Jean Paul Mira

Summary

Country: France

Publications

  1. pmc Residual rates of mortality in patients with severe sepsis: a fatality or a new challenge?
    Pierre Asfar
    Réanimation Médicale Polyvalente, Cochin University Hospital, AP HP, Paris, France
    Ann Intensive Care 3:27. 2013
  2. pmc Impact of early enteral versus parenteral nutrition on mortality in patients requiring mechanical ventilation and catecholamines: study protocol for a randomized controlled trial (NUTRIREA-2)
    Laurent Brisard
    UPRES EA 3826, Clinical and Experimental Therapies for Infections, University of Nantes, Nantes, France
    Trials 15:507. 2014
  3. pmc Specific antioxidant properties of human serum albumin
    Myriam Taverna
    Université Paris Sud Faculté de Pharmacie, 92290, Chatenay Malabry, France
    Ann Intensive Care 3:4. 2013
  4. pmc Design, conduct, and analysis of a multicenter, pharmacogenomic, biomarker study in matched patients with severe sepsis treated with or without drotrecogin Alfa (activated)
    Djillali Annane
    Service de Reanimation Medicale, CIC IT805 INSERM, Hôpital R, Poincare AP HP, 104 Bd Raymond Poincaré, 92380, Garches, France
    Ann Intensive Care 2:15. 2012
  5. pmc Determinants of mortality for adults with cystic fibrosis admitted in Intensive Care Unit: a multicenter study
    Joelle Texereau
    Service de Physiologie, AP HP, Hopital Cochin, 27 rue du Faubourg St Jacques, Paris, F 75014, France
    Respir Res 7:14. 2006
  6. pmc Changes in aortic blood flow induced by passive leg raising predict fluid responsiveness in critically ill patients
    A Lafanechère
    Medical Intensive Care Unit, Cochin Hospital, APHP, Universite Paris Descartes, 27, rue du Faubourg Saint Jacques, 75679 Paris Cedex 14, France
    Crit Care 10:R132. 2006
  7. pmc The role of biomarkers in community-acquired pneumonia: predicting mortality and response to adjunctive therapy
    Jean Paul Mira
    Medical Intensive Care Unit, Cochin University Hospital, Assistance Publique, Hopitaux de Paris, Universite Paris Descartes, and INSERM U567, Paris 75014, France
    Crit Care 12:S5. 2008
  8. doi request reprint Protective effects of FCGR2A polymorphism in invasive pneumococcal diseases
    Adrien Bouglé
    Paris Descartes University, Paris, France
    Chest 142:1474-81. 2012
  9. doi request reprint Intensive care unit mortality after cardiac arrest: the relative contribution of shock and brain injury in a large cohort
    Virginie Lemiale
    Medical Intensive Care Unit, Cochin Hospital, Assistance Publique des Hopitaux de Paris, Groupe Hospitalier Universitaire Cochin Broca Hôtel Dieu, 27 rue du Faubourg Saint Jacques, 75014, Paris, France
    Intensive Care Med 39:1972-80. 2013
  10. doi request reprint Early-onset pneumonia after cardiac arrest: characteristics, risk factors and influence on prognosis
    Sebastien Perbet
    Medical Intensive Care Unit, Cochin Hospital, Paris, France
    Am J Respir Crit Care Med 184:1048-54. 2011

Detail Information

Publications59

  1. pmc Residual rates of mortality in patients with severe sepsis: a fatality or a new challenge?
    Pierre Asfar
    Réanimation Médicale Polyvalente, Cochin University Hospital, AP HP, Paris, France
    Ann Intensive Care 3:27. 2013
    ..The new challenge to enhance the probability of decreasing mortality rates should include a more appropriate definition of sepsis based on more specific criteria involving biomarker use and accurate patient phenotypes. ..
  2. pmc Impact of early enteral versus parenteral nutrition on mortality in patients requiring mechanical ventilation and catecholamines: study protocol for a randomized controlled trial (NUTRIREA-2)
    Laurent Brisard
    UPRES EA 3826, Clinical and Experimental Therapies for Infections, University of Nantes, Nantes, France
    Trials 15:507. 2014
    ..The primary goal of this trial is to assess the hypothesis that early first-line EN, as compared to early first-line PN, decreases day 28 all-cause mortality in patients receiving IMV and vasoactive drugs for shock...
  3. pmc Specific antioxidant properties of human serum albumin
    Myriam Taverna
    Université Paris Sud Faculté de Pharmacie, 92290, Chatenay Malabry, France
    Ann Intensive Care 3:4. 2013
    ..To conclude, we discuss the implication of this recent literature for future clinical trials using albumin as a drug and for elucidating the effects of HSA infusion in critically ill patients...
