P Lawton

Summary

Country: France

Publications

  1. ncbi request reprint Use of Percoll for the infection of cells in vitro with Cryptosporidium parvum oocysts
    P Lawton
    Département Pharmaceutique de Parasitologie et Mycologie Médicale, Faculte de Pharmacie, Universite Claude Bernard, 8 avenue Rockefeller, F 69373 Cedex 08, Lyon, France
    J Microbiol Methods 46:81-4. 2001
  2. ncbi request reprint In vitro effects of isoprinosine and a dipeptide methyl ester on Echinococcus multilocularis protoscoleces
    P Lawton
    Département de Parasitologie et Mycologie Médicale, Faculte de Pharmacie, Lyon, France
    J Helminthol 75:251-7. 2001
  3. ncbi request reprint Effects of purine nucleosides on the in vitro growth of Cryptosporidium parvum
    Philippe Lawton
    Département de Parasitologie et Mycologie Médicale, ISPB Faculté de pharmacie, 8 avenue Rockefeller, F 69373 Cedex 08, Lyon, France
    FEMS Microbiol Lett 226:39-43. 2003
  4. ncbi request reprint Overexpression, purification and characterization of a hexahistidine-tagged recombinant extended nucleotide-binding domain 1 (NBD1) of the Cryptosporidium parvum CpABC3 for rational drug design
    Philippe Lawton
    Universite Claude Bernard Lyon 1, ISPB, Faculte de Pharmacie, EA 3741 Lyon, France
    Mol Biochem Parasitol 152:101-7. 2007
  5. pmc Effects of 2',3'-dideoxyinosine on Toxoplasma gondii cysts in mice
    M E Sarciron
    Department of Parasitology and Medical Mycology, Claude Bernard University, Lyon, France
    Antimicrob Agents Chemother 41:1531-6. 1997
  6. ncbi request reprint Echinococcus multilocularis metacestodes: immunological and immunocytochemical analysis of the relationships between alkaline phosphatase and the Em2 antigen
    P Lawton
    Laboratoire de Parasitologie, Faculte de Pharmacie, Universite Claude Bernard, Lyon, France
    Exp Parasitol 87:142-9. 1997
  7. doi request reprint Synthesis and modulation properties of imidazo[4,5-b]pyridin-7-one and indazole-4,7-dione derivatives towards the Cryptosporidium parvum CpABC3 transporter
    Waël Zeinyeh
    Universite de Lyon, Universite Lyon 1, ISPB Faculté de pharmacie, EA 4443 B2C Biomolécules, Cancer et Chimiorésistances, 8, av Rockefeller, F 69373, Lyon Cedex 08, France
    Eur J Med Chem 45:2480-8. 2010

Collaborators

Detail Information

Publications7

  1. ncbi request reprint Use of Percoll for the infection of cells in vitro with Cryptosporidium parvum oocysts
    P Lawton
    Département Pharmaceutique de Parasitologie et Mycologie Médicale, Faculte de Pharmacie, Universite Claude Bernard, 8 avenue Rockefeller, F 69373 Cedex 08, Lyon, France
    J Microbiol Methods 46:81-4. 2001
    ..Excystation was maximal after 2 h, but toxicity increased with the oocyst/cell ratio and the incubation time. The infection rates did not increase with the oocyst/cell ratio and both cell types were equally parasitized...
  2. ncbi request reprint In vitro effects of isoprinosine and a dipeptide methyl ester on Echinococcus multilocularis protoscoleces
    P Lawton
    Département de Parasitologie et Mycologie Médicale, Faculte de Pharmacie, Lyon, France
    J Helminthol 75:251-7. 2001
    ..Thus, the previously reported in vivo activities of these drugs result largely from a direct effect on the parasite...
  3. ncbi request reprint Effects of purine nucleosides on the in vitro growth of Cryptosporidium parvum
    Philippe Lawton
    Département de Parasitologie et Mycologie Médicale, ISPB Faculté de pharmacie, 8 avenue Rockefeller, F 69373 Cedex 08, Lyon, France
    FEMS Microbiol Lett 226:39-43. 2003
    ....
  4. ncbi request reprint Overexpression, purification and characterization of a hexahistidine-tagged recombinant extended nucleotide-binding domain 1 (NBD1) of the Cryptosporidium parvum CpABC3 for rational drug design
    Philippe Lawton
    Universite Claude Bernard Lyon 1, ISPB, Faculte de Pharmacie, EA 3741 Lyon, France
    Mol Biochem Parasitol 152:101-7. 2007
    ..The recombinant C. parvum H6-NBD1 should be a valuable tool for rational drug design and will allow the discrimination between specific inhibitors of the catalytic site and molecules binding to other sites...
  5. pmc Effects of 2',3'-dideoxyinosine on Toxoplasma gondii cysts in mice
    M E Sarciron
    Department of Parasitology and Medical Mycology, Claude Bernard University, Lyon, France
    Antimicrob Agents Chemother 41:1531-6. 1997
    ..These cysts were not viable, as confirmed by immunofluorescence and reinfection experiments. These experiments suggest a possible role for ddI in the treatment of toxoplasmosis, and this possibility deserves further investigation...
  6. ncbi request reprint Echinococcus multilocularis metacestodes: immunological and immunocytochemical analysis of the relationships between alkaline phosphatase and the Em2 antigen
    P Lawton
    Laboratoire de Parasitologie, Faculte de Pharmacie, Universite Claude Bernard, Lyon, France
    Exp Parasitol 87:142-9. 1997
    ..These results suggest a putative functional relationship between the two antigens and that Em2 could originate from EmAP...
  7. doi request reprint Synthesis and modulation properties of imidazo[4,5-b]pyridin-7-one and indazole-4,7-dione derivatives towards the Cryptosporidium parvum CpABC3 transporter
    Waël Zeinyeh
    Universite de Lyon, Universite Lyon 1, ISPB Faculté de pharmacie, EA 4443 B2C Biomolécules, Cancer et Chimiorésistances, 8, av Rockefeller, F 69373, Lyon Cedex 08, France
    Eur J Med Chem 45:2480-8. 2010
    ..These compounds could thus act like some flavonoid derivatives, which can partly overlap both the nucleotide-binding site and the adjacent hydrophobic steroid-binding region of mammalian P-glycoproteins...