Reinhard Lange

Summary

Country: France

Publications

  1. ncbi request reprint My passion for extreme conditions to solve the cytochrome P450 and NO synthase reaction mechanisms
    Reinhard Lange
    INSERM U128, IFR122, 1919 Route de Mende, 34293 Montpellier Cedex 5, France
    Biochem Biophys Res Commun 312:103-7. 2003
  2. ncbi request reprint Modulation of prion protein structure by pressure and temperature
    Joan Torrent
    INSERM U710, CC 105, IFR 122, Universite Montpellier 2, Place Eugene Bataillon, F 34095 Montpellier Cedex 5, France
    Biochim Biophys Acta 1764:546-51. 2006
  3. ncbi request reprint Alternative prion structural changes revealed by high pressure
    Joan Torrent
    INSERM U128, 1919 Route de Mende, F 34293 Montpellier cedex 5, France
    Biochemistry 42:1318-25. 2003
  4. ncbi request reprint Structural instability and fibrillar aggregation of non-expanded human ataxin-3 revealed under high pressure and temperature
    Stephane Marchal
    INSERM U128, IFR 122, 1919 Route de Mende, F 34293 Montpellier cedex 5, France
    J Biol Chem 278:31554-63. 2003
  5. ncbi request reprint Hunting oxygen complexes of nitric oxide synthase at low temperature and high pressure
    Stephane Marchal
    INSERM U710, Place Eugene Bataillon, Universite Montpellier II, Montpellier, France
    Biochem Biophys Res Commun 338:529-35. 2005
  6. pmc The role of the 132-160 region in prion protein conformational transitions
    Joan Torrent
    INSERM U710, CC 105, Université de Montpellier 2, Place Eugene Bataillon, F 34095 Montpellier Cedex 5, France
    Protein Sci 14:956-67. 2005
  7. ncbi request reprint High-pressure studies of the reaction mechanism of nitric-oxide synthase
    Antonius C F Gorren
    Institut fur Pharmakologie und Toxikologie, Karl Franzens Universitat Graz, Universitatsplatz 2, A 8010 Graz, Austria
    Biochim Biophys Acta 1764:578-85. 2006
  8. pmc Pressure equilibrium and jump study on unfolding of 23-kDa protein from spinach photosystem II
    Cui Yan Tan
    Key Laboratory of Proteomics, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, The Chinese Academy of Sciences, Shanghai, China
    Biophys J 88:1264-75. 2005
  9. ncbi request reprint Pressure- and temperature-induced unfolding studies: thermodynamics of core hydrophobicity and packing of ribonuclease A
    Josep Font
    Laboratori d Enginyeria de Proteïnes, Departament de Biologia, Facultat de Ciencies, Universitat de Girona, Campus de Montilivi s n, E 17071 Girona, Spain
    Biol Chem 387:285-96. 2006
  10. ncbi request reprint High pressure induces scrapie-like prion protein misfolding and amyloid fibril formation
    Joan Torrent
    Université de Montpellier 2, EA3763, Place Eugene Bataillon, F 34095 Montpellier Cedex 5, France
    Biochemistry 43:7162-70. 2004

Collaborators

  • Joan Torrent
  • Claude Balny
  • Antonius C F Gorren
  • Rikimaru Hayashi
  • Robert Phillips
  • Peter McPhie
  • Frederic Heitz
  • R Casadio
  • Stephane Marchal
  • Bernd Mayer
  • Josep Font
  • K Kristoffer Andersson
  • Morten Sørlie
  • Driss El Moustaine
  • Henrik Zakariassen
  • Antoni Benito
  • Emanuela Occhipinti
  • Maria Vilanova
  • Marc Ribo
  • Toru Shimizu
  • Cui Yan Tan
  • Paolo Tortora
  • M Judith Kornblatt
  • Nicole Bec
  • Maria Teresa Alvarez-Martinez
  • Michiko Kato
  • Morten Sorlie
  • Eri Chatani
  • Christiane Jung
  • Frédéric Bancel
  • Veronique Perrier
  • Espen Harbitz
  • Laszlo Smeller
  • F Henning Cederkvist
  • Gabriella Baietta
  • Pier Luigi Martelli
  • Benedetta Gambirasio
  • Jun Wong
  • Shinsuke Sakuma
  • Chun He Xu
  • Yasusi Yamamoto
  • Kang Cheng Ruan
  • Jian Ren Shen
  • Kristoffer K Andersson
  • Erlet Shehi
  • Paola Fusi
  • Yasuhiro Sato
  • Kumiko Shirai
  • Hazel Mary Girvan
  • Jean Michel Verdier
  • Jean Pierre Liautard
  • Marie Cécile Harricane
  • Andrew William Munro
  • Pavel Anzenbacher
  • Gaston Hui Bon Hoa
  • Kazuhiko Nonomura

