C D Partidos

Summary

Country: France

Publications

  1. ncbi Mimotopes of viral antigens and biologically important molecules as candidate vaccines and potential immunotherapeutics
    C D Partidos
    UPR 9021 CNRS, Institut de Biologie Moleculaire et Cellulaire, 15 rue Rene Descartes, F 67084, Strasbourg, France
    Comb Chem High Throughput Screen 5:15-27. 2002
  2. ncbi A retro-inverso peptide analogue of influenza virus hemagglutinin B-cell epitope 91-108 induces a strong mucosal and systemic immune response and confers protection in mice after intranasal immunization
    Tamar Ben-Yedidia
    Department of Immunology, The Weizmann Institute of Science, P O Box 26, 76100, Rehovot, Israel
    Mol Immunol 39:323-31. 2002
  3. pmc Effect of skin barrier disruption on immune responses to topically applied cross-reacting material, CRM(197), of diphtheria toxin
    S Godefroy
    UPR 9021, Institut de Biologie Moleculaire et Cellulaire, CNRS, 15 rue Rene Descartes, F 67084, Strasbourg, France
    Infect Immun 73:4803-9. 2005
  4. ncbi Carbon nanotubes: on the road to deliver
    Alberto Bianco
    UPR 9021, CNRS, Institut de Biologie Moleculaire et Cellulaire, 15 rue Rene Descartes, F 67084, Strasbourg, France
    Curr Drug Deliv 2:253-9. 2005
  5. ncbi Peptide mimotopes as candidate vaccines
    C D Partidos
    UPR 9021 CNRS, Immunochimie des Peptides et des Virus, Institut de Biologie Moleculaire et Cellulaire, 15 rue René Descartes F 67084 Strasbourg, France
    Curr Opin Mol Ther 2:74-9. 2000
  6. ncbi Decision-making at the surface of the intact or barrier disrupted skin: potential applications for vaccination or therapy
    C D Partidos
    UPR 9021 CNRS, Institut de Biologie Moleculaire et Cellulaire, 15 rue Rene Descartes, 67084 Strasbourg, France
    Cell Mol Life Sci 62:1418-24. 2005
  7. ncbi The binding affinity of double-stranded RNA motifs to HIV-1 Tat protein affects transactivation and the neutralizing capacity of anti-Tat antibodies elicited after intranasal immunization
    Charalambos D Partidos
    UPR 9021, Institut de Biologie Moleculaire et Cellulaire, CNRS, Strasbourg, France
    Eur J Immunol 35:1521-9. 2005
  8. ncbi Modulation of immune responses with transcutaneously deliverable adjuvants
    Charalambos D Partidos
    UPR 9021, Immunologie et Chimie Thérapeutiques, Institut de Biologie Moleculaire et Cellulaire, CNRS, 15 rue Rene Descartes, F 67084 Strasbourg, France
    Vaccine 22:2385-90. 2004
  9. ncbi Delivering vaccines into the skin without needles and syringes
    Charalambos D Partidos
    UPR 9021, CNRS, Immunologie et Chimie Thérapeutiques, Institut de Biologie Moleculaire et Cellulaire, 15 rue Rene Descartes, F 67084 Strasbourg, France
    Expert Rev Vaccines 2:753-61. 2003
  10. ncbi Antigens onto bare skin: a 'painless' paradigm shift in vaccine delivery
    Charalambos D Partidos
    UPR 9021, CNRS, Immunologie et Chimie Thérapeutiques, Institut de Biologie Moleculaire et Cellulaire, 15 rue Rene Descartes, F 67084, Strasbourg, France
    Expert Opin Biol Ther 3:895-902. 2003

