H Lesot

Summary

Country: France

Publications

  1. doi request reprint Consequences of X-linked hypohidrotic ectodermal dysplasia for the human jaw bone
    H Lesot
    INSERM UMR 977, Faculty of Medicine, University of Strasbourg, and Reference Center for Dental Manifestations of Rare Diseases, University Hospital, Strasbourg, France
    Front Oral Biol 13:93-9. 2009
  2. ncbi request reprint Cell-cell and cell-matrix interactions during initial enamel organ histomorphogenesis in the mouse
    H Lesot
    INSERM U424, Institut de Biologie Medicale, Faculte de Medecine, 11, rue Humann, 67085 Strasbourg, France
    Connect Tissue Res 43:191-200. 2002
  3. ncbi request reprint Epigenetic signals during odontoblast differentiation
    H Lesot
    INSERM U424, Institut de Biologie Medicale, Faculte de Medecine, II, rue Humann, 67085 Strasbourg, France
    Adv Dent Res 15:8-13. 2001
  4. ncbi request reprint [Effect of the Tabby mutation on the dentition of mice]
    H Lesot
    INSERM U595, Faculte de Medecine, Strasbourg, France
    Bull Group Int Rech Sci Stomatol Odontol 45:1-11. 2003
  5. doi request reprint Epithelial histogenesis during tooth development
    H Lesot
    INSERM UMR595, Faculty of Medicine, 11 rue Humann, 67085 Strasbourg Cedex, France
    Arch Oral Biol 54:S25-33. 2009
  6. ncbi request reprint Cell-matrix interactions and cell-cell junctions during epithelial histo-morphogenesis in the developing mouse incisor
    S Kieffer-Combeau
    INSERM U424, Institut de Biologie Medicale, Faculte de Medecine, Strasbourg, France
    Int J Dev Biol 45:733-42. 2001
  7. ncbi request reprint Vascularization of engineered teeth
    A Nait Lechguer
    INSERM UMR 595, Faculte de Medecine, 11, rue Humann, 67085 Strasbourg Cedex, France
    J Dent Res 87:1138-43. 2008
  8. ncbi request reprint Expression and localization of laminin-5 subunits in the mouse incisor
    N Yoshiba
    INSERM U424, Institut de Biologie Medicale, Faculte de Medecine, 11 rue Humann, F 67085 Strasbourg Cedex, France
    Cell Tissue Res 292:143-9. 1998
  9. doi request reprint Cell differentiation and matrix organization in engineered teeth
    A Nait Lechguer
    INSERM UMR 977, Faculte de Medecine, 11, rue Humann, F 67085 Strasbourg, France
    J Dent Res 90:583-9. 2011
  10. ncbi request reprint Early stages of tooth morphogenesis in mouse analyzed by 3D reconstructions
    H Lesot
    INSERM U424, Institut de Biologie Medicale, Faculte de Medecine, Strasbourg, France
    Eur J Oral Sci 106:64-70. 1998