  4. pmc Design, conduct, and analysis of a multicenter, pharmacogenomic, biomarker study in matched patients with severe sepsis treated with or without drotrecogin Alfa (activated)
    Djillali Annane
    Service de Reanimation Medicale, CIC IT805 INSERM, Hôpital R, Poincare AP HP, 104 Bd Raymond Poincaré, 92380, Garches, France
    Ann Intensive Care 2:15. 2012
    ..This trial was designed to validate biomarkers (improved response polymorphisms (IRPs)). Each IRP (A and B) contains two single nucleotide polymorphisms that were associated with a differential DAA treatment effect...
  5. pmc Determinants of mortality for adults with cystic fibrosis admitted in Intensive Care Unit: a multicenter study
    Joelle Texereau
    Service de Physiologie, AP HP, Hopital Cochin, 27 rue du Faubourg St Jacques, Paris, F 75014, France
    Respir Res 7:14. 2006
    ..This appraisal needs re-evaluation following recent changes in both CF management and ICU daily practice. Objectives were to determine long-term outcome of adults with CF admitted in ICU and to identify prognostic factors...
  6. pmc Changes in aortic blood flow induced by passive leg raising predict fluid responsiveness in critically ill patients
    A Lafanechère
    Medical Intensive Care Unit, Cochin Hospital, APHP, Universite Paris Descartes, 27, rue du Faubourg Saint Jacques, 75679 Paris Cedex 14, France
    Crit Care 10:R132. 2006
    ..Considering passive leg raising (PLR) as a reversible volume expansion (VE), we compared the relative abilities of PLR-induced ABF variations, LVETc and respiratory pulsed pressure variations (DeltaPP) to predict fluid responsiveness...
  7. pmc The role of biomarkers in community-acquired pneumonia: predicting mortality and response to adjunctive therapy
    Jean Paul Mira
    Medical Intensive Care Unit, Cochin University Hospital, Assistance Publique, Hopitaux de Paris, Universite Paris Descartes, and INSERM U567, Paris 75014, France
    Crit Care 12:S5. 2008
    ..In the future it may also be possible to use genomic markers to identify patients at greatest risk for deterioration or complications...
  8. doi request reprint Protective effects of FCGR2A polymorphism in invasive pneumococcal diseases
    Adrien Bouglé
    Paris Descartes University, Paris, France
    Chest 142:1474-81. 2012
    ..However, previous reports need confirmation in a large, well-defined population...
  9. doi request reprint Intensive care unit mortality after cardiac arrest: the relative contribution of shock and brain injury in a large cohort
    Virginie Lemiale
    Medical Intensive Care Unit, Cochin Hospital, Assistance Publique des Hopitaux de Paris, Groupe Hospitalier Universitaire Cochin Broca Hôtel Dieu, 27 rue du Faubourg Saint Jacques, 75014, Paris, France
    Intensive Care Med 39:1972-80. 2013
    ..This study aims to describe the respective incidence, risk factors, and relation to mortality of post-cardiac arrest (CA) shock and brain injury...
  10. doi request reprint Early-onset pneumonia after cardiac arrest: characteristics, risk factors and influence on prognosis
    Sebastien Perbet
    Medical Intensive Care Unit, Cochin Hospital, Paris, France
    Am J Respir Crit Care Med 184:1048-54. 2011
    ..Although induced hypothermia is recommended as a method of improving neurological outcome, its influence on the occurrence of early-onset pneumonia is not well defined...
  11. doi request reprint Infectious complications in out-of-hospital cardiac arrest patients in the therapeutic hypothermia era
    Nicolas Mongardon
    Medical Intensive Care Unit, AP HP, Cochin Hospital, Paris, France
    Crit Care Med 39:1359-64. 2011
    ..We investigated the infectious complications in cardiac arrest survivors and assessed their impact on morbidity and long-term outcome...
  12. ncbi request reprint Importance of hemostatic gene polymorphisms for susceptibility to and outcome of severe sepsis
    Joelle Texereau
    Physiology Department, Cochin University Hospital, and the Cochin Institute, Paris, France
    Crit Care Med 32:S313-9. 2004
    ..As genetic associations are discovered, medical practice can become more preemptive, using the predictive ability of genetics to anticipate disease and recommend therapy...
  13. doi request reprint Emergency Percutaneous Coronary Intervention in Post-Cardiac Arrest Patients Without ST-Segment Elevation Pattern: Insights From the PROCAT II Registry
    Florence Dumas
    INSERM U970 team 4, Parisian Cardiovascular Research Center PARCC, Paris Descartes University, Paris, France Emergency Department, Cochin Hôtel Dieu Hospital, APHP and Paris Descartes University, Paris, France Electronic address
    JACC Cardiovasc Interv 9:1011-8. 2016
    ..In a large cohort of out-of-hospital cardiac arrest (OHCA) patients without ST-segment elevation (STE), the study assessed the relationship between the use of an early invasive strategy and patient outcome...
