Vincent Laudet

Summary

Country: France

Publications

  1. pmc Altered retinoic acid signalling underpins dentition evolution
    Yann Gibert
    Metabolic Genetic Diseases Laboratory, Metabolic Research Unit, School of Medicine, Deakin University, 75 Pigdons Road, Waurn Ponds, Victoria 3217, Australia
    Proc Biol Sci 282:. 2015
  2. pmc Retinoic acid signaling and the evolution of chordates
    Ferdinand Marlétaz
    Laboratoire de Biologie Moleculaire de la Cellule, CNRS UMR5161 INRA 1237 ENS Lyon, IFR128 Biosciences Lyon Gerland, Ecole Normale Superieure de Lyon, 46 allee d Italie, 69364 Lyon Cedex 07, France
    Int J Biol Sci 2:38-47. 2006
  3. pmc Molecular adaptation and resilience of the insect's nuclear receptor USP
    Arnaud Chaumot
    IRSTEA, UR MALY, Lyon F 69336, France
    BMC Evol Biol 12:199. 2012
  4. pmc The fate of the duplicated androgen receptor in fishes: a late neofunctionalization event?
    Veronique Douard
    INRA SCRIBE IFR 140, Campus de Beaulieu, 35042 Rennes Cedex, France
    BMC Evol Biol 8:336. 2008
  5. doi request reprint The origins and evolution of vertebrate metamorphosis
    Vincent Laudet
    Molecular Zoology Team, Institut de Génomique Fonctionnelle de Lyon, Ecole Normale Superieure de Lyon, CNRS UMR 5242, Universite Lyon 1, Universite de Lyon, 46 allee d Italie, 69364 Lyon Cedex 07, France
    Curr Biol 21:R726-37. 2011
  6. pmc Bisphenol A induces otolith malformations during vertebrate embryogenesis
    Yann Gibert
    Institut de Génomique Fonctionnelle de Lyon Université de Lyon Université Lyon 1 CNRS INRA Ecole Normale Supérieure de Lyon 46 allée d Italie, 69364 Lyon Cedex 07, France
    BMC Dev Biol 11:4. 2011
  7. doi request reprint Adaptive diversity: hormones and metabolism in freshwaters
    Vincent Laudet
    Institut de Génomique Fonctionnelle de Lyon, Universite de Lyon, Universite Lyon 1, CNRS, INRA, Ecole Normale Superieure de Lyon, France
    Curr Biol 20:R1016-8. 2010
  8. ncbi request reprint Expression of estrogen-receptor related receptors in amphioxus and zebrafish: implications for the evolution of posterior brain segmentation at the invertebrate-to-vertebrate transition
    Pierre Luc Bardet
    Laboratoire de Biologie Moleculaire de la Cellule, CNRS UMR 5161, IFR128 Biosciences Lyon Gerland, Ecole Normale Superieure de Lyon, 46 allee d Italie, 69007 Lyon, France
    Evol Dev 7:223-33. 2005
  9. pmc Formation of oral and pharyngeal dentition in teleosts depends on differential recruitment of retinoic acid signaling
    Yann Gibert
    Molecular Zoology Group, Institut de Génomique Fonctionnelle de Lyon, Universite de Lyon, CNRS, INRA, UCB Lyon 1, Ecole Normale Superieure de Lyon, 69364 Lyon Cedex 07, France
    FASEB J 24:3298-309. 2010
  10. ncbi request reprint OTX5 regulates pineal expression of the zebrafish REV-ERB alpha through a new DNA binding site
    Shin ichi Nishio
    Universite de Lyon, Institut de Génomique Fonctionnelle de Lyon, Unité Mixte de Recherche 5242 du Centre National de la Recherche Scientifique, 69364 Lyon Cedex 07, France
    Mol Endocrinol 22:23-32. 2008

Detail Information

Publications77

  1. pmc Altered retinoic acid signalling underpins dentition evolution
    Yann Gibert
    Metabolic Genetic Diseases Laboratory, Metabolic Research Unit, School of Medicine, Deakin University, 75 Pigdons Road, Waurn Ponds, Victoria 3217, Australia
    Proc Biol Sci 282:. 2015
    ..Our work illustrates that through subtle changes in the expression of rate-limiting enzymes, the RA pathway is an active player of tooth evolution in fish. ..
  2. pmc Retinoic acid signaling and the evolution of chordates
    Ferdinand Marlétaz
    Laboratoire de Biologie Moleculaire de la Cellule, CNRS UMR5161 INRA 1237 ENS Lyon, IFR128 Biosciences Lyon Gerland, Ecole Normale Superieure de Lyon, 46 allee d Italie, 69364 Lyon Cedex 07, France
    Int J Biol Sci 2:38-47. 2006
    ....
  3. pmc Molecular adaptation and resilience of the insect's nuclear receptor USP
    Arnaud Chaumot
    IRSTEA, UR MALY, Lyon F 69336, France
    BMC Evol Biol 12:199. 2012
    ..This receptor is therefore a good model to study the evolution of plasticity. We tested the hypothesis that selection has shaped the Ligand-Binding Domain (LBD) of USP during evolution of Mecopterida...
  4. pmc The fate of the duplicated androgen receptor in fishes: a late neofunctionalization event?
    Veronique Douard
    INRA SCRIBE IFR 140, Campus de Beaulieu, 35042 Rennes Cedex, France
    BMC Evol Biol 8:336. 2008
    ..It has been proposed that this event might have facilitated the evolutionary radiation and the phenotypic diversification of the teleost fish, notably by allowing the sub- or neo-functionalization of many duplicated genes...
