Ziad A Massy

Summary

Country: France

Publications

  1. doi request reprint Calcium-sensing receptor activation in chronic kidney disease: effects beyond parathyroid hormone control
    Ziad A Massy
    INSERM U 1088, University of Picardie Jules Verne, Amiens, France Division of Nephrology, Ambroise Pare Hospital, Paris Ile de France Ouest University University of Versailles Saint Quentin En Yvelines, Paris Boulogne Billancourt, France Electronic address
    Semin Nephrol 34:648-59. 2014
  2. doi request reprint [Pleiotropic effects of sevelamer: a model of intestinal tract chelating agent]
    Ziad A Massy
    INSERM U 1088, UFR de Medecine et de Pharmacie, Universite de Picardie Jules Verne, 1, rue des Louvels, 80037 Amiens Cedex, France Service de Néphrologie, Université Paris Ile de France Ouest UVSQ, Hopital Ambroise Pare, 9, avenue Charles de Gaulle, 92104 Boulogne Billancourt cedex, France Electronic address
    Nephrol Ther 10:441-50. 2014
  3. pmc Vascular calcification in patients with type 2 diabetes: the involvement of matrix Gla protein
    Sophie Liabeuf
    Inserm U1088, Jules Verne University of Picardy, F 80000 Amiens, France
    Cardiovasc Diabetol 13:85. 2014
  4. doi request reprint The role of lipids and uremic toxins in cardiovascular disease in CKD
    Ziad A Massy
    Division of Nephrology, Ambroise Pare Hospital, Paris Ile de France Ouest University UVSQ, 09 Avenue Charles de Gaulle, Boulogne Billancourt, 92100, Paris, France
    Clin Exp Nephrol 18:255-6. 2014
  5. doi request reprint LDL cholesterol in CKD--to treat or not to treat?
    Ziad A Massy
    Division of Nephrology, Ambroise Pare Hospital, Paris Ile de France Ouest UVSQ University, Boulogne Billancourt Paris, France
    Kidney Int 84:451-6. 2013
  6. pmc Association between free light chain levels, and disease progression and mortality in chronic kidney disease
    Lucie Desjardins
    Inserm U1088, UFR de Medecine et Pharmacie, Universite de Picardie Jules Verne, Amiens 80054, France
    Toxins (Basel) 5:2058-73. 2013
  7. doi request reprint Vascular calcification
    Ziad A Massy
    Unité 1088 de l Inserm, UFR de Medecine et de Pharmacie, Universite de Picardie Jules Verne, Amiens, France
    Curr Opin Nephrol Hypertens 22:405-12. 2013
  8. doi request reprint Uremic toxicity and sclerostin in chronic kidney disease patients
    Lucie Desjardins
    Inserm U1088, UFR de Medecine et Pharmacie, Jules Verne University of Picardy, 1, rue des Louvels, 80037 Amiens Cedex 1, France Clinical Research Centre, Division of Clinical Pharmacology, Amiens University Hospital, avenue Lænnec, 80054 Amiens cedex, France The Jules Verne university of Picardy, 1, rue des Louvels, 80037 Amiens Cedex 1, France
    Nephrol Ther 10:463-70. 2014
  9. doi request reprint Lanthanum carbonate, like sevelamer-HCl, retards the progression of vascular calcification and atherosclerosis in uremic apolipoprotein E-deficient mice
    Igor G Nikolov
    INSERM ERI 12, UFR de Médecine Pharmacie, University of Picardie, Amiens, France
    Nephrol Dial Transplant 27:505-13. 2012
  10. doi request reprint Farnesyltransferase inhibitor R115777 protects against vascular disease in uremic mice
    Igor G Nikolov
    Inserm Unit 1088, Amiens University of Picardie Jules Verne and Amiens University Hospital, Amiens, France
    Atherosclerosis 229:42-51. 2013

Detail Information

Publications84

  1. doi request reprint Calcium-sensing receptor activation in chronic kidney disease: effects beyond parathyroid hormone control
    Ziad A Massy
    INSERM U 1088, University of Picardie Jules Verne, Amiens, France Division of Nephrology, Ambroise Pare Hospital, Paris Ile de France Ouest University University of Versailles Saint Quentin En Yvelines, Paris Boulogne Billancourt, France Electronic address
    Semin Nephrol 34:648-59. 2014
    ..This review summarizes our current knowledge concerning the potential role(s) of the CaSR expressed in various tissues in CKD-related disorders, independently of parathyroid hormone control...
  2. doi request reprint [Pleiotropic effects of sevelamer: a model of intestinal tract chelating agent]
    Ziad A Massy
    INSERM U 1088, UFR de Medecine et de Pharmacie, Universite de Picardie Jules Verne, 1, rue des Louvels, 80037 Amiens Cedex, France Service de Néphrologie, Université Paris Ile de France Ouest UVSQ, Hopital Ambroise Pare, 9, avenue Charles de Gaulle, 92104 Boulogne Billancourt cedex, France Electronic address
    Nephrol Ther 10:441-50. 2014
    ..These effects of sevelamer, restricted to the intestinal lumen, underline the importance of intestinal pathway in CKD and open the way to new therapeutic strategies for the management of the CKD and its complications. ..
