Marion Leboyer

Summary

Country: France

Publications

  1. doi request reprint Is it time for immunopsychiatry in psychotic disorders?
    Marion Leboyer
    Universite Paris Est, INSERM U955, Laboratoire Psychiatrie Translationnelle, et AP HP, DHU Pe Psy, Pôle de Psychiatrie ET d addictologie des Hopitaux Universitaires Henri Mondor, et fondation FondaMental, F 94000, Creteil, France
    Psychopharmacology (Berl) 233:1651-60. 2016
  2. pmc Immuno-psychiatry: an agenda for clinical practice and innovative research
    Marion Leboyer
    Psychiatry Department, University Paris Est Creteil, Mondor Hospital, AP HP, DHU Pepsy, Translational Psychiatry Laboratory, INSERM U955, Paris, France
    BMC Med 14:173. 2016
  3. pmc High-functioning autism spectrum disorder and fragile X syndrome: report of two affected sisters
    Pauline Chaste
    Human Genetics and Cognitive Functions, Institut Pasteur, Paris, France
    Mol Autism 3:5. 2012
  4. pmc A mechanistic basis for amplification differences between samples and between genome regions
    Colin D Veal
    Department of Genetics, University of Leicester, Leicester LE1 7RH, UK
    BMC Genomics 13:455. 2012
  5. pmc Can bipolar disorder be viewed as a multi-system inflammatory disease?
    Marion Leboyer
    INSERM U955, University Paris Est, FondaMental Fondation, Fondation de cooperation scientifique, AP HP, Groupe hospitalier Mondor, 40, rue de Mesly, Creteil, F 94000, France
    J Affect Disord 141:1-10. 2012
  6. doi request reprint [Can we identify biomarkers in bipolar depression? From imaging to biology]
    M Leboyer
    Universite Paris Est, Faculte de Medecine, UMR S 955, Creteil, F 94010, France
    Encephale 37:S185-90. 2011
  7. pmc Psychiatric and psychosocial problems in adults with normal-intelligence autism spectrum disorders
    Björn Hofvander
    Forensic Psychiatry, Department of Clinical Sciences, Lund University, Lund, Sweden
    BMC Psychiatry 9:35. 2009
  8. pmc Mutation screening of ASMT, the last enzyme of the melatonin pathway, in a large sample of patients with intellectual disability
    Cecile Pagan
    Human Genetics and Cognitive Functions, Institut Pasteur, Paris, France
    BMC Med Genet 12:17. 2011
  9. pmc Bipolar disorder: new perspectives in health care and prevention
    Marion Leboyer
    Department of Psychiatry, Hopital Albert Chenevier, University Paris Est, Assistance Publique Hopitaux de Paris, Creteil, France
    J Clin Psychiatry 71:1689-95. 2010
  10. ncbi request reprint Lack of evidence for association between serotonin transporter gene (5-HTTLPR) and obsessive-compulsive disorder by case control and family association study in humans
    Nadia Chabane
    University Department of Psychiatry, INSERM E0 117, Sainte Anne Hospital, Paris, France
    Neurosci Lett 363:154-6. 2004

Collaborators

Detail Information

Publications108 found, 100 shown here

  1. doi request reprint Is it time for immunopsychiatry in psychotic disorders?
    Marion Leboyer
    Universite Paris Est, INSERM U955, Laboratoire Psychiatrie Translationnelle, et AP HP, DHU Pe Psy, Pôle de Psychiatrie ET d addictologie des Hopitaux Universitaires Henri Mondor, et fondation FondaMental, F 94000, Creteil, France
    Psychopharmacology (Berl) 233:1651-60. 2016
    ....
  2. pmc Immuno-psychiatry: an agenda for clinical practice and innovative research
    Marion Leboyer
    Psychiatry Department, University Paris Est Creteil, Mondor Hospital, AP HP, DHU Pepsy, Translational Psychiatry Laboratory, INSERM U955, Paris, France
    BMC Med 14:173. 2016
    ..The emerging field of "immuno-psychiatry" has the potential to widen the exploration of a mechanism-based nosology, possibly leading to the discovery of more effective personalised treatment strategies...
  3. pmc High-functioning autism spectrum disorder and fragile X syndrome: report of two affected sisters
    Pauline Chaste
    Human Genetics and Cognitive Functions, Institut Pasteur, Paris, France
    Mol Autism 3:5. 2012
    ..We describe here the case of two sisters with ASD and FXS but without ID. One of the sisters presented with high-functioning autism, the other one with pervasive developmental disorder not otherwise specified and low normal IQ...
  4. pmc A mechanistic basis for amplification differences between samples and between genome regions
    Colin D Veal
    Department of Genetics, University of Leicester, Leicester LE1 7RH, UK
    BMC Genomics 13:455. 2012
    ..The most affected genome regions tend to correlate with high C + G content, however this relationship is complex and does not explain why the direction and magnitude of effects varies considerably between samples...
  5. pmc Can bipolar disorder be viewed as a multi-system inflammatory disease?
    Marion Leboyer
    INSERM U955, University Paris Est, FondaMental Fondation, Fondation de cooperation scientifique, AP HP, Groupe hospitalier Mondor, 40, rue de Mesly, Creteil, F 94000, France
    J Affect Disord 141:1-10. 2012
    ..In this review, we explore comorbid medical disorders, highlighting evidence that bipolar disorder can be effectively conceptualized as a multi-systemic inflammatory disease...
  6. doi request reprint [Can we identify biomarkers in bipolar depression? From imaging to biology]
    M Leboyer
    Universite Paris Est, Faculte de Medecine, UMR S 955, Creteil, F 94010, France
    Encephale 37:S185-90. 2011
    ..The identification of biomarkers for bipolar depression seems to be an interesting field, but it still remains in the domain of research...
  7. pmc Psychiatric and psychosocial problems in adults with normal-intelligence autism spectrum disorders
    Björn Hofvander
    Forensic Psychiatry, Department of Clinical Sciences, Lund University, Lund, Sweden
    BMC Psychiatry 9:35. 2009
    ..The objective of this paper is to describe the clinical psychiatric presentation and important outcome measures of a large group of normal-intelligence adult patients with ASDs...