  5. doi request reprint The origins and evolution of vertebrate metamorphosis
    Vincent Laudet
    Molecular Zoology Team, Institut de Génomique Fonctionnelle de Lyon, Ecole Normale Superieure de Lyon, CNRS UMR 5242, Universite Lyon 1, Universite de Lyon, 46 allee d Italie, 69364 Lyon Cedex 07, France
    Curr Biol 21:R726-37. 2011
    ..According to this view, metamorphosis of the anurans is an extreme example of a widespread life history transition...
  6. pmc Bisphenol A induces otolith malformations during vertebrate embryogenesis
    Yann Gibert
    Institut de Génomique Fonctionnelle de Lyon Université de Lyon Université Lyon 1 CNRS INRA Ecole Normale Supérieure de Lyon 46 allée d Italie, 69364 Lyon Cedex 07, France
    BMC Dev Biol 11:4. 2011
    ..Here, we investigated BPA effects during embryonic development using the zebrafish and Xenopus models...
  7. doi request reprint Adaptive diversity: hormones and metabolism in freshwaters
    Vincent Laudet
    Institut de Génomique Fonctionnelle de Lyon, Universite de Lyon, Universite Lyon 1, CNRS, INRA, Ecole Normale Superieure de Lyon, France
    Curr Biol 20:R1016-8. 2010
    ..Genes underlying the evolution of morphological traits have recently been identified in a number of model species. In the stickleback, the metabolic adaptations to a freshwater habitat have now been linked to a well-known hormonal system...
  8. ncbi request reprint Expression of estrogen-receptor related receptors in amphioxus and zebrafish: implications for the evolution of posterior brain segmentation at the invertebrate-to-vertebrate transition
    Pierre Luc Bardet
    Laboratoire de Biologie Moleculaire de la Cellule, CNRS UMR 5161, IFR128 Biosciences Lyon Gerland, Ecole Normale Superieure de Lyon, 46 allee d Italie, 69007 Lyon, France
    Evol Dev 7:223-33. 2005
    ....
  9. pmc Formation of oral and pharyngeal dentition in teleosts depends on differential recruitment of retinoic acid signaling
    Yann Gibert
    Molecular Zoology Group, Institut de Génomique Fonctionnelle de Lyon, Universite de Lyon, CNRS, INRA, UCB Lyon 1, Ecole Normale Superieure de Lyon, 69364 Lyon Cedex 07, France
    FASEB J 24:3298-309. 2010
    ..The loss of pharyngeal teeth in this group was cancelled out through a shift in aldh1a2 expression, while oral teeth might have been lost ultimately due to deficient RA signaling in the oral cavity...
  10. ncbi request reprint OTX5 regulates pineal expression of the zebrafish REV-ERB alpha through a new DNA binding site
    Shin ichi Nishio
    Universite de Lyon, Institut de Génomique Fonctionnelle de Lyon, Unité Mixte de Recherche 5242 du Centre National de la Recherche Scientifique, 69364 Lyon Cedex 07, France
    Mol Endocrinol 22:23-32. 2008
    ..Our data establish that PERE is a novel cis-acting element contributing to pineal-specific gene expression and to Otx target gene regulation...
  11. ncbi request reprint Molecular cloning and developmental expression patterns of thyroid hormone receptors and T3 target genes in the turbot (Scophtalmus maximus) during post-embryonic development
    Oriane Marchand
    CNRS UMR 5665, Laboratoire de Biologie Moleculaire et Cellulaire, Ecole Normale Superieure de Lyon, 46 allee d Italie, 69364, 07, France
    Gen Comp Endocrinol 135:345-57. 2004
    ..The fact that TH regulates metamorphosis in amphibian and teleost fishes suggests that TH-regulated metamorphosis is a post-embryonic process conserved in most vertebrates...
  12. pmc The phytoestrogen genistein affects zebrafish development through two different pathways
    Sana Sassi-Messai
    Institut de Génomique Fonctionnelle de Lyon, Universite de Lyon, Universite Lyon 1, CNRS, INRA, Ecole Normale Superieure de Lyon, Lyon, France
    PLoS ONE 4:e4935. 2009
    ..The phytoestrogen, genistein (4', 5, 7-trihydroxy-isoflavone), is a naturally occurring compound found in soy products. Genistein has been the subject of numerous studies because of its known estrogenic activity...
  13. pmc Unexpected novel relational links uncovered by extensive developmental profiling of nuclear receptor expression
    Stephanie Bertrand
    Molecular Zoology, Institut de Génomique Fonctionelle de Lyon UMR 5242 du CNRS, INRA, IFR128 Biosciences Lyon Gerland, Universite de Lyon, UCB Ecole Normale Supérieure de Lyon, France
    PLoS Genet 3:e188. 2007
    ..Altogether, this expression database of NRs provides novel routes for leading investigation into the biological function of each individual NR as well as for the study of their combinatorial regulatory circuitry within the superfamily...
  14. pmc An amphioxus orthologue of the estrogen receptor that does not bind estradiol: insights into estrogen receptor evolution
    Mathilde Paris
    Institut de Génomique Fonctionnelle de Lyon, Molecular Zoology Team, Universite de Lyon, Ecole Normale Superieure de Lyon, Universite Lyon 1, CNRS, INRA, Institut Fédératif 128 Biosciences Gerland Lyon Sud, France
    BMC Evol Biol 8:219. 2008
    ....