  14. doi request reprint Diagnosis performance of high sensitivity troponin assay in out-of-hospital cardiac arrest patients
    Guillaume Geri
    Medical Intensive Care Unit, Cochin Hospital, Groupe Hospitalier Universitaire Cochin Broca Hôtel Dieu, Assistance Publique Hopitaux de Paris, 27 rue du Faubourg Saint Jacques, 75014 Paris, France Université Paris Descartes, Sorbonne Paris Cité, Faculte de Medecine, 15 rue de l Ecole de Medecine, 75006 Paris, France
    Int J Cardiol 169:449-54. 2013
    ..Our aim was to determine whether high-sensitivity cardiac troponin T (HsTnT) was useful to diagnose a recent coronary artery occlusion as the cause of OHCA...
  15. doi request reprint Predictors of external cooling failure after cardiac arrest
    Sylvie Ricome
    Medical Intensive Care Unit, Cochin Hospital, Groupe Hospitalier Cochin Broca Hôtel Dieu, Assistance Publique des Hopitaux de Paris, 27 rue du Faubourg Saint Jacques, 75014, Paris, France
    Intensive Care Med 39:620-8. 2013
    ..We aimed to assess the rate of failure of external cooling after CA and to determine failure predictors...
  16. pmc Timing and causes of death in septic shock
    Fabrice Daviaud
    Réanimation Médicale, Hopital Cochin, 27 rue du Faubourg Saint Jacques, 75014, Paris, France
    Ann Intensive Care 5:16. 2015
    ..Most studies about septic shock report a crude mortality rate that neither distinguishes between early and late deaths nor addresses the direct causes of death. We herein aimed to determine the modalities of death in septic shock...
  17. pmc Platelet transfusions in cancer patients with hypoproliferative thrombocytopenia in the intensive care unit
    Bassem Habr
    Réanimation Médicale, Hopital Cochin, Assistance Publique Hopitaux de Paris, 27 rue du Faubourg Saint Jacques, 75014, Paris, France
    Ann Intensive Care 5:46. 2015
    ..We herein addressed the current practices in platelet transfusion and the risk of bleeding in cancer patients with hypoproliferative thrombocytopenia in the intensive care unit (ICU)...
  18. doi request reprint High Level of Endotoxemia Following Out-of-Hospital Cardiac Arrest Is Associated With Severity and Duration of Postcardiac Arrest Shock
    David Grimaldi
    1Intensive Care Unit, Centre Hospitalier Versailles, Le Chesnay, France 2Medical Intensive Care Unit, Cochin University Hospital, AP HP, Paris, FRANCE 3Paris Descartes University, Sorbonne Paris Cité, Medical School, Paris, France 4Inserm, U970, Paris Cardiovascular Research Center, European Georges Pompidou Hospital, Paris, France 5Emergency Department, Groupe Hospitalier Broca Cochin Hôtel Dieu, AP HP, Paris, France
    Crit Care Med 43:2597-604. 2015
    ..To investigate the contribution of endotoxemia to the severity of postcardiac arrest shock...
  19. ncbi request reprint Combined loss of cRel/p50 subunits of NF-κB leads to impaired innate host response in sepsis
    Emilie Courtine
    CNRS, UMR 8104, INSERM, U1016, Institut Cochin, Paris, France
    Innate Immun 18:753-63. 2012
    ..In conclusion, the cRel and p50 subunits of NF-κB play an important combined role in the innate response and are crucial for survival and pathogen clearance in polymicrobial sepsis...
  20. pmc Risk factors for post-ICU red blood cell transfusion: a prospective study
    Sophie Marque
    Medical Intensive Care Unit, Cochin Hospital, rue du Faubourg Saint Jacques, F 75679 Paris cedex 14, France
    Crit Care 10:R129. 2006
    ..This study aims identifies risk factors for RBC transfusion after discharge from the ICU...
  21. ncbi request reprint Brain natriuretic peptide: A marker of myocardial dysfunction and prognosis during severe sepsis
    Julien Charpentier
    Medical Intensive Care Unit, Groupe Hospitalier Cochin Saint Vincent de Paul La Roche Guyon, Paris, France
    Crit Care Med 32:660-5. 2004
    ..To investigate the value of brain natriuretic peptide plasma levels as a marker of systolic myocardial dysfunction during severe sepsis and septic shock...
