Patrice Nordmann

Summary

Country: France

Publications

  1. pmc NDM-4 metallo-β-lactamase with increased carbapenemase activity from Escherichia coli
    Patrice Nordmann
    Service de Bacteriologie Virologie, INSERM U914, Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculté de Médecine et Université Paris Sud, Kremlin Bicetre, France
    Antimicrob Agents Chemother 56:2184-6. 2012
  2. pmc Phenotypic, biochemical, and molecular techniques for detection of metallo-β-lactamase NDM in Acinetobacter baumannii
    Rémy A Bonnin
    Service de Bacteriologie Virologie, INSERM U914, Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculté de Médecine et Université Paris Sud, K Bicêtre, France
    J Clin Microbiol 50:1419-21. 2012
  3. doi request reprint Identification and screening of carbapenemase-producing Enterobacteriaceae
    P Nordmann
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculté de Médecine et Université Paris Sud, K Bicêtre, France
    Clin Microbiol Infect 18:432-8. 2012
  4. pmc Ertapenem resistance of Escherichia coli
    Marie Frédérique Lartigue
    Universite Paris XI, Kremlin Bicetre, France
    Emerg Infect Dis 13:315-7. 2007
  5. pmc Characterization of an IncFII plasmid encoding NDM-1 from Escherichia coli ST131
    Rémy A Bonnin
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculté de Médecine et Université Paris Sud, Paris, France
    PLoS ONE 7:e34752. 2012
  6. pmc First identification of novel NDM carbapenemase, NDM-7, in Escherichia coli in France
    Gaelle Cuzon
    Service de Bacteriologie Virologie, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, INSERM U914, Faculte de Medecine Paris Sud, France
    PLoS ONE 8:e61322. 2013
  7. doi request reprint Strategies for identification of carbapenemase-producing Enterobacteriaceae
    Patrice Nordmann
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculté de Médecine et Université Paris Sud, K Bicêtre, France
    J Antimicrob Chemother 68:487-9. 2013
  8. pmc Rapid detection of carbapenemase-producing Enterobacteriaceae
    Patrice Nordmann
    Service de Bacteriologie Virologie, Hôpital de Bicêtre 78 Rue du Général Leclerc, 94275 K Bicêtre, France
    Emerg Infect Dis 18:1503-7. 2012
  9. pmc Rapid detection of extended-spectrum-β-lactamase-producing Enterobacteriaceae
    Patrice Nordmann
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, K Bicêtre, France
    J Clin Microbiol 50:3016-22. 2012
  10. pmc Detection of carbapenemase producers in Enterobacteriaceae by use of a novel screening medium
    Patrice Nordmann
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, K Bicêtre, France
    J Clin Microbiol 50:2761-6. 2012

Detail Information

Publications157 found, 100 shown here

  1. pmc NDM-4 metallo-β-lactamase with increased carbapenemase activity from Escherichia coli
    Patrice Nordmann
    Service de Bacteriologie Virologie, INSERM U914, Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculté de Médecine et Université Paris Sud, Kremlin Bicetre, France
    Antimicrob Agents Chemother 56:2184-6. 2012
    ..This amino acid substitution was not located in the known active sites of NDM-1, indicating that remote amino acid substitutions might also play a role in the extended activity of this MBL...
  2. pmc Phenotypic, biochemical, and molecular techniques for detection of metallo-β-lactamase NDM in Acinetobacter baumannii
    Rémy A Bonnin
    Service de Bacteriologie Virologie, INSERM U914, Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculté de Médecine et Université Paris Sud, K Bicêtre, France
    J Clin Microbiol 50:1419-21. 2012
    ..Inhibition activity using EDTA was a sensitive technique but lacked specificity compared to molecular techniques, which remain the gold standard...
  3. doi request reprint Identification and screening of carbapenemase-producing Enterobacteriaceae
    P Nordmann
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculté de Médecine et Université Paris Sud, K Bicêtre, France
    Clin Microbiol Infect 18:432-8. 2012
    ..Phenotypic and molecular-based techniques are able to identify these carbapenemase producers, although with variable efficiencies. The detection of carriers still relies mostly on the use of screening culture media...
  4. pmc Ertapenem resistance of Escherichia coli
    Marie Frédérique Lartigue
    Universite Paris XI, Kremlin Bicetre, France
    Emerg Infect Dis 13:315-7. 2007
    ..Ertapenem resistance may be explained by a defect in the outer membrane protein and production of extended-spectrum beta-lactamase CTX-M-2...
  5. pmc Characterization of an IncFII plasmid encoding NDM-1 from Escherichia coli ST131
    Rémy A Bonnin
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculté de Médecine et Université Paris Sud, Paris, France
    PLoS ONE 7:e34752. 2012
    ..The current spread of the gene encoding the metallo-ß-lactamase NDM-1 in Enterobacteriaceae is linked to a variety of surrounding genetic structures and plasmid scaffolds...
  6. pmc First identification of novel NDM carbapenemase, NDM-7, in Escherichia coli in France
    Gaelle Cuzon
    Service de Bacteriologie Virologie, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, INSERM U914, Faculte de Medecine Paris Sud, France
    PLoS ONE 8:e61322. 2013
    ..Since then, several reports have emphasized its rapid dissemination throughout the world. The spread of NDM carbapenemases involve several bla NDM gene variants associated with various plasmids among several Gram negative species...
  7. doi request reprint Strategies for identification of carbapenemase-producing Enterobacteriaceae
    Patrice Nordmann
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculté de Médecine et Université Paris Sud, K Bicêtre, France
    J Antimicrob Chemother 68:487-9. 2013
    ....
  8. pmc Rapid detection of carbapenemase-producing Enterobacteriaceae
    Patrice Nordmann
    Service de Bacteriologie Virologie, Hôpital de Bicêtre 78 Rue du Général Leclerc, 94275 K Bicêtre, France
    Emerg Infect Dis 18:1503-7. 2012
    ..It was 100% sensitive and specific compared with molecular-based techniques. This rapid (<2 hours), inexpensive technique may be implemented in any laboratory...