  15. doi request reprint Rev-erbalpha2 mRNA encodes a stable protein with a potential role in circadian clock regulation
    Juliette Rambaud
    Molecular Zoology Group, Institut de Génomique Fonctionnelle de Lyon, Universite de Lyon, CNRS, INRA, Universite Claude Bernard Lyon 1, Ecole Normale Superieure de Lyon, Lyon, France
    Mol Endocrinol 23:630-9. 2009
    ..We propose that the relative expression levels of the two REV-ERBalpha variants fine-tune the circadian period length by regulating REV-ERBalpha half-life...
  16. ncbi request reprint Explosive lineage-specific expansion of the orphan nuclear receptor HNF4 in nematodes
    Marc Robinson-Rechavi
    Laboratoire de Biologie Moleculaire de la Cellule, UMR CNRS 5161, Ecole Normale Superieure de Lyon, France
    J Mol Evol 60:577-86. 2005
    ..Our results provide a framework to study nuclear receptors in nematodes, as well as to consider the functional and evolutionary consequences of lineage-specific duplications...
  17. ncbi request reprint Two differentially active alternative promoters control the expression of the zebrafish orphan nuclear receptor gene Rev-erbalpha
    Tomoko Kakizawa
    Laboratoire de Biologie Moleculaire de la Cellule, CNRS UMR 5161, INRA LA 1237, IFR 128 Biosciences Lyon Gerland, Ecole Normale Superieure de Lyon, Lyon Cedex, France
    J Mol Endocrinol 38:555-68. 2007
    ..Together, these data suggest that ZfP1 is orthologous to the mammalian P1 promoter, whereas zebrafish ZfP2 has no mammalian ortholog and does not function like ZfP1 to control Rev-erbalpha expression...
  18. pmc Neofunctionalization in vertebrates: the example of retinoic acid receptors
    Hector Escriva
    Structure and Evolution of Nuclear Hormone Receptors, UMR 5161 du CNRS, INRA LA 1237, Laboratoire de Biologie Moleculaire de la Cellule, IFR128 Biosciences Lyon Gerland, Ecole Normale Superieure de Lyon, Lyon, France
    PLoS Genet 2:e102. 2006
    ..We thus suggest that neofunctionalization occurred at both the expression and the functional levels to shape RAR roles during development in vertebrates...
  19. ncbi request reprint Evolutionary genomics of nuclear receptors: from twenty-five ancestral genes to derived endocrine systems
    Stephanie Bertrand
    Laboratoire de Biologie Moleculaire de la Cellule, Ecole Normale Superieure de Lyon, Lyon, France
    Mol Biol Evol 21:1923-37. 2004
    ..Our results imply that the genes for major receptors such as steroid receptors or thyroid hormone receptors were present in Urbilateria...
  20. doi request reprint Adiponectin and adiponectin receptor genes are coexpressed during zebrafish embryogenesis and regulated by food deprivation
    Shin ichi Nishio
    Molecular Zoology Group, Institut de Génomique Fonctionelle de Lyon, Lyon, France
    Dev Dyn 237:1682-90. 2008
    ..These data indicate that the upstream members of the Adiponectin pathway have complex expression patterns and are regulated by food deprivation in zebrafish...
  21. ncbi request reprint The ERRalpha orphan nuclear receptor controls morphogenetic movements during zebrafish gastrulation
    Pierre Luc Bardet
    Laboratoire de Biologie Moleculaire de la Cellule, CNRS UMR 5161, IFR 128 Biosciences Lyon Gerland, Ecole Normale Superieure de Lyon, 46 allee d Italie, 69364 Lyon Cedex 07, France
    Dev Biol 281:102-11. 2005
    ..Altogether, these results propose ERRalpha as a new regulator of morphogenetic movement during gastrulation, independently of cell fate determination...
  22. doi request reprint The amphioxus genome enlightens the evolution of the thyroid hormone signaling pathway
    Mathilde Paris
    Institut de Génomique Fonctionnelle de Lyon, CNRS UMR5242 INRA 1288 ENS UCBL, IFR128 Biosciences Lyon Gerland, Ecole Normale Superieure de Lyon, 46 allee d Italie, 69364 Lyon Cedex 07, France
    Dev Genes Evol 218:667-80. 2008
    ....
  23. doi request reprint Nuclear hormone receptor signaling in amphioxus
    Michael Schubert
    CNRS UMR5242 INRA 1288 ENS UCBL, Institut de Génomique Fonctionnelle de Lyon, IFR128 Biosciences Lyon Gerland, Ecole Normale Superieure de Lyon, 46 allee d Italie, 69364 Lyon Cedex 07, France
    Dev Genes Evol 218:651-65. 2008
    ....
  24. pmc Patterning of palatal rugae through sequential addition reveals an anterior/posterior boundary in palatal development
    Sophie Pantalacci
    Molecular Zoology, Institut de Génomique Fonctionnelle de Lyon, Universite de Lyon, Universite Lyon 1, CNRS, INRA, Ecole Normale Superieure de Lyon, Lyon, France
    BMC Dev Biol 8:116. 2008
    ..However, rugae could be useful as landmarks to monitor anterior/posterior (A/P) palatal growth, and they provide a simple model of mesenchymal-epithelial structures arranged in a serial pattern...
  25. ncbi request reprint Pedomorphosis revisited: thyroid hormone receptors are functional in Necturus maculosus
    Rachid Safi
    CNRS UMR 5161, INRA LA 913, Laboratoire de Biologie Moleculaire de la Cellule, IFR128 Biosciences Lyon Gerland, Ecole Normale Superieure de Lyon, France
    Evol Dev 8:284-92. 2006
    ..Rather, the absence of metamorphosis may be due to the loss of TH-dependent control of key genes required for tissue transformation...
