D Metzger

Summary

Country: France

Publications

  1. ncbi Site- and time-specific gene targeting in the mouse
    D Metzger
    , CNRS/INSERM/ULP, , BP 163 67404 Illkirch Cedex, C.U. de Strasbourg, France
    Methods 24:71-80. 2001
  2. ncbi Functional role of RXRs and PPARgamma in mature adipocytes
    D Metzger
    Institut de Génétique et de Biologie Moléculaire et Cellulaire IGBMC INSERM CNRS ULP, 1, rue Laurent Fries, 67404 Illkirch, France
    Prostaglandins Leukot Essent Fatty Acids 73:51-8. 2005
  3. ncbi Engineering the mouse genome by site-specific recombination
    D Metzger
    Institut de Génétique et de Biologie Moléculaire et Cellulaire CNRS INSERM ULP Collége de France BP 163, 67404, Illkirch Cedex, CU de Strasbourg, France
    Curr Opin Biotechnol 10:470-6. 1999
  4. ncbi Contribution of targeted conditional somatic mutagenesis to deciphering retinoid X receptor functions and to generating mouse models of human diseases
    D Metzger
    BP10142, Institut de Génétique et de Biologie Moléculaire et Cellulaire CNRS INSERM Université Louis Pasteur, 67404 Illkirch, France
    Handb Exp Pharmacol . 2007
  5. ncbi Temporally controlled targeted somatic mutagenesis in the mouse brain
    P Weber
    Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, Centre National de la Recherche Scientifique, College de France, Universite Louis Pasteur, BP163, 67404 Illkirch Cedex, Communaute Urbaine de Strasbourg, France
    Eur J Neurosci 14:1777-83. 2001
  6. ncbi Targeted somatic mutagenesis in mouse epidermis
    A K Indra
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, College de France, Illkirch, France
    Horm Res 54:296-300. 2000
  7. pmc Selective ablation of retinoid X receptor alpha in hepatocytes impairs their lifespan and regenerative capacity
    T Imai
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, College de France, BP 163, 67404 Illkirch Cedex, Communaute Urbaine de Strasbourg, France
    Proc Natl Acad Sci U S A 98:4581-6. 2001
  8. ncbi RXR-alpha ablation in skin keratinocytes results in alopecia and epidermal alterations
    M Li
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, College de France, BP 163, 67404 Illkirch Cedex, France
    Development 128:675-88. 2001
  9. pmc Impaired adipogenesis and lipolysis in the mouse upon selective ablation of the retinoid X receptor alpha mediated by a tamoxifen-inducible chimeric Cre recombinase (Cre-ERT2) in adipocytes
    T Imai
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, College de France, BP 163, 67404 Illkirch Cedex, France
    Proc Natl Acad Sci U S A 98:224-8. 2001
  10. ncbi Skin abnormalities generated by temporally controlled RXRalpha mutations in mouse epidermis
    M Li
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, College de France, Illkirch
    Nature 407:633-6. 2000

Collaborators

  • W Wahli
  • T Imai
  • Graeme Jones
  • B Mascrez
  • James P Di Santo
  • M Jiang
  • Shigeaki Kato
  • F Radtke
  • P Chambon
  • M Li
  • H Chiba
  • N Messaddeq
  • X Warot
  • A K Indra
  • J Brocard
  • A Rangarajan
  • R Feil
  • L Vallier
  • P Weber
  • C Gerard
  • S Kühbandner
  • S S Abu-Abed
  • C Sumi-Ichinose
  • G P Dotto
  • S Markossian
  • C Dehay
  • H Oh
  • A Lukaszewicz
  • J C Aster
  • M Nicolas
  • C Mammucari
  • M Aguet
  • L Miele
  • J Mancip
  • R Okuyama
  • J Samarut
  • P Savatier
  • S Krishna
  • C Talora
  • F Hofmann
  • J M Bornert
  • S Brummer
  • B R Beckett
  • M Petkovich
  • J V Chithalen
  • H Ichinose
  • J Clifford
  • M LeMeur