  3. pmc Vascular calcification in patients with type 2 diabetes: the involvement of matrix Gla protein
    Sophie Liabeuf
    Inserm U1088, Jules Verne University of Picardy, F 80000 Amiens, France
    Cardiovasc Diabetol 13:85. 2014
    ....
  4. doi request reprint The role of lipids and uremic toxins in cardiovascular disease in CKD
    Ziad A Massy
    Division of Nephrology, Ambroise Pare Hospital, Paris Ile de France Ouest University UVSQ, 09 Avenue Charles de Gaulle, Boulogne Billancourt, 92100, Paris, France
    Clin Exp Nephrol 18:255-6. 2014
    ..Recent data suggest that uremic toxins may modulate lipoprotein levels and composition (e.g., oxidation or carbamylation) and enhance the cardiovascular toxicity of lipoproteins in CKD patients. ..
  5. doi request reprint LDL cholesterol in CKD--to treat or not to treat?
    Ziad A Massy
    Division of Nephrology, Ambroise Pare Hospital, Paris Ile de France Ouest UVSQ University, Boulogne Billancourt Paris, France
    Kidney Int 84:451-6. 2013
    ..In the present review, we discuss these issues and end up with a practical plan aimed to help the nephrologist in managing atherosclerosis-related risk using cholesterol-lowering therapies in CKD patients. ..
  6. pmc Association between free light chain levels, and disease progression and mortality in chronic kidney disease
    Lucie Desjardins
    Inserm U1088, UFR de Medecine et Pharmacie, Universite de Picardie Jules Verne, Amiens 80054, France
    Toxins (Basel) 5:2058-73. 2013
    ..The observed link between elevated FLC levels and mortality appears to depend on other well-known factors. ..
  7. doi request reprint Vascular calcification
    Ziad A Massy
    Unité 1088 de l Inserm, UFR de Medecine et de Pharmacie, Universite de Picardie Jules Verne, Amiens, France
    Curr Opin Nephrol Hypertens 22:405-12. 2013
    ....
  8. doi request reprint Uremic toxicity and sclerostin in chronic kidney disease patients
    Lucie Desjardins
    Inserm U1088, UFR de Medecine et Pharmacie, Jules Verne University of Picardy, 1, rue des Louvels, 80037 Amiens Cedex 1, France Clinical Research Centre, Division of Clinical Pharmacology, Amiens University Hospital, avenue Lænnec, 80054 Amiens cedex, France The Jules Verne university of Picardy, 1, rue des Louvels, 80037 Amiens Cedex 1, France
    Nephrol Ther 10:463-70. 2014
    ....
  9. doi request reprint Lanthanum carbonate, like sevelamer-HCl, retards the progression of vascular calcification and atherosclerosis in uremic apolipoprotein E-deficient mice
    Igor G Nikolov
    INSERM ERI 12, UFR de Médecine Pharmacie, University of Picardie, Amiens, France
    Nephrol Dial Transplant 27:505-13. 2012
    ..We compared the effect of phosphate binder lanthanum (La) carbonate with sevelamer-HCl on atherosclerosis, VC and bone structure and function in mice with chronic renal failure (CRF)...
  10. doi request reprint Farnesyltransferase inhibitor R115777 protects against vascular disease in uremic mice
    Igor G Nikolov
    Inserm Unit 1088, Amiens University of Picardie Jules Verne and Amiens University Hospital, Amiens, France
    Atherosclerosis 229:42-51. 2013
    ..We studied the effects of farnesyltransferase inhibitor R115777 on vascular disease in apolipoprotein E deficient mice with chronic renal failure and on mineral deposition in vitro...
  11. doi request reprint Plasma beta-2 microglobulin is associated with cardiovascular disease in uremic patients
    Sophie Liabeuf
    INSERM U 1088, Amiens, France
    Kidney Int 82:1297-303. 2012
    ..Thus, we confirm the strong relationship between B2M levels and eGFR and confirm the power of B2M to predict overall and cardiovascular mortality and cardiovascular events in patients at different stages of CKD...
  12. ncbi request reprint [Frequency of anaemia and indications for treatment with epoetin in chronic renal failure at the pre-dialysis stage]
    Pierre Yves Jungers
    Services de néphrologie et de biochimie A, Hopital Necker, Paris, France
    Presse Med 32:212-6. 2003
    ....
  13. doi request reprint The calcimimetic R-568 retards uremia-enhanced vascular calcification and atherosclerosis in apolipoprotein E deficient (apoE-/-) mice
    Ognen Ivanovski
    Inserm Unit 845, Necker Hospital, Paris Descartes University Paris V, Paris, France
    Atherosclerosis 205:55-62. 2009
    ....
  14. doi request reprint Possible involvement of microRNAs in vascular damage in experimental chronic kidney disease
    Fatiha Taïbi
    Inserm U1088, 1 rue des Louvels, F 80037 Amiens, University of Picardie Jules Verne, Amiens, France
    Biochim Biophys Acta 1842:88-98. 2014
    ..In conclusion, these miRNAs could have role(s) in CKD vascular remodeling and may therefore represent useful targets to prevent or treat complications of CKD. ..
  15. doi request reprint Effects of phosphate on vascular function under normal conditions and influence of the uraemic state
    Isabelle Six
    INSERM, Unit 1088 and Jules Verne University of Picardie, Amiens, France
    Cardiovasc Res 96:130-9. 2012
    ..High phosphate levels may play a direct role in vascular dysfunction. We investigated here the effects of phosphate loading and of the phosphate binder sevelamer-HCl on vascular function...