  22. doi request reprint Benefit of an early and systematic imaging procedure after cardiac arrest: insights from the PROCAT (Parisian Region Out of Hospital Cardiac Arrest) registry
    Jonathan Chelly
    Medical Intensive Care Unit, Cochin Hospital, Groupe Hospitalier Cochin Broca Hôtel Dieu, Assistance Publique des Hopitaux de Paris, 27 rue du Faubourg Saint Jacques, 75014 Paris, France
    Resuscitation 83:1444-50. 2012
    ..We investigated the ability of our imaging strategy to provide an early etiological diagnosis of OHCA and the influence of this strategy on ICU survival...
  23. doi request reprint Short- and long-term outcome in elderly patients after out-of-hospital cardiac arrest: a cohort study
    David Grimaldi
    1Medical Intensive Care Unit, Cochin University Hospital, Hôpitaux Universitaires Paris Centre, AP HP, Paris, France 2Paris Descartes University, Sorbonne Paris Cité Medical School, Paris, France 3INSERM U970, Paris Cardiovascular Research Center, Paris, France 4Emergency Department, Cochin University Hospital, Hôpitaux Universitaires Paris Centre, AP HP, Paris, France 5Cardiology Department, Cochin University Hospital, Hôpitaux Universitaires Paris Centre, AP HP, Paris, France 6SAMU 75, Necker University Hospital, AP HP, Paris, France
    Crit Care Med 42:2350-7. 2014
    ..Our aim was to identify factors associated with short- and long-term neurologic outcome in such patients...
  24. doi request reprint Acute kidney injury after out-of-hospital cardiac arrest: risk factors and prognosis in a large cohort
    Guillaume Geri
    Medical Intensive Care Unit, Cochin Hospital, Assistance Publique Hôpitaux de Paris 27 rue du Faubourg Saint Jacques, 75014, Paris, France
    Intensive Care Med 41:1273-80. 2015
    ..We aimed to evaluate the prevalence of AKI, identifying risk factors and assessing the impact of AKI on outcome after OHCA...
  25. doi request reprint Is copeptin level associated with 1-year mortality after out-of-hospital cardiac arrest? Insights from the Paris registry*
    Guillaume Geri
    1Medical Intensive Care Unit, Cochin Hospital, APHP, Paris, France 2Paris Descartes University, Sorbonne Paris Cité, Paris, France 3Sudden Death Expertise Centre, INSERM U970, Paris Cardiovascular Research Center, Paris, France 4Emergency Department, Cochin Hospital, APHP, Paris, France 5Department of Automated Biological Diagnosis, Cochin Hospital, APHP, Paris, France
    Crit Care Med 43:422-9. 2015
    ..Our aim was to prospectively study the association between copeptin and 1-year mortality in patients with out-of-hospital cardiac arrest admitted in a tertiary cardiac arrest center...
  26. pmc Association of REL polymorphisms and outcome of patients with septic shock
    Julie Toubiana
    Medical School, Paris Descartes University, Paris, France
    Ann Intensive Care 6:28. 2016
    ..Whether genetic variants in the human REL gene are associated with severity of septic shock is unknown...
  27. doi request reprint Impact of case volume on survival of septic shock in patients with malignancies
    Benjamin Zuber
    Réanimation Médicale, Hopital Cochin, Réanimation Médicale, AP HP, Paris, France
    Crit Care Med 40:55-62. 2012
    ..In a large multicenter cohort of septic shock patients with hematologic malignancies and solid tumors, we assessed the temporal trend in survival and the prognostic factors, with particular emphasis on case volume...
  28. doi request reprint Delayed awakening after cardiac arrest: prevalence and risk factors in the Parisian registry
    Marine Paul
    Medical ICU, Cochin Hospital, AP HP, 27 rue du Faubourg Saint Jacques, 75014, Paris, France
    Intensive Care Med 42:1128-36. 2016
    ..We investigated the prevalence and the predictive factors of delayed awakening in comatose CA survivors treated with targeted temperature management (TTM)...
  29. doi request reprint Influence of body mass index on the prognosis of patients successfully resuscitated from out-of-hospital cardiac arrest treated by therapeutic hypothermia
    Guillaume Geri
    Medical Intensive Care Unit, Cochin Hospital, Assistance Publique Hopitaux de Paris, France Paris Descartes University, France Sudden Death Expertise Center, Paris Cardiovascular Research Centre, INSERM U970, France
    Resuscitation 109:49-55. 2016
    ..Obesity prevalence has dramatically increased over recent years and is associated with cardiovascular diseases, but data are lacking on its prognostic impact in out-of-hospital cardiac arrest (OHCA) patients...
