Genomes and Genes
- Cardiovascular abnormalities with normal blood pressure in tissue kallikrein-deficient miceP Meneton
Institut National de la Santé et de la Recherche Médicale INSERM U367, 17 Rue du Fer a Moulin, 75005 Paris, France
Proc Natl Acad Sci U S A 98:2634-9. 2001..They suggest that the kallikrein-kinin system could be involved in the development or progression of cardiovascular diseases...
- Comparative roles of the renal apical sodium transport systems in blood pressure controlP Meneton
INSERM U367, Paris, France
J Am Soc Nephrol 11:S135-9. 2000..The overall effect of NHE3 inactivation on BP may also involve absorptive defects in the intestine and colon, where the exchanger normally reabsorbs significant amounts of Na(+) and water...
- Sodium and potassium handling by the aldosterone-sensitive distal nephron: the pivotal role of the distal and connecting tubulePierre Meneton
Unité 367 de l Institut National de la Santé et de la Recherche Médicale, 75005 Paris, France
Am J Physiol Renal Physiol 287:F593-601. 2004....
- Links between dietary salt intake, renal salt handling, blood pressure, and cardiovascular diseasesPierre Meneton
Institut National de la Santé et de la Recherche Médicale U367, Département de Santé Publique et d Informatique Médicale, Faculté de Médecine Broussais Hôtel Dieu, Paris, France
Physiol Rev 85:679-715. 2005..Thus chronic exposure to a high-salt diet appears to be a major factor involved in the frequent occurrence of hypertension and cardiovascular diseases in human populations...
- Flow-dependent dilation mediated by endogenous kinins requires angiotensin AT2 receptorsSonia Bergaya
Institut National de la Sante et de la Recherche Medicale, Unit 541, Hopital Lariboisiere, Paris, France
Circ Res 94:1623-9. 2004..In conclusion, this study demonstrates that the presence of functional AT2 receptors is necessary to observe the contribution of the vascular kinin-kallikrein system to flow-dependent dilation...
- Pendrin regulation in mouse kidney primarily is chloride-dependentMarion Vallet
INSERM U652, IFR58, Institut des Cordeliers, Paris, France
J Am Soc Nephrol 17:2153-63. 2006..These results suggest that factors that are associated with changes in distal chloride delivery govern pendrin expression in the connecting tubule and cortical collecting duct...
- Inactivation of the Na-Cl co-transporter (NCC) gene is associated with high BMD through both renal and bone mechanisms: analysis of patients with Gitelman syndrome and Ncc null miceLaurence Nicolet-Barousse
Departement de Physiologie, Hôpital Européen George Pompidou, Institut National de la Santé et de la Recherche Médicale INSERM U 652, IFR 58, Universite Paris V, Paris, France
J Bone Miner Res 20:799-808. 2005....
- Defective ENaC processing and function in tissue kallikrein-deficient miceNicolas Picard
INSERM U872 Centre de Recherche des Cordeliers, Universite Paris 5, Faculté de Médecine René Descartes, and Département de Physiologie, Hopital Necker Enfants Malades, F 75015, Paris, France
J Biol Chem 283:4602-11. 2008..The results demonstrate that TK, like several other proteases, can activate ENaC in the kidney and the colon...
- Tissue kallikrein-deficient mice display a defect in renal tubular calcium absorptionNicolas Picard
INSERM, Unité 652, and Institut Fédératif de Recherche 58, Paris, France
J Am Soc Nephrol 16:3602-10. 2005..TK deficiency had no effect on the renal abundance of distal Ca transporter mRNA. These data suggest that TK may be a physiologic regulator of RTCa transport, acting through a non-kinin-mediated mechanism...
- Arterial stiffness and angiotensinogen gene in hypertensive patients and mutant miceErwan Bozec
Department of Pharmacology, Hôpital Européen Georges Pompidou and Institut National de la Santé et de la Recherche Médicale EMI 0107, Paris, France
J Hypertens 22:1299-307. 2004....
- Unemployment is associated with high cardiovascular event rate and increased all-cause mortality in middle-aged socially privileged individualsPierre Meneton
INSERM U1142 LIMICS, UMR_S 1142 Sorbonne Universités, UPMC Universite Paris 06, Universite Paris 13, Campus des Cordeliers, 15 rue de l Ecole de Medecine, 75006, Paris, France
Int Arch Occup Environ Health 88:707-16. 2015..To assess prospectively the association between employment status and cardiovascular health outcomes in socially privileged individuals...