  16. doi request reprint Indoxyl sulphate inhibits osteoclast differentiation and function
    Anaïs Mozar
    INSERM ERI 12, EA4292, Amiens, France
    Nephrol Dial Transplant 27:2176-81. 2012
    ..Indeed, it was recently reported that IS induces skeletal resistance to parathyroid hormone in cultured osteoblastic cells. However, it is not yet known whether IS also affects osteoclast cells...
  17. doi request reprint The circulating soluble TRAIL is a negative marker for inflammation inversely associated with the mortality risk in chronic kidney disease patients
    Sophie Liabeuf
    INSERM ERI 12 EA 4292, Amiens, France
    Nephrol Dial Transplant 25:2596-602. 2010
    ....
  18. doi request reprint Effect of simvastatin in apolipoprotein E deficient mice with surgically induced chronic renal failure
    Ognen Ivanovski
    Institut National en Santé et Recherche Médicale Unit 845, Paris, France
    J Urol 179:1631-6. 2008
    ....
  19. doi request reprint Chronic kidney disease bone and mineral disorder (CKD-MBD) in apolipoprotein E-deficient mice with chronic renal failure
    Igor G Nikolov
    INSERM ERI 12, University of Picardie, Amiens, France
    Bone 47:156-63. 2010
    ..With ApoE being also involved in bone metabolism, we compared the effects of CRF on the bone of apoE(-/-) mice to those observed in wild type mice (WT) of the same genetic background, C57/BL6...
  20. doi request reprint Tumor necrosis factor-related apoptosis-inducing ligand and vascular calcification
    Maud Chasseraud
    French National Institute of Health and Medical Research INSERM, ERI 12 EA 4292 and University of Picardie Jules Verne, Amiens, France
    Ther Apher Dial 15:140-6. 2011
    ..Our results suggest that TRAIL may be involved in the formation of vascular calcification in certain experimental settings; however, its role in chronic kidney disease patients requires further evaluation...
  21. doi request reprint Prognostic implications of plasma myoglobin levels in patients with chronic kidney disease
    Aurelie Lenglet
    French National Institute of Health and Medical Research INSERM, ERI 12 EA 4292, Amiens, France
    Int J Artif Organs 35:959-68. 2012
    ..The objective of this study was to evaluate plasma myoglobin (Mb) levels according to the CKD stage and to determine whether they are associated with overall, cardiovascular (CV) mortality, CV events, and renal outcomes...
  22. ncbi request reprint Effects of oral vitamin C supplementation on oxidative stress and inflammation status in haemodialysis patients
    Christine Fumeron
    AURA Centre Henri Küntziger, INSERM ERI 12, Amiens University Hospital and University of Picardie, Amiens, France
    Nephrol Dial Transplant 20:1874-9. 2005
    ..Limited data, however, are available regarding the effects of vitamin C supplementation on oxidative stress and inflammation markers in such patients...
  23. doi request reprint Mechanisms of aortic and cardiac dysfunction in uremic mice with aortic calcification
    Julien Maizel
    INSERM, Unit ERI 12, and Jules Verne University of Picardie and Amiens University Medical Center, Amiens, France
    Circulation 119:306-13. 2009
    ..Chronic renal failure (CRF) is associated with cardiac dysfunction and increased aortic stiffness. The mechanisms involved are not clearly understood. We examined changes over time in cardiac and aortic function in a murine CRF model...
  24. pmc Does p-cresylglucuronide have the same impact on mortality as other protein-bound uremic toxins?
    Sophie Liabeuf
    INSERM U 1088, Jules Verne University of Picardy, Amiens, France
    PLoS ONE 8:e67168. 2013
    ..e. PCS, PCG and indoxylsulfate (IS)) differed in their ability to predict mortality...
  25. ncbi request reprint Effect of oral calcium carbonate on aortic calcification in apolipoprotein E-deficient (apoE-/-) mice with chronic renal failure
    Olivier Phan
    INSERM, Unit 845, Necker Hospital, Universite Paris V, Paris, France
    Nephrol Dial Transplant 23:82-90. 2008
    ..The aim of this study was to reexamine the role of calcium carbonate in vascular calcification and to analyse its effect on aortic calcification-related gene expression in chronic renal failure (CRF)...
  26. ncbi request reprint Sevelamer prevents uremia-enhanced atherosclerosis progression in apolipoprotein E-deficient mice
    Olivier Phan
    INSERM Unit 507, Necker Hospital, Paris, France
    Circulation 112:2875-82. 2005
    ....
  27. doi request reprint Free p-cresylsulphate is a predictor of mortality in patients at different stages of chronic kidney disease
    Sophie Liabeuf
    INSERM ERI 12 EA 4292 and the Clinical Research Centre Division of Clinical Pharmacology, Amiens University Hospital, Amiens, France
    Nephrol Dial Transplant 25:1183-91. 2010
    ....
  28. ncbi request reprint Calcium-sensing receptor as a potential modulator of vascular calcification in chronic kidney disease
    Axelle Caudrillier
    INSERM, ERI 12, EA 4292, Amiens, France
    J Nephrol 23:17-22. 2010
    ..In this review, the authors describe the recently demonstrated role played by calcium-sensing receptor and its modulation by calcimimetics on uremia-induced vascular calcification...