  9. pmc Rapid detection of extended-spectrum-β-lactamase-producing Enterobacteriaceae
    Patrice Nordmann
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, K Bicêtre, France
    J Clin Microbiol 50:3016-22. 2012
    ..The test was rapid (less than 1 h) and cost-effective. It can be implemented in any health care facility and is well adapted for infection control purposes in particular...
  10. pmc Detection of carbapenemase producers in Enterobacteriaceae by use of a novel screening medium
    Patrice Nordmann
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, K Bicêtre, France
    J Clin Microbiol 50:2761-6. 2012
    ..The Supercarba medium provides a significant improvement for detection of the most common types of carbapenemase producers...
  11. pmc Broad-spectrum β-lactam antibiotics for treating experimental peritonitis in mice due to Klebsiella pneumoniae producing the carbapenemase OXA-48
    Olivier Mimoz
    INSERM ERI 23 Pharmacology of Antimicrobial Agents, Centre Hospitalier Universitaire de Poitiers, and Universite de Poitiers, Poitiers, France
    Antimicrob Agents Chemother 56:2759-60. 2012
    ..Therefore, ceftazidime may be recommended for the treatment of infections due to OXA-48 producers if they do not coproduce an extended-spectrum β-lactamase or a plasmid-mediated AmpC cephalosporinase...
  12. ncbi request reprint Extended-spectrum cephalosporinases: structure, detection and epidemiology
    Patrice Nordmann
    Service de Bacteriologie Virologie, Hopital de Bicetre, Le Kremlin Bicetre, France
    Future Microbiol 2:297-307. 2007
    ..An overview of the molecular and biochemical characterization of this recently identified mechanism of resistance to beta-lactams is provided as well as its prevalence and possible clinical significance...
  13. ncbi request reprint Superbugs in the coming new decade; multidrug resistance and prospects for treatment of Staphylococcus aureus, Enterococcus spp. and Pseudomonas aeruginosa in 2010
    Patrice Nordmann
    Service de Bacteriologie Virologie, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, Universite Paris Sud, 94275 K Bicêtre, France
    Curr Opin Microbiol 10:436-40. 2007
    ..Whereas novel molecules are being developed for treating Gram-positive infections, difficult to non possible-to-treat pandrug-resistant P. aeruginosa infections may become a therapeutic challenge soon...
  14. pmc Beta-lactam induction of ISEcp1B-mediated mobilization of the naturally occurring bla(CTX-M) beta-lactamase gene of Kluyvera ascorbata
    Patrice Nordmann
    Service de Bacteriologie Virologie, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, INSERM U 914, and Faculté de Médecine et Université Paris Sud, Le Kremlin Bicetre, France
    FEMS Microbiol Lett 288:247-9. 2008
    ..2+/-2.7 x 10(-5)). Therefore, it is likely that neither amoxicillin/clavulanic acid nor cefquinome concentrations as found in the gut flora may enhance mobilization of the bla(CTX-M) genes in Enterobacteriaceae...
  15. doi request reprint [Carbapenemases in enterobacteriaceae]
    P Nordmann
    Service de Bactériologie Virologie Hygiène, Hopital de Bicetre, 78, rue du General Leclerc, 94275 Le Kremlin Bicetre, France
    Arch Pediatr 17:S154-62. 2010
    ..Detection of infected patients and carriers remain difficult which may explain an underlying spread with dramatic therapeutic consequences...
  16. doi request reprint [Gram-negative bacteriae with resistance to carbapenems]
    Patrice Nordmann
    Service de Bacteriologie Virologie, hôpital de Bicêtre et unité INSERM U914, 78 rue du General Leclerc, Le Kremlin Bicetre, France
    Med Sci (Paris) 26:950-9. 2010
    ..Novel carbapenemases are continuously being identified worldwide with exchange of the resistance genes between Enterobacteriaceae, P. aeruginosa and A. baumannii...
  17. pmc How to detect NDM-1 producers
    Patrice Nordmann
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, Le Kremlin Bicetre, France
    J Clin Microbiol 49:718-21. 2011
    ..Colonies growing on these screening media can be verified as NDM-1 producers with molecular methods as described herein...
  18. doi request reprint Does broad-spectrum beta-lactam resistance due to NDM-1 herald the end of the antibiotic era for treatment of infections caused by Gram-negative bacteria?
    Patrice Nordmann
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculté de Médecine et Université Paris Sud, K Bicêtre, France
    J Antimicrob Chemother 66:689-92. 2011
    ..To stem the onslaught of NDM producers, early identification of cases of NDM-related infections and prevention of their spread by implementing screening, hygiene measures and the isolation of carriers is needed...
  19. pmc Genetic features of CTX-M-15-producing Acinetobacter baumannii from Haiti
    Anais Potron
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculté de Médecine et Université Paris Sud, Le Kremlin Bicetre Cedex, France
    Antimicrob Agents Chemother 55:5946-8. 2011
    ..That ESBL gene was associated with ISEcp1, involved in its acquisition by a one-ended transposition mechanism. In all isolates, the ISEcp1-bla(CTX-M-15) compound transposon was apparently chromosomally located...
  20. pmc Global spread of Carbapenemase-producing Enterobacteriaceae
    Patrice Nordmann
    Bicetre Hospital, Le Kremlin Bicetre, France
    Emerg Infect Dis 17:1791-8. 2011
    ..This strategy may help prevent development of nosocomial outbreaks caused by carbapenemase producers, particularly K. pneumoniae...
  21. pmc Genetic features of the widespread plasmid coding for the carbapenemase OXA-48
    Laurent Poirel
    Service de Bacteriologie Virologie, INSERM U914, Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculté de Médecine et Université Paris Sud, K Bicêtre, France
    Antimicrob Agents Chemother 56:559-62. 2012
    ..Molecular epidemiology using a collection of international OXA-48 producers revealed the wide diffusion of pOXA-48a or closely related plasmids...