  8. pmc Mutation screening of ASMT, the last enzyme of the melatonin pathway, in a large sample of patients with intellectual disability
    Cecile Pagan
    Human Genetics and Cognitive Functions, Institut Pasteur, Paris, France
    BMC Med Genet 12:17. 2011
    ..Thus the aim of the study was to ascertain the genetic variability of ASMT in a large cohort of patients with ID and controls...
  9. pmc Bipolar disorder: new perspectives in health care and prevention
    Marion Leboyer
    Department of Psychiatry, Hopital Albert Chenevier, University Paris Est, Assistance Publique Hopitaux de Paris, Creteil, France
    J Clin Psychiatry 71:1689-95. 2010
    ....
  10. ncbi request reprint Lack of evidence for association between serotonin transporter gene (5-HTTLPR) and obsessive-compulsive disorder by case control and family association study in humans
    Nadia Chabane
    University Department of Psychiatry, INSERM E0 117, Sainte Anne Hospital, Paris, France
    Neurosci Lett 363:154-6. 2004
    ..We also performed a family association study on 116 trios including an OCD patient (73 French and 43 German). No association was detected between the 5-HTTLPR polymorphism and OCD in either the case control study or the family study...
  11. pmc Platelet serotonergic markers as endophenotypes for obsessive-compulsive disorder
    Richard Delorme
    INSERM U 513, Faculte de Medecine, Creteil, France
    Neuropsychopharmacology 30:1539-47. 2005
    ..These alterations may serve as endophenotypic markers in OCD, and could contribute to the study of the biological mechanisms and genetic underpinnings of the disorder...
  12. pmc Bipolar disorder with seasonal pattern: clinical characteristics and gender influences
    Pierre Alexis Geoffroy
    INSERM, U955, Psychiatrie Génétique, Creteil, 94000, France
    Chronobiol Int 30:1101-7. 2013
    ..The authors suggest that SP represents a potentially important specifier of BD. These findings indicate that seasonality may reflect increased severity or complexity of disorder. ..
  13. doi request reprint Factor analyses of the Suicidal Intent Scale (SIS) and the Risk-Rescue Rating Scale (RRRS): toward the identification of homogeneous subgroups of suicidal behaviors
    Helene Misson
    INSERM, Unit 955, IMRB, Psychiatry Genetics Team, Creteil, France
    J Affect Disord 121:80-7. 2010
    ..This heterogeneity has major implications for clinical management of patients and identification of risk factors. Our study aims at identifying homogeneous subgroups of patients with suicidal behavior...
  14. ncbi request reprint Schizotypal dimensions: an intermediate phenotype associated with the COMT high activity allele
    Franck Schurhoff
    Département Hospitalo Universitaire de Psychiatrie, Hôpital Albert Chenevier et Henri Mondor, 40 rue Mesly, Creteil, France
    Am J Med Genet B Neuropsychiatr Genet 144:64-8. 2007
    ....
  15. ncbi request reprint No evidence for physical anhedonia as a candidate symptom or an endophenotype in bipolar affective disorder
    Bruno Etain
    AP HP, Hopital Albert Chenevier, Département Hospitalo Universitaire de Psychiatrie, Universite Paris XII, France
    Bipolar Disord 9:706-12. 2007
    ..Physical anhedonia (PA) is considered a possible candidate symptom and endophenotype in schizophrenia, but has never been specifically investigated in BPAD...
  16. pmc Heterozygous FA2H mutations in autism spectrum disorders
    Isabelle Scheid
    Human Genetics and Cognitive Functions, Institut Pasteur, Paris, France
    BMC Med Genet 14:124. 2013
    ..We hypothesized that rare deleterious heterozygous mutations of FA2H might constitute risk factors for ASD...
  17. pmc Reduced 3-O-methyl-dopa levels in OCD patients and their unaffected parents is associated with the low activity M158 COMT allele
    Richard Delorme
    INSERM U955, Institut Mondor de Recherche Biomedicale, Psychiatric Genetics, Creteil, France
    Am J Med Genet B Neuropsychiatr Genet 153:542-8. 2010
    ..These findings further support a role of COMT in the susceptibility to OCD and provide evidence that 3-OMD levels could represent an endophenotype in OCD...
  18. pmc Mutation screening of NOS1AP gene in a large sample of psychiatric patients and controls
    Richard Delorme
    Human Genetics and Cognitive Functions, Institut Pasteur, Paris, France
    BMC Med Genet 11:108. 2010
    ..Previous genetic and functional studies explored the role of NOS1AP in these psychiatric conditions, but only a limited number explored the sequence variability of NOS1AP...
  19. doi request reprint Genetic variations of the melatonin pathway in patients with attention-deficit and hyperactivity disorders
    Pauline Chaste
    Human Genetics and Cognitive Functions, Institut Pasteur, Paris, France
    J Pineal Res 51:394-9. 2011
    ..These genetic and functional results represent the first comprehensive ascertainment of melatonin signaling deficiency in ADHD...
  20. ncbi request reprint Population-based and family-based association study of 5'UTR polymorphism of the reelin gene and schizophrenia
    Celine Goldberger
    INSERM E117, Université de Paris 5, CH Sainte Anne, 2ter rue d Alesia, Paris, France
    Am J Med Genet B Neuropsychiatr Genet 137:51-5. 2005
    ..2 (CI = [1.4;12.4]). Our results weakly support an association of reelin gene variants with schizophrenia as a whole, yet suggest that reelin could be associated with treatment-resistant schizophrenia...
  21. pmc Shared executive dysfunctions in unaffected relatives of patients with autism and obsessive-compulsive disorder
    Richard Delorme
    INSERM U513, Neurobiologie et Psychiatrie, Universite Paris XII, Creteil, France
    Eur Psychiatry 22:32-8. 2007
    ....