Collaborators

Detail Information

Publications26

  1. ncbi Mimotopes of viral antigens and biologically important molecules as candidate vaccines and potential immunotherapeutics
    C D Partidos
    UPR 9021 CNRS, Institut de Biologie Moleculaire et Cellulaire, 15 rue Rene Descartes, F 67084, Strasbourg, France
    Comb Chem High Throughput Screen 5:15-27. 2002
    ....
  2. ncbi A retro-inverso peptide analogue of influenza virus hemagglutinin B-cell epitope 91-108 induces a strong mucosal and systemic immune response and confers protection in mice after intranasal immunization
    Tamar Ben-Yedidia
    Department of Immunology, The Weizmann Institute of Science, P O Box 26, 76100, Rehovot, Israel
    Mol Immunol 39:323-31. 2002
    ..This approach might be advantageous for vaccine development...
  3. pmc Effect of skin barrier disruption on immune responses to topically applied cross-reacting material, CRM(197), of diphtheria toxin
    S Godefroy
    UPR 9021, Institut de Biologie Moleculaire et Cellulaire, CNRS, 15 rue Rene Descartes, F 67084, Strasbourg, France
    Infect Immun 73:4803-9. 2005
    ..Moreover, these results provide the first evidence that the development of a transcutaneous immunization strategy for diphtheria, based on simple and practical methods to disrupt the skin barrier, is feasible...
  4. ncbi Carbon nanotubes: on the road to deliver
    Alberto Bianco
    UPR 9021, CNRS, Institut de Biologie Moleculaire et Cellulaire, 15 rue Rene Descartes, F 67084, Strasbourg, France
    Curr Drug Deliv 2:253-9. 2005
    ..This opens new therapeutic and preventive opportunities to combat diseases. The scope of this review is to summarize our recent work in this rapidly growing field...
  5. ncbi Peptide mimotopes as candidate vaccines
    C D Partidos
    UPR 9021 CNRS, Immunochimie des Peptides et des Virus, Institut de Biologie Moleculaire et Cellulaire, 15 rue René Descartes F 67084 Strasbourg, France
    Curr Opin Mol Ther 2:74-9. 2000
    ..As a result of screening peptide libraries, novel peptide sequences can be identified, which mimic native protective epitopes (mimotopes), and have the potential for use as vaccine candidates...
  6. ncbi Decision-making at the surface of the intact or barrier disrupted skin: potential applications for vaccination or therapy
    C D Partidos
    UPR 9021 CNRS, Institut de Biologie Moleculaire et Cellulaire, 15 rue Rene Descartes, 67084 Strasbourg, France
    Cell Mol Life Sci 62:1418-24. 2005
    ....
  7. ncbi The binding affinity of double-stranded RNA motifs to HIV-1 Tat protein affects transactivation and the neutralizing capacity of anti-Tat antibodies elicited after intranasal immunization
    Charalambos D Partidos
    UPR 9021, Institut de Biologie Moleculaire et Cellulaire, CNRS, Strasbourg, France
    Eur J Immunol 35:1521-9. 2005
    ....
  8. ncbi Modulation of immune responses with transcutaneously deliverable adjuvants
    Charalambos D Partidos
    UPR 9021, Immunologie et Chimie Thérapeutiques, Institut de Biologie Moleculaire et Cellulaire, CNRS, 15 rue Rene Descartes, F 67084 Strasbourg, France
    Vaccine 22:2385-90. 2004
    ..In this review we give a brief overview of transcutaneously deliverable adjuvants and we discuss how they modulate immune responses to topically applied antigens...
  9. ncbi Delivering vaccines into the skin without needles and syringes
    Charalambos D Partidos
    UPR 9021, CNRS, Immunologie et Chimie Thérapeutiques, Institut de Biologie Moleculaire et Cellulaire, 15 rue Rene Descartes, F 67084 Strasbourg, France
    Expert Rev Vaccines 2:753-61. 2003
    ..This article reviews current attempts to administer vaccines into the skin and discusses some of the scientific issues related to the emerging delivery technologies...
  10. ncbi Antigens onto bare skin: a 'painless' paradigm shift in vaccine delivery
    Charalambos D Partidos
    UPR 9021, CNRS, Immunologie et Chimie Thérapeutiques, Institut de Biologie Moleculaire et Cellulaire, 15 rue Rene Descartes, F 67084, Strasbourg, France
