Laurent Kiger

Summary

Country: France

Publications

  1. doi request reprint Dynamics of α-Hb chain binding to its chaperone AHSP depends on heme coordination and redox state
    Laurent Kiger
    INSERM, U779, University Paris 11, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre, France Electronic address
    Biochim Biophys Acta 1840:277-87. 2014
  2. pmc Globin-like proteins in Caenorhabditis elegans: in vivo localization, ligand binding and structural properties
    Eva Geuens
    Department of Biomedical Sciences, University of Antwerp, Universiteitsplein 1, B 2610 Antwerp, Belgium
    BMC Biochem 11:17. 2010
  3. pmc Electron transfer function versus oxygen delivery: a comparative study for several hexacoordinated globins across the animal kingdom
    Laurent Kiger
    INSERM U779, Universities Paris VI and XI, Le Kremlin Bicetre, France
    PLoS ONE 6:e20478. 2011
  4. ncbi request reprint Hyperthermal stability of neuroglobin and cytoglobin
    Djemel Hamdane
    INSERM U473, Le Kremlin Bicetre, France
    FEBS J 272:2076-84. 2005
  5. ncbi request reprint High pressure enhances hexacoordination in neuroglobin and other globins
    Djemel Hamdane
    INSERM U473, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre, France
    J Biol Chem 280:36809-14. 2005
  6. doi request reprint Cytoglobin conformations and disulfide bond formation
    Christophe Lechauve
    INSERM U779, Universités Paris VI et XI, Le Kremlin Bicetre, France
    FEBS J 277:2696-704. 2010
  7. pmc Alpha-hemoglobin stabilizing protein (AHSP), a kinetic scheme of the action of a human mutant, AHSPV56G
    Thomas Brillet
    INSERM U779, Universite de Paris 7, 11 CHU Bicêtre, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre, France
    J Biol Chem 285:17986-92. 2010
  8. ncbi request reprint Neuroglobin ligand binding kinetics
    Laurent Kiger
    INSERM U473, 94275 Le Kremlin Bicetre, France
    IUBMB Life 56:709-19. 2004
  9. doi request reprint Octamers and nanoparticles as hemoglobin based blood substitutes
    Veronique Baudin-Creuza
    Institut National de la Sante et de la Recherche Medicale, INSERM U779, University of Paris XI, 94275 Le Kremlin Bicetre, France
    Biochim Biophys Acta 1784:1448-53. 2008
  10. doi request reprint Neuroglobin and prion cellular localization: investigation of a potential interaction
    Christophe Lechauve
    INSERM U779, Universités Paris VI et XI, Hopital de Bicetre, Le Kremlin Bicetre, France
    J Mol Biol 388:968-77. 2009

