Francoise Lenfant

Summary

Country: France

Publications

  1. doi request reprint Timing of the vascular actions of estrogens in experimental and human studies: why protective early, and not when delayed?
    Francoise Lenfant
    INSERM U1048 I2MC, Faculte de Medecine, Université de Toulouse III et CHU de Toulouse, Toulouse, France
    Maturitas 68:165-73. 2011
  2. doi request reprint Prevention of skin flap necrosis by estradiol involves reperfusion of a protected vascular network
    Céline E Toutain
    Institut National de la Sante et de la Recherche Medicale, U858, Toulouse, France
    Circ Res 104:245-54, 12p following 254. 2009
  3. doi request reprint Structure-function relationship of estrogen receptors in cardiovascular pathophysiological models
    Jean Francois Arnal
    INSERM U1048 I2MC, Faculte de Medecine, Université de Toulouse et CHU de Toulouse, 31432 Toulouse France
    Thromb Res 130:S7-11. 2012
  4. pmc From in vivo gene targeting of oestrogen receptors to optimization of their modulation in menopause
    Jean Francois Arnal
    INSERM U1048 I2MC, Faculte de Medecine, Université de Toulouse et CHU de Toulouse, Toulouse, France
    Br J Pharmacol 165:57-66. 2012
  5. doi request reprint Estrogen receptors and endothelium
    Jean Francois Arnal
    INSERM U858 I2MC, Faculte de Medecine, Université de Toulouse et Centre Hospitalier Universitaire, de Toulouse, BP 84225, 31432 Toulouse Cedex 4, France
    Arterioscler Thromb Vasc Biol 30:1506-12. 2010
  6. doi request reprint Chronic estradiol treatment reduces platelet responses and protects mice from thromboembolism through the hematopoietic estrogen receptor α
    Marie Cecile Valera
    INSERM, U1048 and Université Toulouse 3, I2MC, Toulouse, France
    Blood 120:1703-12. 2012
  7. doi request reprint Estrogen receptor alpha expression in both endothelium and hematopoietic cells is required for the accelerative effect of estradiol on reendothelialization
    Céline E Toutain
    Institut National de la Sante et de la Recherche Medicale, U858, IFR150, and Université de Toulouse III, Toulouse, France
    Arterioscler Thromb Vasc Biol 29:1543-50. 2009
  8. doi request reprint In vivo dissection of the estrogen receptor alpha: uncoupling of its physiological effects and medical perspectives
    Jean Francois Arnal
    INSERM U1048 I2MC, Equipe 9, Estrogen receptor in vivo dissection and modulation, Faculte de Medecine, Universite de Toulouse, CHU Rangueil, Batiment L3, 3e Etage, 1, avenue Jean Poulhes, BP 84225, 31432 Toulouse Cedex 4, France
    Ann Endocrinol (Paris) 74:82-9. 2013
  9. pmc Protective Hematopoietic Effect of Estrogens in a Mouse Model of Thrombosis: Respective Roles of Nuclear Versus Membrane Estrogen Receptor α
    Marie Cecile Valera
    INSERM U1048 and Université Toulouse III I2MC M C V, C F, F L, C C, M G, N S, B P, J F A, Toulouse, 31432 France Faculté de Chirurgie Dentaire M C V, Universite de Toulouse III, Toulouse, 31432 France Department of Chemistry H H K, J A K, University of Illinois at Urbana Champaign, Urbana, IL 61801 Institut de Génétique et de Biologie Moléculaire et Cellulaire P C, College de France, Universite de Strasbourg, Illkirch, 67400 France Department of Physiology and Cell Biology B S K, University of Illinois at Urbana Champaign, Urbana, IL 61801 and Laboratoire d Hématologie B P, Centre Hospitalier Universitaire de Toulouse, Toulouse, 31432 France
    Endocrinology 156:4293-301. 2015
  10. doi request reprint Lessons from the dissection of the activation functions (AF-1 and AF-2) of the estrogen receptor alpha in vivo
    Jean Francois Arnal
    INSERM U1048 I2MC, Faculte de Medecine, Université de Toulouse et CHU de Toulouse, 31432 Toulouse, France
    Steroids 78:576-82. 2013