  26. doi request reprint Amphioxus postembryonic development reveals the homology of chordate metamorphosis
    Mathilde Paris
    Institut de Génomique Fonctionnelle de Lyon, Universite de Lyon, CNRS, INRA, UCB Lyon 1, IFR128 Lyon Biosciences, Ecole Normale Superieure de Lyon, 69364 Lyon Cedex 07, France
    Curr Biol 18:825-30. 2008
    ..Therefore, TH-regulated metamorphosis, mediated by TR, is an ancestral feature of all chordates. This conservation of a regulatory network supports the homology of metamorphosis in the chordate lineage...
  27. pmc Independent elaboration of steroid hormone signaling pathways in metazoans
    Gabriel V Markov
    Molecular Zoology Team, Institut de Génomique Fonctionnelle de Lyon, Universite de Lyon, Université Lyon 1 and Centre National de Recherche Scientifique, Institut National de Recherche Agronomique, Ecole Normale Superieure de Lyon, Lyon Cedex 07, France
    Proc Natl Acad Sci U S A 106:11913-8. 2009
    ..Our analysis reveals that steroidogenesis has been independently elaborated in the 3 main bilaterian lineages, and that steroidogenic cytochrome P450 enzymes descended from those that detoxify xenobiotics...
  28. ncbi request reprint Retinoic acid signaling acts via Hox1 to establish the posterior limit of the pharynx in the chordate amphioxus
    Michael Schubert
    Ecole Normale Superieure de Lyon, Laboratoire de Biologie Moleculaire de la Cellule, CNRS UMR5161 INRA UMR1237, 46, Allee d Italie, 69364 Lyon Cedex 07, France
    Development 132:61-73. 2005
    ..This work highlights the potential of amphioxus, a genomically simple, vertebrate-like invertebrate chordate, as a paradigm for understanding gene hierarchies similar to the more complex ones of vertebrates...
  29. pmc Evolutionary trends of the pharyngeal dentition in Cypriniformes (Actinopterygii: Ostariophysi)
    Emmanuel Pasco-Viel
    Evo devo of Vertebrate Dentition, Institut de Génomique Fonctionnelle de Lyon, Universite de Lyon, CNRS, INRA, Ecole Normale Superieure de Lyon, Lyon, France
    PLoS ONE 5:e11293. 2010
    ..Here we provide a further description of this diversity using X-ray microtomography and we map the resulting dental characters on a phylogenetic tree to explore evolutionary trends...
  30. doi request reprint Conserved features and evolutionary shifts of the EDA signaling pathway involved in vertebrate skin appendage development
    Sophie Pantalacci
    Molecular Zoology Team, Institut de Génomique Fonctionnelle de Lyon, Universite de Lyon, Institut Fédératif Biosciences 128 Gerland Lyon Sud, CNRS, INRA, Universite Claude Bernard Lyon 1, 69364 Lyon Cedex 07, France
    Mol Biol Evol 25:912-28. 2008
    ....
  31. doi request reprint Estrogen-related receptor γ is an in vivo receptor of bisphenol A
    Marie Tohmé
    Institut de Génomique Fonctionnelle de Lyon, Ecole Normale Superieure de Lyon, Centre National de la Recherche Scientifique CNRS, Unité Mixte de Recherche UMR 5242, Universite Lyon 1, Universite de Lyon, Lyon, France
    FASEB J 28:3124-33. 2014
    ..Tohmé, M., Prud'homme, S. M., Boulahtouf, A., Samarut, E., Brunet, F., Bernard, L., Bourguet, W., Gibert, Y., Balaguer, P., Laudet, V. Estrogen-related receptor γ is an in vivo receptor of bisphenol A. ..
  32. doi request reprint From carrot to clinic: an overview of the retinoic acid signaling pathway
    Maria Theodosiou
    Institut de Génomique Fonctionnelle de Lyon, Université de Lyon Université Lyon 1, CNRS, INRA, Ecole Normale Superieure de Lyon, 46 allee d Italie, 69364 Lyon Cedex 07, France
    Cell Mol Life Sci 67:1423-45. 2010
    ..Moreover, we discuss the origin and diversification of the retinoid pathway, which are important factors for understanding the evolution of ligand-specificity among retinoid receptors...
  33. pmc Update of NUREBASE: nuclear hormone receptor functional genomics
    David Ruau
    Laboratoire de Biologie Moleculaire de la Cellule, CNRS UMR 5161, Ecole Normale Superieure de Lyon, 46 allee d Italie, 69364 Lyon Cedex 07, France
    Nucleic Acids Res 32:D165-7. 2004
    ..The core of NUREBASE is reviewed, and it is completed by NUREBASE_DAILY, automatically updated every 24 h. All information on accessing and installing NUREBASE may be found at http://www. ens-lyon.fr/LBMC/laudet/nurebase/nurebase.html...
  34. ncbi request reprint The axolotl (Ambystoma mexicanum), a neotenic amphibian, expresses functional thyroid hormone receptors
    Rachid Safi
    Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5665, Laboratoire de Biologie Moleculaire et Cellulaire, Ecole Normale Superieure de Lyon, 46 allee d Italie, 69364 Lyon Cedex 07, France
    Endocrinology 145:760-72. 2004
    ..Taken together, these results suggest that axolotl TRs are functional and that the molecular basis of neoteny in the axolotl is not linked to a major defect in TH response in peripheral tissues...
  35. doi request reprint Origin and evolution of the ligand-binding ability of nuclear receptors
    Gabriel V Markov
    Molecular Zoology Team, Institut de Génomique Fonctionnelle de Lyon, Universite de Lyon, Ecole Normale Superieure de Lyon, Universite Lyon 1, CNRS, INRA, Institut Fédératif 128 Biosciences Gerland Lyon Sud, France
    Mol Cell Endocrinol 334:21-30. 2011
    ....