Collaborators

Detail Information

Publications39

  1. doi request reprint Consequences of X-linked hypohidrotic ectodermal dysplasia for the human jaw bone
    H Lesot
    INSERM UMR 977, Faculty of Medicine, University of Strasbourg, and Reference Center for Dental Manifestations of Rare Diseases, University Hospital, Strasbourg, France
    Front Oral Biol 13:93-9. 2009
    ..If the changes in jaw bone morphology can be a consequence of oligodontia, the changes in bone structure seem to be tooth-independent and suggest a direct effect of the mutation on bone formation and/or remodeling...
  2. ncbi request reprint Cell-cell and cell-matrix interactions during initial enamel organ histomorphogenesis in the mouse
    H Lesot
    INSERM U424, Institut de Biologie Medicale, Faculte de Medecine, 11, rue Humann, 67085 Strasbourg, France
    Connect Tissue Res 43:191-200. 2002
    ..Time and space regulation of cell-matrix and cell-cell interactions might thus play complementary roles in allowing plasticity during tooth morphogenesis and stabilization at later stages of epithelial histogenesis...
  3. ncbi request reprint Epigenetic signals during odontoblast differentiation
    H Lesot
    INSERM U424, Institut de Biologie Medicale, Faculte de Medecine, II, rue Humann, 67085 Strasbourg, France
    Adv Dent Res 15:8-13. 2001
    ..Analysis of molar development suggested that odontoblast differentiation and crown morphogenesis are interdependent, although the possibility of co-regulation requires further investigation...
  4. ncbi request reprint [Effect of the Tabby mutation on the dentition of mice]
    H Lesot
    INSERM U595, Faculte de Medecine, Strasbourg, France
    Bull Group Int Rech Sci Stomatol Odontol 45:1-11. 2003
    ....
  5. doi request reprint Epithelial histogenesis during tooth development
    H Lesot
    INSERM UMR595, Faculty of Medicine, 11 rue Humann, 67085 Strasbourg Cedex, France
    Arch Oral Biol 54:S25-33. 2009
    ..Deposition of a mineralized matrix determines the final shape of the crown. All data reviewed in this paper were investigated in the mouse...
  6. ncbi request reprint Cell-matrix interactions and cell-cell junctions during epithelial histo-morphogenesis in the developing mouse incisor
    S Kieffer-Combeau
    INSERM U424, Institut de Biologie Medicale, Faculte de Medecine, Strasbourg, France
    Int J Dev Biol 45:733-42. 2001
    ..Apoptosis was transiently observed in the contiguous mesenchyme. This affected osteoblasts and also nerve cells close to the labial part of the cervical loop...
  7. ncbi request reprint Vascularization of engineered teeth
    A Nait Lechguer
    INSERM UMR 595, Faculte de Medecine, 11, rue Humann, 67085 Strasbourg Cedex, France
    J Dent Res 87:1138-43. 2008
    ..In implanted re-associations, newly formed blood vessels originated from the host, allowing for their survival, and affording conditions organ growth, mineralization, and enamel secretion...
  8. ncbi request reprint Expression and localization of laminin-5 subunits in the mouse incisor
    N Yoshiba
    INSERM U424, Institut de Biologie Medicale, Faculte de Medecine, 11 rue Humann, F 67085 Strasbourg Cedex, France
    Cell Tissue Res 292:143-9. 1998
    ....
  9. doi request reprint Cell differentiation and matrix organization in engineered teeth
    A Nait Lechguer
    INSERM UMR 977, Faculte de Medecine, 11, rue Humann, F 67085 Strasbourg, France
    J Dent Res 90:583-9. 2011
    ..The implantation of cultured dental cell re-associations allows for reproduction of complete functional differentiation at the cell, matrix, and mineral levels...
  10. ncbi request reprint Early stages of tooth morphogenesis in mouse analyzed by 3D reconstructions
    H Lesot
    INSERM U424, Institut de Biologie Medicale, Faculte de Medecine, Strasbourg, France
    Eur J Oral Sci 106:64-70. 1998
    ..Computer-aided 3D reconstructions clearly demonstrated that morphologically different developmental stages coexist along the anteroposterior axis of M1 in both jaws...
  11. ncbi request reprint Dental Epithelial Histomorphogenesis in vitro
    B Hu
    UMR INSERM 595, Faculte de Medecine, Universite Louis Pasteur, 11 rue Humann, 67085 Strasbourg Cedex, France
    J Dent Res 84:521-5. 2005
    ..Experiments performed at E13 demonstrated that the initial potentialities of the mesenchyme are not specified by the PEK. Positional information of dental epithelial cells does not require the memorization of their history...
  12. ncbi request reprint Crown morphology and pattern of odontoblast differentiation in lower molars of tabby mice
    S Lisi
    INSERM U424, , Faculty of Medicine, Strasbourg, France
    J Dent Res 80:1980-3. 2001
    ..The mesial part of the M1 in Tabby fetuses may correspond to the L2, B2 area from wild-type mice. The ante-molar dental primordium observed in some samples would thus represent remnants of cusps L1 and B1...
  13. ncbi request reprint Tooth morphogenesis and pattern of odontoblast differentiation
    S Lisi
    INSERM U424, Faculte de Medecine, Strasbourg, France
    Connect Tissue Res 44:167-70. 2003
    ..This discrepancy might result from cusp-specific differences either in the timing of the initiation of odontoblast terminal differentiation and/or in cell proliferation kinetics...