Detail Information

Publications30

  1. ncbi request reprint My passion for extreme conditions to solve the cytochrome P450 and NO synthase reaction mechanisms
    Reinhard Lange
    INSERM U128, IFR122, 1919 Route de Mende, 34293 Montpellier Cedex 5, France
    Biochem Biophys Res Commun 312:103-7. 2003
    ..These exciting achievements were initiated by numerous discussions with Professor Gunsalus and also reflect a long-lasting collaboration and friendship...
  2. ncbi request reprint Modulation of prion protein structure by pressure and temperature
    Joan Torrent
    INSERM U710, CC 105, IFR 122, Universite Montpellier 2, Place Eugene Bataillon, F 34095 Montpellier Cedex 5, France
    Biochim Biophys Acta 1764:546-51. 2006
    ..In this paper, we discuss the mechanism and the origin of these opposing effects of pressure, taking the truncated form of hamster prion protein (SHaPrP(90-231)) as a model...
  3. ncbi request reprint Alternative prion structural changes revealed by high pressure
    Joan Torrent
    INSERM U128, 1919 Route de Mende, F 34293 Montpellier cedex 5, France
    Biochemistry 42:1318-25. 2003
    ..At pressures over 400 MPa, strong thioflavin-T binding was observed, suggesting a further structural change to a metastable oligomeric structure...
  4. ncbi request reprint Structural instability and fibrillar aggregation of non-expanded human ataxin-3 revealed under high pressure and temperature
    Stephane Marchal
    INSERM U128, IFR 122, 1919 Route de Mende, F 34293 Montpellier cedex 5, France
    J Biol Chem 278:31554-63. 2003
    ..Several intermediate structures were detected in this process. Two factors appear to govern ataxin unfolding and aggregation, the length of the polyglutamine tract and its protein context...
  5. ncbi request reprint Hunting oxygen complexes of nitric oxide synthase at low temperature and high pressure
    Stephane Marchal
    INSERM U710, Place Eugene Bataillon, Universite Montpellier II, Montpellier, France
    Biochem Biophys Res Commun 338:529-35. 2005
    ..Finally, work in the presence of a BH4 analog indicated that proton transfer to the activated oxygen complex is a second essential function of BH4...
  6. pmc The role of the 132-160 region in prion protein conformational transitions
    Joan Torrent
    INSERM U710, CC 105, Université de Montpellier 2, Place Eugene Bataillon, F 34095 Montpellier Cedex 5, France
    Protein Sci 14:956-67. 2005
    ..Furthermore, salt-induced conformational changes suggested a structural stabilizing role of Tyr150 and Phe141 residues, slowing down the conversion to a beta-sheet form...
  7. ncbi request reprint High-pressure studies of the reaction mechanism of nitric-oxide synthase
    Antonius C F Gorren
    Institut fur Pharmakologie und Toxikologie, Karl Franzens Universitat Graz, Universitatsplatz 2, A 8010 Graz, Austria
    Biochim Biophys Acta 1764:578-85. 2006
    ..This exposition is followed by a summary of the results obtained thus far in high-pressure studies and of the conclusions that can be drawn from them...
  8. pmc Pressure equilibrium and jump study on unfolding of 23-kDa protein from spinach photosystem II
    Cui Yan Tan
    Key Laboratory of Proteomics, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, The Chinese Academy of Sciences, Shanghai, China
    Biophys J 88:1264-75. 2005
    ..The diverse pressure-refolding pathways of 23-kDa protein in some conditions were revealed in pressure-jump kinetics...
  9. ncbi request reprint Pressure- and temperature-induced unfolding studies: thermodynamics of core hydrophobicity and packing of ribonuclease A
    Josep Font
    Laboratori d Enginyeria de Proteïnes, Departament de Biologia, Facultat de Ciencies, Universitat de Girona, Campus de Montilivi s n, E 17071 Girona, Spain
    Biol Chem 387:285-96. 2006
    ....
  10. ncbi request reprint High pressure induces scrapie-like prion protein misfolding and amyloid fibril formation
    Joan Torrent
    Université de Montpellier 2, EA3763, Place Eugene Bataillon, F 34095 Montpellier Cedex 5, France
    Biochemistry 43:7162-70. 2004
    ..Both aggregate types were resistant to digestion by PK, and can be considered as potential scrapie-like forms or precursors. These results may be useful for the search for compounds preventing pathogenic PrP misfolding and aggregation...