  30. doi request reprint Early High-Dose Erythropoietin Therapy After Out-of-Hospital Cardiac Arrest: A Multicenter, Randomized Controlled Trial
    Alain Cariou
    Medical Intensive Care Unit, Cochin Hospital APHP, Paris, France Paris Descartes University, Paris, France INSERM U970 team 4, Parisian Cardiovascular Research Center, Paris Descartes University, Paris, France Electronic address
    J Am Coll Cardiol 68:40-9. 2016
    ..Preliminary data suggested a clinical benefit in treating out-of-hospital cardiac arrest (OHCA) patients with a high dose of erythropoietin (Epo) analogs...
  31. doi request reprint Out-of-hospital cardiac arrest from brain cause: epidemiology, clinical features, and outcome in a multicenter cohort*
    Michel Arnaout
    1Medical Intensive Care Unit, Cochin Hospital, Hôpitaux Universitaires Paris Centre, Assistance Publique des Hopitaux de Paris, Paris, France 2Université Paris Descartes, Sorbonne Paris Cité, Faculte de Medecine, Paris, France 3INSERM U955, Equipe 3, Physiopathologie et Pharmacologie des Insuffisances Coronaires et Cardiaques, Creteil, Paris, France 4Medical and Toxicological Intensive Care Unit, Lariboisiere Hospital, Université Paris Sorbonne Cité, Paris Diderot, Assistance Publique des Hopitaux de Paris, Paris, France 5Intensive Care Unit, Versailles Hospital Center, Le Chesnay, France 6Emergency Department, Cochin Hospital, Hôpitaux Universitaires Paris Centre, Assistance Publique des Hopitaux de Paris, Paris, France 7INSERM U970, Paris Cardiovascular Research Centre PARCC, European Georges Pompidou Hospital, Paris, France
    Crit Care Med 43:453-60. 2015
    ..We aimed to describe clinical features and prognosis of these patients and identify characteristics that could suggest a cerebrovascular etiology of the out-of-hospital cardiac arrest...
  32. pmc Critical role of cRel subunit of NF-κB in sepsis survival
    Emilie Courtine
    Département de Biologie Cellulaire des Interactions Hôte Pathogène, Institut Cochin, Paris, France
    Infect Immun 79:1848-54. 2011
    ..In conclusion, cRel is a key NF-κB member required for host antimicrobial defenses and a regulatory transcription subunit that controls the inflammatory and immune responses in severe infection...
  33. doi request reprint Etiologies, clinical features and outcome of cardiac arrest in HIV-infected patients
    Nicolas Mongardon
    Medical Intensive Care Unit, Cochin University Hospital, groupe hospitalier Paris Centre, Assistance Publique Hopitaux de Paris, Paris, France Université Paris Descartes, Sorbonne Paris Cité, Faculte de Medecine, Paris, France
    Int J Cardiol 201:302-7. 2015
    ..We investigated causes, clinical features and outcome of these patients, and assessed the specific burden of HIV on outcome...
  34. doi request reprint Specific MAIT cell behaviour among innate-like T lymphocytes in critically ill patients with severe infections
    David Grimaldi
    Réanimation Médicale, Hopital Cochin AP HP, 27 rue du Faubourg Saint Jacques, 75014, Paris, France
    Intensive Care Med 40:192-201. 2014
    ....
  35. doi request reprint Src-family-tyrosine kinase Lyn is critical for TLR2-mediated NF-κB activation through the PI 3-kinase signaling pathway
    Julie Toubiana
    Department of Infection, Immunity and Inflammation, Institut Cochin, INSERM, U1016, Paris, France Université Paris Descartes, Paris, France Department of Pediatrics, Hopital Necker Enfants Malades, AP HP, Paris, France
    Innate Immun 21:685-97. 2015
    ..Thus, Lyn kinase activity is crucial in TLR2-mediated activation of the innate immune response in human mononuclear cells. ..
  36. doi request reprint Immediate percutaneous coronary intervention is associated with better survival after out-of-hospital cardiac arrest: insights from the PROCAT (Parisian Region Out of hospital Cardiac ArresT) registry
    Florence Dumas
    INSERM U970, Paris Cardiovascular Research Center, European Georges Pompidou Hospital, Paris, France
    Circ Cardiovasc Interv 3:200-7. 2010
    ..Using data from the Parisian Region Out of hospital Cardiac ArresT prospective registry, we performed an analysis to assess the effect of an invasive strategy on hospital survival...