  22. pmc Complete sequence of broad-host-range plasmid pRIO-5 harboring the extended-spectrum-β-lactamase gene blaBES₋₁
    Rémy A Bonnin
    Service de Bacteriologie Virologie, INSERM U914, Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculté de Médecine et Université Paris Sud, K Bicêtre, France
    Antimicrob Agents Chemother 56:1116-9. 2012
    ..The promoter responsible for the bla(BES-1) expression was hybrid, made of a -35 box located inside the inverted repeat of IS26 and a -10 box inside a remnant of an insertion sequence...
  23. pmc Value of the modified Hodge test for detection of emerging carbapenemases in Enterobacteriaceae
    Delphine Girlich
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, K Bicêtre, France
    J Clin Microbiol 50:477-9. 2012
    ..Its sensitivity is low for NDM-1 producers (50%) but is increased to 85.7% by adding ZnSO(4) (100 μg/ml) in the culture medium. However, this test has a low specificity and is time-consuming...
  24. pmc Evolution of IncA/C blaCMY-₂-carrying plasmids by acquisition of the blaNDM-₁ carbapenemase gene
    Alessandra Carattoli
    Department of Infectious, Parasitic, and Immuno Mediated Diseases, Istituto Superiore di Sanita, Rome, Italy
    Antimicrob Agents Chemother 56:783-6. 2012
    ..Considering that IncA/C plasmids possess a broad host range, this scaffold might support a large-scale diffusion of the bla(NDM-1) gene among Gram-negative rods...
  25. pmc Tn125-related acquisition of blaNDM-like genes in Acinetobacter baumannii
    Laurent Poirel
    Service de Bacteriologie Virologie, INSERM U914, Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculté de Médecine et Université Paris Sud, K Bicêtre, France
    Antimicrob Agents Chemother 56:1087-9. 2012
    ..This transposon was also associated with the acquisition and expression of the bla(NDM-2) gene in an A. baumannii isolate in Germany. Tn125 appears to be the main vehicle for dissemination of bla(NDM) genes in that species...
  26. pmc Group IIC intron with an unusual target of integration in Enterobacter cloacae
    José Manuel Rodríguez-Martínez
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Assistance Publique Hôpital de Paris, and Université Paris Sud, Hopital de Bicetre, K Bicêtre, France
    J Bacteriol 194:150-60. 2012
    ..A phylogenetic tree showed that the identified element was located in a branch separate from group IIC-attC introns, being an IIC intron possessing the ability to integrate using the core site of the attC sites as target...
  27. doi request reprint The emerging NDM carbapenemases
    Patrice Nordmann
    Service de Bacteriologie Virologie, Hopital de Bicetre, Institut National de la Santé et de la Recherche Médical INSERM Unité 914, Faculté de Médecine et Université Paris Sud, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre, France
    Trends Microbiol 19:588-95. 2011
    ..Bacteria with NDM-1 are typically resistant to nearly all antibiotics, and reliable detection and surveillance are crucial...
  28. pmc Complex genetic structures with repeated elements, a sul-type class 1 integron, and the blaVEB extended-spectrum beta-lactamase gene
    Thierry Naas
    Service de Bacteriologie Virologie, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre cedex, France
    Antimicrob Agents Chemother 50:1745-52. 2006
    ..It also reports for the first time a CR1 element in P. aeruginosa that is associated with an aminoglycoside resistance aphA-6 gene that is expressed from a composite promoter...
  29. pmc Prevalence and genetic analysis of plasmid-mediated quinolone resistance determinants QnrA and QnrS in Enterobacteriaceae isolates from a French university hospital
    Laurent Poirel
    Service de Bacteriologie Virologie, Hopital de Bicetre, Faculte de Medecine Paris Sud, Universite Paris XI, 94275 Le Kremlin Bicetre cedex, France
    Antimicrob Agents Chemother 50:3992-7. 2006
    ..This is the first study identifying the QnrS resistance determinant in Europe and indicating that this determinant might also be widespread...
  30. pmc Functional and structural characterization of the genetic environment of an extended-spectrum beta-lactamase blaVEB gene from a Pseudomonas aeruginosa isolate obtained in India
    Daniel Aubert
    Service de Bacteriologie Virologie, Hopital de Bicetre, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre cedex, France
    Antimicrob Agents Chemother 48:3284-90. 2004
    ....
  31. doi request reprint Plasmid-mediated quinolone resistance determinants among enterobacterial isolates from outpatients in Brazil
    Luciene A R Minarini
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Universite Paris XI, 78, rue du General Leclerc, 94275 K Bicêtre, France
    J Antimicrob Chemother 62:474-8. 2008
    ....
  32. pmc Functional characterization of IS1999, an IS4 family element involved in mobilization and expression of beta-lactam resistance genes
    Daniel Aubert
    Service de Bacteriologie Virologie, Hopital de Bicetre, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre cedex, France
    J Bacteriol 188:6506-14. 2006
    ..This reduced transposition frequency of IS1999.2-based elements may result from a lower transcription of the transposase gene, as revealed by reverse transcription-PCR analyses...
  33. pmc OXA-60, a chromosomal, inducible, and imipenem-hydrolyzing class D beta-lactamase from Ralstonia pickettii
    Delphine Girlich
    Service de Bacteriologie Virologie, Hopital de Bicetre, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre cedex, France
    Antimicrob Agents Chemother 48:4217-25. 2004
    ..pickettii strains. Gene inactivation and induction studies of the bla(OXA-60) and bla(OXA-22) genes in R. pickettii identified the relative contribution of each oxacillinase to the resistance profile of R. pickettii to beta-lactams...
  34. pmc TEM-121, a novel complex mutant of TEM-type beta-lactamase from Enterobacter aerogenes
    Laurent Poirel
    Service de Bacteriologie Virologie, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, Universite Paris XI, Le Kremlin Bicetre, France
    Antimicrob Agents Chemother 48:4528-31. 2004
    ..Thus, TEM-121 is a novel complex mutant TEM beta-lactamase (CMT-4) combining the kinetic properties of an ESBL and an inhibitor-resistant TEM enzyme...
