- Efficacy of ertapenem in severe hidradenitis suppurativa: a pilot study in a cohort of 30 consecutive patientsOlivier Join-Lambert
Universite Paris Descartes, Sorbonne Paris Cité, Paris, France Laboratoire de Microbiologie, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, Paris, France Centre d infectiologie Necker Pasteur, Paris, France INSERM U1151, eq 11, Paris, France
J Antimicrob Chemother 71:513-20. 2016..This study was designed to assess the efficacy of a 6 week course of ertapenem (1 g daily) and of antibiotic consolidation treatments for 6 months (M6) in severe HS...
- The complete genome sequence of Corynebacterium pseudotuberculosis FRC41 isolated from a 12-year-old girl with necrotizing lymphadenitis reveals insights into gene-regulatory networks contributing to virulenceEva Trost
Institut für Genomforschung und Systembiologie, Centrum für Biotechnologie, Universitat Bielefeld, Bielefeld, Germany
BMC Genomics 11:728. 2010..To detect potential virulence factors and corresponding gene-regulatory networks in this human isolate, the genome sequence of C. pseudotuberculosis FCR41 was determined by pyrosequencing and functionally annotated...
- Mechanisms of meningeal invasion by a bacterial extracellular pathogen, the example of Neisseria meningitidisOlivier Join-Lambert
INSERM, Unité 570, 156 rue de Vaugirard, 75015 Paris, France
Prog Neurobiol 91:130-9. 2010..meningitidis is also able to recruit the polarity complex Par3/Par6/aPKC that re-routes endothelial cell adhesion molecules of interendothelial junctions, opening a paracellular route for bacteria to cross the endothelial barrier...
- Efficacy of rifampin-moxifloxacin-metronidazole combination therapy in hidradenitis suppurativaOlivier Join-Lambert
Universite Paris Descartes, Faculté de Médecine Paris Descartes, Paris, France
Dermatology 222:49-58. 2011..Antibiotics have been shown to improve hidradenitis suppurativa (HS) patients but complete remission is rare using these treatments...
- Remission of refractory pyoderma gangrenosum, severe acne, and hidradenitis suppurativa (PASH) syndrome using targeted antibiotic therapy in 4 patientsOlivier Join-Lambert
INSERM U1151 eq 11, Université Paris Descartes Sorbonne Paris Cité, Laboratory of Microbiology, Necker Enfants Malades Hospital, Paris, France
J Am Acad Dermatol 73:S66-9. 2015..To date, anecdotal reports support the use of surgery and medical therapy, but controlled investigations with extended follow-up are necessary to substantiate preliminary data observed with individual cases. ..
- Neisseria meningitidis colonization of the brain endothelium and cerebrospinal fluid invasionFlorence Miller
INSERM, unité U1002, Paris, France Université Paris Descartes, Sorbonne Paris Cité, Faculte de Medecine, Paris, France
Cell Microbiol 15:512-9. 2013..In this review, strategies used by the bacteria to survive in the bloodstream, to colonize the brain vasculature and to cross the blood-brain barrier will be discussed...
- Piperacillin/tazobactam as an alternative antibiotic therapy to carbapenems in the treatment of urinary tract infections due to extended-spectrum β-lactamase-producing Enterobacteriaceae: an in silico pharmacokinetic studyHélène Guet-Revillet
Universite Paris Descartes, Paris, France Service de Microbiologie hygiène hospitalière, Hopital Necker Enfants Malades, AP HP, Paris, France
Int J Antimicrob Agents 49:62-66. 2017..Conversely, for ESBL-Kp the risk of treatment failure may be higher, supporting the use of continuous infusion...
- Mechanism of meningeal invasion by Neisseria meningitidisMathieu Coureuil
INSERM U1002, Paris, France
Virulence 3:164-72. 2012..The consequence of these bacterial-induced signaling events is the recruitment of intercellular junction components in the docking structure and the subsequent opening of the intercellular junctions...