  22. ncbi request reprint Platelet serotonergic predictors of clinical improvement in obsessive compulsive disorder
    Richard Delorme
    Service de Psychopathologie de l Enfant et de l Adolescent, AP HP, Hopital Robert Debre, Paris, France
    J Clin Psychopharmacol 24:18-23. 2004
    ..We tried to identify further peripheral serotonergic parameters that could help predict the clinical outcome of SRI treatment in a sample of patients with OCD...
  23. ncbi request reprint Lack of association between 5HT2A receptor gene haplotype, bipolar disorder and its clinical subtypes in a West European sample
    Bruno Etain
    Department of Psychiatry, Henri Mondor Hospital, AP HP, Creteil, France
    Am J Med Genet B Neuropsychiatr Genet 129:29-33. 2004
    ..Our study suggests that the 5HT2AR gene is unlikely to be involved in genetic susceptibility to BPAD but should be further investigated in a pharmacogenetic study...
  24. doi request reprint Genetic heterogeneity according to age at onset in bipolar disorder: a combined positional cloning and candidate gene approach
    Marie Hélène Dizier
    INSERM UMR S946, Paris, France
    Am J Med Genet B Neuropsychiatr Genet 159:653-9. 2012
    ....
  25. doi request reprint Correlations between cognitive performances and psychotic or schizotypal dimensions
    Andrei Szoke
    INSERM U955, 94000 Creteil, France
    Eur Psychiatry 24:244-50. 2009
    ..To test if specific correlations exist between cognitive measures and psychotic dimensions in schizophrenic subjects and if similar correlations, between cognition and schizotypal dimensions, are present in non-psychotic subjects...
  26. ncbi request reprint Admixture analysis of age at onset in obsessive-compulsive disorder
    Richard Delorme
    INSERM U513, Faculte de Medecine, Creteil, France
    Psychol Med 35:237-43. 2005
    ..If AAO is a clinical indicator of different biological subtypes, then subgroups based on distinct AAOs should have separate normal distributions as well as different clinical characteristics...
  27. pmc Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are associated with autism spectrum disorders
    Christelle M Durand
    Human Genetics and Cognitive Functions, Institut Pasteur, Paris, France
    Nat Genet 39:25-7. 2007
    ..These mutations concern only a small number of individuals, but they shed light on one gene dosage-sensitive synaptic pathway that is involved in autism spectrum disorders...
  28. pmc Search for copy number variants in chromosomes 15q11-q13 and 22q11.2 in obsessive compulsive disorder
    Richard Delorme
    INSERM, U955, Institut Mondor de Recherche Biomedicale, PsychiatricGenetics, Creteil, France
    BMC Med Genet 11:100. 2010
    ..Therefore, the aim of this study was to search for microrearrangements in these two regions in OCD patients...
  29. doi request reprint Exploring the relationships between tobacco smoking and schizophrenia in first-degree relatives
    Aziz Ferchiou
    AP HP, Hôpital H Mondor A Chenevier, pôle de psychiatrie, Creteil 94000, France
    Psychiatry Res 200:674-8. 2012
    ..Our results support the hypothesis that the relationship between schizophrenia and smoking is largely mediated by common familial factors, which may be genetic...
  30. pmc Analysis of X chromosome inactivation in autism spectrum disorders
    Xiaohong Gong
    Human Genetics and Cognitive Functions, Institut Pasteur, Paris, France
    Am J Med Genet B Neuropsychiatr Genet 147:830-5. 2008
    ..We propose that the XCI profile could be a useful criteria to prioritize families for mutation screening of X-linked candidate genes...
  31. pmc An investigation of ribosomal protein L10 gene in autism spectrum disorders
    Xiaohong Gong
    Human Genetics and Cognitive Functions, CNRS URA 2182 Genes, Synapses and Cognition, Institut Pasteur, Paris, France
    BMC Med Genet 10:7. 2009
    ..To confirm these initial findings, we re-sequenced RPL10 exons and quantified mRNA transcript level of RPL10 in our samples...
  32. doi request reprint European collaborative study of early-onset bipolar disorder: Evidence for genetic heterogeneity on 2q14 according to age at onset
    Flavie Mathieu
    INSERM, U 955, IMRB, Department of Medical Genetics, Psychiatry Genetics, Creteil, France
    Am J Med Genet B Neuropsychiatr Genet 153:1425-33. 2010
    ..Our findings illustrate that stratification according to AAO may be valuable for the identification of genetic vulnerability polymorphisms. © 2010 Wiley-Liss, Inc...
  33. doi request reprint Admixture analysis of age at first suicide attempt
    Frederic Slama
    INSERM, U955, IMRB, Department of Genetics, Psychiatry Genetics Team, Creteil, France
    J Psychiatr Res 43:895-900. 2009
    ..The aim of this study was to try to define different subgroups according to age at first SA subtypes using admixture analysis...
  34. ncbi request reprint Frequency and transmission of glutamate receptors GRIK2 and GRIK3 polymorphisms in patients with obsessive compulsive disorder
    Richard Delorme
    INSERM U 513, Faculte de Medecine, 8 rue du General Sarrail, 94010 Creteil, France
    Neuroreport 15:699-702. 2004
    ..03), supporting a functional role for this variant. These findings suggest the need for further investigation of the role of GRIK2 in OCD...
  35. pmc Exploratory analysis of obsessive compulsive symptom dimensions in children and adolescents: a prospective follow-up study
    Richard Delorme
    INSERM U513, Faculte de Medecine, Universite Paris XII, Creteil, France
    BMC Psychiatry 6:1. 2006
    ..Although a phenotypic continuum from childhood to adulthood has been hypothesized, no factor analytic studies have been performed in juvenile patients, and the stability of OC dimensions in children and adolescents has not been assessed...
  36. pmc Genetic and functional analyses of SHANK2 mutations suggest a multiple hit model of autism spectrum disorders
    Claire S Leblond
    Human Genetics and Cognitive Functions, Institut Pasteur, Paris, France
    PLoS Genet 8:e1002521. 2012
    ..A better knowledge of these genetic interactions will be necessary to understand the complex inheritance pattern of ASD...