  29. doi request reprint Chronic renal failure alters endothelial function in cerebral circulation in mice
    Jean Marc Bugnicourt
    Institut National de Santé et de Recherche Médicale, ERI12, Amiens, France
    Am J Physiol Heart Circ Physiol 301:H1143-52. 2011
    ..In conclusion, endothelial function is impaired in a mouse model of early stage CRF. These alterations may be related (at least in part) to a decrease in NO production...
  30. doi request reprint Effects of calcimimetic on vascular calcification and atherosclerosis in uremic mice
    Nobuhiko Joki
    Inserm Unit 845, Necker Hospital, University Paris 5, Paris, France
    Bone 45:S30-4. 2009
    ..The present review is therefore devoted to the effects of calcimimetics on uremia-induced vascular disease...
  31. pmc Magnesium Attenuates Phosphate-Induced Deregulation of a MicroRNA Signature and Prevents Modulation of Smad1 and Osterix during the Course of Vascular Calcification
    Loïc Louvet
    INSERM U 1088, CURS, University of Picardie Jules Verne, Amiens, France
    Biomed Res Int 2016:7419524. 2016
    ....
  32. doi request reprint Peritoneal delivery of sodium pyrophosphate blocks the progression of pre-existing vascular calcification in uremic apolipoprotein-E knockout mice
    Rodrigo B de Oliveira
    Inserm Unit 1088, UFR de Medecine et de Pharmacie, University of Picardie Jules Verne UPJV, 1 rue des Louvels, 80037, Amiens, France
    Calcif Tissue Int 97:179-92. 2015
    ..Further studies are needed to gain more precise insight into underlying mechanisms and to see whether PPi administration may also be useful in patients with CKD and VC. ..
  33. doi request reprint Effects of sevelamer treatment on cardiovascular abnormalities in mice with chronic renal failure
    Julien Maizel
    INSERM, Unit 1088 and Jules Verne University of Picardie, Amiens, France
    Kidney Int 84:491-500. 2013
    ..The phosphate-lowering, rather than FGF23-lowering, effect appears to be responsible for the observed cardiovascular improvement. ..
  34. pmc The clinical impact of plasma leptin levels in a cohort of chronic kidney disease patients
    Rodrigo Bueno de Oliveira
    INSERM U 1088, The Jules Verne University of Picardy, Amiens, France
    Clin Kidney J 6:63-70. 2013
    ..However, despite leptin fulfilling the definition of a uremic toxin, its exact role in chronic kidney disease (CKD) has yet to be determined...
  35. doi request reprint Impact of disturbances of calcium and phosphate metabolism on vascular calcification and clinical outcomes in patients with chronic kidney disease
    Igor G Nikolov
    INSERM ERI 12, University of Picardie and Amiens University Hospital, av René Laënnec, Amiens, France
    Blood Purif 27:350-9. 2009
    ..In order to improve outcome in patients with CKD-MBD, early medical intervention is of utmost importance...
  36. doi request reprint Levels of Indoxyl Sulfate in Kidney Transplant Patients, and the Relationship With Hard Outcomes
    Sophie Liabeuf
    Inserm U1088, Jules Verne University of Picardy
    Circ J 80:722-30. 2016
    ..Data on levels of protein-bound uremic toxins in kidney transplant patients are scarce. The study's objective was to evaluate the levels of IS in kidney transplant patients and the relationship with hard outcomes...
  37. ncbi request reprint Animal models--what they can tell us about vascular calcification in CKD
    Ziad A Massy
    INSERM, ERI12, Amiens, France, and Amiens University Hospital, UPJV, Amiens, France
    Semin Dial 20:110-2. 2007
    ..In this review, we discuss how animal models could help us understand better the pathophysiology and management of calcifying cardiovascular complications associated with CKD...
  38. ncbi request reprint Increased pasma S-nitrosothiol concentrations predict cardiovascular outcomes among patients with end-stage renal disease: a prospective study
    Ziad A Massy
    INSERM U507, Necker Hospital, Paris, France
    J Am Soc Nephrol 15:470-6. 2004
    ..These findings support the hypothesis that impaired S-nitrosothiol bioavailability in uremia is an important factor for the excessive cardiovascular risk among HD patients...
  39. doi request reprint Para-cresyl sulfate acutely impairs vascular reactivity and induces vascular remodeling
    Priscilla Gross
    Inserm Unit 1088, Jules Verne University of Picardie, Amiens, France
    J Cell Physiol 230:2927-35. 2015
    ..In conclusion, elevated PCS concentrations such as those observed in CKD patients, by promoting both vascular dysfunction and vascular remodeling, may contribute to the development of hypertension and to cardiovascular mortality in CKD...
  40. doi request reprint Uremic toxin indoxyl sulfate inhibits human vascular smooth muscle cell proliferation
    Anaïs Mozar
    French National Institute of Health and Medical Research INSERM, ERI 12 EA 4292, Amiens, France
    Ther Apher Dial 15:135-9. 2011
    ..Chronic exposure to indoxyl sulfate produces a significant inhibitory effect on hVASMC proliferation. The relevance of these findings must be evaluated by further studies, particularly in an in vivo setting...
  41. pmc Inorganic phosphate accelerates the migration of vascular smooth muscle cells: evidence for the involvement of miR-223
    Ashraf Yusuf Rangrez
    Inserm U1088, Amiens, France
    PLoS ONE 7:e47807. 2012
    ..We focused on the effect of Pi levels on human aortic vascular smooth muscle cells (VSMCs), with an emphasis on the role of microRNAs (miRNAs)...