  35. ncbi request reprint Extension of the hydrolysis spectrum of AmpC beta-lactamase of Escherichia coli due to amino acid insertion in the H-10 helix
    Hedi Mammeri
    Service de Bacteriologie Virologie, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, Universite Paris Sud, 94275 K Bicêtre, France
    J Antimicrob Chemother 60:490-4. 2007
    ..To characterize the naturally occurring expanded-spectrum beta-lactamase from an Escherichia coli clinical isolate and to compare it with a wild-type beta-lactamase...
  36. doi request reprint Metallo-beta-lactamase-producing Pseudomonas aeruginosa isolates in Tunisia
    Wejdene Mansour
    Service de Bacteriologie Virologie, INSERM U914, Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculté de Médecine et Université Paris Paris Sud, 94275 K Bicêtre, France
    Diagn Microbiol Infect Dis 64:458-61. 2009
    ..This carbapenemase was very likely chromosomally located and as a form of a gene cassette in a class 1 integron. This is the 1st report of spread of VIM-2 producers in Tunisia...
  37. pmc AmpC beta-lactamase in an Escherichia coli clinical isolate confers resistance to expanded-spectrum cephalosporins
    Hedi Mammeri
    Service de Bacteriologie Virologie, Hopital de Bicetre, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre cedex, France
    Antimicrob Agents Chemother 48:4050-3. 2004
    ..This enzyme, exhibiting 14 amino acid substitutions compared to a reference AmpC cephalosporinase of E. coli, hydrolyzed ceftazidime and cefepime significantly...
  38. pmc Emergence of oxacillinase-mediated resistance to imipenem in Klebsiella pneumoniae
    Laurent Poirel
    Service de Bacteriologie Virologie, Universite Paris XI, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, 94275 Le Kremlin Bicetre, France
    Antimicrob Agents Chemother 48:15-22. 2004
    ..36 kDa. Thus, the high-level resistance to beta-lactams of this clinical isolate resulted from peculiar beta-lactamases and modification of outer membrane proteins...
  39. pmc Genetic environment and expression of the extended-spectrum beta-lactamase blaPER-1 gene in gram-negative bacteria
    Laurent Poirel
    Service de Bacteriologie Virologie, Hopital de Bicetre, Universite Paris XI, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre cedex, France
    Antimicrob Agents Chemother 49:1708-13. 2005
    ..baumannii isolates. In both cases, expression of the bla(PER-1) gene was driven by promoter sequences located in ISPa12...
  40. pmc BEL-1, a novel clavulanic acid-inhibited extended-spectrum beta-lactamase, and the class 1 integron In120 in Pseudomonas aeruginosa
    Laurent Poirel
    Service de Bacteriologie Virologie, Hopital de Bicetre, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre cedex, France
    Antimicrob Agents Chemother 49:3743-8. 2005
    ..In addition, this integron was bracketed by Tn1404 transposon sequences at its right end and by P. aeruginosa-specific sequences at its left end...
  41. pmc Characterization of the naturally occurring oxacillinase of Acinetobacter baumannii
    Claire Héritier
    Service de Bacteriologie Virologie, Hopital de Bicetre, Le Kremlin Bicetre, France
    Antimicrob Agents Chemother 49:4174-9. 2005
    ..By PCR and sequencing bla(OXA-69)-like genes were identified in all A. baumannii strains tested (n = 12), suggesting that this oxacillinase is naturally occurring in that species...
  42. ncbi request reprint Vibrionaceae as a possible source of Qnr-like quinolone resistance determinants
    Laurent Poirel
    Service de Bacteriologie Virologie, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, 94275 K Bicêtre Cedex, France
    J Antimicrob Chemother 56:1118-21. 2005
    ..To gain insight into the functionality of qnr-like genes of several bacterial species of Vibrionaceae that may encode quinolone resistance determinants...
  43. pmc Genetic and biochemical characterization of a chromosome-encoded carbapenem-hydrolyzing ambler class D beta-lactamase from Shewanella algae
    Claire Héritier
    Service de Bacteriologie Virologie, Universite Paris XI, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, 94275 Le Kremlin Bicetre, France
    Antimicrob Agents Chemother 48:1670-5. 2004
    ..algae KB-1. Very similar oxacillinases were found in other S. algae isolates...
  44. pmc Genetic structure associated with blaOXA-18, encoding a clavulanic acid-inhibited extended-spectrum oxacillinase
    Thierry Naas
    Service de Bacteriologie Virologie, INSERM U914, Hopital de Bicetre, Le Kremlin Bicetre Cedex, France
    Antimicrob Agents Chemother 52:3898-904. 2008
    ..aeruginosa and suggests the spread of oxacillin-type extended-spectrum beta-lactamases in P. aeruginosa at the Saint-Luc University hospital of Brussels, Belgium...
  45. doi request reprint Dissemination of OXA-23-producing and carbapenem-resistant Acinetobacter baumannii in a University Hospital in Tunisia
    Wejdene Mansour
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculté de Médecine et Université Paris Paris Sud, Bicetre, France
    Microb Drug Resist 14:289-92. 2008
    ..This study further highlights the worldwide emergence of OXA-23-producing A. baumannii isolates...
  46. doi request reprint Outbreak of CTX-M-15-producing Klebsiella pneumoniae in the intensive care unit of a French hospital
    Amélie Carrër
    Service de Bacteriologie Virologie, Hopital de Bicetre, Le Kremlin Bicetre, France
    Microb Drug Resist 15:47-54. 2009
    ..This study highlights the possible occurrence of outbreaks due to CTX-M-producing K. pneumoniae within hospital settings, whereas CTX-Ms are mostly reported in E. coli in community-acquired infections...
  47. pmc Novel ambler class A carbapenem-hydrolyzing beta-lactamase from a Pseudomonas fluorescens isolate from the Seine River, Paris, France
    Delphine Girlich
    Service de Bacteriologie Virologie, Hopital de Bicetre, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre cedex, France
    Antimicrob Agents Chemother 54:328-32. 2010
    ..The bla(BIC-1) gene was chromosomally located and was also identified in two other P. fluorescens strains isolated from the Seine River 3 months later...