Collaborators

  • Jean Francois Arnal
  • Pierre Gourdy
  • Benita S Katzenellenbogen
  • Jean Michel Foidart
  • Gilles Flouriot
  • Bernard Payrastre
  • Florence Tremollieres
  • Anne Gompel
  • Anne Catherine Prats
  • Philippe Le Bouteiller
  • Vera Rebmann
  • Romain Solinhac
  • Agnes Noel
  • Marie Cecile Valera
  • Céline E Toutain
  • Coralie Fontaine
  • Isabelle Raymond-Letron
  • Laurent Brouchet
  • John A Katzenellenbogen
  • Christel Pequeux
  • Pierre Chambon
  • Cédric Filipe
  • Nathalie Pizzato
  • Maeva Guillaume
  • Natalia F Smirnova
  • Melissa Buscato
  • Anne Abot
  • Cendrine Cabou
  • Marine Adlanmerini
  • Andree Krust
  • Marie José Fouque
  • Audrey Billon
  • Caroline Conte
  • Nicole Malet
  • Sung Hoon Kim
  • Alexia Vinel
  • Adrien Lupieri
  • Muriel Laffargue
  • Natalia Smirnova
  • Anne Drougard
  • SHYAMALA RAJAN
  • Philippe Valet
  • Alain Milon
  • Muriel Laine
  • Céline Gerard
  • François Ferrière
  • Daniel Henrion
  • Corinne Solier
  • Claude Knauf
  • Melanie Mestdagt
  • Geoffrey L Greene
  • Isabelle Muller
  • Aurelie Fabre
  • Marlène Marcellin
  • Pierre Sie
  • Nathalie Saint Laurent
  • Silvia Blacher
  • Michel Sixou
  • Marie Pierre Gratacap
  • Philippe Rochaix
  • Frederic Boudou
  • Hortense Berges
  • Anne Marie Schmitt
  • Jean Charles Guéry
  • Patricia Vicendo
  • Julie Favre
  • Laetitia Lam Shang Leen
  • Vincent Fontaine
  • Céline Toutain
  • Elodie Riant
  • Alain Pierre Gadeau
  • Vincent Benouaich
  • Henrik Laurell
  • Françoise Pujol
  • Muriel Derrien
  • Barbara Garmy-Susini
  • Alain Berrebi
  • Maryse Aguerre-Girr
  • Hans Grosse-Wilde
  • Agnès Campan