  36. ncbi request reprint Nuclear receptors are markers of animal genome evolution
    Hector Escriva Garcia
    Laboratoire de Biologie Moleculaire et Cellulaire, Ecole Normale Superieure de Lyon, 46 allee d Italie, F 69364 Lyon Cedex 07, France
    J Struct Funct Genomics 3:177-84. 2003
    ..We illustrate this with examples from differents nuclear receptors and different groups of species...
  37. ncbi request reprint A retinoic acid-Hox hierarchy controls both anterior/posterior patterning and neuronal specification in the developing central nervous system of the cephalochordate amphioxus
    Michael Schubert
    Laboratoire de Biologie Moleculaire de la Cellule, CNRS UMR5161 INRA UMR1237 ENS Lyon, IFR128 Biosciences Lyon Gerland, Ecole Normale Superieure de Lyon, 46 allee d Italie, 69364 Lyon Cedex 07, France
    Dev Biol 296:190-202. 2006
    ....
  38. pmc Retinoic acid influences anteroposterior positioning of epidermal sensory neurons and their gene expression in a developing chordate (amphioxus)
    Michael Schubert
    Laboratoire de Biologie Moleculaire de la Cellule, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5161, and Institut National de la Recherche Agronomique, Ecole Normale Superieure de Lyon, 69364 Lyon, France
    Proc Natl Acad Sci U S A 101:10320-5. 2004
    ....
  39. pmc Tinkering signaling pathways by gain and loss of protein isoforms: the case of the EDA pathway regulator EDARADD
    Alexa Sadier
    Institut de Génomique Fonctionnelle de Lyon, UMR 5242 du CNRS, Universite de Lyon, Universite Claude Bernard Lyon 1, Ecole Normale Superieure de Lyon, 46 allee d Italie, 69364, Lyon, Cedex 07, France
    BMC Evol Biol 15:129. 2015
    ..A previous study had suggested a scenario of isoform gain and loss with an alternative isoform (A) newly gained in mammals but secondarily lost in mouse lineage...
  40. doi request reprint Fasting induces CART down-regulation in the zebrafish nervous system in a cannabinoid receptor 1-dependent manner
    Shin ichi Nishio
    Institut de Génomique Fonctionelle de Lyon, Unité Mixte de Recherche 5242 du Centre National de la Recherche Scientifique, Universite de Lyon, Lyon, France
    Mol Endocrinol 26:1316-26. 2012
    ..Our data reveal that CB1 lies upstream of CART and signals the appetite through the down-regulation of CART expression. Thus, our results establish the zebrafish as a promising system to study appetite regulation...
  41. ncbi request reprint Cloning and developmental expression of five estrogen-receptor related genes in the zebrafish
    Pierre Luc Bardet
    Laboratoire de Biologie Moleculaire de la Cellule, CNRS UMR 5161, Ecole Normale Superieure de Lyon, 46 allee d Italie, 69364, Lyon Cedex 07, France
    Dev Genes Evol 214:240-9. 2004
    ..Our analysis also points to tissues in which err expression is conserved through evolution, such as slow muscles that specifically express erralpha, suggesting important functions in these tissues...
  42. ncbi request reprint Gene loss and evolutionary rates following whole-genome duplication in teleost fishes
    Frédéric G Brunet
    Laboratoire de Biologie Moleculaire de la Cellule, INRA LA 1237, CNRS UMR5161, IFR 128 Biosciences Lyon Gerland, Ecole Normale Superieure de Lyon, Lyon, France
    Mol Biol Evol 23:1808-16. 2006
    ..These results show that similar mechanisms are at work in fishes as in yeast or plants and provide a framework for future investigation of the consequences of duplication in fishes and other animals...
  43. pmc The orphan receptor Rev-erbalpha gene is a target of the circadian clock pacemaker
    Gerard Triqueneaux
    Laboratoire de Biologie Moleculaire et Cellulaire, CNRS UMR 5161, Ecole Normale Supérieur de Lyon, 46 allee d Italie, 69364 Lyon Cedex, France
    J Mol Endocrinol 33:585-608. 2004
    ..Together these data demonstrate that CLOCK is a critical regulator of Rev-erbalpha circadian gene expression in evolutionarily distant vertebrates and suggest a role for Rev-erbalpha in the circadian clock output...
  44. ncbi request reprint Identification and developmental expression of the zebrafish orthologue of the tumor suppressor gene HIC1
    Stephanie Bertrand
    UMR 5161 CNRS, Ecole Normale Superieure de Lyon, 46 allee d Italie, 69364 Lyon Cedex 07, France
    Biochim Biophys Acta 1678:57-66. 2004
    ....
  45. doi request reprint Inhibition of endothelial cell apoptosis by netrin-1 during angiogenesis
    Marie Castets
    Apoptosis, Cancer, and Development Laboratory, Equipe Labellisée La Ligue, CNRS UMR5238, Universite de Lyon, Centre Leon Berard, Lyon, France
    Dev Cell 16:614-20. 2009
    ..Thus, the proapoptotic effect of unbound UNC5B and the survival effect of netrin-1 on endothelial cells finely tune the angiogenic process...
  46. ncbi request reprint Thyroid hormone receptor expression in the obligatory paedomorphic salamander Necturus maculosus
    Virginie Vlaeminck-Guillem
    Laboratorie de Biologie Moléculaire de la Cellule, CNRS UMR 5161, INRA LA1237, Ecole Normale Superieure de Lyon, 46 allee d Italie, 69394 Lyon cedex 07, France
    Int J Dev Biol 50:553-60. 2006
    ..Our results thus indicate that, in contrast to previously held hypotheses, Necturus tissues are TH responsive...