  37. doi request reprint Outcome of Patients with Systemic Sclerosis in the Intensive Care Unit
    Frédéric Pène
    From the Réanimation médicale, and Médecine Interne, and Rhumatologie A, Centre National de Référence des maladies systémiques et autoimmunes rares, Hopital Cochin, Assistance Publique Hôpitaux de Paris AP HP Faculté de Médecine, Universite Paris Descartes, Sorbonne Paris Cité, Paris, France F Pène, MD, PhD, Réanimation Médicale, Hopital Cochin, AP HP, and Faculté de Médecine, Universite Paris Descartes, Sorbonne Paris Cité T Hissem, MD, Réanimation Médicale, Hopital Cochin, AP HP A Bérezné, MD, Medecine Interne, and Centre National de Référence des maladies systémiques et autoimmunes rares, Hopital Cochin, AP HP Y Allanore, MD, PhD, Rhumatologie A, Hopital Cochin, AP HP, and Faculté de Médecine, Universite Paris Descartes, Sorbonne Paris Cité G Geri, MD, Réanimation Médicale
    J Rheumatol 42:1406-12. 2015
    ..We assessed the characteristics and current outcome of patients with SSc admitted to the ICU...
  38. ncbi request reprint Outcome of critically ill allogeneic hematopoietic stem-cell transplantation recipients: a reappraisal of indications for organ failure supports
    Frédéric Pène
    Medical Intensive Care Unit, Cochin Hospital, AP HP, Paris, France
    J Clin Oncol 24:643-9. 2006
    ....
  39. doi request reprint Temporal changes in management and outcome of septic shock in patients with malignancies in the intensive care unit
    Frédéric Pène
    Medical Intensive Care Unit, Cochin Hospital, AP HP, Paris, France
    Crit Care Med 36:690-6. 2008
    ..We wished to explore whether outcome from septic shock has similarly improved for cancer patients, with regard to implementation of recent adjuvant therapies...
  40. pmc Predictive features of severe acquired ADAMTS13 deficiency in idiopathic thrombotic microangiopathies: the French TMA reference center experience
    Paul Coppo
    Service d Hématologie et de Thérapie Cellulaire, AP HP, Hopital Saint Antoine, Paris, France
    PLoS ONE 5:e10208. 2010
    ..3%, sensitivity of 98.8%, and specificity of 48.1%. Our criteria should be useful to identify rapidly newly diagnosed patients with an acquired ADAMTS13 deficiency to better tailor treatment for different pathophysiological groups...
  41. ncbi request reprint Histocompatibility leukocyte antigen-D related expression is specifically altered and predicts mortality in septic shock but not in other causes of shock
    Vincent Caille
    Department of Anesthesiology and Critical Care Medicine and Laboratory of Hematology, Lariboisiere University Hospital, IFR 06, University Paris 7, Paris, France
    Shock 22:521-6. 2004
    ..Thus, the decrease in HLA-DR expression is specific to septic shock and is associated, in septic shock patients, with increased mortality risk...
  42. ncbi request reprint The importance of Toll-like receptor 2 polymorphisms in severe infections
    Joelle Texereau
    Institut Cochin, INSERM 567, Universite Paris V, Paris, France
    Clin Infect Dis 41:S408-15. 2005
    ....
  43. doi request reprint Sepsis-induced expansion of granulocytic myeloid-derived suppressor cells promotes tumour growth through Toll-like receptor 4
    Jean François Llitjos
    Institut Cochin, Inserm U1016, CNRS UMR8104, Paris, France
    J Pathol 239:473-83. 2016
    ..Copyright © 2016 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. ..
  44. pmc Hyperoxia toxicity after cardiac arrest: What is the evidence?
    Jean François Llitjos
    Medical Intensive Care Unit, Cochin Hospital, Hôpitaux Universitaires Paris Centre, Assistance Publique des Hopitaux de Paris, 27 rue du Faubourg Saint Jacques, 75014, Paris, France
    Ann Intensive Care 6:23. 2016
    ..Up to now, the strategy recommended by international guidelines on cardiac arrest (i.e., targeting an oxyhemoglobin saturation of 94-98 %) should be applied in order to avoid deleterious hypoxia and potent hyperoxia. ..
  45. ncbi request reprint Use of Neuromuscular Blockers During Therapeutic Hypothermia After Cardiac Arrest: A Nursing Protocol
    Coraline Boulila
    Coraline Boulila, Samia Ben Abdallah, Aude Marincamp, Vincent Coic, and Romuald Lauverjat are research nurses and Nicole Ericher is the charge nurse, Medical Intensive Care Unit, Cochin Hospital, Assistance Publique Hopitaux de Paris, Paris, France
    Crit Care Nurse 36:33-40. 2016
    ..Neuromuscular blockers used to prevent shivering during therapeutic hypothermia in comatose patients after out-of-hospital cardiac arrest are associated with adverse events...