    Expert Opin Biol Ther 3:895-902. 2003
    ..However, despite these successes, there are several challenges ahead to be addressed before vaccines administered with a patch will be available over the counter...
  11. ncbi Immunity under the skin: potential application for topical delivery of vaccines
    C D Partidos
    UPR 9021, CNRS, Immunologie et Chimie Thérapeutiques, Institut de Biologie Moleculaire et Cellulaire, 15 rue Rene Descartes, Strasbourg F 67084, France
    Vaccine 21:776-80. 2003
    ..This review gives a brief account of the latest developments of application of candidate vaccine antigens onto bare skin and describes some of our recent observations using peptide and glycoconjugate vaccines as immunogens...
  12. ncbi Applying peptide antigens onto bare skin: induction of humoral and cellular immune responses and potential for vaccination
    Charalambos D Partidos
    UPR 9021, Institut de Biologie Moleculaire et Cellulaire, CNRS, 15 rue Rene Descartes, F 67084, Strasbourg, France
    J Control Release 85:27-34. 2002
    ..Therefore, they could be the most suitable candidate immunogens for skin immunisation. This review describes our recent observations on the immunogenicity of synthetic peptides applied onto bare skin in relation to vaccination...
  13. ncbi The bare skin and the nose as non-invasive routes for administering peptide vaccines
    C D Partidos
    Institut de Biologie Moleculaire et Cellulaire, UPR 9021 CNRS, 15 rue Rene Descartes, F 67084, Strasbourg, France
    Vaccine 19:2708-15. 2001
    ..In this review, we discuss and present some preliminary data on the advantages of synthetic peptides and peptidomimetics as candidate vaccines, and their potential for administration via the skin and the nose...
  14. pmc Immunization onto bare skin with heat-labile enterotoxin of Escherichia coli enhances immune responses to coadministered protein and peptide antigens and protects mice against lethal toxin challenge
    A S Beignon
    , CNRS, Strasbourg, France
    Immunology 102:344-51. 2001
    ..This immunization strategy might be advantageous for vaccination programmes in Third World countries, because administration by this route is simple, painless and economical...
  15. pmc The LTR72 mutant of heat-labile enterotoxin of Escherichia coli enhances the ability of peptide antigens to elicit CD4(+) T cells and secrete gamma interferon after coapplication onto bare skin
    A S Beignon
    UPR 9021, Institut de Biologie Moleculaire et Cellulaire, CNRS, F 67084 Strasbourg, France
    Infect Immun 70:3012-9. 2002
    ..Moreover, the use of adjuvants such the LTK63 and LTR72 mutants, with no or low residual toxicity, holds a lot of promise for the future application of vaccines to the bare skin of humans...
  16. ncbi Cationic carbon nanotubes bind to CpG oligodeoxynucleotides and enhance their immunostimulatory properties
    Alberto Bianco
    Institut de Biologie Moleculaire et Cellulaire, UPR9021 CNRS, Immunologie et Chimie Thérapeutiques, 67084 Strasbourg, France
    J Am Chem Soc 127:58-9. 2005
    ..Functionalized cationic carbon nanotubes are able to form a stable complex with CpG ODN based on charge interaction and to increase the immunostimulatory activity of CpG motifs...
  17. pmc Immunization onto bare skin with synthetic peptides: immunomodulation with a CpG-containing oligodeoxynucleotide and effective priming of influenza virus-specific CD4+ T cells
    Anne Sophie Beignon
    Immunologie et Chimie Thérapeutiques, Institut de Biologie Moleculaire et Cellulaire, 15 rue Rene Descartes, F 67084 Strasbourg, France
    Immunology 105:204-12. 2002
    ..Furthermore, with the selection and combination of the appropriate type of adjuvants, immune responses can be modulated towards the desired type of Th phenotype...
  18. ncbi Immunization with peptide-functionalized carbon nanotubes enhances virus-specific neutralizing antibody responses
    Davide Pantarotto
    Institut de Biologie Moleculaire et Cellulaire, UPR 9021 CNRS, Immunologie et Chimie Thérapeutiques, 15 rue Rene Descartes, 67084 Strasbourg, France