  48. pmc VIM-19, a metallo-beta-lactamase with increased carbapenemase activity from Escherichia coli and Klebsiella pneumoniae
    José Manuel Rodríguez-Martínez
    Service de Bacteriologie Virologie, Hopital de Bicetre, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre cedex, France
    Antimicrob Agents Chemother 54:471-6. 2010
    ..This study indicates that MBLs with enhanced activity toward carbapenems may be obtained as a result of very few amino acid substitutions...
  49. pmc Worldwide diversity of Klebsiella pneumoniae that produce beta-lactamase blaKPC-2 gene
    Gaelle Cuzon
    Institut National de la Santwe et de la Recherche Medicale, Paris, France
    Emerg Infect Dis 16:1349-56. 2010
    ..Different clones harboring different plasmids but having identical genetic structure, Tn4401, could be at the origin of the worldwide spread of this emerging resistance gene...
  50. pmc Biochemical characterization of the naturally occurring oxacillinase OXA-50 of Pseudomonas aeruginosa
    Delphine Girlich
    Service de Bacteriologie Virologie, Universite Paris XI, Hopital de Bicetre, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre cedex, France
    Antimicrob Agents Chemother 48:2043-8. 2004
    ..aeruginosa. The study indicated that P. aeruginosa harbors two naturally encoded beta-lactamase genes, one of which encodes an inducible cephalosporinase and the other of which encodes a constitutively expressed oxacillinase...
  51. ncbi request reprint A nosocomial outbreak of Acinetobacter baumannii isolates expressing the carbapenem-hydrolysing oxacillinase OXA-58
    Claire Héritier
    Service de Bacteriologie Virologie, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, Universite Paris XI, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre cedex, France
    J Antimicrob Chemother 55:115-8. 2005
    ..The aim of this study was to analyse the spread of the bla(OXA-58) gene as a source of carbapenem resistance in Acinetobacter baumannii in the burns unit of a university hospital in Toulouse in 2003-2004...
  52. pmc Acinetobacter radioresistens as a silent source of carbapenem resistance for Acinetobacter spp
    Laurent Poirel
    Service de Bacteriologie Virologie, INSERM U914, Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Universite Paris XI, Le Kremlin Bicetre, France
    Antimicrob Agents Chemother 52:1252-6. 2008
    ..Therefore, A. radioresistens, a commensal bacterial species which is identified on the skin of hospitalized and healthy patients (a property shared with A. baumannii), was identified as the source of the bla OXA-23 gene...
  53. pmc Spread of OXA-48-encoding plasmid in Turkey and beyond
    Amélie Carrër
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, K Bicêtre, France
    Antimicrob Agents Chemother 54:1369-73. 2010
    ..That gene was located within either transposon Tn1999 or transposon Tn1999.2, which was always inserted within the same gene. This work highlights the current plasmid-mediated dissemination of the OXA-48 carbapenemase worldwide...
  54. pmc Naturally occurring extended-spectrum cephalosporinases in Escherichia coli
    Hedi Mammeri
    Service de Bacteriologie Virologie, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, Universite Paris Sud, 94275 Le Kremlin Bicetre, France
    Antimicrob Agents Chemother 50:2573-6. 2006
    ....
  55. ncbi request reprint Nosocomial spread of Pseudomonas aeruginosa isolates expressing the metallo-beta-lactamase VIM-2 in a hematology unit of a French hospital
    Cecile Aubron
    Service de Bacteriologie Virologie, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, 94275 Le Kremlin Bicetre cedex, France
    Microb Drug Resist 11:254-9. 2005
    ..aeruginosa isolates all harboring an approximately 45-kb plasmid with bla (VIM-2)-positive class 1 integrons varying in structures. This study identified a hidden reservoir of carbapenemase producers...
  56. pmc Genetic and biochemical characterization of CGB-1, an Ambler class B carbapenem-hydrolyzing beta-lactamase from Chryseobacterium gleum
    Samuel Bellais
    Service de Bacteriologie Virologie, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, 94275 Le Kremlin Bicetre cedex, France
    Antimicrob Agents Chemother 46:2791-6. 2002
    ..meningosepticum, respectively. Thus, in addition to the previously characterized clavulanic acid-inhibited extended-spectrum beta-lactamase CGA-1 of Ambler class A, C. gleum produces a very likely chromosome-borne class B beta-lactamase...
  57. ncbi request reprint Multiplex PCR for detection of plasmid-mediated quinolone resistance qnr genes in ESBL-producing enterobacterial isolates
    Vincent Cattoir
    Service de Bacteriologie Virologie, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, Universite Paris XI, 78, rue du General Leclerc, 94275 K Bicêtre, France
    J Antimicrob Chemother 60:394-7. 2007
    ..To develop a rapid and reliable single-tube-based PCR technique for detecting simultaneously the plasmid-mediated quinolone resistance qnrA, qnrB and qnrS genes...
  58. pmc BEL-2, an extended-spectrum beta-lactamase with increased activity toward expanded-spectrum cephalosporins in Pseudomonas aeruginosa
    Laurent Poirel
    Service de Bacteriologie Virologie, Hopital de Bicetre, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre cedex, France
    Antimicrob Agents Chemother 54:533-5. 2010
    ..The bla(BEL-2) gene was identified from a P. aeruginosa isolate clonally related to another bla(BEL-1)-positive isolate...
  59. pmc Extended-spectrum cephalosporinase in Acinetobacter baumannii
    José Manuel Rodríguez-Martínez
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Assistance Publique Hôpital de Paris, Faculté deMédecine and Université Paris Sud, France
    Antimicrob Agents Chemother 54:3484-8. 2010
    ..Site-directed mutagenesis confirmed the role of both substitutions in its ESAC property...
  60. doi request reprint Plasmid-mediated quinolone resistance in Aeromonas allosaccharophila recovered from a Swiss lake
    Renata Cristina Picão
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculté de Médecine et Université Paris Sud, K Bicêtre, France
    J Antimicrob Chemother 62:948-50. 2008
    ..To search for plasmid-mediated qnr genes among waterborne environmental Aeromonas spp. recovered from Switzerland...