  14. ncbi request reprint Mouse molar morphogenesis revisited by three-dimensional reconstruction. II. Spatial distribution of mitoses and apoptosis in cap to bell staged first and second upper molar teeth
    H Lesot
    INSERM U424, Institut de Biologie Medicale, Faculte de Medecine, Strasbourg, France
    Int J Dev Biol 40:1017-31. 1996
    ..Apoptosis might correspond to the programmed destruction of cells whose function had to be suppressed or whose potential activity had to be avoided...
  15. ncbi request reprint Morphogenesis of the lower incisor in the mouse from the bud to early bell stage
    S Kieffer
    INSERM U424, Institut de Biologie Medicale, Faculte de Medecine, Strasbourg, France
    Int J Dev Biol 43:531-9. 1999
    ..5. The disappearance of the enamel knot despite a low apoptotic activity and the maintenance of the protrusion suggested a histological reorganization specific for rodent incisor...
  16. ncbi request reprint Initial features of the inner dental epithelium histo-morphogenesis in the first lower molar in mouse
    H Lesot
    INSERM U424, Institut de Biologie Medicale, Faculte de Medecine, Strasbourg, France
    Int J Dev Biol 43:245-54. 1999
    ....
  17. ncbi request reprint Mouse odontogenesis in vitro: the cap-stage mesenchyme controls individual molar crown morphogenesis
    R Schmitt
    INSERM U424, Institut de Biologie Medicale, Faculte de Medecine, Strasbourg, France
    Int J Dev Biol 43:255-60. 1999
    ..Furthermore, the mesenchyme apparently also controls the typical mirror symmetry of right and left handed teeth...
  18. ncbi request reprint Immunolocalization of BMP-2/-4, FGF-4, and WNT10b in the developing mouse first lower molar
    A Nadiri
    INSERM U595, Institut de Biologie Medicale, Faculte de Medecine, Strasbourg, France
    J Histochem Cytochem 52:103-12. 2004
    ..At E19 there was a decreasing gradient of staining from the cervical loop where cells divide to the tip of the cusp in the inner dental epithelium where cells become postmitotic. The target cells for FGF-4 and WNT10b appeared different...
  19. ncbi request reprint Bone marrow cells can give rise to ameloblast-like cells
    B Hu
    INSERM, U595, Faculty of Medicine, Strasbourg, France
    J Dent Res 85:416-21. 2006
    ....
  20. ncbi request reprint Expression and localization of laminin-5 subunits during mouse tooth development
    K Yoshiba
    INSERM U424, Institut de Biologie Medicale, Faculte de Medicine, Strasbourg, France
    Dev Dyn 211:164-76. 1998
    ....
  21. ncbi request reprint Alterations in the incisor development in the Tabby mouse
    S Miard
    INSERM U424, Institut de Biologie Medicale, Faculte de Medecine, Strasbourg, France
    Int J Dev Biol 43:517-29. 1999
    ..Our observations suggest independent development of the labial and lingual parts of the cervical loop. Furthermore, it appeared that the consequences of Ta mutation could not be interpreted only as a delay in tooth development...
  22. doi request reprint X-linked and autosomal recessive Hypohidrotic Ectodermal Dysplasia: genotypic-dental phenotypic findings
    F Clauss
    Department of Pediatric Dentistry, National French Reference Center for Dental Manifestations of Rare Diseases, University Hospital, 1 Place de l Hopital, F 67000 Strasbourg, France
    Clin Genet 78:257-66. 2010
    ....
  23. ncbi request reprint Expression patterns of BMPRs in the developing mouse molar
    A Nadiri
    INSERM UMR S595, Faculte de Chirurgie Dentaire, Universite Louis Pasteur, 67085, Strasbourg, France
    Cell Tissue Res 324:33-40. 2006
    ....
  24. ncbi request reprint Comparative analysis of TGF beta s, BMPs, IGF1, msxs, fibronectin, osteonectin and bone sialoprotein gene expression during normal and in vitro-induced odontoblast differentiation
    C Begue-Kirn
    Institut de Biologie Medicale, Universite Louis Pasteur, Faculte de Medecine, Strasbourg, France
    Int J Dev Biol 38:405-20. 1994
    ....
  25. ncbi request reprint Localization of antigens associated with adherens junctions, desmosomes, and hemidesmosomes during murine molar morphogenesis
    J L Fausser
    INSERM U 424, Institut de Biologie Medicale, Faculte de Medecine, Strasbourg, France
    Differentiation 63:1-11. 1998
    ..The specific temporospatial distributions patterns of these antigens suggests a direct involvement of adherens junctions, desmosomes, and hemidesmosomes in the development of the murine first lower molar...
  26. ncbi request reprint Dento-craniofacial phenotypes and underlying molecular mechanisms in hypohidrotic ectodermal dysplasia (HED): a review
    F Clauss
    Department of Pediatric Dentistry, Louis Pasteur University, National French Reference Center for Dental Manifestations of Rare Diseases, University Hospital, Place de l Hopital, F 67000 Strasbourg, France
    J Dent Res 87:1089-99. 2008
    ..All these clinical observations and molecular data allow for the specification of the craniofacial phenotypic spectrum in HED and provide a better understanding of the mechanisms involved in the pathogenesis of this syndrome...
  27. ncbi request reprint Aspects of cell proliferation kinetics of the inner dental epithelium during mouse molar and incisor morphogenesis: a reappraisal of the role of the enamel knot area
    R Coin
    INSERM U 424, Faculté de médecine de Strasbourg, France
    Int J Dev Biol 43:261-7. 1999
