposition of bla(OXA-181) was also demonstrated...
  79. pmc Genetic and biochemical characterization of the first extended-spectrum CARB-type beta-lactamase, RTG-4, from Acinetobacter baumannii
    Anais Potron
    Service de Bactériologie Virologie Hygiène, Hopital de Bicetre, Faculté de Médecine et Université Paris Sud, 78 Rue de Général Leclerc, Le Kremlin Bicêtre Cedex 94275, France
    Antimicrob Agents Chemother 53:3010-6. 2009
    ..50-kb plasmid. ISAba9, located upstream of bla(RTG-4), may be responsible for its acquisition by recognizing a secondary right inverted repeat sequence, thus acting by a one-ended transposition process...
  80. pmc Genetic features of CTX-M-15-producing Acinetobacter baumannii from Haiti
    Anais Potron
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculté de Médecine et Université Paris Sud, Le Kremlin Bicetre Cedex, France
    Antimicrob Agents Chemother 55:5946-8. 2011
    ..That ESBL gene was associated with ISEcp1, involved in its acquisition by a one-ended transposition mechanism. In all isolates, the ISEcp1-bla(CTX-M-15) compound transposon was apparently chromosomally located...
  81. ncbi Broad-spectrum beta-lactams for treating experimental peritonitis in mice due to Escherichia coli producing plasmid-encoded cephalosporinases
    Sophie Vimont
    Service de Bacteriologie Virologie, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculté de Médecine de Paris Sud, 94275 K Bicêtre, France
    J Antimicrob Chemother 60:1045-50. 2007
    ....
  82. pmc In vivo selection of reduced susceptibility to carbapenems in Acinetobacter baumannii related to ISAba1-mediated overexpression of the natural bla(OXA-66) oxacillinase gene
    Samy Figueiredo
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre cedex, France
    Antimicrob Agents Chemother 53:2657-9. 2009
    ....
  83. pmc PER-6, an extended-spectrum beta-lactamase from Aeromonas allosaccharophila
    Delphine Girlich
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, 94275 Le Kremlin Bicetre cedex, France
    Antimicrob Agents Chemother 54:1619-22. 2010
    ..The kinetic properties of PER-6 showed a slightly increased affinity for carbapenems. The bla(PER-6) gene was chromosomally located and bracketed by non-transposon-related structures...
  84. pmc OXA-58, a novel class D {beta}-lactamase involved in resistance to carbapenems in Acinetobacter baumannii
    Laurent Poirel
    Service de Bacteriologie Virologie, Hopital de Bicetre, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre cedex, France
    Antimicrob Agents Chemother 49:202-8. 2005
    ..The bla(OXA-58) gene was bracketed by two novel ISAba3-like insertion elements. This study describes a newly characterized beta-lactamase that may contribute to carbapenem resistance in A. baumannii...
  85. pmc OXA-134, a naturally occurring carbapenem-hydrolyzing class D beta-lactamase from Acinetobacter lwoffii
    Samy Figueiredo
    Service de Bacteriologie Virologie, INSERM U914, Emerging Resistance to Antibiotics, Hopital de Bicetre, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre, France
    Antimicrob Agents Chemother 54:5372-5. 2010
    ..This species may therefore constitute a reservoir for carbapenemase genes that may spread among other Acinetobacter species...
  86. pmc Carbapenem-hydrolyzing GES-type extended-spectrum beta-lactamase in Acinetobacter baumannii
    Rémy A Bonnin
    Service de Bacteriologie Virologie, INSERM U914, Emerging Resistance to Antibiotics, Assistance Publique Hopitaux de Paris, Faculté de Médecine et Université Paris Sud, Hopital de Bicetre, Le Kremlin Bicetre, France
    Antimicrob Agents Chemother 55:349-54. 2011
    ..The bla(GES-14) gene was located into a class 1 integron structure and located onto a ca. 95-kb self-transferable plasmid. This study identified a very broad-spectrum β-lactamase in A. baumannii...
  87. pmc Seagulls and beaches as reservoirs for multidrug-resistant Escherichia coli
    Romeo Rocha Simoes
    Hopital de Bicetre, Bicetre 94275, France
    Emerg Infect Dis 16:110-2. 2010
    ..Beaches may therefore present a risk to public health because of the potential pathogen-spreading capacity of migratory birds...
  88. pmc Characterization of a naturally occurring class D beta-lactamase from Achromobacter xylosoxidans
    Yohei Doi
    Service de Bacteriologie Virologie, INSERM U914, Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculté deMédecine Paris Sud, Universite Paris XI, 94275 K Bicêtre, France
    Antimicrob Agents Chemother 52:1952-6. 2008
    ..xylosoxidans strains tested (n = 5), indicating that this beta-lactamase is naturally occurring in that species. Induction experiments with imipenem and cefoxitin did not show inducibility of bla(OXA-114) expression...
  89. pmc ISEcp1-mediated transposition of qnrB-like gene in Escherichia coli
    Vincent Cattoir
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculté de Médecine et Université Paris Sud, K Bicêtre, France
    Antimicrob Agents Chemother 52:2929-32. 2008
    ..Its gene was associated with an ISEcp1-like insertion element that did not act as a promoter for its expression. Using an in vitro model of transposition, we showed that the ISEcp1-like element was able to mobilize the qnrB19 gene...