    Chem Biol 10:961-6. 2003
  19. ncbi A synthetic HIV-1 Tat protein breaches the skin barrier and elicits Tat-neutralizing antibodies and cellular immunity
    Charalambos D Partidos
    UPR 9021, Institut de Biologie Moleculaire et Cellulaire, CNRS, Strasbourg, France
    Eur J Immunol 34:3723-31. 2004
    ..Transcutaneous immunization may be advantageous for the non-invasive delivery of other HIV candidate vaccine antigens...
  20. ncbi A peptide vaccine administered transcutaneously together with cholera toxin elicits potent neutralising anti-FMDV antibody responses
    Anne Sophie Beignon
    UPR 9021, Institut de Biologie Moleculaire et Cellulaire, CNRS, 15 rue Rene Descartes, F 67084 Strasbourg, France
    Vet Immunol Immunopathol 104:273-80. 2005
    ..However, experiments in target species will be required to confirm the potential of this simple vaccination procedure in livestock...
  21. doi Immunomodulatory consequences of ODN CpG-polycation complexes
    Charalambos D Partidos
    CNRS UPR 9021, Institut de Biologie Moleculaire et Cellulaire, Strasbourg, France
    Methods 49:328-33. 2009
    ..Overall, our findings together with published data support the view that for harnessing the beneficial effects of ODN CpGs a careful consideration has to be given depending on the target intervention...
  22. ncbi Synthesis, structural characterization, and immunological properties of carbon nanotubes functionalized with peptides
    Davide Pantarotto
    Institute of Molecular and Cellular Biology, UPR 9021 CNRS, 67084 Strasbourg, France
    J Am Chem Soc 125:6160-4. 2003
    ..In addition, this peptide-NT conjugate is immunogenic, eliciting antibody responses of the right specificity. Such a system could be greatly advantageous for diagnostic purposes and could find future applications in vaccine delivery...
  23. ncbi Binding and condensation of plasmid DNA onto functionalized carbon nanotubes: toward the construction of nanotube-based gene delivery vectors
    Ravi Singh
    Centre for Drug Delivery Research and Electron Microscopy Unit, The School of Pharmacy, University of London, London WC1N 1AX, United Kingdom
    J Am Chem Soc 127:4388-96. 2005
    ..This study constitutes the first thorough investigation into the physicochemical interactions between cationic functionalized carbon nanotubes and DNA toward construction of carbon nanotube-based gene transfer vector systems...
  24. ncbi Successful induction of protective antibody responses against Haemophilus influenzae type b and diphtheria after transcutaneous immunization with the glycoconjugate polyribosyl ribitol phosphate-cross-reacting material 197 vaccine
    Fatme Mawas
    Division of Bacteriology, National Institute for Biological Standards and Control, Hertfordshire, United Kingdom
    J Infect Dis 190:1177-82. 2004
    ..However, further studies are required to confirm the potential of TCI with glycoconjugate vaccines in humans...
  25. ncbi Transcutaneous immunization with tetanus toxoid and mutants of Escherichia coli heat-labile enterotoxin as adjuvants elicits strong protective antibody responses
    Rob Tierney
    Division of Bacteriology, National Institute for Biological Standards and Control, Potters Bar, United Kingdom
    J Infect Dis 188:753-8. 2003
    ..Overall, these findings demonstrate that mutants of enterotoxins with reduced toxicity are effective adjuvants for transcutaneous immunization...
  26. pmc Transcutaneous immunization with cross-reacting material CRM(197) of diphtheria toxin boosts functional antibody levels in mice primed parenterally with adsorbed diphtheria toxoid vaccine
    Paul Stickings
    Division of Bacteriology, National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, Hertfordshire EN6 3QG, United Kingdom
    Infect Immun 76:1766-73. 2008
    ..These findings highlight the promising prospect of using booster administrations of CRM(197) via the transcutaneous route to establish good herd immunity against diphtheria...