  11. pmc The contribution of the residues from the main hydrophobic core of ribonuclease A to its pressure-folding transition state
    Josep Font
    Laboratori d Enginyeria de Proteïnes, Departament de Biologia, Facultat de Ciencies, Universitat de Girona, 17071 Girona, Spain
    Protein Sci 15:1000-9. 2006
    ....
  12. ncbi request reprint Comparison of heat- and pressure-induced unfolding of ribonuclease a: the critical role of Phe46 which appears to belong to a new hydrophobic chain-folding initiation site
    Eri Chatani
    Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Biochemistry 41:4567-74. 2002
    ..Mutation of Phe46 decreases protein stability by weakening the unfolding cooperativity between these domains. This essential function of Phe46 in RNase A stability indicates that it belongs to a chain-folding initiation site...
  13. ncbi request reprint The propeptide in the precursor form of carboxypeptidase Y ensures cooperative unfolding and the carbohydrate moiety exerts a protective effect against heat and pressure
    Michiko Kato
    Laboratory of Biomacromolecular Chemistry, Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Japan
    Eur J Biochem 270:4587-93. 2003
    ..The carbohydrate moiety has a slightly protective role in heat-induced unfolding and a highly protective role in pressure-induced unfolding...
  14. ncbi request reprint UV-visible derivative spectroscopy under high pressure
    Reinhard Lange
    INSERM, Unité 128, IFR 24, CNRS, Montpellier, France
    Biochim Biophys Acta 1595:80-93. 2002
    ..How to detect these changes? In this paper, via some selected examples, we show the potentiality (but also the limits) of the ultraviolet derivative spectroscopy specially adapted to high pressure experiments...
  15. doi request reprint Full-length prion protein aggregates to amyloid fibrils and spherical particles by distinct pathways
    Driss El Moustaine
    UMR S710 Unit, Département Biologie Santé, Universite Montpellier 2, France
    FEBS J 275:2021-31. 2008
    ..The use of high-pressure perturbation thus provides an insight into the molecular mechanism of the first stages of PrP misfolding into amyloids...
  16. pmc Distinct unfolding and refolding pathways of ribonuclease a revealed by heating and cooling temperature jumps
    Joan Torrent
    Universite Montpellier 2, UMR S710, and INSERM Unit 710, Montpellier, France
    Biophys J 94:4056-65. 2008
    ..A very fast protein folding/unfolding phase appears to precede both processes. The path dependence of the observed kinetics is suggestive of a rugged energy protein folding funnel...
  17. ncbi request reprint High pressure: a new tool to study P450 structure and function
    Frédéric Bancel
    French National Institute for Health and Medical Research U 128, IFR 24, F 34293 Montpellier, France
    Methods Enzymol 357:145-57. 2002
  18. ncbi request reprint Optimized overproduction, purification, characterization and high-pressure sensitivity of the prion protein in the native (PrP(C)-like) or amyloid (PrP(Sc)-like) conformation
    Maria Teresa Alvarez-Martinez
    INSERM U431, CC100, Dept Biologie Sante, Université de Montpellier 2, Place Eugene Bataillon, F 34095 Montpellier Cedex 5, France
    Biochim Biophys Acta 1645:228-40. 2003
    ....
  19. pmc Formation of transient oxygen complexes of cytochrome p450 BM3 and nitric oxide synthase under high pressure
    Stephane Marchal
    Institut National de la Sante et de la Recherche Medicale, Montpellier, France
    Biophys J 85:3303-9. 2003
    ..Altogether, high pressure appears to be a useful tool to characterize elementary steps in the reaction cycle of heme-thiolate proteins...
  20. ncbi request reprint Pressure and temperature as tools for investigating the role of individual non-covalent interactions in enzymatic reactions Sulfolobus solfataricus carboxypeptidase as a model enzyme
    Emanuela Occhipinti
    Department of Biotechnology and Biosciences, University of Milano Bicocca, Piazza della Scienza 2, I 20126 Milano, Italy
    Biochim Biophys Acta 1764:563-72. 2006
    ..e., stacking and van der Waals) are mainly involved, but their contribution varies strongly, probably due to changes in the conformational state of the enzyme...