    ..These non-dividing inner dental epithelium cells of the enamel knot area which are either redistributed or not according to the tooth type specific morphogenesis might represent the organizers of morphogenetic units (OMU), the cusps...
  28. doi request reprint Three-dimensional Micro-culture System for Tooth Tissue Engineering
    S Kuchler-Bopp
    INSERM, Unité Mixte de Recherche UMR 1109, team Osteoarticular and Dental Regenerative NanoMedicine, Fédération de Médecine Translationnelle de Strasbourg, UDS, Strasbourg, France Faculté de Chirurgie Dentaire, UDS, Strasbourg, France
    J Dent Res 95:657-64. 2016
    ..This experimental model can be employed to study the development, physiology, metabolism, or toxicology in forming teeth and test other cell sources. ..
  29. doi request reprint Three-dimensional analysis of molar development in the mouse from the cap to bell stage
    H Lesot
    Institut National de la Sante et de la Recherche Medicale, UMR 1109, team Osteoarticular and Dental Regenerative NanoMedicine, Strasbourg, France Université de Strasbourg, Faculte de Chirurgie Dentaire, Strasbourg, France
    Aust Dent J 59:81-100. 2014
    ....
  30. ncbi request reprint Interaction of vinculin with the clathrin heavy chain
    J L Fausser
    Institut de Biologie Medicale, Faculte de Medecine, Strasbourg, France
    J Biochem 114:498-503. 1993
    ..Presence of clathrin light chain (CLC) associated with the CHC did not affect its interaction with vinculin. Vinculin did not interact with the CLC...
  31. ncbi request reprint Differential expression of laminin-5 subunits during incisor and molar development in the mouse
    K Yoshiba
    Department of Operative Dentistry and Endodontics, Faculty of Dentistry, Niigata University, Japan
    Int J Dev Biol 44:337-40. 2000
    ..The asymmetrical expression of laminin-5 might be related to incisor morphogenesis and to the differences in histogenesis and cytodifferentiation of the IDE that exist in the labial versus lingual aspect of the cervical loop...
  32. ncbi request reprint Different morphotypes of functional dentition in the lower molar region of tabby (EDA) mice
    P Kristenová
    Institute of Experimental Medicine, Academy of Sciences CR, Prague, Czech Republic
    Orthod Craniofac Res 5:205-14. 2002
    ..The Ta syndome is homologous to the anhidrotic (hypohidrotic) ectodermal dysplasia (EDA) in human and includes severe developmental defects of teeth, hair and sweat glands...
  33. ncbi request reprint Different morphotypes of the tabby (EDA) dentition in the mouse mandible result from a defect in the mesio-distal segmentation of dental epithelium
    R Peterkova
    Institute of Experimental Medicine, Academy of Sciences CR, Prague, Czech Republic
    Orthod Craniofac Res 5:215-26. 2002
    ..The mouse Ta syndrome and its counterpart anhidrotic (hypohidrotic) ectodermal dysplasia (EDA) in human are characterized by absence or hypoplasia of sweat glands, hair and teeth...
  34. ncbi request reprint Body weight in mouse embryos specifies staging of tooth development
    M Peterka
    Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic
    Connect Tissue Res 43:186-90. 2002
    ..The cyto-differentiation of odontoblasts exhibited a high interlitter variability and was similar within specimens of the same litter, regardless of their body weight differences...
  35. ncbi request reprint Increased apoptosis during morphogenesis of the lower cheek teeth in tabby/EDA mice
    T Boran
    Department of Teratology, Institute of Experimental Medicine, Academy of Sciences of the CR, Prague, Czech Republic
    J Dent Res 84:228-33. 2005
    ..Analysis of the present data suggests that the increased apoptosis in Ta mice is a consequence of impaired tooth development caused by a defect in segmentation of dental epithelium...
  36. ncbi request reprint Postnatal lower jaw dentition in different phenotypes of tabby mice
    P Kristenová-Cermáková
    Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic
    Connect Tissue Res 43:283-8. 2002
    ..The incidence of a reduction in tooth number in homozygous and hemizygous mice was dependent on the breeding scheme...
  37. ncbi request reprint Origin of the deciduous upper lateral incisor and its clinical aspects
    M Hovorakova
    Department of Teratology, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic
    J Dent Res 85:167-71. 2006
    ..The composite origin of the i2 may be associated with its developmental vulnerability. From a clinical aspect, a supernumerary i2 might be a form of cleft caused by a non-fusion of the dental epithelia...
  38. ncbi request reprint Development of the vestigial tooth primordia as part of mouse odontogenesis
    R Peterkova
    Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic
    Connect Tissue Res 43:120-8. 2002
    ..The differentiation of a mammalian tooth germ during both ontogeny and phylogeny might thus include the concrescence (connation) of more primordia, putatively corresponding to simple teeth in mammalian ancestors...
  39. ncbi request reprint The supernumerary cheek tooth in tabby/EDA mice-a reminiscence of the premolar in mouse ancestors
    R Peterkova
    Department of Teratology, Institute of Experimental Medicine, Academy of Sciences CR, Videnska 1083, 14220 Prague, Czech Republic
    Arch Oral Biol 50:219-25. 2005
    ..The supernumerary tooth (S) has been hypothetically homologized to the premolar, which has disappeared during mouse evolution...