  42. doi request reprint Effects of pyrophosphate delivery in a peritoneal dialysis solution on bone tissue of apolipoprotein-E knockout mice with chronic kidney disease
    Fellype C Barreto
    Inserm Unit 1088, UFR de Medecine et Pharmacie, Picardie University Jules Verne UPJV, 1, rue des Louvels, Bat A, 3ème, 80037, Amiens Cedex, France
    J Bone Miner Metab 32:636-44. 2014
    ..In conclusion, PPi does not appear to be deleterious to bone tissue in apoE(-/-) mice with CKD, although a possible stimulatory PPi effect on osteoid formation may be worth further investigation...
  43. doi request reprint miR-223: An inflammatory oncomiR enters the cardiovascular field
    Fatiha Taïbi
    Inserm U1088, University of Picardie Jules Verne, 1 rue des Louvels, F 80037 Amiens, France
    Biochim Biophys Acta 1842:1001-9. 2014
    ..miR-223 is one of the growing number of RNA biomarkers of various human metabolic diseases and is thus of special interest to both researchers and clinicians in the cardiovascular field. ..
  44. doi request reprint Calcimimetics increase CaSR expression and reduce mineralization in vascular smooth muscle cells: mechanisms of action
    Lucie Hénaut
    Inserm Unit 1088, University of Picardie Jules Verne, 1 rue des Louvels, 80037 Amiens, France
    Cardiovasc Res 101:256-65. 2014
    ..The aim of this study was to examine the effects of calcimimetics on CaSR expression, cell phenotype, and mineral deposition in human vascular smooth muscle cells (h-VSMCs)...
  45. doi request reprint Effects of uremic toxins on vascular and bone remodeling
    Fellype C Barreto
    INSERM ERI 12, Amiens, France
    Semin Dial 22:433-7. 2009
    ..In this review, we discuss the role of uremic toxins in the cross-talk between bone and vessel, and emphasize their potential contribution to the development of both vascular and bone remodeling disorders in patients with CKD...
  46. ncbi request reprint The antioxidant N-acetylcysteine prevents accelerated atherosclerosis in uremic apolipoprotein E knockout mice
    Ognen Ivanovski
    INSERM Unit 507, Necker Hospital, Paris, France
    Kidney Int 67:2288-94. 2005
    ..Here we examine a possible direct effect of NAC supplementation on uremia-enhanced atherosclerosis in apolipoprotein E-deficient (apoE(-/-)) mice...
  47. ncbi request reprint New insights into the effects of the protein moiety of oxidized LDL (oxLDL)
    Stéphanie Vicca
    INSERM U507 and Laboratory of Biochemistry A, Necker Hospital, Paris, France
    Kidney Int Suppl . 2003
    ..These in vitro oxidative changes of LDL protein moiety, if shown to occur to a significant extent in uremic patients in vivo, may represent an important pathway in the pathogenesis of atherogenesis...
  48. pmc Uremic Toxicity of Advanced Glycation End Products in CKD
    Andréa E M Stinghen
    Institut National de la Santé et de la Recherche Médicale INSERM U 1088, Jules Verne University of Picardie, Amiens, France
    J Am Soc Nephrol 27:354-70. 2016
    ..Finally, we speculate on preventive and therapeutic strategies that focus on the AGE-RAGE axis to prevent vascular complications in patients with CKD. ..
  49. ncbi request reprint Increased plasma S-nitrosothiol levels in chronic haemodialysis patients
    Ziad A Massy
    INSERM U507, Necker Hospital, Paris, France
    Nephrol Dial Transplant 18:153-7. 2003
    ..The aim of our study was to determine the plasma levels of S-nitrosothiol and nitrotyrosine in chronic HD patients, and to evaluate potential factors influencing their levels...
  50. pmc Use of nicotinamide to treat hyperphosphatemia in dialysis patients
    Aurelie Lenglet
    Inserm Unit 1088, Jules Verne University of Picardie, 1 rue des Louvels, 80037, Amiens Cedex, France
    Drugs R D 13:165-73. 2013
    ..However, we consider that more data on pharmacodynamics, pharmacokinetics and safety are needed before this compound can be recommended as a treatment for hyperphosphatemia in ESRD patients. ..
  51. doi request reprint Inhibitors of vascular calcification as potential therapeutic targets
    Raja Rezg
    INSERM ERI 12 EA 4292, Amiens, France
    J Nephrol 24:416-27. 2011
    ..In the present overview we discuss the roles of several among these vascular calcification inhibitors which represent potential therapeutic targets...
  52. doi request reprint Presence of intracranial artery calcification is associated with mortality and vascular events in patients with ischemic stroke after hospital discharge: a cohort study
    Jean Marc Bugnicourt
    Service de Neurologie, CHU Amiens, France, Place Victor Pauchet, F 80054 Amiens Cedex 1, France
    Stroke 42:3447-53. 2011
    ..The purpose of this study was to determine the association between IAC and risk of vascular events and death in patients with stroke after hospital discharge...