  61. doi request reprint Predominance of CTX-M-type extended-spectrum beta-lactamase genes among enterobacterial isolates from outpatients in Brazil
    Luciene A R Minarini
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculté de Médecine et Université Paris Sud, K Bicêtre, France
    Diagn Microbiol Infect Dis 65:202-6. 2009
    ..Eleven isolates (4.2%) harbored a bla(CTX-M-2) gene, 3 isolates bla(CTX-M-9), 2 isolates bla(CTX-M-8), and 6 isolates bla(SHV-5). Two novel bla(CTX-M-2) variants, namely, bla(CTX-M-74) and bla(CTX-M-75), were identified...
  62. pmc Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene
    Thierry Naas
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Le Kremlin Bicêtre 94275, and Faculté de Médecine Paris Sud, Paris, France
    Antimicrob Agents Chemother 52:1257-63. 2008
    ..Tn4401 is likely at the origin of carbapenem-hydrolyzing beta-lactamase KPC mobilization to plasmids and its further insertion into various-sized plasmids identified in nonclonally related K. pneumoniae and P. aeruginosa isolates...
  63. ncbi request reprint A nosocomial outbreak of Pseudomonas aeruginosa isolates expressing the extended-spectrum beta-lactamase GES-2 in South Africa
    Laurent Poirel
    Service de Bacteriologie Virologie, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, 94275 Le Kremlin Bicetre, France
    J Antimicrob Chemother 49:561-5. 2002
    ..aeruginosa expressing the GES-2 beta-lactamase...
  64. pmc In vivo selection of a chromosomally encoded beta-lactamase variant conferring ceftazidime resistance in Klebsiella oxytoca
    Hedi Mammeri
    Service de Bacteriologie Virologie, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, Universite Paris XI, 94275 Le Kremlin Bicetre, France
    Antimicrob Agents Chemother 47:3739-42. 2003
    ..This is the first report of in vivo selection of a K. oxytoca isolate that produced a chromosomally encoded beta-lactamase conferring resistance to ceftazidime...
  65. pmc Resistance to cefepime and cefpirome due to a 4-amino-acid deletion in the chromosome-encoded AmpC beta-lactamase of a Serratia marcescens clinical isolate
    Hedi Mammeri
    Service de Bacteriologie Virologie, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, Universite Paris XI, 94275 Le Kremlin Bicetre, France
    Antimicrob Agents Chemother 48:716-20. 2004
    ..This work underlined that resistance to the latest expanded-spectrum cephalosporins may be mediated by structurally modified AmpC-type beta-lactamases...
  66. pmc Association of plasmid-mediated quinolone resistance with extended-spectrum beta-lactamase VEB-1
    Laurent Poirel
    Service de Bacteriologie Virologie, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, Universite Paris XI, Le Kremlin Bicetre, France
    Antimicrob Agents Chemother 49:3091-4. 2005
    ..Bicêtre, France, and in 11 out of 23 bla(VEB-1)-positive enterobacterial isolates from Bangkok, Thailand. This result may explain in part the association between quinolone and extended-spectrum beta-lactam resistance...
  67. pmc First nosocomial outbreak of vancomycin-resistant Enterococcus faecium expressing a VanD-like phenotype associated with a vanA genotype
    Thierry Naas
    Service de Bacteriologie Virologie, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, Université Paris IX, 78 Rue du Général Leclerc 94275 Le Kremlin Bicêtre Cedex, France
    J Clin Microbiol 43:3642-9. 2005
    ..This report is the first description of a VRE outbreak in France and underlines the difficulty in detecting this organism due to variability on the expression of the glycopeptide resistance trait, if any...
  68. ncbi request reprint Cloning and functional characterization of the ambler class C beta-lactamase of Yersinia ruckeri
    Hedi Mammeri
    Service de Bacteriologie Virologie, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, Le Kremlin Bicetre, France
    FEMS Microbiol Lett 257:57-62. 2006
    ..This work provides further evidence that fish-pathogenic gram-negative rod species may constitute a reservoir of antibiotic resistance genes...
  69. ncbi request reprint Regulation of class D beta-lactamase gene expression in Ralstonia pickettii
    Delphine Girlich
    Service de Bacteriologie Virologie, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, Universite Paris XI, 94275 Le Kremlin Bicetre, France
    Microbiology 152:2661-72. 2006
    ..pickettii resulted in a complex pleiotropic phenotype, with increased lag phase and reduced survival after heat exposure, suggesting that ORF-RP3 might be a global regulator involved in unrelated regulatory pathways...
  70. pmc Carbapenem-hydrolyzing GES-5-encoding gene on different plasmid types recovered from a bacterial community in a sewage treatment plant
    Delphine Girlich
    Service de Bacteriologie Virologie, INSERM U914, Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, Le Kremlin Bicetre, France
    Appl Environ Microbiol 78:1292-5. 2012
    ..These plasmids have different backbones, belong to different incompatibility groups, and could replicate in both Pseudomonas aeruginosa and Escherichia coli...
  71. pmc Identification of the novel narrow-spectrum beta-lactamase SCO-1 in Acinetobacter spp. from Argentina
    Laurent Poirel
    Service de Bacteriologie Virologie, Hopital de Bicetre, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre cedex, France
    Antimicrob Agents Chemother 51:2179-84. 2007
    ..40% with the enzymes TEM, SHV, and CTX-M. A gene encoding a putative resolvase was identified downstream of the bla(SCO-1) gene, but its precise way of acquisition remains to be determined...
  72. pmc Extended-spectrum beta-lactamases of the CTX-M type now in Switzerland
    Marie Frédérique Lartigue
    Service de Bacteriologie Virologie, Hopital de Bicetre, 78 rue du General Leclerc, Bicetre, France
    Antimicrob Agents Chemother 51:2855-60. 2007
    ..The plasmid-located bla(CTX-M) genes were associated with either ISEcp1 or ISCR1 insertion sequences. This study is the first published report of CTX-M-type beta-lactamases in Switzerland...