  47. ncbi request reprint The evolution of the nuclear receptor superfamily
    Hector Escriva
    UMR 5161 du CNRS, Ecole Normale Superieure de Lyon, 69364 Lyon Cedex 07, France
    Essays Biochem 40:11-26. 2004
    ....
  48. ncbi request reprint Phylogenetic dating and characterization of gene duplications in vertebrates: the cartilaginous fish reference
    Marc Robinson-Rechavi
    Laboratoire de Biologie Moleculaire de la Cellule, UMR CNRS5161, Ecole Normale Superieure de Lyon, Lyon, France
    Mol Biol Evol 21:580-6. 2004
    ..Our results support rounds of gene or genome duplications during a limited period of early vertebrate evolution and allow a better characterization of these events...
  49. doi request reprint Programmed genome rearrangements: in lampreys, all cells are not equal
    Marie Semon
    Institut de Génomique Fonctionnelle de Lyon UMR 5242 du CNRS, Ecole Normale Superieure de Lyon, Universite Claude Bernard Lyon 1, Universite de Lyon, 46 allee d Italie, 69364 Lyon Cedex 07, France
    Curr Biol 22:R641-3. 2012
    ..How can organisms silence deleterious gene loci? A recent study has shed light on a very brute mechanism in a jawless vertebrate: the irreversible deletion of massive chunks of genomic DNA...
  50. pmc Netrin-4 acts as a pro-angiogenic factor during zebrafish development
    Elise Lambert
    Apoptosis, Cancer, and Development Laboratory, Equipe Labellisée La Ligue, LabEx DEVweCAN, Centre de Cancérologie de Lyon, INSERM U1052, CNRS UMR5286, Universite de Lyon, 28 rue Laennec, Lyon 69008, France
    J Biol Chem 287:3987-99. 2012
    ..Together these data underscore the crucial role of Netrin-4 in blood vessel formation and the involvement of protein kinases activation in Netrin-4-induced biological effects related to vascular development...
  51. doi request reprint The history of a developmental stage: metamorphosis in chordates
    Mathilde Paris
    Institut de Génomique Fonctionnelle de Lyon, Universite de Lyon, CNRS, INRA, UCB Lyon 1, IFR128 Lyon Biosciences, Ecole Normale Superieure de Lyon, 69364 Lyon Cedex 07, France
    Genesis 46:657-72. 2008
    ..The intensity and the nature of the morphological remodeling varies extensively among taxa, from drastic remodeling like in some ascidians or amphibians to more subtle events, as in mammals...
  52. pmc Thyroglobulin Represents a Novel Molecular Architecture of Vertebrates
    Guillaume Holzer
    From the Institut de Génomique Fonctionnelle de Lyon, Universite Claude Bernard Lyon 1, CNRS UMR 5242, Ecole Normale Superieure de Lyon, 46 allee d Italie, 69364 Lyon Cedex 07, France
    J Biol Chem 291:16553-66. 2016
    ..By contrast, we have not been able to find any orthologs of Tg among non-vertebrate species. Thus, Tg appears to be a novel protein elaborated as a single event at the base of vertebrates and virtually unchanged thereafter. ..
  53. pmc Evolutionary diversification of retinoic acid receptor ligand-binding pocket structure by molecular tinkering
    Juliana Gutierrez-Mazariegos
    Molecular Zoology Team, Institut de Génomique Fonctionnelle de Lyon, Universite de Lyon, Universite Lyon 1, CNRS, INRA, Ecole Normale Superieure de Lyon, 46 allee d Italie, 69364 Lyon Cedex 07, France
    R Soc Open Sci 3:150484. 2016
    ..This iterative process thus provides a rare example for the diversification of receptor-ligand interactions of NRs following WGDs. ..
  54. doi request reprint The ectodysplasin pathway: from diseases to adaptations
    Alexa Sadier
    Institut de Génomique Fonctionnelle de Lyon, Universite de Lyon, Universite Lyon 1, Centre National de la Recherche Scientifique CNRS, Ecole Normale Superieure de Lyon, 46 allee d Italie, 69364 Lyon Cedex 07, France
    Trends Genet 30:24-31. 2014
    ....
  55. ncbi request reprint Bioinformatics of nuclear receptors
    Marc Robinson-Rechavi
    Laboratoire de Biologie Moleculaire et Cellulaire, UMR CNRS 5665, Ecole Normale Superieure de Lyon, 46 allee d Italie, 69364 Lyon, France
    Methods Enzymol 364:95-118. 2003
  56. ncbi request reprint Amphioxus and tunicates as evolutionary model systems
    Michael Schubert
    Laboratoire de Biologie Moleculaire de la Cellule, CNRS UMR5161, INRA LA 1237, IFR 128 Biosciences Lyon Gerland, Ecole Normale Superieure de Lyon, 46 allee d Italie, 69364 Lyon Cedex 07, France
    Trends Ecol Evol 21:269-77. 2006
    ..We also review the two major groups of invertebrate chordates and compare relative advantages (and disadvantages) of each as model systems for elucidating the origin of the vertebrates...
  57. doi request reprint The dependence receptor UNC5H2/B triggers apoptosis via PP2A-mediated dephosphorylation of DAP kinase
    Céline Guenebeaud
    Apoptosis, Cancer and Development Laboratory Equipe labellisée La Ligue, CNRS UMR5238, Universite de Lyon, Centre Leon Berard, 69008 Lyon, France
    Mol Cell 40:863-76. 2010
    ..Thus we show here that, in the absence of netrin-1, recruitment of PP2A to UNC5H2/B allows the activation of DAPk via a PP2A-mediated dephosphorylation and that this mechanism is involved in angiogenesis regulation...
