Emmanuel Letavernier

Summary

Country: France

Publications

  1. doi request reprint Calcium and vitamin D have a synergistic role in a rat model of kidney stone disease
    Emmanuel Letavernier
    Sorbonne Universités, UPMC Univ Paris 6, UMR S 1155, Paris, France INSERM, UMR S 1155, Paris, France Physiology Unit, AP HP, Hopital Tenon, Paris, France Electronic address
    Kidney Int 90:809-17. 2016
  2. doi request reprint Williams-Beuren syndrome hypercalcemia: is TRPC3 a novel mediator in calcium homeostasis?
    Emmanuel Letavernier
    Institut National de la Sante et de la Recherche Medicale, Paris, France
    Pediatrics 129:e1626-30. 2012
  3. pmc Determinants of osteopenia in male renal-stone-disease patients with idiopathic hypercalciuria
    Emmanuel Letavernier
    Service des explorations fonctionnelles multidisciplinaires, Hopital Tenon, 4 rue de la Chine, 75020 Paris, France
    Clin J Am Soc Nephrol 6:1149-54. 2011
  4. doi request reprint The role of calpains in myocardial remodelling and heart failure
    Emmanuel Letavernier
    UMR_S702, INSERM, Universite Pierre et Marie Curie PARIS6, Paris, France
    Cardiovasc Res 96:38-45. 2012
  5. doi request reprint Sirolimus interacts with pathways essential for podocyte integrity
    Emmanuel Letavernier
    INSERM, U702 and Université Pierre et Marie Curie Paris 6, UMRS702, Paris, France
    Nephrol Dial Transplant 24:630-8. 2009
  6. ncbi request reprint Ureteral obstruction promotes proliferation and differentiation of the renal urothelium into a bladder-like phenotype
    Alexey Girshovich
    UPMC et Inserm UMR_S 702, Remodelage et Réparation du Tissu Rénal, Paris, France
    Kidney Int 82:428-35. 2012
  7. doi request reprint Critical role of the calpain/calpastatin balance in acute allograft rejection
    Emmanuel Letavernier
    INSERM, UMR S 702, Paris, France
    Eur J Immunol 41:473-84. 2011
  8. pmc Calpain activity is essential in skin wound healing and contributes to scar formation
    Dany Nassar
    Universite Pierre et Marie Curie Paris 6, UMRS938, Paris, France
    PLoS ONE 7:e37084. 2012
  9. pmc The calpain/calpastatin system has opposing roles in growth and metastatic dissemination of melanoma
    Quentin Raimbourg
    Unité Mixte de Recherche 702 UMR S 702, Université Pierre et Marie Curie Paris VI et Institut National de la Santé et de la Recherche Médicale, Hopital Tenon, Paris, France
    PLoS ONE 8:e60469. 2013
  10. doi request reprint Calpains contribute to vascular repair in rapidly progressive form of glomerulonephritis: potential role of their externalization
    Béatrice Letavernier
    INSERM U702, Hopital Tenon, 4 rue de la Chine, 75020 Paris, France
    Arterioscler Thromb Vasc Biol 32:335-42. 2012