  73. ncbi request reprint Prevalence of qnr genes in Salmonella in France
    Vincent Cattoir
    Service de Bacteriologie Virologie, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, Universite Paris XI, K Bicêtre, France
    J Antimicrob Chemother 59:751-4. 2007
    ..To detect the qnrA, qnrB and qnrS genes among Salmonella isolates received at the French National Reference Centre for Salmonella in Paris, France...
  74. pmc Plasmid-mediated quinolone resistance pump QepA2 in an Escherichia coli isolate from France
    Vincent Cattoir
    INSERM U914 Emerging Resistance to Antibiotics, Service de Bacteriologie Virologie, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Universite Paris Sud, K Bicêtre, France
    Antimicrob Agents Chemother 52:3801-4. 2008
    ..8%) that produced the putative pump QepA2 was identified. This qepA2 gene was located onto a 90-kb mobilizable plasmid that conferred reduced susceptibility to hydrophilic fluoroquinolones...
  75. pmc Naturally occurring Class A ss-lactamases from the Burkholderia cepacia complex
    Laurent Poirel
    Service de Bacteriologie Virologie, Hopital de Bicetre, Le Kremlin Bicetre Cedex, France
    Antimicrob Agents Chemother 53:876-82. 2009
    ..cenocepacia were identified from other Burkholderia species. The corresponding ss-lactamase genes might be used as genetic tools for accurate Burkholderia species identification...
  76. pmc Extended-spectrum cephalosporinases in Pseudomonas aeruginosa
    José Manuel Rodríguez-Martínez
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Assistance Publique Hopitaux de Paris, Faculté de Médecine and Université Paris Sud, Hopital de Bicetre, 94275 K Bicêtre, France
    Antimicrob Agents Chemother 53:1766-71. 2009
    ..This report identified a novel resistance mechanism that may contribute to imipenem resistance in P. aeruginosa...
  77. doi request reprint In vivo selection of imipenem-resistant Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-15 and plasmid-encoded DHA-1 cephalosporinase
    Gaelle Cuzon
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, 94275 Le Kremlin Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, France
    Int J Antimicrob Agents 35:265-8. 2010
    ..pneumoniae isolate harbouring extended-spectrum beta-lactamase and plasmid-mediated cephalosporinase genes following prolonged imipenem exposure...
  78. doi request reprint Performance of chromID ESBL, a chromogenic medium for detection of Enterobacteriaceae producing extended-spectrum beta-lactamases
    Hélène Réglier-Poupet
    Service de Bacteriologie, Hopital Cochin, Assistance Publique Hopitaux de Paris, Faculté de Médecine Paris Descartes, Paris, France
    J Med Microbiol 57:310-5. 2008
    ..Its chromogenic properties and its selectivity are particularly useful in specimens containing resident associated flora...
  79. pmc OXA-58, a novel class D {beta}-lactamase involved in resistance to carbapenems in Acinetobacter baumannii
    Laurent Poirel
    Service de Bacteriologie Virologie, Hopital de Bicetre, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre cedex, France
    Antimicrob Agents Chemother 49:202-8. 2005
    ..The bla(OXA-58) gene was bracketed by two novel ISAba3-like insertion elements. This study describes a newly characterized beta-lactamase that may contribute to carbapenem resistance in A. baumannii...
  80. pmc Regional occurrence of plasmid-mediated carbapenem-hydrolyzing oxacillinase OXA-58 in Acinetobacter spp. in Europe
    Sophie Marque
    Service de Bacteriologie Virologie, Hopital de Bicetre, Le Kremlin Bicetre, France
    J Clin Microbiol 43:4885-8. 2005
    ..clinical isolates from southern Europe, the Balkans, and central Turkey. It may contribute significantly to the emergence of carbapenem resistance in Acinetobacter spp., at least in this part of the world...
  81. pmc Genetic features of blaNDM-1-positive Enterobacteriaceae
    Laurent Poirel
    Service de Bacteriologie Virologie, Hopital de Bicetre, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre cedex, France
    Antimicrob Agents Chemother 55:5403-7. 2011
    ..The bla(NDM-1) plasmids coharbored a variety of resistance determinants, including β-lactamase genes, quinolone resistance genes, and 16S RNA methylase genes...
  82. pmc Contribution of acquired carbapenem-hydrolyzing oxacillinases to carbapenem resistance in Acinetobacter baumannii
    Claire Héritier
    Service de Bacteriologie Virologie, Hopital de Bicetre, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre, France
    Antimicrob Agents Chemother 49:3198-202. 2005
    ..baumannii, and overexpression of efflux pump AdeABC may also contribute to higher levels of resistance to beta-lactams, including carbapenems...
  83. pmc Carbapenem-resistant Acinetobacter baumannii isolates from Tunisia producing the OXA-58-like carbapenem-hydrolyzing oxacillinase OXA-97
    Laurent Poirel
    Service de Bacteriologie Virologie, INSERM U914, Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculté de Médecine et Université Paris Paris Sud, K Bicêtre 94275, France
    Antimicrob Agents Chemother 52:1613-7. 2008
    ..In addition, the novel ISAba8 element (which is of the IS21 family) was identified. This is the first report of the nosocomial spread of carbapenemase producers in A. baumannii isolates in Africa...
  84. pmc Spread of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in Istanbul, Turkey
    Amélie Carrër
    Service de Bacteriologie Virologie, INSERM U914, Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, Le Kremlin Bicetre, France
    Antimicrob Agents Chemother 52:2950-4. 2008
    ....
  85. pmc Use of ChromID extended-spectrum beta-lactamase medium for detecting carbapenemase-producing Enterobacteriaceae
    Amélie Carrër
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, 78 rue du General Leclerc, 94275 K Bicêtre, France
    J Clin Microbiol 48:1913-4. 2010
    ..The OXA-48 producers were not detected on ChromID ESBL medium unless coexpressing ESBLs, whereas carbapenemase-producing isolates with MICs of <4 microg/ml were not detected on CHROMagar KPC medium...