- Tissue kallikrein deficiency aggravates cardiac remodelling and decreases survival after myocardial infarction in miceSandrine Pons
INSERM U 652 872, CRC, IFR 58, Paris, France
Eur J Heart Fail 10:343-51. 2008..TK is involved in cardioprotection in the setting of acute myocardial ischaemia but its role in post-ischaemic heart failure (HF), a major cause of delayed mortality after myocardial infarction (MI), is unknown...
- Chronic potassium depletion increases adrenal progesterone production that is necessary for efficient renal retention of potassiumBoutaïna Elabida
UPMC Univ Paris 6 INSERM CNRS, Laboratoire de Génomique, Physiologie et Physiopathologie Rénales, Centre de Recherche des Cordeliers, Paris, France
Kidney Int 80:256-62. 2011..Thus, in males, a specific progesterone concentration profile induced by chronic potassium restriction regulates potassium balance...
- Role of tissue kallikrein in response to flow in mouse resistance arteriesSonia Bergaya
Institut National de la Sante et de la Recherche Medicale INSERM, Unit 541, Hôpital Lariboisière and Inserm Unit 367, 17 Rue du Fer a Moulin, Paris, France
J Hypertens 22:745-50. 2004..We hypothesized that the vascular kinin-kallikrein system may be involved in shear stress signalling in small resistance arteries, which have a key role in the systemic regulation of blood pressure...
- Distinctive unhealthy eating pattern in free-living middle-aged hypertensives when compared with dyslipidemic or overweight patientsPierre Meneton
Inserm U872, Centre de Recherche des Cordeliers, Paris, France
J Hypertens 31:1554-63. 2013..To evaluate habitual dietary intakes in patients with established hypertension, dyslipidemia and/or overweight...
- Evaluation of the agreement between guidelines and initial antihypertensive drug treatment using a national health care reimbursement databasePierre Meneton
Institut National de la Sante et de la Recherche Medicale, Centre de Recherche des Cordeliers, Paris, France
J Eval Clin Pract 18:623-9. 2012....
- Decreased flow-dependent dilation in carotid arteries of tissue kallikrein-knockout miceS Bergaya
Institut National de la Sante et de la Recherche Medicale, Unit 541 Hôpital Lariboisière, Paris, France
Circ Res 88:593-9. 2001..This study demonstrates the active contribution of the vascular kallikrein-kinin system to one-third of the flow-dependent dilation response via activation of B(2) receptors coupled to endothelial NO release...
- Health insurance coverage is the single most prominent socioeconomic factor associated with cardiovascular drug delivery in the French populationPierre Meneton
Institut National de la Sante et de la Recherche Medicale, Unite 872, Centre de Recherche des Cordeliers, Paris, France
J Hypertens 30:617-23. 2012....
- Bone mineral measurements in mice: comparison of two devicesSami Kolta
Rheumatology Department, Cochin Hospital, Assistance Publique, Hôpitaux de Paris René Descartes University, Paris, France
J Clin Densitom 6:251-8. 2003..We concluded that bone density and bone-density changes in mice can be measured precisely in vivo using the Hologic and Piximus devices; the latter being able to measure the whole body BMD with good precision...
- Altered renin synthesis and secretion in the kidneys of heterozygous mice with a null mutation in the TGF-beta(2) geneLaurence Pietri
INSERM U367, Hopital Broussais, Paris, France
Exp Nephrol 10:374-82. 2002..These data suggest that TGF-beta(2) exerts an inhibitory effect on renin synthesis and release from the juxtaglomerular apparatuses...
- Genetically increased angiotensin I-converting enzyme level and renal complications in the diabetic mouseW Huang
Institut National de la Sante et de la Recherche Medicale, Unit 367, 17 Rue du Fer a Moulin, 75005 Paris, France
Proc Natl Acad Sci U S A 98:13330-4. 2001..Proteinuria was correlated to plasma ACE level in the three-copy diabetic mice. Thus, a modest genetic increase in ACE levels is sufficient to cause nephropathy in diabetic mice...
- High plasma aldosterone and low renin predict blood pressure increase and hypertension in middle-aged Caucasian populationsP Meneton
Inserm U872, Centre de Recherche des Cordeliers, Paris, France
J Hum Hypertens 22:550-8. 2008..03 and 0.05). These results reinforce the hypothesis that high plasma aldosterone and low plasma renin levels precede blood pressure increase and the occurrence of hypertension in middle-aged Caucasian populations...
- Genetic renal tubular disorders of renal ion channels and transportersP Meneton
INSERM U367, Paris, France
Semin Nephrol 21:81-93. 2001....
- Cardiovascular phenotypes of kinin B2 receptor- and tissue kallikrein-deficient miceFabien Trabold
Departement de Pharmacologie, Faculte de Medecine Paris Sud, INSERM 00 01, Le Kremlin Bicetre, France
Hypertension 40:90-5. 2002..The phenotypic differences observed between TK-/- and B2-/- mice could be underlain by tissue kallikrein kinin-independent effect and/or kinin B1 receptor activation...