Collaborators

Detail Information

Publications30

  1. doi request reprint Calcium and vitamin D have a synergistic role in a rat model of kidney stone disease
    Emmanuel Letavernier
    Sorbonne Universités, UPMC Univ Paris 6, UMR S 1155, Paris, France INSERM, UMR S 1155, Paris, France Physiology Unit, AP HP, Hopital Tenon, Paris, France Electronic address
    Kidney Int 90:809-17. 2016
    ..Hence, one should be cautious about the cumulative risk of kidney stone formation in humans when exposed to both vitamin D supplementation and high calcium intake. ..
  2. doi request reprint Williams-Beuren syndrome hypercalcemia: is TRPC3 a novel mediator in calcium homeostasis?
    Emmanuel Letavernier
    Institut National de la Sante et de la Recherche Medicale, Paris, France
    Pediatrics 129:e1626-30. 2012
    ..This original observation prompts further investigation of TRPC3 as a novel actor of calcium homeostasis...
  3. pmc Determinants of osteopenia in male renal-stone-disease patients with idiopathic hypercalciuria
    Emmanuel Letavernier
    Service des explorations fonctionnelles multidisciplinaires, Hopital Tenon, 4 rue de la Chine, 75020 Paris, France
    Clin J Am Soc Nephrol 6:1149-54. 2011
    ..Although this pathologic link has been recognized for decades, the underlying mechanisms and risk factors associated with osteopenia/osteoporosis in this population remain partially understood...
  4. doi request reprint The role of calpains in myocardial remodelling and heart failure
    Emmanuel Letavernier
    UMR_S702, INSERM, Universite Pierre et Marie Curie PARIS6, Paris, France
    Cardiovasc Res 96:38-45. 2012
    ....
  5. doi request reprint Sirolimus interacts with pathways essential for podocyte integrity
    Emmanuel Letavernier
    INSERM, U702 and Université Pierre et Marie Curie Paris 6, UMRS702, Paris, France
    Nephrol Dial Transplant 24:630-8. 2009
    ..Podocyte injury and focal segmental glomerulosclerosis have been related to sirolimus therapy in some patients but the pathways underlying these lesions remain hypothetical...
  6. ncbi request reprint Ureteral obstruction promotes proliferation and differentiation of the renal urothelium into a bladder-like phenotype
    Alexey Girshovich
    UPMC et Inserm UMR_S 702, Remodelage et Réparation du Tissu Rénal, Paris, France
    Kidney Int 82:428-35. 2012
    ..Presumably, this ensures efficient barrier protection and repair...
  7. doi request reprint Critical role of the calpain/calpastatin balance in acute allograft rejection
    Emmanuel Letavernier
    INSERM, UMR S 702, Paris, France
    Eur J Immunol 41:473-84. 2011
    ..This is the first study establishing that calpain inhibition delays allograft rejection by slowing down T-cell migration rather than proliferation...
  8. pmc Calpain activity is essential in skin wound healing and contributes to scar formation
    Dany Nassar
    Universite Pierre et Marie Curie Paris 6, UMRS938, Paris, France
    PLoS ONE 7:e37084. 2012
    ..In conclusion, calpains are major players in granulation tissue formation. In view of their specific effects on fibroblasts a late inhibition of calpains should be considered for scar reduction...
  9. pmc The calpain/calpastatin system has opposing roles in growth and metastatic dissemination of melanoma
    Quentin Raimbourg
    Unité Mixte de Recherche 702 UMR S 702, Université Pierre et Marie Curie Paris VI et Institut National de la Santé et de la Recherche Médicale, Hopital Tenon, Paris, France
    PLoS ONE 8:e60469. 2013
    ....
  10. doi request reprint Calpains contribute to vascular repair in rapidly progressive form of glomerulonephritis: potential role of their externalization
    Béatrice Letavernier
    INSERM U702, Hopital Tenon, 4 rue de la Chine, 75020 Paris, France
    Arterioscler Thromb Vasc Biol 32:335-42. 2012
    ..However, their involvement in vascular repair has not been investigated and the underlying mechanisms remain to be fully elucidated...
  11. pmc Prevalence and correlates of metabolic acidosis among patients with homozygous sickle cell disease
    Stéphane Maurel
    Service d Explorations Fonctionnelles, Sickle Cell Centre, and, Internal Medicine Service, Assistance Publique Hopitaux de Paris, Hopital Tenon, Paris, France, Institut National de la Sante et de la Recherche Medicale, UMR_S 1155, Paris, France, Sorbonne Universités, UPMC Univ Paris 06, DHUI2B, Paris, France