  46. doi request reprint High prevalence of infectious events in thrombotic thrombocytopenic purpura and genetic relationship with toll-like receptor 9 polymorphisms: experience of the French Thrombotic Microangiopathies Reference Center
    Marjolaine Morgand
    Service d Hematologie, Centre de référence des microangiopathies thrombotiques, Hopital Saint Antoine, Universite Pierre et Marie Curie, Paris, France Service de Réanimation Polyvalente, hôpitaux universitaires de l est parisien, AP HP et UPMC Univ Paris 06, Paris, France Inserm U1009, Institut Gustave Roussy, Villejuif, France Laboratoire Jean Dausset d Immunologie et d Histocompatibilité and INSERM, AP HP, UMRS 940, Paris, France Service d Immunopathologie, Service de Reanimation, Hopital Saint Louis, Universite Paris 7 Denis Diderot, Paris, France Service de réanimation médicale, Hopital Charles Nicolle, Rouen, France Service de Néphrologie, Hopital Maison Blanche, Reims, France Service de Néphrologie, Centre Hospitalier Universitaire, Lille, France Service d Hémaphérèse, Service de Medecine Interne, Hopital de la Conception, Marseille, France Service de Néphrologie, Centre Hospitalier de Valenciennes, Valenciennes, France Service de Néphrologie Médecine Interne, Hopital Sud, UK
    Transfusion 54:389-97. 2014
    ..Infectious events have been reported as major environmental triggers of thrombotic thrombocytopenic purpura (TTP). We detail here the potential association between infections and TTP...
  47. doi request reprint Stent thrombosis: an increased adverse event after angioplasty following resuscitated cardiac arrest
    Jeremie Joffre
    Medical Intensive Care Unit, Cochin Hospital, Hôpitaux Universitaires Paris Centre, Assistance Publique des Hopitaux de Paris, 27 rue du Faubourg Saint Jacques, 75014 Paris, France Université Paris Descartes, Sorbonne Paris Cité, Faculte de Medecine, 15 rue de l Ecole de Medecine, 75006 Paris, France Inserm U970, Paris Cardiovascular Research Center PARCC, European Georges Pompidou Hospital, 56 rue Leblanc, 75015 Paris, France
    Resuscitation 85:769-73. 2014
    ..However after cardiac arrest (CA), shock, hypothermia and changes in antiplatelet pharmacokinetic may promote stent thrombosis (ST). Incidence of ST in this situation has never been studied...
  48. pmc Diagnosis of non-occlusive acute mesenteric ischemia in the intensive care unit
    Simon Bourcier
    Service de Reanimation Medicale, Hopital Cochin, Hôpitaux Universitaires Paris Centre, Assistance Publique Hopitaux de Paris, 27 rue du Faubourg Saint Jacques, 75014, Paris, France
    Ann Intensive Care 6:112. 2016
    ..We addressed the performance of the diagnostic strategy of NOMI in the intensive care unit, with emphasis on contrast-enhanced abdominal CT-scan...
  49. doi request reprint IRAK1 functional genetic variant affects severity of septic shock
    Julie Toubiana
    Universite Paris Descartes, Faculte de Medecine, Cochin Institute, INSERM U567, CNRS UMR 8104, The Medical Intensive Care Unit, Cochin University Hospital, Assistance Publique Hopitaux de Paris, Paris France
    Crit Care Med 38:2287-94. 2010
    ....
  50. ncbi request reprint Soluble thrombomodulin, plasma-derived unactivated protein C, and recombinant human activated protein C in sepsis
    Jean Francois Dhainaut
    Medical Intensive Care Unit, Cochin St V de Paul Hospital, AP HP, Cochin Institut Cochin Port Royal Medical School, University of Paris V, France
    Crit Care Med 30:S318-24. 2002
    ..To review the physiologic and biochemical mechanisms and the rationale for the use of soluble thrombomodulin, plasma-derived protein C, and recombinant human activated protein C in sepsis...
  51. doi request reprint Evaluating the efficacy and safety of two doses of the polyclonal anti-tumor necrosis factor-α fragment antibody AZD9773 in adult patients with severe sepsis and/or septic shock: randomized, double-blind, placebo-controlled phase IIb study*
    Gordon R Bernard
    1Division of Pulmonary and Critical Care Medicine, Vanderbilt University, Nashville, TN 2Service de Réanimation Polyvalente, CIC P 0801, CHU Dupuytren, Limoges, Cedex, France 3Hôpitaux Paris Centre, AP HP Universite Paris Descartes, Faculte de Medecine, Paris, France and Cochin Institute, INSERM U567, CNRS UMR 8104, Paris, France 4Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium 5Department of Medicine, Cooper University Hospital, Camden, NJ 6Centre for Heart Lung Innovation, University of British Columbia, Vancouver, BC, Canada 7Division of Infectious Diseases, Beverly Hospital, Beverly, MA 8Critical Care Department, St Luc University Hospital, Universite Catholique de Louvain, Brussels, Belgium 9Department of Medicine, Brown University, Providence, RI 10Worldwide Medical Services Department, PAREXEL International, Durham, NC 11AstraZeneca, Alderley Park, India
    Crit Care Med 42:504-11. 2014
    ..This trial compared the efficacy/safety of two IV doses of AZD9773, a polyclonal antibody to tumor necrosis factor-α, in adult patients with severe sepsis/septic shock...