  53. ncbi request reprint Efficacy and safety of nicotinamide in haemodialysis patients: the NICOREN study
    Aurelie Lenglet
    Inserm U1088, Jules Verne University of Picardie, Amiens, France Pharmacy, University Hospital, Amiens, France
    Nephrol Dial Transplant . 2016
    ..Nicotinamide (NAM) has been proposed as an alternative treatment to phosphate binders for hyperphosphataemia in chronic kidney disease...
  54. pmc The Addition of Vascular Calcification Scores to Traditional Risk Factors Improves Cardiovascular Risk Assessment in Patients with Chronic Kidney Disease
    Sophie Liabeuf
    Inserm U1088, Jules Verne University of Picardy Amiens, France Clinical Research Centre and Division of Clinical Pharmacology, Amiens University Hospital and the Jules Verne University of Picardy, Amiens, France
    PLoS ONE 10:e0131707. 2015
    ..Here, we looked at whether the addition of non-invasive methods to traditional risk factors (TRFs) improves prediction of the CV risk in patients at different CKD stages...
  55. doi request reprint Deleterious vascular effects of indoxyl sulfate and reversal by oral adsorbent AST-120
    Isabelle Six
    Inserm Unit 1088, Jules Verne University of Picardie, Amiens, France
    Atherosclerosis 243:248-56. 2015
    ..In chronic kidney disease (CKD), blood vessels are permanently exposed to uremic toxins such as indoxyl sulfate (IS). We hypothesized that IS could alter vascular tone and that reducing its serum concentration could be beneficial...
  56. pmc Direct, acute effects of Klotho and FGF23 on vascular smooth muscle and endothelium
    Isabelle Six
    Inserm Unit 1088, Jules Verne University of Picardie, Amiens, France
    PLoS ONE 9:e93423. 2014
    ..This novel observation is in line with the theory that Klotho deficiency is deleterious whereas Klotho sufficiency is protective against the negative effects of phosphate and FGF23 which are additive. ..
  57. doi request reprint [Inflammation and vascular calcifications]
    Isabelle Six
    INSERM, Facultes de Medecine et de Pharmacie, Amiens, France
    Nephrol Ther 6:S13-8. 2010
    ..A new idea emerges related to the role of calcifications as a cause of inflammation resulting in a vicious circle between inflammation and vascular calcification. This revue proposes to present an update on these different phenomenons...
  58. pmc Vitamin D affects survival independently of vascular calcification in chronic kidney disease
    Daniela Veit Barreto
    Institut National de la Sante et de la Recherche Medicale, Equipe Région INSERM 12 Equipe d Accueil 4292, Amiens, France
    Clin J Am Soc Nephrol 4:1128-35. 2009
    ....
  59. doi request reprint [Reverse epidemiology in chronic kidney disease: beyond traditional explanations]
    Ziad A Massy
    Inserm ERI12, Amiens France, Services de Pharmacologie Clinique et de Néphrologie CHU Amiens, Universite de Picardie Jules Verne, Amiens, France
    Nephrol Ther 4:221-2. 2008
  60. doi request reprint High inorganic phosphate concentration inhibits osteoclastogenesis by modulating miR-223
    Eléonore M'baya-Moutoula
    Inserm U1088, CURS, CHU Amiens Sud, Avenue Rene Laennec, Salouel, F 80054 Amiens, France
    Biochim Biophys Acta 1852:2202-12. 2015
    ..This approach could alleviate vascular calcification without altering bone structure. ..
  61. pmc miR-126 Is Involved in Vascular Remodeling under Laminar Shear Stress
    Ana Mondadori dos Santos
    Inserm U1088, Faculty of Pharmacy and Medicine, University of Picardie Jules Verne, rue des Louvels, 80037 Amiens, France INSERM U1148, LVTS, UFR SMBH, University Paris 13 Sorbonne Paris Cité, 74 rue Marcel Cachin, 93000 Bobigny, France
    Biomed Res Int 2015:497280. 2015
    ..In conclusion, our results suggest that miR-126 (i) is overexpressed by long-term LSS, (ii) has a role in up- and downregulation of genes involved in atherosclerosis, and (iii) affects SDC-4 expression. ..
  62. doi request reprint Below-knee arterial calcification in type 2 diabetes: association with receptor activator of nuclear factor κB ligand, osteoprotegerin, and neuropathy
    Olivier Bourron
    Diabetes and Metabolic Diseases O B, C E A, S J, A H, Radiology P C, Vascular Surgery F L K, M D, Biostatistics and Clinical Research A P, and Cardiology M K Departments and Laboratory of Biochemistry F M, Assistance Publique Hopitaux de Paris, Pitie Salpetriere Hospital, 75013 Paris, France Sorbonne Universités O B, P C, M K, A H, Université Pierre et Marie Curie University Paris 06, Paris, France Inserm U1088 S L, R M, M B, Z A M, Unité de formation et de recherche de Médecine et Pharmacie, Jules Verne Université of Picardy, Amiens, France Clinical Research Centre Division of Clinical Pharmacology S L, Amiens University Hospital and the Jules Verne University of Picardy, 80000 Amiens, France Division of Nephrology Z A M, Ambroise Pare Hospital, 92100 Boulogne Billancourt, France Institute of Cardiometabolism and Nutrition O B, P C, Department of Otorhinolaryngology
    J Clin Endocrinol Metab 99:4250-8. 2014
    ..The osteoprotegerin (OPG)/receptor activator of nuclear factor κB ligand (RANKL) system is suspected to be involved in the calcification process...