  37. doi request reprint The HLA-G low expressor genotype is associated with protection against bipolar disorder
    Monojit Debnath
    INSERM, UMRS 940, Hopital Saint Louis, Paris, France
    Hum Immunol 74:593-7. 2013
    ..006). Possible mechanisms between low HLA G expression and resistance to infections as well as potential relationships between infections in early life and susceptibility to BD are discussed...
  38. doi request reprint Polymorphism of Toll-like receptor 4 gene in bipolar disorder
    José Oliveira
    INSERM, UMRS 940, Hopital Saint Louis, Paris F75010, France INSERM, U 955, IMRB, Psychiatrie Génétique, Créteil F94000, France Fondation FondaMental, Fondation de cooperation scientifique, Creteil, France
    J Affect Disord 152:395-402. 2014
    ..Given the pivotal role of Toll-like receptor 4 (TLR-4), a major innate immune sensor molecule, we hypothesized that genetic variations of TLR-4 may be associated to BD...
  39. doi request reprint 11q24.2-25 micro-rearrangements in autism spectrum disorders: Relation to brain structures
    Anna Maruani
    Human Genetics and Cognitive Functions, Institut Pasteur, Paris, France
    Am J Med Genet A 167:3019-30. 2015
    ..Finally our explorations could not incriminate NTM as a susceptibility gene for ASD, but provides new information on the impact of the 11q24.2-25 deletion on brain anatomy...
  40. doi request reprint Effects of Cumulative Herpesviridae and Toxoplasma gondii Infections on Cognitive Function in Healthy, Bipolar, and Schizophrenia Subjects
    Nora Hamdani
    Pôle de Psychiatrie ET d addictologie des Hopitaux Universitaires Henri Mondor, Hôpital A Chenevier, 40 rue de Mesly, Creteil 94000, France
    J Clin Psychiatry 78:e18-e27. 2017
    ....
  41. doi request reprint Reconsideration of bipolar disorder as a developmental disorder: importance of the time of onset
    Pierre Alexis Geoffroy
    INSERM U955, Creteil 94000, France
    J Physiol Paris 107:278-85. 2013
    ..We argue that age at onset should be included as a specifier for bipolar disorders...
  42. doi request reprint Immunity, inflammation, and bipolar disorder: diagnostic and therapeutic implications
    Nora Hamdani
    Universite Paris Est, Faculte de Medecine, Creteil, 94000, France
    Curr Psychiatry Rep 15:387. 2013
    ....
  43. doi request reprint Is processing speed a valid cognitive endophenotype for bipolar disorder?
    Claire Daban
    INSERM, U955, Creteil, 94000, France
    J Affect Disord 139:98-101. 2012
    ..The current study investigated whether a single brief cognitive assessment, processing speed, could be considered as a valid endophenotype for bipolar disorder (BD)...
  44. ncbi request reprint Apolipoprotein E in schizophrenia: a French association study and meta-analysis
    Franck Schurhoff
    Service de Psychiatrie Adulte, Hopital Albert Chenevier, Creteil, France
    Am J Med Genet B Neuropsychiatr Genet 119:18-23. 2003
    ..However, ApoE may be associated with particular forms of schizophrenia...
  45. pmc Selective attention impairment in Schizophrenia: can it explain source monitoring failure?
    Abdelaziz Ferchiou
    INSERM, U 955, Institut Mondor de Recherches Biomédicales IMRB, Département de Génomique Médicale, Equipe de Psychiatrie Génétique, Creteil, France
    J Nerv Ment Dis 198:779-81. 2010
    ..Selective attention impairments do not explain source monitoring deficits observed in schizophrenia. Source monitoring deficits deserve continued efforts to elucidate their causes and consequences...
  46. doi request reprint Gender differences in autism spectrum disorders: Divergence among specific core symptoms
    Anita Beggiato
    Department of Child and Adolescent Psychiatry, Robert Debre Hospital, APHP, Paris, France
    Autism Res . 2016
    ..The potential gender bias thus induced may participate in the underestimation of the prevalence of ASD in females. Autism Res 2016,. © 2016 International Society for Autism Research, Wiley Periodicals, Inc...
  47. doi request reprint Cognitive deterioration among bipolar disorder patients infected by Toxoplasma gondii is correlated to interleukin 6 levels
    Nora Hamdani
    INSERM U955, Equipe 15 Psychiatrie Génétique, Créteil F 94000, France AP HP, DHU Pe Psy, Université Paris Est Créteil, Groupe Henri Mondor Albert Chenevier, Pôle de psychiatrie et d addictologie, Créteil F 94000, France Fondation FondaMental, Fondation de cooperation scientifique, Créteil F94000, France Electronic address
    J Affect Disord 179:161-6. 2015
    ..As Toxoplasma gondii is known to induce the synthesis of pro-inflammatory cytokines such as IL-6, we will explore here the possible role of T. gondii in the cognitive decline observed in BD...
  48. pmc Genetic association study of circadian genes with seasonal pattern in bipolar disorders
    Pierre Alexis Geoffroy
    1 INSERM, U1144, Paris, F 75006, France 2 AP HP, GH Saint Louis Lariboisière Fernand Widal, Pole NeuroSciences, 75475 Paris Cedex 10, France 3 Université Paris Descartes, UMR S 1144, Paris, F 75006, France 4 Fondation FondaMental, Creteil, 94000, France
    Sci Rep 5:10232. 2015
    ..The epistasis analysis between rs6738097 (NPAS2) and rs1554338 (CRY2) suggested an additive effect. Genetic variations in NPAS2 might be a biomarker for a seasonal pattern in BD. ..
  49. pmc Biomarkers of bipolar disorder: specific or shared with schizophrenia?
    Frank Bellivier
    INSERM, U955, Psychiatrie Génétique, Creteil, France
    Front Biosci (Elite Ed) 5:845-63. 2013
    ..It may be more apposite to think in terms of genetic influences on six continuous symptom dimensions: neurobiological, cognitive, positive, negative, depressive and manic symptoms...