    Clin J Am Soc Nephrol 9:648-53. 2014
    ..This study aimed to assess the prevalence of metabolic acidosis and to identify its risk factors and mechanisms...
  12. pmc Demographics and characterization of 10,282 Randall plaque-related kidney stones: a new epidemic?
    Emmanuel Letavernier
    From the Sorbonne universités UPMC Univ Paris 06 EL, SV, OT, LB, PR, J PH, MD INSERM UMR S 1155 EL, SV, LB, PR, J PH, MD AP HP EL, LB, J PH, MD, Hopital Tenon, Explorations fonctionnelles multidisciplinaires and Cristal Laboratory AP HP OT, MT, Hopital Tenon, Service d Urologie and AP HP PR, Hopital Tenon, Service de Nephrologie, Paris, France
    Medicine (Baltimore) 94:e566. 2015
    ..047). In conclusion, these findings point to an epidemic of Randall plaque-associated renal stones in young patients, and suggest a possible implication of altered vitamin D response...
  13. doi request reprint Targeting the calpain/calpastatin system as a new strategy to prevent cardiovascular remodeling in angiotensin II-induced hypertension
    Emmanuel Letavernier
    Institut National de la Sante et de la Recherche Medicale, U702, Paris, France
    Circ Res 102:720-8. 2008
    ..These results indicate a critical role for calpains as downstream mediators in Ang II-induced cardiovascular remodeling and, thus, highlight an attractive therapeutic target...
  14. doi request reprint Topography, Composition and Structure of Incipient Randall Plaque at the Nanoscale Level
    Cécile Verrier
    Institut National de la Sante et de la Recherche Medicale, Unité Mixte de Recherche S 1155, Paris, France Urology Unit, Assistance Publique Hopitaux de Paris, Hopital Saint Louis, Paris, France
    J Urol 196:1566-1574. 2016
    ..Our objective was to characterize the composition and the initial formation site of incipient Randall plaque in nonstone forming, living patients...
  15. doi request reprint Calpains Released by T Lymphocytes Cleave TLR2 To Control IL-17 Expression
    Joelle Perez
    UMR_S 1155 and Département Inflammation Immunopathologie Biothérapie, Universite Pierre et Marie Curie Paris 06, Sorbonne Universités, F 75020 Paris, France UMR_S 1155, INSERM, F 75020 Paris, France
    J Immunol 196:168-81. 2016
    ..Thus, this study identifies calpain exteriorization as a potential target for immune modulation. ..
  16. pmc An animal model of type A cystinuria due to spontaneous mutation in 129S2/SvPasCrl mice
    Marine Livrozet
    Sorbonne Universités, UPMC Univ Paris 06, UMR S 702, Paris, France INSERM, UMR S 702, Paris, France
    PLoS ONE 9:e102700. 2014
    ..This novel mouse model mimicking human disease would allow us further pathophysiological studies and may be useful to analyse the crystal/tissue interactions in cystinuria. ..
  17. pmc Glomerular hyperfiltration in adult sickle cell anemia: a frequent hemolysis associated feature
    Jean Philippe Haymann
    Universite Pierre et Marie Curie, Universite Paris 6, Institut National de la Santé et de la Recherche Médicale Unit 702, Physiology, Paris, France
    Clin J Am Soc Nephrol 5:756-61. 2010
    ..Glomerular damage is a common feature revealed by a microalbuminuria or a macroalbuminuria. Although glomerular hyperfiltration has been described for decades in this population, its prevalence in young adults is unknown...
  18. pmc Calpastatin controls polymicrobial sepsis by limiting procoagulant microparticle release
    Lara Zafrani
    Universite Pierre et Marie Curie, Paris VI, UMR S 702, Paris, France
    Am J Respir Crit Care Med 185:744-55. 2012
    ..Calpains, calcium-activated cysteine proteases, have been shown to increase inflammatory reactions and lymphocyte apoptosis. Moreover, calpain plays an essential role in microparticle release...
  19. pmc Plasma heme-induced renal toxicity is related to a capillary rarefaction
    Nahid Tabibzadeh
    Sorbonne Universités UPMC Univ Paris 06, Paris, France
    Sci Rep 7:40156. 2017
    ....
  20. pmc Vancomycin-Associated Cast Nephropathy
    Yosu Luque
    Urgences néphrologiques et transplantation rénale, Hopital Tenon, Assistance Publique Hopitaux de Paris, Paris, France
    J Am Soc Nephrol . 2017
