- The new IL-1 family member IL-1F8 stimulates production of inflammatory mediators by synovial fibroblasts and articular chondrocytesDavid Magne
Division of Rheumatology, Department of Internal Medicine, University Hospital and Department of Pathology and Immunology, University of Geneva School of Medicine, Geneva, Switzerland
Arthritis Res Ther 8:R80. 2006..It remains to be determined whether circulating IL-1F8 can contribute to joint inflammation in rheumatoid arthritis...
- The active metabolite of leflunomide, A77 1726, increases the production of IL-1 receptor antagonist in human synovial fibroblasts and articular chondrocytesGaby Palmer
Division of Rheumatology, University Hospital, and Department of Pathology, University of Geneva School of Medicine, Geneva, Switzerland
Arthritis Res Ther 6:R181-9. 2004..The effect of A77 1726 may be partially mediated by inhibition of COX-2, but other mechanisms likely concur to stimulate IL-1Ra production...
- Pre-interleukin-1alpha expression reduces cell growth and increases interleukin-6 production in SaOS-2 osteosarcoma cells: Differential inhibitory effect of interleukin-1 receptor antagonist (icIL-1Ra1)Gaby Palmer
Division of Rheumatology, University Hospital, Geneva, Switzerland Department of Pathology and Immunology, University of Geneva School of Medicine, Geneva, Switzerland
Cytokine 31:153-60. 2005..Co-expression of icIL-1Ra1 did not antagonize this effect, indicating that intracellular effects of preIL-1alpha are not necessarily susceptible to inhibition by icIL-1Ra1...
- Interleukin-1 plays a major role in vascular inflammation and atherosclerosis in male apolipoprotein E-knockout miceFaten Merhi-Soussi
Division of Rheumatology, Department of Internal Medicine, University Hospital of Geneva, Switzerland
Cardiovasc Res 66:583-93. 2005..To examine the role of the balance between interleukin (IL)-1 and IL-1 receptor antagonist (IL-1Ra) in atherosclerosis and vascular inflammation...