  58. ncbi request reprint International Union of Pharmacology. LXVI. Orphan nuclear receptors
    Gerard Benoit
    Unité Mixte de Recherche 5161 du Centre National de la Recherche Scientifique, Institut National de la Recherche Agronomique 1237, Institut Fédératif de Recherche 128 BioSciences Lyon Gerland, Ecole Normale Superieure de Lyon, Lyon, France
    Pharmacol Rev 58:798-836. 2006
    ..The paradoxical existence of a pharmacology of orphan receptors, a rapidly growing and innovative field, is highlighted...
  59. ncbi request reprint Reciprocal regulation of brain and muscle Arnt-like protein 1 and peroxisome proliferator-activated receptor alpha defines a novel positive feedback loop in the rodent liver circadian clock
    Laurence Canaple
    Structure and Evolution of Nuclear Receptors, Centre National de la Recherche Scientifique CNRS Unité Mixte de Recherche 5161, Institut Fédératif de Recherche IFR 128 BioSciences Lyon Gerland, Lyon, France
    Mol Endocrinol 20:1715-27. 2006
    ..Together, these results provide evidence for an additional regulatory feedback loop involving BMAL1 and PPARalpha in peripheral clocks...
  60. doi request reprint Genome sequence of the metazoan plant-parasitic nematode Meloidogyne incognita
    Pierre Abad
    INRA, UMR 1301, 400 Route des Chappes, F 06903 Sophia Antipolis, France
    Nat Biotechnol 26:909-15. 2008
    ..Our results provide insights into the adaptations required by metazoans to successfully parasitize immunocompetent plants, and open the way for discovering new antiparasitic strategies...
  61. doi request reprint Retinoic acid signaling in development: tissue-specific functions and evolutionary origins
    Florent Campo-Paysaa
    Institut de Génomique Fonctionnelle de Lyon, CNRS UMR5242 INRA 1288 ENS UCBL, IFR128 Biosciences Lyon Gerland, Ecole Normale Superieure de Lyon, Lyon, France
    Genesis 46:640-56. 2008
    ..On the basis of this hypothesis, we conclude by proposing a scenario for the evolution of RA functions during development, which highlights functional gains and lineage-specific losses during metazoan diversification...
  62. doi request reprint Annotation of Tribolium nuclear receptors reveals an increase in evolutionary rate of a network controlling the ecdysone cascade
    François Bonneton
    Universite de Lyon, Universite Lyon 1, IFR Gerland Lyon Sud, IGFL, CNRS, INRA, Ecole Normale Superieure de Lyon, Lyon Cedex 07, France
    Insect Biochem Mol Biol 38:416-29. 2008
    ..We suggest that coevolution occurred within a network of regulators that control the ecdysone cascade. The advent of Tribolium as a powerful model should allow a better understanding of this evolutionary event...
  63. pmc Lineage-specific duplication of amphioxus retinoic acid degrading enzymes (CYP26) resulted in sub-functionalization of patterning and homeostatic roles
    João E Carvalho
    Sorbonne Universités, UPMC Universite Paris 06, CNRS, Laboratoire de Biologie du Développement de Villefranche sur Mer, Observatoire Oceanologique de Villefranche sur Mer, 181 Chemin du Lazaret, 06230, Villefranche sur Mer, France
    BMC Evol Biol 17:24. 2017
    ....
  64. pmc In Vivo Screening Using Transgenic Zebrafish Embryos Reveals New Effects of HDAC Inhibitors Trichostatin A and Valproic Acid on Organogenesis
    Ling Li
    Institut de Génomique Fonctionnelle de Lyon, Universite de Lyon, Universite Lyon 1, CNRS, INRA, Ecole Normale Superieure de Lyon, Lyon, France
    PLoS ONE 11:e0149497. 2016
    ..Our results show that EDCs can induce a large range of developmental alterations during embryogenesis of zebrafish and establish GFP transgenic lines as powerful tools to screen for EDCs effects in vivo. ..
  65. pmc RAR/RXR binding dynamics distinguish pluripotency from differentiation associated cis-regulatory elements
    Amandine Chatagnon
    Universite de Lyon, Universite Claude Bernard Lyon1, CGphiMC UMR CNRS 5534, 69622 Villeurbanne, France
    Nucleic Acids Res 43:4833-54. 2015
    ....
  66. ncbi request reprint The nuclear receptor superfamily
    Marc Robinson-Rechavi
    Laboratoire de Biologie Moleculaire et Cellulaire, UMR CNRS 5665, Ecole Normale Superieure de Lyon, 46 allee d Italie, 69364 Lyon Cedex 07, France
    J Cell Sci 116:585-6. 2003
  67. doi request reprint Heterochronic shifts explain variations in a sequentially developing repeated pattern: palatal ridges of muroid rodents
    Sophie Pantalacci
    Institut de Génomique Fonctionnelle de Lyon, Universite de Lyon, CNRS, INRA, Ecole Normale Superieure de Lyon, 69364 Lyon Cedex 07, France
    Evol Dev 11:422-33. 2009
    ..We also interpret our results in the light of developmental constraints specifically linked to this kind of process...