Detail Information

Publications18

  1. ncbi Site- and time-specific gene targeting in the mouse
    D Metzger
    , CNRS/INSERM/ULP, , BP 163 67404 Illkirch Cedex, C.U. de Strasbourg, France
    Methods 24:71-80. 2001
    ..This conditional site-specific recombination system should allow the analysis of knockout phenotypes that cannot be addressed by conventional gene targeting...
  2. ncbi Functional role of RXRs and PPARgamma in mature adipocytes
    D Metzger
    Institut de Génétique et de Biologie Moléculaire et Cellulaire IGBMC INSERM CNRS ULP, 1, rue Laurent Fries, 67404 Illkirch, France
    Prostaglandins Leukot Essent Fatty Acids 73:51-8. 2005
    ..Thus, in adipocytes, RXRalpha is essential for lipogenesis, but RXRgamma can functionally replace RXRalpha for the adipocyte vital functions exerted by PPARgamma/RXR heterodimers...
  3. ncbi Engineering the mouse genome by site-specific recombination
    D Metzger
    Institut de Génétique et de Biologie Moléculaire et Cellulaire CNRS INSERM ULP Collége de France BP 163, 67404, Illkirch Cedex, CU de Strasbourg, France
    Curr Opin Biotechnol 10:470-6. 1999
    ....
  4. ncbi Contribution of targeted conditional somatic mutagenesis to deciphering retinoid X receptor functions and to generating mouse models of human diseases
    D Metzger
    BP10142, Institut de Génétique et de Biologie Moléculaire et Cellulaire CNRS INSERM Université Louis Pasteur, 67404 Illkirch, France
    Handb Exp Pharmacol . 2007
    ....
  5. ncbi Temporally controlled targeted somatic mutagenesis in the mouse brain
    P Weber
    Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, Centre National de la Recherche Scientifique, College de France, Universite Louis Pasteur, BP163, 67404 Illkirch Cedex, Communaute Urbaine de Strasbourg, France
    Eur J Neurosci 14:1777-83. 2001
    ..Some limitations of presently available reporter lines for Cre-mediated recombination in adult mouse CNS are discussed...
  6. ncbi Targeted somatic mutagenesis in mouse epidermis
    A K Indra
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, College de France, Illkirch, France
    Horm Res 54:296-300. 2000
    ..These two transgenic lines should be very useful to analyse the functional role of a number of genes expressed in keratinocytes...
  7. pmc Selective ablation of retinoid X receptor alpha in hepatocytes impairs their lifespan and regenerative capacity
    T Imai
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, College de France, BP 163, 67404 Illkirch Cedex, Communaute Urbaine de Strasbourg, France
    Proc Natl Acad Sci U S A 98:4581-6. 2001
    ..We conclude that RXRalpha plays important cell-autonomous function(s) in the mechanism(s) involved in the lifespan of hepatocytes and liver regeneration...
  8. ncbi RXR-alpha ablation in skin keratinocytes results in alopecia and epidermal alterations
    M Li
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, College de France, BP 163, 67404 Illkirch Cedex, France
    Development 128:675-88. 2001
    ....
  9. pmc Impaired adipogenesis and lipolysis in the mouse upon selective ablation of the retinoid X receptor alpha mediated by a tamoxifen-inducible chimeric Cre recombinase (Cre-ERT2) in adipocytes
    T Imai
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, College de France, BP 163, 67404 Illkirch Cedex, France
    Proc Natl Acad Sci U S A 98:224-8. 2001
    ....
  10. ncbi Skin abnormalities generated by temporally controlled RXRalpha mutations in mouse epidermis
    M Li
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, College de France, Illkirch
    Nature 407:633-6. 2000
    ..We show that RXRalpha has key roles in hair cycling, probably through RXR/VDR heterodimers, and in epidermal keratinocyte proliferation and differentiation...
  11. pmc Specific and redundant functions of retinoid X Receptor/Retinoic acid receptor heterodimers in differentiation, proliferation, and apoptosis of F9 embryonal carcinoma cells
    H Chiba
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, College de France, 67404 Illkirch Cedex, France
    J Cell Biol 139:735-47. 1997
    ..The present approach for multiple gene targeting should allow inactivation of any set of genes in a given cell...
  12. pmc SNF2beta-BRG1 is essential for the viability of F9 murine embryonal carcinoma cells
    C Sumi-Ichinose
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, College de France, Illkirch, CU de Strasbourg
    Mol Cell Biol 17:5976-86. 1997
    ..Thus, in F9 EC cells, SNF2beta-BRG1 appears to play an essential role in basal processes involved in cell proliferation, in addition to its putative role in the activation of transcription mediated by nuclear receptors...
  13. ncbi Mouse P450RAI (CYP26) expression and retinoic acid-inducible retinoic acid metabolism in F9 cells are regulated by retinoic acid receptor gamma and retinoid X receptor alpha
    S S Abu-Abed
    Cancer Research Laboratories, Queen s University, Kingston, Ontario, Canada
    J Biol Chem 273:2409-15. 1998
    ..These experiments, as well as others using synthetic receptor subtype-specific retinoids, suggest that the RAR gamma and RXR alpha receptors mediate the effects of retinoic acid on the expression of the P450RAI gene...
  14. pmc Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation
    A Rangarajan
    Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA
    EMBO J 20:3427-36. 2001
    ..Thus, Notch signaling triggers two distinct pathways leading to keratinocyte growth arrest and differentiation...
  15. pmc Mammalian TAF(II)30 is required for cell cycle progression and specific cellular differentiation programmes
    D Metzger
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, College de France, BP 163 67404 Illkirch Cedex, CU de Strasbourg, France
    EMBO J 18:4823-34. 1999
    ..Thus, TAF(II)30 is not indispensable for class II gene transcription in general, but seems to be required for the expression of a subset of genes...
  16. pmc An efficient system for conditional gene expression in embryonic stem cells and in their in vitro and in vivo differentiated derivatives
    L Vallier
    , , , , 69364 Lyon Cedex 07, France
    Proc Natl Acad Sci U S A 98:2467-72. 2001
    ..Therefore, this approach can be applied to drive conditional expression of virtually any transgene in a large variety of cell types, both in vitro and in vivo...
  17. ncbi Temporally controlled somatic mutagenesis in smooth muscle
    S Kühbandner
    Institut fur Pharmakologie und Toxikologie, Technische Universitat Munchen, Munchen, Germany
    Genesis 28:15-22. 2000
    ..The recombined genome persisted for at least four months after tamoxifen treatment. SM-CreER(T2)(ki) transgenic mice should be useful to study the effects of various somatic mutations in smooth muscle...
  18. pmc Ligand-activated site-specific recombination in mice
    R Feil
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Universite Louis Pasteur, College de France, C U de Strasbourg, France
    Proc Natl Acad Sci U S A 93:10887-90. 1996
    ..This conditional site-specific recombination system should allow the analysis of knockout phenotypes that cannot be addressed by conventional gene targeting...