  50. ncbi request reprint Prefrontal cortex dysfunction in patients with suicidal behavior
    Aurelie Raust
    Department of Psychiatry, Chenevier Mondor Hospital, Assistance Publique Hopitaux de Paris, Creteil Cedex, France
    Psychol Med 37:411-9. 2007
    ..We investigated PFC-related neuropsychological function in patients with suicidal behavior, separating dorsolateral PFC (DLPFC)- and orbitofrontal cortex (OFC)-related functions...
  51. doi request reprint Clinical expression of bipolar disorder type I as a function of age and polarity at onset: convergent findings in samples from France and the United States
    Bruno Etain
    Institut National de la Sante et de la Recherche Medicale INSERM, Creteil, France
    J Clin Psychiatry 73:e561-6. 2012
    ..Certain onset characteristics (eg, age and polarity at onset) may delineate subgroups differing in clinical expression and outcome...
  52. ncbi request reprint Neuroimaging biomarkers in bipolar disorder
    Josselin Houenou
    AP HP, University Paris East, Department of Psychiatry, Henri Mondor Albert Chenevier Hospitals, Creteil, F 94010, France
    Front Biosci (Elite Ed) 4:593-606. 2012
    ..Future research should include studies to validate biomarkers for the assessment of bipolar disorder and studies of large and well characterized samples of patients with bipolar disorder...
  53. pmc Autism multiplex family with 16p11.2p12.2 microduplication syndrome in monozygotic twins and distal 16p11.2 deletion in their brother
    Anne Claude Tabet
    AP HP, Robert Debre Hospital, Department of Genetics, Cytogenetics Unit, Paris, France
    Eur J Hum Genet 20:540-6. 2012
    ..We discuss the clinical and genetic implications of two different 16p chromosomal rearrangements in this family, and suggest that the 16p11.2 deletion in the father predisposed to the formation of the duplication in his twin children...
  54. pmc Spatial distribution of psychotic disorders in an urban area of France: an ecological study
    Baptiste Pignon
    AP HP, DHU Pepsy, Hôpitaux Universitaires Henri Mondor, pôle de psychiatrie, Creteil, 94000, France
    Sci Rep 6:26190. 2016
    ..13, 95% CI [1.02-1.25]). In comparison with frequentist methods, the Bayesian model showed a better fit. The number of cases showed non-random spatial distribution and was linked to economic deprivation. ..
  55. doi request reprint Bipolar patients referred to specialized services of care: Not resistant but impaired by sub-syndromal symptoms. Results from the FACE-BD cohort
    Chantal Henry
    Universite Paris Est, UMR_S955, UPEC, Creteil, France INSERM, U955, Equipe 15 Psychiatrie Génétique, Creteil, France AP HP, Hôpital H Mondor A Chenevier, pôle de psychiatrie, Creteil, France Fondation FondaMental, Fondation de cooperation scientifique, Creteil, France
    Aust N Z J Psychiatry 49:898-905. 2015
    ....
  56. doi request reprint Relationship between Toxoplasma gondii infection and bipolar disorder in a French sample
    Nora Hamdani
    INSERM U955, Equipe 15 Psychiatrie Génétique, Creteil, F 94000, France
    J Affect Disord 148:444-8. 2013
    ..However, the relationship between past exposure to Toxoplasma gondii (T. gondii) and incidence of bipolar disorders (BD) is poorly documented across populations...
  57. doi request reprint Age at onset in bipolar I affective disorder in the USA and Europe
    Frank Bellivier
    AP HP, Groupe Henri Mondor Albert Chenevier, pôle de psychiatrie, Creteil, F 94000, France
    World J Biol Psychiatry 15:369-76. 2014
    ..To test for differences in reported age at onset (AAO) of bipolar I affective disorder in clinical samples drawn from Europe and the USA...
  58. ncbi request reprint [Early onset bipolar disorder: validation from admixture analyses and biomarkers]
    Pierre Alexis Geoffroy
    Hôpital H Mondor A Chenevier, pôle de psychiatrie, et Fondation Fonda Mental, Creteil, France
    Can J Psychiatry 58:240-8. 2013
    ..The relevance of such an indicator has been discussed as a potential specifier in future nosographical classification...
  59. doi request reprint Longitudinal studies of cognition in schizophrenia: meta-analysis
    Andrei Szoke
    Service de Psychiatrie Adulte, Hopital Albert Chenevier, Creteil, France
    Br J Psychiatry 192:248-57. 2008
    ..A wide range of cognitive deficits have been demonstrated in schizophrenia, but their longitudinal course remains unclear...
  60. doi request reprint Beyond genetics: childhood affective trauma in bipolar disorder
    Bruno Etain
    INSERM, Unite 841, IMRB, Département de génétique, Equipe de Psychiatrie Génétique, Creteil, France
    Bipolar Disord 10:867-76. 2008
    ..The objectives are to review the arguments in favor of an association between childhood trauma and bipolar disorder and to discuss the interpretations of such an observation...
  61. pmc Mutation screening of the ARX gene in patients with autism
    Pauline Chaste
    INSERM U513, Universite Paris XII, Creteil, France
    Am J Med Genet B Neuropsychiatr Genet 144:228-30. 2007
    ..The mutation analysis was performed by direct sequencing of all exons and flanking regions. No ARX mutations were identified in any of the patients tested. These findings indicate that mutations in the ARX gene are very rare in autism...
  62. ncbi request reprint Early-onset obsessive-compulsive disorder: a subgroup with a specific clinical and familial pattern?
    Nadia Chabane
    Service de Psychopathologie de l Enfant et de l Adolescent, Assistance Publique Hopitaux de Paris, Hopital Robert Debre, Paris, France
    J Child Psychol Psychiatry 46:881-7. 2005
    ..In this study, the specificity of early-onset OCD was investigated, focusing on the effect of gender, comorbid conditions and familial risk of tics and OCD by studying a population consisting exclusively of patients with early-onset OCD...
  63. doi request reprint The role of causal and intentional judgments in moral reasoning in individuals with high functioning autism
    Marine Buon
    Laboratoire de Sciences Cognitives et de Psycholinguistique, Centre Nationale de Recherche Scientifique, Departement d Etudes Cognitives, Ecole Normale Superieure, Paris, France
    J Autism Dev Disord 43:458-70. 2013
    ..These results are discussed in the light of emerging studies that deal with integrity of moral reasoning in individuals with autism spectrum disorders...