- Genetic deficiency in tissue kallikrein activity in mouse and man: effect on arteries, heart and kidneyAnne Pizard
INSERM U652 U872, Centre de Recherche des Cordeliers, 15 rue de l Ecole de Medecine, F 75006 Paris, France
Biol Chem 389:701-6. 2008..Potential clinical and therapeutic developments are discussed...
- Change in salt intake affects blood pressure of chimpanzees: implications for human populationsPaul Elliott
Department of Epidemiology and Public Health, Imperial College London, Faculty of Medicine, St Mary s Campus, Norfolk Place, London W2 1PG, UK
Circulation 116:1563-8. 2007..Effects of more modest alterations to sodium intakes in chimpanzees, akin to current efforts to lower sodium intakes in the human population, are unknown...
- Tissue kallikrein is involved in the cardioprotective effect of AT1-receptor blockade in acute myocardial ischemiaErij Messadi-Laribi
INSERM U652 872, 15 rue de l Ecole de Medecine, 75270 Paris, France
J Pharmacol Exp Ther 323:210-6. 2007..Our results support the hypothesis of a coupling between AT2 receptors and kallikrein during AT1 receptor blockade, which plays a major role in cardioprotection...
- A second expressed kininogen gene in miceEdward G Shesely
Hypertension and Vascular Research, Henry Ford Hospital, Detroit, Michigan 48202, USA
Physiol Genomics 26:152-7. 2006..Conversely, in the kidney K2 is strongly expressed as both HMWK and LMWK, whereas K1 is not expressed as HMWK and expressed only very weakly as LMWK...
- Protective effects of high dietary potassium: nutritional and metabolic aspectsChristian Demigne
Metabolic Diseases and Micronutriments Unit, INRA Theix CRNH Clermont Ferrand, 63122 St Genes Champanelle, France
J Nutr 134:2903-6. 2004..The need to ensure a 2.5- to 3.5-g daily K+ supply from fruits and vegetables represents a strong rationale for the "5-10 servings per day" recommendations...
- Uterine artery structural and functional changes during pregnancy in tissue kallikrein-deficient miceRob H P Hilgers
Department of Pharmacology and Toxicology, Cardiovascular Research Institute Maastricht, Universiteit Maastricht, Netherlands
Arterioscler Thromb Vasc Biol 23:1826-32. 2003..We investigated whether TK deficiency blunts FID and alters chronic flow-related arterial structural and functional changes in resistance-sized muscular arteries...
- Transforming growth factor beta in cardiovascular development and functionMohamad Azhar
Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
Cytokine Growth Factor Rev 14:391-407. 2003..The evidence for TGFbeta activities during cardiovascular development and physiologic function will be given and areas which need further investigation will be discussed...
- Altered renal distal tubule structure and renal Na(+) and Ca(2+) handling in a mouse model for Gitelman's syndromeJohannes Loffing
Department of Pharmacology and Toxicology, University of Lausanne, Rue du Bugnon 27, CH 1005 Lausanne
J Am Soc Nephrol 15:2276-88. 2004..Thus, loss of NCC leads to major structural remodeling of the renal distal tubule that goes along with marked changes in glomerular and tubular function, which may explain some of the clinical features of Gitelman's syndrome...
- Proximal renal tubular acidosis in TASK2 K+ channel-deficient mice reveals a mechanism for stabilizing bicarbonate transportRichard Warth
Institute of Physiology, Universitatsstrasse 31, 93053 Regensburg, Germany
Proc Natl Acad Sci U S A 101:8215-20. 2004..The consequences of the task2 gene inactivation in mice are reminiscent of the clinical manifestations seen in human proximal renal tubular acidosis syndrome...
- Renin and kallikrein in connecting tubule of mouseAndreas Rohrwasser
Department of Human Genetics, University of Utah, Health Sciences Center, Salt Lake City, Utah 84112, USA
Kidney Int 64:2155-62. 2003..Are the genes expressed in the same or in different cells of connecting tubule? Does this topography support the hypothesis that KLK-1 activates prorenin or is it more likely that it affords coordinated gene regulation?..
- The sequential cleavage of membrane anchored pro-EGF requires a membrane serine protease other than kallikrein in rat kidneySylvain M Le Gall
Institut de Biochimie et Biophysique Moléculaire et Cellulaire CNRS UMR 8619, Université Paris XI Bât 430, 91405 Orsay Cedex, France
Regul Pept 122:119-29. 2004..By use of wild-type and knockout mice urines, we found that tissue kallikrein (TK) was not involved in the regulation of this processing...