  63. pmc Characterisation of calcium phosphate crystals on calcified human aortic vascular smooth muscle cells and potential role of magnesium
    Loïc Louvet
    INSERM U 1088, Amiens, France University of Picardie Jules Verne, Amiens, France
    PLoS ONE 10:e0115342. 2015
    ..In this study, the crystal formation and the role of Mg2+ were investigated in an in vitro model of primary human aortic vascular smooth muscle cells (HAVSMC) with physical techniques...
  64. doi request reprint Beta2-microglobulin
    Tilman B Drueke
    Inserm Unit 845, Necker Medical School, University Paris Descartes, Paris, France
    Semin Dial 22:378-80. 2009
    ..The prevalence and severity of beta2-M amyloidosis appear to have decreased in the last 20 years, although its occurrence may simply be delayed...
  65. doi request reprint Coronary and abdominal aorta calcification in rheumatoid arthritis: relationships with traditional cardiovascular risk factors, disease characteristics, and concomitant treatments
    Julien Paccou
    From the Department of Rheumatology INSERM U1088 Pathophysiological mechanisms and consequences of cardiovascular calcification role of cardiovascular and bone remodelling Clinical Research Center, Division of Clinical Pharmacology Department of Endocrine and Bone Biology, Amiens University Hospital, Amiens Department of Nephrology, Amboise Paré University Hospital, Boulogne Billancourt, France J Paccou, MD, PhD P Fardellone, MD, PhD, Department of Rheumatology, INSERM U1088 C Renard, MD S Kamel, PhD, INSERM U1088 S Liabeuf, PharmD, PhD, Inserm U1088, Clinical Research Center, Division of Clinical Pharmacology, Amiens University Hospital Z A Massy, MD, PhD, Inserm U1088, Amiens University Hospital, Department of Nephrology, Amboise Paré University Hospital M Brazier, MD, PharmD, PhD R Mentaverri, PharmD, PhD, INSERM U1088 Department of Endocrine and Bone Biology, Amiens University Hospital
    J Rheumatol 41:2137-44. 2014
    ....
  66. doi request reprint Circulating Klotho levels: clinical relevance and relationship with tissue Klotho expression
    Tilman B Drueke
    UFR de Medecine et de Pharmacie, Unité 1088 de l Inserm, Universite de Picardie Jules Verne, Amiens, France
    Kidney Int 83:13-5. 2013
    ..The clinical diagnosis of Klotho deficiency is not easy. The relevance of circulating Klotho levels, if any, needs to be adequately defined. Serum Klotho may not reflect tissue Klotho concentration...
  67. doi request reprint Clinical studies and chronic kidney disease: what did we learn recently?
    Sophie Liabeuf
    INSERM U 1088, Amiens, France Clinical Research Centre, Division of Clinical Pharmacology, Amiens University Medical Center, the medical center is part of Jules Verne University Jules Verne University of Picardy, Amiens, France
    Semin Nephrol 34:164-79. 2014
    ..We conclude that although there are more and more data on how to better remove uremic toxins by dialysis and nondialysis strategies, convincing evidence of the impact of these strategies on hard outcomes is much scarcer. ..
  68. doi request reprint Atherosclerosis in CKD: differences from the general population
    Tilman B Drueke
    INSERM ERI 12, UFR de Medecine et de Pharmacie, Universite de Picardie Jules Verne, 80037 Amiens, France
    Nat Rev Nephrol 6:723-35. 2010
    ..The cardiovascular events associated with atherosclerosis are more often fatal in patients with CKD than in individuals without CKD...
  69. pmc Impact of non-dialysis chronic kidney disease on survival in patients with septic shock
    Julien Maizel
    Medical Intensive Care Unit, Department of Nephrology, Amiens University Medical Center, Amiens, France and INSERM U 1088, Jules Verne University of Picardie, Amiens, France
    BMC Nephrol 14:77. 2013
    ..73 m2, for three months prior to the onset of septic shock is an independent risk factor for death...
  70. ncbi request reprint microRNAs are dysregulated in the cerebral microvasculature of CKD mice
    Valérie Metzinger-Le Meuth
    Inserm U1088, Faculty of Pharmacy and Medicine, University of Picardie Jules Verne, rue des Louvels, F 80037, Amiens, France
    Front Biosci (Elite Ed) 6:80-8. 2014
    ..Our results suggest that miR-17 and miR-126 are potential new biomarkers of cerebral troubles of CKD patients and new therapeutic targets for innovative treatments. ..
  71. pmc Magnesium prevents phosphate-induced calcification in human aortic vascular smooth muscle cells
    Loïc Louvet
    INSERM U 1088, Amiens, France
    Nephrol Dial Transplant 28:869-78. 2013
    ..Recently, an inverse relationship between serum magnesium concentrations and VC has been reported. The present study aimed to investigate the effects of magnesium on Pi-induced VC at the cellular level using primary HAVSMC...
  72. doi request reprint Vascular calcification in chronic kidney disease: a review
    Rodrigo Bueno de Oliveira
    INSERM U 1088, UFR de Medecine et de Pharmacie, Universite de Picardie Jules Verne, Amiens, France
    J Bras Nefrol 35:147-61. 2013
    ..The principal aim of this review is to provide an updated overview of VC in patients with CKD, with particular focus on pathophysiology, diagnosis, prevention and treatment. ..
