Christophe Lechauve

Summary

Country: France

Publications

  1. doi request reprint Neuroglobin involvement in visual pathways through the optic nerve
    Christophe Lechauve
    INSERM, U968, Paris F 75012, France
    Biochim Biophys Acta 1834:1772-8. 2013
  2. doi request reprint Neuroglobin involvement in respiratory chain function and retinal ganglion cell integrity
    Christophe Lechauve
    INSERM, U968, Paris, 75012, France
    Biochim Biophys Acta 1823:2261-73. 2012
  3. pmc Neuroglobin gene therapy prevents optic atrophy and preserves durably visual function in Harlequin mice
    Christophe Lechauve
    1 INSERM, U968, Paris, France 2 Sorbonne Universités, UPMC Univ Paris, Institut de la Vision, Paris, France 3 Centre National de la Recherche Scientifique, Paris, France
    Mol Ther 22:1096-109. 2014
  4. doi request reprint Downregulation of apoptosis-inducing factor in Harlequin mice induces progressive and severe optic atrophy which is durably prevented by AAV2-AIF1 gene therapy
    Aicha Bouaita
    INSERM, U968, Paris, F 75012, France
    Brain 135:35-52. 2012
  5. pmc Neuroglobins, pivotal proteins associated with emerging neural systems and precursors of metazoan globin diversity
    Christophe Lechauve
    INSERM, UMR S 968, Centre National de la Recherche Scientifique CNRS, Unité Mixte de Recherche UMR _7210, Institut de la Vision Université Pierre et Marie Curie UPMC Centre Hospitalier National d Ophtalmologie des Quinze Vingts, 17 rue Moreau, 75012 Paris, France
    J Biol Chem 288:6957-67. 2013
  6. pmc Genotypic and phenotypic characterization of P23H line 1 rat model
    Elise Orhan
    INSERM, U968, Paris, France CNRS, UMR_7210, Paris, France Sorbonne Universités, UPMC Univ Paris 06, UMR_S 968, Institut de la Vision, Paris, France
    PLoS ONE 10:e0127319. 2015

Collaborators

Detail Information

Publications6

  1. doi request reprint Neuroglobin involvement in visual pathways through the optic nerve
    Christophe Lechauve
    INSERM, U968, Paris F 75012, France
    Biochim Biophys Acta 1834:1772-8. 2013
    ..This suggests the pivotal role of neuroglobin in retinal glia involved in neuronal support and/or healing. This article is part of a Special Issue entitled: Oxygen Binding and Sensing Proteins. ..
  2. doi request reprint Neuroglobin involvement in respiratory chain function and retinal ganglion cell integrity
    Christophe Lechauve
    INSERM, U968, Paris, 75012, France
    Biochim Biophys Acta 1823:2261-73. 2012
    ..Hence, neuroglobin should be considered as a novel mitochondrial protein involved in respiratory chain function which is essential for retinal ganglion cell integrity...
  3. pmc Neuroglobin gene therapy prevents optic atrophy and preserves durably visual function in Harlequin mice
    Christophe Lechauve
    1 INSERM, U968, Paris, France 2 Sorbonne Universités, UPMC Univ Paris, Institut de la Vision, Paris, France 3 Centre National de la Recherche Scientifique, Paris, France
    Mol Ther 22:1096-109. 2014
    ..Hence, we established that NGB prevents respiratory chain impairment, therefore, protecting visual function otherwise compromised by mitochondrial energetic failure. ..
  4. doi request reprint Downregulation of apoptosis-inducing factor in Harlequin mice induces progressive and severe optic atrophy which is durably prevented by AAV2-AIF1 gene therapy
    Aicha Bouaita
    INSERM, U968, Paris, F 75012, France
    Brain 135:35-52. 2012
    ..Therefore, we demonstrate that gene therapy for mitochondrial diseases due to mutations in nuclear DNA can be achieved, so long as the 'therapeutic gene' permits the accurate cellular localization of the corresponding messenger RNA...
  5. pmc Neuroglobins, pivotal proteins associated with emerging neural systems and precursors of metazoan globin diversity
    Christophe Lechauve
    INSERM, UMR S 968, Centre National de la Recherche Scientifique CNRS, Unité Mixte de Recherche UMR _7210, Institut de la Vision Université Pierre et Marie Curie UPMC Centre Hospitalier National d Ophtalmologie des Quinze Vingts, 17 rue Moreau, 75012 Paris, France
    J Biol Chem 288:6957-67. 2013
    ..e. convergent evolution)...
  6. pmc Genotypic and phenotypic characterization of P23H line 1 rat model
    Elise Orhan
    INSERM, U968, Paris, France CNRS, UMR_7210, Paris, France Sorbonne Universités, UPMC Univ Paris 06, UMR_S 968, Institut de la Vision, Paris, France
    PLoS ONE 10:e0127319. 2015
    ..These results provide precise genotypic information of the P23H-1 rat with additional phenotypic characterization that will serve basis for therapeutic interventions, especially for those aiming at gene editing. ..