    ..In conclusion, the interaction of uromodulin with nanospheric vancomycin aggregates represents a new mode of tubular cast formation, revealing the hitherto unsuspected mechanism of vancomycin-associated renal injury...
  21. pmc MMP9 and SCF protect from apoptosis in acute kidney injury
    Soraya Bengatta
    UPMC University of Paris 06, Paris, France
    J Am Soc Nephrol 20:787-97. 2009
    ..In conclusion, these data show that MMP9 protects the S3 segment of the proximal tubule and the I-CD from apoptosis in AKI, most likely by releasing sSCF...
  22. doi request reprint Calcium phosphate stone morphology can reliably predict distal renal tubular acidosis
    Arnaud Dessombz
    Centre National de la Recherche, Laboratoire de Physique des Solides, Université Paris 11, Orsay, France Institut National de la Santé et de la Recherche Médicale, Unités Mixtes de Recherche 1138, Centre de Recherche des Cordeliers, Laboratoire de Physiopathologie Orale Moléculaire, Equipe Berdal, Universite Paris 5, Universite Paris 6, Universite Paris 7, Paris, France Electronic address
    J Urol 193:1564-9. 2015
    ..Identifying the stone etiology often requires extensive metabolic evaluation. We assessed whether stone analysis including morphological typing in addition to stone composition could be a valuable help for diagnosis...
  23. pmc Invariant natural killer T cells and TGF-beta attenuate anti-GBM glomerulonephritis
    Laurent Mesnard
    INSERM, UMR S 702, Hopital Tenon, Paris, France
    J Am Soc Nephrol 20:1282-92. 2009
    ..In conclusion, in experimental anti-GBM GN, iNKT cells attenuate disease severity and TGF-beta has a renoprotective role...
  24. ncbi request reprint Peroxisome proliferator-activated receptor beta/delta exerts a strong protection from ischemic acute renal failure
    Emmanuel Letavernier
    INSERM U489, Hopital Tenon, 4 rue de la Chine, Paris, France 75020
    J Am Soc Nephrol 16:2395-402. 2005
    ..These results point to PPARbeta/delta as a remarkable new target for preconditioning strategies...
  25. doi request reprint Randall's plaque as the origin of calcium oxalate kidney stones
    Michel Daudon
    Laboratoire des Lithiases, Service des Explorations Fonctionnelles, Hopital Tenon, APHP, 4, rue de la Chine, 75970, Paris Cedex 20, France
    Urolithiasis 43:5-11. 2015
    ....
  26. doi request reprint Prediction of high-degree steroid dependency in pediatric idiopathic nephrotic syndrome
    Béatrice Letavernier
    Department of Pediatric Nephrology, Armand Trousseau Hospital, AP HP, University Paris VI, Paris, France
    Pediatr Nephrol 23:2221-6. 2008
    ..Patients who need MPP are at high risk to require CyA to achieve disease control. By identifying these children, we could use adequate immunosuppressive drugs earlier and reduce morbidity related to steroids and multiple relapses...
  27. doi request reprint Blood pressure outcome of adrenalectomy in patients with primary hyperaldosteronism with or without unilateral adenoma
    Emmanuel Letavernier
    AP HP, Hopital Europeen Georges Pompidou, Hypertension Unit, Faculte de Medecine, Universite Paris Descartes, Paris, France
    J Hypertens 26:1816-23. 2008
    ....
  28. doi request reprint Targeting host calpain proteases decreases influenza A virus infection
    Fany Blanc
    Institut Pasteur, Unité de Défense Innée et Inflammation, Paris, France Institut National de la Santé et de la Recherche Médicale U874, Paris, France
    Am J Physiol Lung Cell Mol Physiol 310:L689-99. 2016
    ..Hence, our study suggests that calpains are promising therapeutic targets for treating IAV acute pneumonia. ..
  29. pmc Renal function can improve at any stage of chronic kidney disease
    Lise Weis
    Department of Nephrology, AP HP, Hopital Tenon, Paris, France
    PLoS ONE 8:e81835. 2013
    ..Whether this can occur in any type of nephropathy and at any stage is unknown as are the features of patients who improve...
  30. ncbi request reprint Proteinuria following a switch from calcineurin inhibitors to sirolimus
    Emmanuel Letavernier
    Service de Transplantation Adulte, Hopital Necker, and Paris V University Service de Néphrologie et Transplantation, Hopital Saint Louis, Paris, France
    Transplantation 80:1198-203. 2005
    ..However, the incidence of proteinuria following a switch from CNI to sirolimus has caused concern, and was therefore investigated here...