  86. pmc Characterization of DIM-1, an integron-encoded metallo-beta-lactamase from a Pseudomonas stutzeri clinical isolate in the Netherlands
    Laurent Poirel
    Service de Bacteriologie Virologie, Hopital de Bicetre, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre cedex, France
    Antimicrob Agents Chemother 54:2420-4. 2010
    ..This MBL gene was embedded in a class 1 integron containing two other gene cassettes, encoding resistance to aminoglycosides and disinfectants, that was located on a 70-kb plasmid...
  87. doi request reprint Detection of the carbapenemase GIM-1 in Enterobacter cloacae in Germany
    Axel Hamprecht
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculté de Médecine et Université Paris Sud, Kremlin Bicetre, France
    J Antimicrob Chemother 68:558-61. 2013
    ..To characterize the mechanisms involved in reduced susceptibility to carbapenems in two Enterobacter cloacae clinical isolates...
  88. pmc Extended-spectrum beta-lactamase CTX-M-1 in Escherichia coli isolates from healthy poultry in France
    Delphine Girlich
    Service de Bacteriologie Virologie, Hopital de Bicetre, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre cedex, France
    Appl Environ Microbiol 73:4681-5. 2007
    ..Eleven of those strains were not clonally related and had a bla(CTX-M-1) gene located on transferable plasmids of different sizes and structures...
  89. doi request reprint OXA-48-like carbapenemases: the phantom menace
    Laurent Poirel
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Faculté de Médecine et Université Paris Sud, 94275 K Bicêtre, France
    J Antimicrob Chemother 67:1597-606. 2012
    ..Adequate screening and detection methods are therefore required to prevent and control their dissemination...
  90. pmc Novel Ambler class A beta-lactamase LAP-1 and its association with the plasmid-mediated quinolone resistance determinant QnrS1
    Laurent Poirel
    Service de Bacteriologie Virologie, Hopital de Bicetre, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre cedex, and Faculté de Médecine Paris Sud, Universite Paris Sud, K Bicêtre, France
    Antimicrob Agents Chemother 51:631-7. 2007
    ..cloacae isolates from France and Vietnam. These genes were plasmid located and associated with similar insertion sequences but were not associated with sul1-type class 1 integrons, as opposed to the qnrA genes...
  91. pmc Chromosome-encoded narrow-spectrum Ambler class A beta-lactamase GIL-1 from Citrobacter gillenii
    Thierry Naas
    Service de Bacteriologie Virologie, Hopital de Bicetre, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre cedex, France
    Antimicrob Agents Chemother 51:1365-72. 2007
    ..This work further illustrates the heterogeneity of beta-lactamases in Citrobacter spp., which may indicate that the variability of Citrobacter species is greater than expected...
  92. pmc CTX-M expression and selection of ertapenem resistance in Klebsiella pneumoniae and Escherichia coli
    Delphine Girlich
    Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculté de Médecine et Université Paris Sud, K Bicêtre, France
    Antimicrob Agents Chemother 53:832-4. 2009
    ..Frequencies of mutants with decreased susceptibilities to ertapenem were similar for all beta-lactamases expressed...
  93. pmc Integron mobilization unit as a source of mobility of antibiotic resistance genes
    Laurent Poirel
    Service de Bactériologie Virologie Hygiène, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, 78 Rue de Général Leclerc, 94275 Le Kremlin Bicetre cedex, France
    Antimicrob Agents Chemother 53:2492-8. 2009
    ..This is the first identification of MITE-type structures as a source of gene mobilization, implicating here a clinically relevant antibiotic resistance gene...
  94. pmc Association of the emerging carbapenemase NDM-1 with a bleomycin resistance protein in Enterobacteriaceae and Acinetobacter baumannii
    Laurent Dortet
    Service de Bacteriologie Virologie, INSERM U914, Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, K Bicêtre, France
    Antimicrob Agents Chemother 56:1693-7. 2012
    ..This study suggests that the emerging carbapenemase NDM-1 is selected by bleomycin-like molecules, and that BRP(MBL) producers (and consequently NDM producers) are better suited to various environments...
  95. pmc Origin of plasmid-mediated quinolone resistance determinant QnrA
    Laurent Poirel
    Service de Bacteriologie Virologie, Hopital de Bicetre, 78, rue du General Leclerc, 94275 Le Kremlin Bicetre, France
    Antimicrob Agents Chemother 49:3523-5. 2005
    ..Shewanella algae, an environmental species from marine and fresh water, was identified as its reservoir. This is a one of the very few examples of progenitor identification of an acquired antibiotic resistance gene...
  96. ncbi request reprint Broad-spectrum beta-lactams for treating experimental peritonitis in mice due to Escherichia coli producing plasmid-encoded cephalosporinases
    Sophie Vimont
    Service de Bacteriologie Virologie, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculté de Médecine de Paris Sud, 94275 K Bicêtre, France
    J Antimicrob Chemother 60:1045-50. 2007
    ....
  97. pmc Diversity of beta-lactamases produced by ceftazidime-resistant Pseudomonas aeruginosa isolates causing bloodstream infections in Brazil
    Renata C Picão
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, K Bicêtre, France
    Antimicrob Agents Chemother 53:3908-13. 2009
    ..This study underlines the spread of MBL- and ESBL-producing P. aeruginosa isolates as an important source of ceftazidime resistance in Brazil...
  98. pmc PER-6, an extended-spectrum beta-lactamase from Aeromonas allosaccharophila
    Delphine Girlich
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, 94275 Le Kremlin Bicetre cedex, France
    Antimicrob Agents Chemother 54:1619-22. 2010
    ..The kinetic properties of PER-6 showed a slightly increased affinity for carbapenems. The bla(PER-6) gene was chromosomally located and bracketed by non-transposon-related structures...
  99. doi request reprint A novel IncQ plasmid type harbouring a class 3 integron from Escherichia coli
    Laurent Poirel
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculté de Médecine et Université Paris Sud, K Bicêtre, France
    J Antimicrob Chemother 65:1594-8. 2010
    ..To determine the genetic structures at the origin of the mobilization of the extended-spectrum beta-lactamase (ESBL) bla(GES-1) gene in an Escherichia coli clinical isolate...