  90. pmc Detection of NDM-1-producing Klebsiella pneumoniae in Kenya
    Laurent Poirel
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, Le Kremlin Bicetre, France
    Antimicrob Agents Chemother 55:934-6. 2011
    ..This work corresponds to the first report of NDM-1 producers in Africa...
  91. doi NDM-1-producing Klebsiella pneumoniae isolated in the Sultanate of Oman
    Laurent Poirel
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculté de Médecine et Université Paris Sud, K Bicêtre, Paris, France
    J Antimicrob Chemother 66:304-6. 2011
    ..To analyse the mechanisms responsible for multidrug resistance in two carbapenem-resistant Klebsiella pneumoniae isolates recovered from patients hospitalized in Oman...
  92. doi Molecular analysis of NDM-1-producing enterobacterial isolates from Geneva, Switzerland
    Laurent Poirel
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculté de Médecine et Université Paris Sud, K Bicêtre, Paris, France
    J Antimicrob Chemother 66:1730-3. 2011
    ..To analyse the mechanisms responsible for decreased susceptibility or resistance to carbapenems in several enterobacterial isolates recovered in 2009-10 in Geneva University Hospitals, Switzerland...
  93. pmc Group IIC intron with an unusual target of integration in Enterobacter cloacae
    José Manuel Rodríguez-Martínez
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Assistance Publique Hôpital de Paris, and Université Paris Sud, Hopital de Bicetre, K Bicêtre, France
    J Bacteriol 194:150-60. 2012
    ..A phylogenetic tree showed that the identified element was located in a branch separate from group IIC-attC introns, being an IIC intron possessing the ability to integrate using the core site of the attC sites as target...
  94. pmc How to detect NDM-1 producers
    Patrice Nordmann
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, Le Kremlin Bicetre, France
    J Clin Microbiol 49:718-21. 2011
    ..Colonies growing on these screening media can be verified as NDM-1 producers with molecular methods as described herein...
  95. pmc Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa
    José Manuel Rodríguez-Martínez
    Service de Bacteriologie Virologie, INSERM U914, Emerging Resistance to Antibiotics, Assistance Publique Hopitaux de Paris, Faculté de Médecine et Université Paris Sud, Hopital de Bicetre, 94275 K Bicêtre, France
    Antimicrob Agents Chemother 53:4783-8. 2009
    ..P. aeruginosa can very often accumulate different resistance mechanisms, including ESAC production, leading to carbapenem resistance...
  96. pmc ISCR2, another vehicle for bla(VEB) gene acquisition
    Laurent Poirel
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculté de Médecine Paris Sud et Université Paris Sud, Le Kremlin Bicetre, France
    Antimicrob Agents Chemother 53:4940-3. 2009
    ..We report here the first association of bla(VEB-1a) with the insertion sequence ISCR2 in six Acinetobacter species isolates recovered from Argentina. That genetic structure was likely at the origin of the mobilization of this ESBL gene...
  97. doi Does broad-spectrum beta-lactam resistance due to NDM-1 herald the end of the antibiotic era for treatment of infections caused by Gram-negative bacteria?
    Patrice Nordmann
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculté de Médecine et Université Paris Sud, K Bicêtre, France
    J Antimicrob Chemother 66:689-92. 2011
    ..To stem the onslaught of NDM producers, early identification of cases of NDM-related infections and prevention of their spread by implementing screening, hygiene measures and the isolation of carriers is needed...
  98. pmc Ertapenem resistance of Escherichia coli
    Marie Frédérique Lartigue
    Universite Paris XI, Kremlin Bicetre, France
    Emerg Infect Dis 13:315-7. 2007
    ..Ertapenem resistance may be explained by a defect in the outer membrane protein and production of extended-spectrum beta-lactamase CTX-M-2...
  99. pmc Origin of OXA-181, an emerging carbapenem-hydrolyzing oxacillinase, as a chromosomal gene in Shewanella xiamenensis
    Anais Potron
    Service de Bactériologie Virologie Hygiène, Hopital de Bicetre, 78 Rue de Général Leclerc, 94275 Le Kremlin Bicetre cedex, France
    Antimicrob Agents Chemother 55:4405-7. 2011
    ..Shewanella xiamenensis, an environmental species from marine and freshwater, was identified as the progenitor of the bla(OXA-181) gene. This work identifies the reservoir of an emerging carbapenemase gene that is clinically significant...
  100. pmc Analysis of the resistome of a multidrug-resistant NDM-1-producing Escherichia coli strain by high-throughput genome sequencing
    Laurent Poirel
    Service de Bacteriologie Virologie, Hopital de Bicetre, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre cedex, France
    Antimicrob Agents Chemother 55:4224-9. 2011
    ..coli that was weakly expressed. The multidrug resistance pattern observed for E. coli 271 was therefore the result of combined chromosome- and plasmid-encoded mechanisms...