- Horizontal transmission of Streptococcus pneumoniae in the surgical ward: a rare source of nosocomial wound infectionMarlène Guillet
Microbiology Infection Control Unit, Necker Hospital, Assistance Public Hospital of Paris, Paris, France
Am J Infect Control 40:71-2. 2012..The likely source was detected in the rhinopharynx of the surgeon. After the implementation of recommendations, no new cases have been recorded...
- Human listeriosis caused by Listeria ivanoviiChristelle Guillet
Universite Paris Descartes, Paris, France
Emerg Infect Dis 16:136-8. 2010..We report L. ivanovii-associated gastroenteritis and bacteremia in a man. This isolate was indistinguishable from prototypic ruminant strains. L. ivanovii is thus an enteric opportunistic human pathogen...
- Experimental Evidence of Bacterial Colonization of Human Coronary Microvasculature and Myocardial Tissue during MeningococcemiaJean Bergounioux
INSERM, U1151, Institut Necker Enfants Malades, Paris, France Université Versailles Saint Quentin en Yvelines, Versailles, France Service de Neurologie et Réanimation pédiatrique, Hopital Raymond Poincare, APHP, Garches, France
Infect Immun 84:3017-23. 2016..These results suggest a novel mechanism of myocardial injury in the course of severe N. meningitidis sepsis that is likely to participate in primary myocardial dysfunction. ..
- Pasteurella multocida sepsis and meningitis in 2-month-old twin infants after household exposure to a slaughtered sheepChristelle Guillet
Microbiology Laboratory, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, Paris, France
Clin Infect Dis 45:e80-1. 2007..These cases emphasize the necessity of respecting basic hygiene rules and the danger involved in animal sacrifice without suitable professional structure...
- Monitoring of blood vessels and tissues by a population of monocytes with patrolling behaviorCedric Auffray
Institut Nationale de la Santé et de la Recherche Médicale INSERM U838, Laboratory of Biology of the Mononuclear Phagocyte System, and Cellular and Molecular imaging core facility, Institut Federatif de Recherche Necker Enfants Malades, Paris, France
Science 317:666-70. 2007....
- ESBL-producing enterobacteriaceae-related urinary tract infections in kidney transplant recipients: incidence and risk factors for recurrenceBenoit Pilmis
From the Service de Maladies Infectieuses et Tropicales, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, IHU Imagine, Paris, France
Infect Dis (Lond) 47:714-8. 2015....
- Contribution of molecular tools for the diagnosis of endogenous pneumococcal endophthalmitis in a patient with the acquired immunodeficiency syndromeMarie Olivia Chandesris
Departments of Infectious Diseases and Tropical Medicine, Necker Enfants Malades Hospital, Paris, France
Scand J Infect Dis 39:1080-1. 2007..Here we report the first case of Streptococcus pneumoniae endophthalmitis diagnosed by polymerase chain reaction. Molecular biology should be considered as a new tool for the diagnosis of such sequestered sites as the eye...
- Pathogenic Neisseria meningitidis utilizes CD147 for vascular colonizationSandra C Bernard
1 INSERM, U1016, Institut Cochin, Paris, France 2 CNRS, UMR8104, Paris, France 3 Université Paris Descartes, Sorbonne Paris Cité, Paris, France 4 Université Paris Diderot, Paris, France 5
Nat Med 20:725-31. 2014..These findings establish the molecular events by which meningococci target human endothelia, and they open new perspectives for treatment and prevention of meningococcus-induced vascular dysfunctions. ..
- Rapid eradication of Listeria monocytogenes by moxifloxacin in a murine model of central nervous system listeriosisSolène Grayo
Laboratoire de Listeria, Centre National de Référence des Listeria, World Health Organization Collaborating Centre for Foodborne Listeriosis, Institut Pasteur, Paris, France
Antimicrob Agents Chemother 52:3210-5. 2008..Our results indicate that moxifloxacin combines useful pharmacokinetic properties and rapid bactericidal activity and that it may be a valuable alternative for the treatment of CNS listeriosis...