  68. ncbi request reprint A functionally conserved member of the FTZ-F1 nuclear receptor family from Schistosoma mansoni
    Ricardo L De Mendonça
    INSERM U 547, Institut Pasteur, Lille, France CNRS UMR 49, Ecole Normale Superieure de Lyon, Lyon, France
    Eur J Biochem 269:5700-11. 2002
    ..Moreover, SmFTZ-F1 transactivated reporter gene transcription from SFRE similarly to SF-1. This functional conservation argues for a conserved biological role of the FTZ-F1 nuclear receptor family throughout the metazoa...
  69. doi request reprint Thyroid hormones and postembryonic development in amniotes
    Guillaume Holzer
    Molecular Zoology Team, Institut de Génomique Fonctionnelle de Lyon, Ecole Normale Superieure de Lyon, UMR5242 CNRS, Universite Lyon, Lyon, France
    Curr Top Dev Biol 103:397-425. 2013
    ..Thus, according to this view, at the molecular level all vertebrates undergo a period of remodeling controlled by TH that is reminiscent of metamorphosis...
  70. pmc NUREBASE: database of nuclear hormone receptors
    Jorge Duarte
    Laboratoire de Biologie Moleculaire et Cellulaire, CNRS UMR 5665, Ecole Normale Superieure de Lyon, 46 allee d Italie, 69364 Lyon Cedex 07, France
    Nucleic Acids Res 30:364-8. 2002
    ..NUREBASE sequence data is also accessible through a World Wide Web server, allowing complex queries. All information on accessing and installing NUREBASE may be found at http://www.ens-lyon.fr/LBMC/laudet/nurebase.html...
  71. ncbi request reprint Analysis of lamprey and hagfish genes reveals a complex history of gene duplications during early vertebrate evolution
    Hector Escriva
    CNRS UMR 5665, Laboratoire de Biologie Moleculaire et Cellulaire, Ecole Normale Superieure de Lyon, Lyon Cedex, France
    Mol Biol Evol 19:1440-50. 2002
    ..Thus, the complexity of all the paralogy groups present in vertebrates should be explained by the contribution of genome duplications (2R hypothesis), extra gene duplications, and gene losses...
  72. doi request reprint ZebRA: An overview of retinoic acid signaling during zebrafish development
    Eric Samarut
    Institut de Génomique Fonctionnelle de Lyon, Ecole Normale Superieure de Lyon, CNRS UMR 5242, Universite Lyon 1, Universite de Lyon, 46 allee d Italie, 69364 Lyon Cedex 07, France
    Biochim Biophys Acta 1849:73-83. 2015
    ..This review demonstrates that the zebrafish is a convenient and powerful model to study retinoic acid signaling during vertebrate embryogenesis. This article is part of a Special Issue entitled: Nuclear receptors in animal development. ..
  73. pmc Identification, evolution and expression of an insulin-like peptide in the cephalochordate Branchiostoma lanceolatum
    Claire Lecroisey
    Molecular Zoology Team, Institut de Génomique Fonctionnelle de Lyon, Ecole Normale Superieure de Lyon, CNRS, Universite Lyon, Lyon, France
    PLoS ONE 10:e0119461. 2015
    ..We hypothesize that ILP has critical implications in both developmental processes and metabolism and could display IGF- and insulin-like functions in amphioxus supporting the idea of a common ancestral protein. ..
  74. pmc Stability versus diversity of the dentition during evolutionary radiation in cyprinine fish
    Emmanuel Pasco-Viel
    Evo devo of Vertebrate Dentition, Institut de Génomique Fonctionnelle de Lyon IGFL, UMR CNRS 5242, Universite de Lyon, Universite Claude Bernard Lyon 1, Ecole Normale Superieure de Lyon, Lyon, France, Molecular Zoology, Institut de Génomique Fonctionnelle de Lyon IGFL, UMR CNRS 5242, Universite de Lyon, Universite Claude Bernard Lyon 1, Ecole Normale Superieure de Lyon, Lyon, France, Department of Biology, Saint Louis University, St Louis, MO 63103, USA, Centre de Recherches sur la Paléobiodiversité et les Paléoenvironnements CRP2, Departement Histoire de la Terre, UMR CNRS 7207, Museum national d histoire naturelle, Paris, France, Laboratoire de Géologie de Lyon LGLTPE, UMR CNRS 5276, Universite de Lyon, Universite Claude Bernard Lyon 1, Ecole Normale Superieure de Lyon, Lyon, France
    Proc Biol Sci 281:20132688. 2014
    ..By integrating morphological, ecological and phylogenetic analyses, it becomes possible to investigate ancient radiation events that have shaped the present diversity of species. ..
  75. doi request reprint The cephalochordate amphioxus: a key to reveal the secrets of nuclear receptor evolution
    Claire Lecroisey
    Institut de Génomique Fonctionnelle de Lyon, UCBL, CNRS UMR, ENSL, INRA, Ecole Normale Superieure de Lyon, France
    Brief Funct Genomics 11:156-66. 2012
    ....
  76. doi request reprint Amphioxus spawning behavior in an artificial seawater facility
    Maria Theodosiou
    Institut de Génomique Fonctionnelle de Lyon, Universite Lyon 1, CNRS UMR5242, INRA 1288, Ecole Normale Superieure de Lyon, Lyon, France
    J Exp Zool B Mol Dev Evol 316:263-75. 2011
    ..Taken together, this work represents an important step toward further establishing amphioxus as a laboratory animal making it more amenable to experimental research, and hence assists the coming of age of this emerging model...
  77. doi request reprint Developmental constraints revealed by co-variation within and among molar rows in two murine rodents
    Sabrina Renaud
    Paléoenvironnements et Paléobiosphère, UMR 5125, CNRS, Universite Lyon 1, 69622 Villeurbanne, France
    Evol Dev 11:590-602. 2009
    ....