  73. doi request reprint The role of oxidative stress in chronic kidney disease
    Ziad A Massy
    INSERM ERI 12, Amiens, France
    Semin Dial 22:405-8. 2009
    ..Thus, although existing data suggest a prominent role of CKD-associated oxidative stress in uremic toxicity, further studies are required to definitively prove this concept...
  74. ncbi request reprint Prediction model of coronary heart disease in patients with chronic kidney disease: role of plasma fibrinogen as a new prognostic variable
    Ziad A Massy
    Divisions of Clinical Pharmacology and Nephrology, INSERM ERI 12, University of Picardie and Amiens University Hospital, Amiens, France
    Prilozi 26:63-77. 2005
    ..However, this formula's validity in predicting CHD risk in chronic kidney disease (CKD) patients is not extensively evaluated...
  75. ncbi request reprint Therapy of hyperhomocysteinemia in chronic kidney disease
    Ziad A Massy
    Division of Clinical Pharmacology, Amiens University Hospital, Amiens, France
    Semin Nephrol 26:24-7. 2006
    ..The relevance of decreasing Hcy levels for cardiovascular disease in CKD patients should be shown definitively by the results of ongoing randomized trials...
  76. doi request reprint Upregulation of BAD, a pro-apoptotic protein of the BCL2 family, in vascular smooth muscle cells exposed to uremic conditions
    Eric Trécherel
    Inserm U1088, Faculte de Medecine, Universite de Picardie Jules Verne, France
    Biochem Biophys Res Commun 417:479-83. 2012
    ..We explore the regulation of BAD by uremic toxins and report the sensitization of vascular smooth muscle cells to apoptosis upon BAD induction...
  77. doi request reprint Vascular calcification in chronic kidney disease: are biomarkers useful for probing the pathobiology and the health risks of this process in the clinical scenario?
    Sophie Liabeuf
    INSERM, U 1088, and Jules Verne University of Picardie, Amiens, France Division of Clinical Pharmacology, Clinical Research Centre, Amiens University Medical Center, Amiens, France
    Nephrol Dial Transplant 29:1275-84. 2014
    ..Well-designed clinical trials are now urgently needed to test the potential value of these biomarkers as a guide for interventions targeting VC. ..
  78. pmc Differential effects of indoxyl sulfate and inorganic phosphate in a murine cerebral endothelial cell line (bEnd.3)
    Andréa E M Stinghen
    Inserm U1088, Department of Pharmacy, 1 rue des Louvels, Amiens F 80037 Cédex 1, France
    Toxins (Basel) 6:1742-60. 2014
    ..This study shows, for the first time, that IS and Pi induce cerebral endothelial dysfunction by decreasing NO levels due to enhanced oxidative stress. However, Pi appears to be more deleterious, as it also induces eNOS uncoupling...
  79. ncbi request reprint Apoptotic pathways involved in U937 cells exposed to LDL oxidized by hypochlorous acid
    Stéphanie Vicca
    Laboratory of Biochemistry A, Necker Hospital, Paris, France
    Free Radic Biol Med 35:603-15. 2003
    ..The interference of Bcl-2 overexpression with HOCl-oxLDL-induced apoptosis suggests the importance of mitochondrial involvement in this apoptotic mechanism...
  80. ncbi request reprint Oxidative stress and chronic renal failure: markers and management
    Ziad A Massy
    Division of Nephrology, CH Beauvais, INSERM U507, Necker Hospital, Paris, France
    J Nephrol 15:336-41. 2002
    ..Therefore, no practical recommendations can be given at this stage, and further studies are clearly needed...
  81. ncbi request reprint High extracellular inorganic phosphate concentration inhibits RANK-RANKL signaling in osteoclast-like cells
    Anaïs Mozar
    INSERM, ERI 12, Amiens, France
    J Cell Physiol 215:47-54. 2008
    ..These results demonstrate that Pi downregulates the differentiation of osteoclasts via a negative feedback exerted on RANK-RANKL signaling...
  82. ncbi request reprint [Management of dyslipidemia in diabetic CKD patients]
    Ziad A Massy
    Service de Pharmacologie Clinique, CHU Amiens Sud, et INSERM ERI 12, UPJV, Amiens, France
    Nephrol Ther 2:S49-52. 2006
    ..The dyslipidemia management in patients with diabetic nephropathy not yet in dialysis includes diet, insulin sensitizers (glitazones, metformin?), and hypolipemic agents, with statins as a first choice...
  83. pmc Neurological disorders in a murine model of chronic renal failure
    Jean Marc Chillon
    Inserm U1088, UFR de Pharmacie, 1 rue des Louvels, F 80037 Amiens Cedex 1, France
    Toxins (Basel) 6:180-93. 2014
    ..Our data confirm the role of uremic toxicity in the genesis of neurological abnormalities (other than anxiety). ..
  84. ncbi request reprint Cerebral arterioles preparation and PECAM-1 expression in C57BL/6J and ApoE-/- mice
    Abderrahmane Bengrine
    INSERM ERI 12 EA4292 and University of Picardie Jules Verne, Amiens, France
    Front Biosci (Landmark Ed) 16:2367-71. 2011
    ..These findings indicate that the present method of mice cerebral arterioles isolation is a valid method. Moreover, PECAM-1 expression, a marker of endothelial cells, changes with age in cerebral arterioles of ApoE(-/-) mice...