  52. pmc Unusual "flesh-eating" strain of Escherichia coli
    David Grimaldi
    Intensive Care Unit, Cochin University Hospital, 75014 Assistance Publique Hôpitaux de Paris, Paris, France
    J Clin Microbiol 48:3794-6. 2010
    ..coli can be a dermonecrotic pathogen...
  53. doi request reprint Postresuscitation syndrome: potential role of hydroxyl radical-induced endothelial cell damage
    Olivier Huet
    Réanimation Médicale, Universite Paris Descartes, hôpital Cochin Port Royal, Assistance Publique des Hopitaux de Paris, Paris, France
    Crit Care Med 39:1712-20. 2011
    ..However, the consequences of the reperfusion phase on endothelial reactive oxygen species production and redox homeostasis have not been explored in out of hospital cardiac arrest patients...
  54. ncbi request reprint Prognostic value of relative adrenal insufficiency after out-of-hospital cardiac arrest
    Frédéric Pène
    Medical Intensive Care Unit, Cochin University Hospital, Assistance Publique Hopitaux de Paris, 27 rue du Faubourg Saint Jacques, 75679 Paris Cedex 14, France
    Intensive Care Med 31:627-33. 2005
    ..To assess the prevalence of relative adrenal insufficiency in patients successfully resuscitated after cardiac arrest, and its prognostic role in post-resuscitation disease...
  55. doi request reprint Causes and risk factors of death in patients with thrombotic microangiopathies
    Vincent Peigne
    AP HP, Hôpital Saint Louis Medical ICU, 1 avenue Claude Vellefaux, 75010, Paris, France
    Intensive Care Med 38:1810-7. 2012
    ..Although plasma therapy of thrombotic micro-angiopathies (TMAs) has dramatically improved survival, the outcome remains fatal in up to 15 % of patients. We investigated the causes and risk factors of death in patients with TMA...
  56. doi request reprint Endovascular Versus External Targeted Temperature Management for Patients With Out-of-Hospital Cardiac Arrest: A Randomized, Controlled Study
    Nicolas Deye
    From Réanimation Médicale Toxicologique, CHU Lariboisière, AP HP, Paris, France N D, B M, F J B Réanimation Médicale, CHU Cochin, AP HP, Paris, France A C, J C, J P M Réanimation Polyvalente, CHU Salengro, Lille, France P G, D G Réanimation Médico Chirurgicale, CHU Dupuytren, Limoges, France N P, B F Réanimation Médicale, CHU Minjoz, Besancon, France P M Réanimation Médicale, CHU La Cavale Blanche, Brest, France J M T Réanimation Polyvalente, CHR, Orleans, France T B Réanimation Médicale, CHI, Poissy, France H O Réanimation Polyvalente, CHR, Rodez, France A D Réanimation Médicale, Department of Epidemiology and Public Health Medicine
    Circulation 132:182-93. 2015
    ..Whether advanced internal cooling is superior to basic external cooling remains unknown. The aim of this multicenter, controlled trial was to evaluate the benefit of endovascular versus basic surface cooling...
  57. doi request reprint Value of procalcitonin for diagnosis of early onset pneumonia in hypothermia-treated cardiac arrest patients
    Nicolas Mongardon
    Medical Intensive Care Unit, Cochin Hospital, AP HP, 27 rue du Faubourg Saint Jacques, 75679 Paris Cedex 14, France
    Intensive Care Med 36:92-9. 2010
    ..We aimed to assess the ability of serum procalcitonin (PCT) measurements to help diagnose pneumonia in this setting...
  58. ncbi request reprint Early high-dose erythropoietin therapy and hypothermia after out-of-hospital cardiac arrest: a matched control study
    Alain Cariou
    Medical Intensive Care Unit, Cochin Hospital, Paris Cedex, France
    Resuscitation 76:397-404. 2008
    ..To test the possible neuroprotective effect of early high-dose erythropoietin-alpha (Epo-alpha) after out-of-hospital cardiac arrest (OHCA)...
  59. ncbi request reprint Erythropoiesis abnormalities contribute to early-onset anemia in patients with septic shock
    Yann Erick Claessens
    Medical Intensive Care Unit, Cochin Hospital, APHP Université Paris Descartes, 27 rue du Faubourg Saint Jacques, F 75679 Paris, Cedex 14, France
    Am J Respir Crit Care Med 174:51-7. 2006
    ..The intimate mechanisms of early onset anemia observed in critically ill patients with septic shock remain unclear...