Detail Information

Publications19

  1. doi request reprint Timing of the vascular actions of estrogens in experimental and human studies: why protective early, and not when delayed?
    Francoise Lenfant
    INSERM U1048 I2MC, Faculte de Medecine, Université de Toulouse III et CHU de Toulouse, Toulouse, France
    Maturitas 68:165-73. 2011
    ..Finally, we will analyze the possibilities to uncouple some beneficial from other undesirable actions following the partial/selective activation of estrogen receptors...
  2. doi request reprint Prevention of skin flap necrosis by estradiol involves reperfusion of a protected vascular network
    Céline E Toutain
    Institut National de la Sante et de la Recherche Medicale, U858, Toulouse, France
    Circ Res 104:245-54, 12p following 254. 2009
    ....
  3. doi request reprint Structure-function relationship of estrogen receptors in cardiovascular pathophysiological models
    Jean Francois Arnal
    INSERM U1048 I2MC, Faculte de Medecine, Université de Toulouse et CHU de Toulouse, 31432 Toulouse France
    Thromb Res 130:S7-11. 2012
    ..2) To describe an unexpected action of E2 treatment at the level of platelet responses in mice, that protects the animals from thromboembolism through the haematopoietic ER alpha. (Valéra MC et al. Blood. 2012, in press)...
  4. pmc From in vivo gene targeting of oestrogen receptors to optimization of their modulation in menopause
    Jean Francois Arnal
    INSERM U1048 I2MC, Faculte de Medecine, Université de Toulouse et CHU de Toulouse, Toulouse, France
    Br J Pharmacol 165:57-66. 2012
    ..In the present review, we attempted to summarize recent advances provided by the in vivo molecular 'dissection' of ERα, allowing the uncoupling of some of its actions and potentially paving the way to optimized selective ER modulators...
  5. doi request reprint Estrogen receptors and endothelium
    Jean Francois Arnal
    INSERM U858 I2MC, Faculte de Medecine, Université de Toulouse et Centre Hospitalier Universitaire, de Toulouse, BP 84225, 31432 Toulouse Cedex 4, France
    Arterioscler Thromb Vasc Biol 30:1506-12. 2010
    ..In contrast, AF-1 is necessary for the E2 actions in reproductive targets. Thus, it appears conceivable to uncouple the vasculoprotective and sexual actions with appropriate selective ER modulators...
  6. doi request reprint Chronic estradiol treatment reduces platelet responses and protects mice from thromboembolism through the hematopoietic estrogen receptor α
    Marie Cecile Valera
    INSERM, U1048 and Université Toulouse 3, I2MC, Toulouse, France
    Blood 120:1703-12. 2012
    ..Overall, these data demonstrate a previously unrecognized role for E2 in regulating the platelet proteome and platelet function, and point to new potential antithrombotic and vasculoprotective therapeutic strategies...
  7. doi request reprint Estrogen receptor alpha expression in both endothelium and hematopoietic cells is required for the accelerative effect of estradiol on reendothelialization
    Céline E Toutain
    Institut National de la Sante et de la Recherche Medicale, U858, IFR150, and Université de Toulouse III, Toulouse, France
    Arterioscler Thromb Vasc Biol 29:1543-50. 2009
    ..E2 accelerates reendothelialization through estrogen receptor alpha (ER alpha), and we now aimed at defining the precise local and systemic cellular actors of this process...
  8. doi request reprint In vivo dissection of the estrogen receptor alpha: uncoupling of its physiological effects and medical perspectives
    Jean Francois Arnal
    INSERM U1048 I2MC, Equipe 9, Estrogen receptor in vivo dissection and modulation, Faculte de Medecine, Universite de Toulouse, CHU Rangueil, Batiment L3, 3e Etage, 1, avenue Jean Poulhes, BP 84225, 31432 Toulouse Cedex 4, France
    Ann Endocrinol (Paris) 74:82-9. 2013
    ..We summarize here an in vivo molecular "dissection" that allows to delineate in mouse the role of the main "subfunctions" of the receptor. This could pave the way to an optimization of the ER modulation...
  9. pmc Protective Hematopoietic Effect of Estrogens in a Mouse Model of Thrombosis: Respective Roles of Nuclear Versus Membrane Estrogen Receptor α
    Marie Cecile Valera
    INSERM U1048 and Université Toulouse III I2MC M C V, C F, F L, C C, M G, N S, B P, J F A, Toulouse, 31432 France Faculté de Chirurgie Dentaire M C V, Universite de Toulouse III, Toulouse, 31432 France Department of Chemistry H H K, J A K, University of Illinois at Urbana Champaign, Urbana, IL 61801 Institut de Génétique et de Biologie Moléculaire et Cellulaire P C, College de France, Universite de Strasbourg, Illkirch, 67400 France Department of Physiology and Cell Biology B S K, University of Illinois at Urbana Champaign, Urbana, IL 61801 and Laboratoire d Hématologie B P, Centre Hospitalier Universitaire de Toulouse, Toulouse, 31432 France