  21. ncbi request reprint High pressure modulates amyloid formation
    Joan Torrent
    INSERM U710, CC 105, Universite Montpellier 2, Place Eugene Bataillon, F 34095 Montpellier Cedex 5, France
    Protein Pept Lett 13:271-7. 2006
    ..High pressure can also be used to dissociate aggregates and amyloid fibrils or on the opposite to generate such species...
  22. ncbi request reprint Quantitative effects of allosteric ligands and mutations on conformational equilibria in Salmonella typhimurium tryptophan synthase
    Robert S Phillips
    Department of Chemistry, University of Georgia, 1001 Cedar Street, Athens, GA 30602 2556, USA
    Arch Biochem Biophys 470:8-19. 2008
    ..These allosteric effects are finely tuned to control the synthesis of l-Trp without resulting in substrate or product inhibition...
  23. ncbi request reprint The use of pressure-jump relaxation kinetics to study protein folding landscapes
    Joan Torrent
    INSERM U710, Universite Montpellier 2, CC105, Place Eugene Bataillon, 34095 Montpellier Cedex 5, France
    Biochim Biophys Acta 1764:489-96. 2006
    ..These results cannot be explained by sequential reaction schemes. Instead, they are in line with a more complex free energy landscape involving multiple pathways...
  24. ncbi request reprint Use of hydrostatic pressure to produce 'native' monomers of yeast enolase
    M Judith Kornblatt
    Department of Chemistry and Biochemistry, Concordia University, Montreal, Quebec H4B 1R6, Canada
    Eur J Biochem 271:3897-904. 2004
    ....
  25. ncbi request reprint CO exchange of the oxyferrous complexes of endothelial nitric-oxide synthase oxygenase domain in the presence of 4-amino-tetrahydrobiopterin
    Stephane Marchal
    INSERM U431, Département Biologie Santé, Universite Montpellier II, IFR 122, Montpellier, France
    J Inorg Biochem 98:1217-22. 2004
    ....
  26. ncbi request reprint Evidence of two distinct oxygen complexes of reduced endothelial nitric oxide synthase
    Stephane Marchal
    INSERM U431, Département Biologie Santé, Universite Montpellier II, IFR 122, Place Eugene Bataillon, 34095 Montpellier Cedex 5, France
    J Biol Chem 279:19824-31. 2004
    ..Heme-oxy II, which is the oxygen complex competent for product formation, appears to represent a distinct conformation in which the electronic configuration is essentially locked in the ferric superoxide complex...
  27. ncbi request reprint Single-turnover of nitric-oxide synthase in the presence of 4-amino-tetrahydrobiopterin: proposed role for tetrahydrobiopterin as a proton donor
    Morten Sorlie
    Department of Chemistry and Biotechnology, Agricultural University of Norway, PO Box 5040, N 1432 As, Norway
    J Biol Chem 278:48602-10. 2003
    ..NO and reduced 4-amino-BH4. These results suggest that BH4 donates a proton to Fe(II).O2- during catalysis and that inhibition by 4-amino-BH4 may be due to its inability to support this essential protonation step...
  28. ncbi request reprint Redox role for tetrahydrobiopterin in nitric oxide synthase catalysis: low-temperature optical absorption spectral detection
    Antonius C F Gorren
    Institute for Pharmacology and Toxicology, Karl Franzens Universitat Graz, A 8010 Graz, Austria
    Methods Enzymol 353:114-21. 2002
  29. ncbi request reprint Substrates modulate the rate-determining step for CO binding in cytochrome P450cam (CYP101). A high-pressure stopped-flow study
    Christiane Jung
    Max Delbruck Center for Molecular Medicine, Protein Dynamics Laboratory, Berlin, Germany
    Eur J Biochem 269:2989-96. 2002
    ..In addition, subconformers have been found for the substrate-free and camphane-bound protein which show different CO binding kinetics...
  30. doi request reprint Thermodynamic analysis of L-arginine and N omega-hydroxy-L-arginine binding to nitric oxide synthase
    Henrik Zakariassen
    Department of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, P O Box 5003, N 1432 Aas, Norway
    Biochim Biophys Acta 1784:806-10. 2008
    ..The changes in heat capacity (DeltaC(p)) are relatively small for binding of both NHA and L-Arg (-53+/-18 and -95+/-23 cal/L mol, respectively), which indicates that hydrophobic interactions contribute little to binding...