Collaborators

Detail Information

Publications17

  1. doi request reprint Dynamics of α-Hb chain binding to its chaperone AHSP depends on heme coordination and redox state
    Laurent Kiger
    INSERM, U779, University Paris 11, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre, France Electronic address
    Biochim Biophys Acta 1840:277-87. 2014
    ..AHSP is an erythroid molecular chaperone of the α-hemoglobin chains (α-Hb). Upon AHSP binding, native ferric α-Hb undergoes an unprecedented structural rearrangement at the heme site giving rise to a 6th coordination bond with His(E7)...
  2. pmc Globin-like proteins in Caenorhabditis elegans: in vivo localization, ligand binding and structural properties
    Eva Geuens
    Department of Biomedical Sciences, University of Antwerp, Universiteitsplein 1, B 2610 Antwerp, Belgium
    BMC Biochem 11:17. 2010
    ..No information is available on the physicochemical properties and the in vivo expression...
  3. pmc Electron transfer function versus oxygen delivery: a comparative study for several hexacoordinated globins across the animal kingdom
    Laurent Kiger
    INSERM U779, Universities Paris VI and XI, Le Kremlin Bicetre, France
    PLoS ONE 6:e20478. 2011
    ..These efficient mechanisms for electron transfer could indicate a family of hexacoordinated globin which are functionally different from that of pentacoordinated globins...
  4. ncbi request reprint Hyperthermal stability of neuroglobin and cytoglobin
    Djemel Hamdane
    INSERM U473, Le Kremlin Bicetre, France
    FEBS J 272:2076-84. 2005
    ....
  5. ncbi request reprint High pressure enhances hexacoordination in neuroglobin and other globins
    Djemel Hamdane
    INSERM U473, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre, France
    J Biol Chem 280:36809-14. 2005
    ....
  6. doi request reprint Cytoglobin conformations and disulfide bond formation
    Christophe Lechauve
    INSERM U779, Universités Paris VI et XI, Le Kremlin Bicetre, France
    FEBS J 277:2696-704. 2010
    ..An internal disulfide bond may form which modifies the rate of dissociation of the distal histidine and apparently leads to different cytoglobin conformations, which may affect the observed oxygen affinity by an order of magnitude...
  7. pmc Alpha-hemoglobin stabilizing protein (AHSP), a kinetic scheme of the action of a human mutant, AHSPV56G
    Thomas Brillet
    INSERM U779, Universite de Paris 7, 11 CHU Bicêtre, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre, France
    J Biol Chem 285:17986-92. 2010
    ..The overall replacement reaction (AHSP.alpha-Hb + beta-Hb --> AHSP + alphabeta) can be quite long, especially if there is an excess of AHSP relative to beta-Hb monomers...
  8. ncbi request reprint Neuroglobin ligand binding kinetics
    Laurent Kiger
    INSERM U473, 94275 Le Kremlin Bicetre, France
    IUBMB Life 56:709-19. 2004
    ..This effect could be of biological relevance for certain organisms, since it would lead to an oxygen affinity that is nearly independent of temperature...
  9. doi request reprint Octamers and nanoparticles as hemoglobin based blood substitutes
    Veronique Baudin-Creuza
    Institut National de la Sante et de la Recherche Medicale, INSERM U779, University of Paris XI, 94275 Le Kremlin Bicetre, France
    Biochim Biophys Acta 1784:1448-53. 2008
    ..After a general introduction of these basic criteria, we will focus on two strategies concerning the size of the oxygen transporter: Hb octamers, and Hb integrated within a nanoparticle...
  10. doi request reprint Neuroglobin and prion cellular localization: investigation of a potential interaction
    Christophe Lechauve
    INSERM U779, Universités Paris VI et XI, Hopital de Bicetre, Le Kremlin Bicetre, France
    J Mol Biol 388:968-77. 2009
    ....
  11. doi request reprint Kinetics inside the protein: shape of the geminate kinetics in myoglobin
    Djemel Hamdane
    INSERM U779, University Paris 11, 94275 Le Kremlin Bicetre, France
    J Phys Chem B 115:3919-23. 2011
    ..Samples with glycerol display the extended geminate kinetics, while samples in water under pressure do not...
  12. pmc Neuroglobins, pivotal proteins associated with emerging neural systems and precursors of metazoan globin diversity
    Christophe Lechauve
    INSERM, UMR S 968, Centre National de la Recherche Scientifique CNRS, Unité Mixte de Recherche UMR _7210, Institut de la Vision Université Pierre et Marie Curie UPMC Centre Hospitalier National d Ophtalmologie des Quinze Vingts, 17 rue Moreau, 75012 Paris, France
    J Biol Chem 288:6957-67. 2013
    ..e. convergent evolution)...
  13. pmc Heme ligand binding properties and intradimer interactions in the full-length sensor protein dos from Escherichia coli and its isolated heme domain
    Christophe Lechauve
    INSERM U779, Universités Paris VI et XI, 94276 Le Kremlin Bicetre, France
    J Biol Chem 284:36146-59. 2009
    ..Dimerization effects were also observed for cyanide binding to the ferric heme domains, suggesting a similar role for Met-95 in ferric proteins...
  14. doi request reprint Structure and function evolution in the superfamily of globins
    Henri Wajcman
    INSERM U841, Equipe 11, CHU Henri Mondor, 94010 Creteil, France
    C R Biol 332:273-82. 2009
    ..All these aspects are discussed in this review...
  15. ncbi request reprint Exploiting a list of protein sequences
    Michael C Marden
    Department of Biomedical Sciences, University of Antwerp, B 2610 Antwerp, Belgium
    Gene 398:35-41. 2007
    ..Examples are shown based on globin sequences from various species and on the abnormal human hemoglobins. The software should be of interest to protein engineers who need to know what variants are already known...
  16. ncbi request reprint [Hemoglobin, from microorganisms to man: a single structural motif, multiple functions]
    Henri Wajcman
    INSERM U468, Hopital Henri Mondor, 94010 Creteil, France
    C R Biol 325:1159-74. 2002
    ..In some species, several haemoglobins, with completely different structure and function, may coexist. This demonstrates how hazardous may be to extrapolate the function of a protein from only structural data...
  17. pmc Control of the allosteric equilibrium of hemoglobin by cross-linking agents
    Michael C Marden
    INSERM U473, Hopital de Bicetre, 94276 Le Kremlin Bicetre Cedex, France
    Protein Sci 11:1376-83. 2002
    ....