    Endocrinology 156:4293-301. 2015
    ....
  10. doi request reprint Lessons from the dissection of the activation functions (AF-1 and AF-2) of the estrogen receptor alpha in vivo
    Jean Francois Arnal
    INSERM U1048 I2MC, Faculte de Medecine, Université de Toulouse et CHU de Toulouse, 31432 Toulouse, France
    Steroids 78:576-82. 2013
    ....
  11. doi request reprint Stromal estrogen receptor-α promotes tumor growth by normalizing an increased angiogenesis
    Christel Pequeux
    INSERM U1048, I2MC, IFR31, UPS, France
    Cancer Res 72:3010-9. 2012
    ..These findings significantly deepen mechanistic insights into the impact of E2 on tumor development with potential consequences for cancer treatment...
  12. ncbi request reprint Induction of HLA-G-restricted human cytomegalovirus pp65 (UL83)-specific cytotoxic T lymphocytes in HLA-G transgenic mice
    Francoise Lenfant
    INSERM U 563, Centre de Physiopathologie de Toulouse Purpan, Hopital Purpan, 31059 Toulouse Cedex 3, France
    J Gen Virol 84:307-17. 2003
    ..The weak HLA-G-restricted anti-HCMV response is probably due to HLA-G-mediated inhibitory signals on the development of an antiviral CTL response...
  13. pmc The Activation Function-1 of Estrogen Receptor Alpha Prevents Arterial Neointima Development Through a Direct Effect on Smooth Muscle Cells
    Natalia F Smirnova
    From the Department of Vascular Biology of the Institute of Metabolic and Cardiovascular Diseases I2MC, Université de Toulouse 3, Institut National de la Santé et de la Recherche Médicale INSERM UMR1048, Institut des Maladies Métaboliques et Cardiovasculaires, Toulouse, France N F S, C F, M B, A L, A V, M C V, M G, N M, F L, P G, M L, J F A Laboratory of Tumor and Developmental Biology, GIGA Cancer, Universite de Liege, Groupe Interdisciplinaire de Genoproteomique Appliquee, Liege, Belgique J M F UMR INRA DGER 1225, Universite de Toulouse, INP, ENVT, Toulouse, France I R L Departments of Molecular and Integrative Biology B S K and Chemistry, University of Illinois at Urbana Champaign J A K
    Circ Res 117:770-8. 2015
    ..The role of E2 on the endothelium relies on membrane ERα activation, but the molecular mechanisms of its action on vascular smooth muscle cells (VSMCs) are not fully understood...
  14. pmc The uterine and vascular actions of estetrol delineate a distinctive profile of estrogen receptor α modulation, uncoupling nuclear and membrane activation
    Anne Abot
    INSERM U1048, Institut des Maladies Métaboliques et Cardiovasculaires, Université de Toulouse UPS, Toulouse, France
    EMBO Mol Med 6:1328-46. 2014
    ..This profile of ERα activation by E4, uncoupling nuclear and membrane activation, characterizes E4 as a selective ER modulator which could have medical applications that should now be considered further. ..
  15. ncbi request reprint Down-regulation of HLA-G1 cell surface expression in human cytomegalovirus infected cells
    Nathalie Pizzato
    INSERM U563, Centre de Physiopathologie Toulouse Purpan, Toulouse, France
    Am J Reprod Immunol 50:328-33. 2003
    ..To explore the level of HLA-G1 cell surface expression after HCMV infection and to investigate the influence of US viral proteins, we infected HLA-G1 expressing cells by HCMV laboratory strains...
  16. doi request reprint Estradiol accelerates endothelial healing through the retrograde commitment of uninjured endothelium
    Cédric Filipe
    Institut national de la santé et de la recherche médicale INSERM U858, I2MR, Equipe 9, Université de Toulouse III Paul Sabatier and Centre Hospitalier Universitaire de Toulouse Rangueil, Toulouse, France
    Am J Physiol Heart Circ Physiol 294:H2822-30. 2008
    ..This process is accelerated by E2 as a consequence of the retrograde commitment of an uninjured endothelial zone to migrate and proliferate, contributing to an enlargement of the regenerative area...
  17. pmc FGF2 translationally induced by hypoxia is involved in negative and positive feedback loops with HIF-1alpha
    Caroline Conte
    Institut National de la Sante et de la Recherche Medicale INSERM, U858, Toulouse, France
    PLoS ONE 3:e3078. 2008
    ..FGF2 mRNA contains an internal ribosome entry site (IRES), a translational regulator expected to allow mRNA expression during cellular stress...
  18. ncbi request reprint The short cytoplasmic tail of HLA-G determines its resistance to HIV-1 Nef-mediated cell surface downregulation
    Nathalie Pizzato
    Centre de Physiopathologie Toulouse Purpan, INSERM U563, Hopital Purpan, Toulouse, France
    Hum Immunol 65:1389-96. 2004
    ..This resistance may have functional consequences during the course of HIV infection...
  19. ncbi request reprint Secretion of pro-apoptotic intron 4-retaining soluble HLA-G1 by human villous trophoblast
    Corinne Solier
    INSERM U563, Hopital Purpan, Toulouse, France
    Eur J Immunol 32:3576-86. 2002
    ....