  64. ncbi request reprint Clinical factors associated with lithium response in bipolar disorders
    Sarah Sportiche
    INSERM, U1144, Paris, France AP HP, GH Saint Louis Lariboisière F Widal, Pôle de Psychiatrie et de Médecine Addictologique, Paris, France Fondation FondaMental, Creteil, France
    Aust N Z J Psychiatry . 2016
    ..Lithium is one of the gold standard mood stabilizer treatments, but the identification of good, partial and non-responders in clinical settings is inconsistent...
  65. pmc Dectin-1 Polymorphism: A Genetic Disease Specifier in Autism Spectrum Disorders?
    Meriem Bennabi
    INSERM, U1160, Hopital Saint Louis, Paris, France INSERM, U955, Psychiatrie Génétique, Creteil, France Fondation FondaMental, Creteil, France
    PLoS ONE 10:e0137339. 2015
    ....
  66. doi request reprint Anxiety and depression comorbidities in irritable bowel syndrome (IBS): a systematic review and meta-analysis
    Guillaume Fond
    Pôle de psychiatrie des hôpitaux universitaires H Mondor, DHU Pe Psy, INSERM U955, Eq Psychiatrie Génétique, Fondation FondaMental Fondation de coopération scientifique en santé mentale, Universite Paris Est, Creteil, France
    Eur Arch Psychiatry Clin Neurosci 264:651-60. 2014
    ....
  67. pmc Combined effect of TLR2 gene polymorphism and early life stress on the age at onset of bipolar disorders
    José Oliveira
    INSERM, U1160, Hopital Saint Louis, Paris, France Fondation FondaMental, Creteil, France
    PLoS ONE 10:e0119702. 2015
    ..Clinical characteristics of illness severity, immune phenotypes and history of early life infectious insults should be included in future studies involving large patient cohorts. ..
  68. doi request reprint The cost of mental disorders in France
    Karine Chevreul
    AP HP, Henri Mondor Albert Chenevier Hospitals, Department of Public Health, Creteil, F 94000, France
    Eur Neuropsychopharmacol 23:879-86. 2013
    ..To provide burden estimates of mental disorders in France and compare the results with findings from other countries and EU in general...
  69. pmc A first national survey of knowledge, attitudes and behaviours towards schizophrenia, bipolar disorders and autism in France
    Isabelle Durand-Zaleski
    Department of Public Health and Psychiatry, AP HP, URCEco and Henri Mondor Albert Chenevier Hospitals, 51 Avenue du Marechal de Lattre de Tassigny, Creteil, F 94000, France
    BMC Psychiatry 12:128. 2012
    ..This study explores public perceptions and quantifies stigma for three chronic mental disorders: autism, schizophrenia and bipolar disorders in France...
  70. doi request reprint A French network of bipolar expert centres: a model to close the gap between evidence-based medicine and routine practice
    Chantal Henry
    INSERM, U 995, IMRB, Psychiatry Genetics, Creteil, France
    J Affect Disord 131:358-63. 2011
    ....
  71. pmc Prevalence of psychotic disorders in an urban area of France
    Andrei Szoke
    AP HP, DHU Pepsy, Groupe hospitalier Mondor, pôle de psychiatrie, Creteil, 94000, France
    BMC Psychiatry 15:204. 2015
    ..The objective of this study is to provide period prevalence estimates, detailed by gender and age groups, for treated psychotic disorders in an adult population (aged 18 years and over) from an urban area in France...
  72. doi request reprint Treatment with anti-toxoplasmic activity (TATA) for toxoplasma positive patients with bipolar disorders or schizophrenia: a cross-sectional study
    Guillaume Fond
    INSERM U955, Équipe de Psychiatrie Translationnelle, Université Paris Est Créteil, DHU Pe Psy, Pôle de psychiatrie des hôpitaux universitaire H Mondor, Creteil, France Fondation FondaMental Fondation de coopération scientifique en santé mentale, France Electronic address
    J Psychiatr Res 63:58-64. 2015
    ..gondii infection compared to patients receiving a treatment without anti-toxoplasmic activity (TATA-)...
  73. doi request reprint Association between cannabis use and schizotypal dimensions--a meta-analysis of cross-sectional studies
    Andrei Szoke
    AP HP, Groupe hospitalier Mondor, pôle de psychiatrie, Creteil 94000, France INSERM, U955, Equipe 15, Creteil 94000, France Université Paris Est, Faculte de Medecine, Creteil 94000, France Fondation FondaMental, Creteil 94000, France Electronic address
    Psychiatry Res 219:58-66. 2014
    ..other comparison, statistically significant. Cannabis consumption is associated with increased schizotypal traits. More research, using different approaches (e.g. longitudinal studies) is needed to explore the cause of this association. ..
  74. doi request reprint A meta-analysis of whole-brain diffusion tensor imaging studies in bipolar disorder
    François Eric Vederine
    AP HP, University Paris East, Department of Psychiatry, Henri Mondor Albert Chenevier Hospitals, Creteil, F 94010, France
    Prog Neuropsychopharmacol Biol Psychiatry 35:1820-6. 2011
    ....
  75. doi request reprint Correlations between objective and subjective sleep and circadian markers in remitted patients with bipolar disorder
    Carole Boudebesse
    INSERM, U955, Creteil, France
    Chronobiol Int 31:698-704. 2014
    ..We conclude that the CSM and the PSQI could be useful in routine practice and research when actigraphy is not easily available. ..
  76. ncbi request reprint Circadian abnormalities as markers of susceptibility in bipolar disorders
    Vanessa Milhiet
    AP HP, centre expert troubles bipolaires, pôle de psychiatrie, Hoapital Hopital, Albert Chenevier, 40 rue de Mesly, 94000 Creteil, France
    Front Biosci (Schol Ed) 6:120-37. 2014
    ..Additionally, the circadian model theory may help explain how mood stabilizers (in particular lithium carbonate) bring about their therapeutic effects. ..
  77. doi request reprint Human endogenous retrovirus type W (HERV-W) in schizophrenia: a new avenue of research at the gene-environment interface
    Marion Leboyer
    AP HP, Henri Mondor Albert Chenevier Hospitals, Department of Psychiatry, Creteil, France
    World J Biol Psychiatry 14:80-90. 2013
    ..Provide a synthetic review of recent studies evidencing an association between human endogenous retrovirus-W (HERV-W) and schizophrenia...
  78. pmc Emotional dysfunction as a marker of bipolar disorders
    Chantal Henry
    INSERM, U955, IMRB, Département de génétique, Creteil, F 94000, France
    Front Biosci (Elite Ed) 4:2722-30. 2012
    ..This article reviews data showing the relevance of using emotional reactivity to better characterize bipolar mood episodes...
  79. doi request reprint Neuroimaging-based markers of bipolar disorder: evidence from two meta-analyses
    Josselin Houenou
    INSERM, U 955, IMRB, Department of Medical Genomic, Psychiatry Genetic Team, University Paris Est Creteil, Creteil, F 94000, France
    J Affect Disord 132:344-55. 2011
    ..The identification of objective biomarkers, such as functional and structural brain abnormalities of BD might improve diagnosis and help elucidate its pathophysiology...
  80. pmc Association between the PPP3CC gene, coding for the calcineurin gamma catalytic subunit, and bipolar disorder
    Flavie Mathieu
    INSERM U 513, Faculte de Medecine, 8 rue de General Sarrail, 94000, Creteil, France
    Behav Brain Funct 4:2. 2008
    ..Recently, genetic association between schizophrenia and genetic variation of the human calcineurin A gamma subunit gene (PPP3CC) has been reported...
  81. pmc Corpus callosum area in patients with bipolar disorder with and without psychotic features: an international multicentre study
    Samuel Sarrazin
    From AP HP, Hôpital H Mondor A Chenevier, DHU Pepsy, pôle de psychiatrie, Creteil, France Sarrazin, d Albis, Daban, Hamdani, Leboyer, Houenou Université Paris Est, UMR_S955, UPEC, F 94000, Creteil, France Sarrazin, Leboyer Fondation FondaMental, Fondation de cooperation scientifique, F 94000, Creteil, France Sarrazin, d Albis, Daban, Hamdani, Leboyer, Houenou UNIACT, Neurospin, Commissariat a l Energie Atomique, Centre d Etudes de Saclay, Gif sur Yvette Sarrazin, d Albis, Houenou INSERM, Guangzhou 510515
    J Psychiatry Neurosci 40:352-9. 2015
    ..We sought to compare regional callosal areas in a large international multicentre sample of patients with BD and healthy controls...
  82. doi request reprint Ketamine administration in depressive disorders: a systematic review and meta-analysis
    Guillaume Fond
    Pôle de psychiatrie des hôpitaux universitaires H Mondor, Université Paris Est Créteil, INSERM U955, Eq Psychiatrie Génétique, Fondation FondaMental Fondation de coopération scientifique en santé mentale, 40, rue de Mesly, 94010, Creteil, France
    Psychopharmacology (Berl) 231:3663-76. 2014
    ..Secondary outcomes were the duration of ketamine's effect, the efficacy on suicidal ideations, the existence of a dose effect, and the safety/tolerance of the treatment...
  83. doi request reprint [Anti-NR1 antibodies in anti-N-methyl-D-aspartate receptor encephalitis and schizophrenia]
    Emmanuel Le Guen
    Pôle psychiatrie des hôpitaux universitaires Henri Mondor, AP HP, Universite Paris Est, DHU Pepsy, Hopital Albert Chenevier, 40, rue de Mesly, 94000 Creteil, France INSERM U955, Equipe 15, Psychiatrie Génétique, Creteil, France Fondation FondaMental, Creteil, France
    Med Sci (Paris) 31:60-7. 2015
    ..These findings suggest new therapeutic perspectives in some schizophrenic patients, despite a low seroprevalence and pathogenic effects that remain to be demonstrated. ..
  84. ncbi request reprint Age at onset in bipolar I affective disorder: further evidence for three subgroups
    Frank Bellivier
    Department of Psychiatry, Hôpital Henri Mondor et Albert Chenevier, Assistance Publique Hopitaux de Paris, 51 avenue du Mal de Lattre de Tassigny, 94010 Creteil Cedex, France
    Am J Psychiatry 160:999-1001. 2003
    ..Preliminary data suggested that there are three subgroups of bipolar affective disorder based on age at onset. The authors sought to replicate those findings and determine the cut-off age of each subgroup...
  85. ncbi request reprint Age at onset in bipolar affective disorders: a review
    Marion Leboyer
    Service de Psychiatrie, Hôpital Henri Mondor et Albert Chenevier, Assistance Publique Hopitaux de Paris, Creteil, France
    Bipolar Disord 7:111-8. 2005
    ..A recently proposed theoretical model with three AAO sub-groups (onset age 17, 27 and 46) is discussed...
  86. pmc Autism risk factors: genes, environment, and gene-environment interactions
    Pauline Chaste
    INSERM U 955, IMRB, Psychiatry Genetics, Creteil, France
    Dialogues Clin Neurosci 14:281-92. 2012
    ..One aspect of this search that has been neglected so far is the study of interactions between genes and environmental factors...
  87. doi request reprint MRI exploration of pineal volume in bipolar disorder
    Samuel Sarrazin
    AP HP, University Paris East, Department of Psychiatry, Henri Mondor Albert Chenevier Hospitals, Creteil, F 94010, France
    J Affect Disord 135:377-9. 2011
    ..Melatonin is secreted by the pineal gland. We investigated pineal volume in patients with bipolar disorder, and expected to observe smaller than normal pineal glands in cases of bipolar disorder...
  88. ncbi request reprint Handedness and schizotypal features in healthy subjects
    Franck Schurhoff
    AP HP Groupe Henri Mondor Albert Chenevier, pôle de psychiatrie, Creteil, France
    World J Biol Psychiatry 9:121-5. 2008
    ..Several studies have attempted to identify correlations between handedness and dimensions of psychosis but the results obtained so far remain inconclusive...
  89. ncbi request reprint Association between the dopamine receptor D4 (DRD4) gene and obsessive-compulsive disorder
    Bruno Millet
    INSERM E0117 Paris V, University Department of Psychiatry, Sainte Anne Hospital, Paris, France
    Am J Med Genet B Neuropsychiatr Genet 116:55-9. 2003
    ..The results suggest that the 2 allele or a nearby genetic variation could have a protective effect against OCD symptoms...
  90. ncbi request reprint Anxiety disorders in 318 bipolar patients: prevalence and impact on illness severity and response to mood stabilizer
    Chantal Henry
    Department of Adult Psychiatry, Charles Perrens Hospital, and INSERM U 394, Integrative Neurobiology, Bordeaux, France
    J Clin Psychiatry 64:331-5. 2003
    ..The aim of this study was to assess the frequency and impact of anxiety disorders on illness severity and response to mood stabilizers in bipolar disorders...
  91. ncbi request reprint Emotional hyper-reactivity as a fundamental mood characteristic of manic and mixed states
    Chantal Henry
    Service de Psychiatrie Adulte, Centre Hospitalier Charles Perrens, 121, rue de la Béchade, 33076 Bordeaux, France
    Eur Psychiatry 18:124-8. 2003
    ..It is possible that the fundamental mood characteristic of mania is not tonality of mood (e.g. euphoric, irritable or depressed mood), but rather the intensity of emotions...
  92. ncbi request reprint No human tryptophan hydroxylase-2 gene R441H mutation in a large cohort of psychiatric patients and control subjects
    Richard Delorme
    Human Genetics and Cognitive Functions, Pasteur Institute, Paris, France
    Biol Psychiatry 60:202-3. 2006
    ..1.4% in control subjects)...
  93. doi request reprint Preferential association between childhood emotional abuse and bipolar disorder
    Bruno Etain
    INSERM, Unité 955 and Assistance Publique Hôpitaux de Paris AP HP, Groupe Henri Mondor Albert Chenevier, pôle de psychiatrie, Creteil Cedex, France
    J Trauma Stress 23:376-83. 2010
    ..Clinical practice should include systematic assessment of childhood trauma among bipolar patients with a particular focus on emotional abuse...
  94. pmc Rural-urban variation in incidence of psychosis in France: a prospective epidemiologic study in two contrasted catchment areas
    Andrei Szoke
    AP HP, Groupe Hospitalier Mondor Pôle de Psychiatrie, Creteil 94000, France
    BMC Psychiatry 14:78. 2014
    ..The aim of our study is to provide data on the incidence of psychotic disorders in France and compare the incidence rates in populations with different levels of urbanization...
  95. pmc Smoking behavior characteristics of non-selected smokers with childhood attention-deficit/hyperactivity disorder (AD/HD) history: a systematic review and meta-analysis
    Guillaume Fond
    Pôle de psychiatrie des hôpitaux universitaires H Mondor, INSERM U955, Eq 15, Fondation FondaMental, Fondation de Coopération Scientifique en Santé Mentale, Universite Paris Est, 94000, Creteil, France
    Eur Arch Psychiatry Clin Neurosci 264:379-89. 2014
    ..Further high-quality studies are needed to confirm this finding, as only two studies included participants with a mean age below 20 years. ..
  96. doi request reprint Quality of life instruments used in mental health research: properties and utilization
    Amélie Prigent
    AP HP, URC Eco Ile de France, 1, Place du Parvis Notre Dame, Paris F 75004, France LIC EA4393, University Paris Est, Faculty of Medicine, IFR10, Créteil F 94000, France Fondation FondaMental, French National Science Foundation, Créteil F 94000, France Electronic address
    Psychiatry Res 215:1-8. 2014
    ..A consensus about common QoL instruments must be reached to facilitate the choice of instruments, the comparison of results and thus to have an impact on clinical and policy decision-making. ..
  97. doi request reprint Comparative analysis of anti-toxoplasmic activity of antipsychotic drugs and valproate
    Guillaume Fond
    Fondation FondaMental Fondation de coopération scientifique en santé mentale, Eq Psychiatrie Génétique, INSERM U955, DHU Pepsy, Pôle de Psychiatrie du Groupe des Hôpitaux Universitaires de Mondor, Université Paris Est Créteil, 94000, Creteil, France
    Eur Arch Psychiatry Clin Neurosci 264:179-83. 2014
    ..These findings may be potentially relevant for the choice of the first-line antipsychotic drug or mood stabilizer in previously infected patients. ..
  98. ncbi request reprint Can the response to mood stabilizers be predicted in bipolar disorder?
    Pierre Alexis Geoffroy
    pôle de psychiatrie, Centre Expert Bipolaire, Hopital Albert Chenevier, pavillon Hartman, 40, rue de Mesly, 94000 Creteil Cedex, France
    Front Biosci (Elite Ed) 6:120-38. 2014
    ....
  99. pmc A bipolar disorder patient becoming asymptomatic after adjunctive anti-filiarasis treatment: a case report
    Nora Hamdani
    Faculte de Medecine, Universite Paris Est, Creteil 94000, France
    BMC Psychiatry 13:81. 2013
    ..We present here, to our knowledge, the first description of a filariasis infected manic bipolar disorder patient fully improved in terms of psychiatric symptoms by anti-heminthic treatment...
  100. ncbi request reprint Immuno- inflammatory markers of bipolar disorder: a review of evidence
    Nora Hamdani
    Universite Paris Est, Faculte de Medecine, Creteil, 94000, France
    Front Biosci (Elite Ed) 4:2170-82. 2012
    ....
  101. doi request reprint Defining bipolar mood states with quantitative measurement of inhibition/activation and emotional reactivity
    Chantal Henry
    INSERM, U 995, IMRB, Département de génétique, Creteil, France
    J Affect Disord 127:300-4. 2010
    ..The aim of the study is to determine whether two dimensions (activation/inhibition and emotional reactivity) improve assessment of bipolar states in which both manic and depressive symptoms are associated...