Pierre Hainaut

Summary

Affiliation: International Agency for Research on Cancer
Country: France

Publications

  1. pmc TP53 Mutations and HBX Status Analysis in Hepatocellular Carcinomas from Iran: Evidence for Lack of Association between HBV Genotype D and TP53 R249S Mutations
    Behnoush Abedi-Ardekani
    Mechanisms of Carcinogenesis Section, Molecular Carcinogenesis Group, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon, France
    Hepat Res Treat 2011:475965. 2011
  2. pmc Extremely high Tp53 mutation load in esophageal squamous cell carcinoma in Golestan Province, Iran
    Behnoush Abedi-Ardekani
    Digestive Disease Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
    PLoS ONE 6:e29488. 2011
  3. pmc Mutations in TP53 and CTNNB1 in Relation to Hepatitis B and C Infections in Hepatocellular Carcinomas from Thailand
    Olivier Galy
    INSERM U1052, 151 Cours Albert Thomas, 69003 Lyon, France
    Hepat Res Treat 2011:697162. 2011
  4. pmc The role of the pathologist in tissue banking: European Consensus Expert Group Report
    Generoso Bevilacqua
    Division of Surgical, Molecular and Ultrastructural Pathology, University of Pisa and Pisa University Hospital, Medical School, Via Roma 57, 56126 Pisa, Italy
    Virchows Arch 456:449-54. 2010
  5. pmc Biological characterization of two xenografts derived from human CUPs (carcinomas of unknown primary)
    Delphine Lequin
    Universite Paris Sud, CNRS UMR 8126 and Institut Gustave Roussy, 39 rue Camille Desmoulins, F 94805 Villejuif, France
    BMC Cancer 7:225. 2007
  6. doi 30 years and a long way into p53 research
    Pierre Hainaut
    International Agency for Research on Cancer, Lyon, France
    Lancet Oncol 10:913-9. 2009
  7. doi The European Prospective Investigation into Cancer and Nutrition biobank
    Pierre Hainaut
    International Agency for Research on Cancer, Lyon, France
    Methods Mol Biol 675:179-91. 2011
  8. ncbi Zinc binding and redox control of p53 structure and function
    P Hainaut
    Group of Molecular Carcinogenesis, International Agency for Research on Cancer, Lyon, France
    Antioxid Redox Signal 3:611-23. 2001
  9. ncbi Patterns of p53 G-->T transversions in lung cancers reflect the primary mutagenic signature of DNA-damage by tobacco smoke
    P Hainaut
    International Agency for Research on Cancer WHO, 150 cours Albert Thomas, 69372 Lyon Cedex, France
    Carcinogenesis 22:367-74. 2001
  10. pmc IARC Database of p53 gene mutations in human tumors and cell lines: updated compilation, revised formats and new visualisation tools
    P Hainaut
    International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
    Nucleic Acids Res 26:205-13. 1998

Detail Information

Publications120 found, 100 shown here

  1. pmc TP53 Mutations and HBX Status Analysis in Hepatocellular Carcinomas from Iran: Evidence for Lack of Association between HBV Genotype D and TP53 R249S Mutations
    Behnoush Abedi-Ardekani
    Mechanisms of Carcinogenesis Section, Molecular Carcinogenesis Group, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon, France
    Hepat Res Treat 2011:475965. 2011
    ..This paper suggests that association between HBV genotype D and aflatoxin-induced TP53 mutation is uncommon, explaining the relatively lower incidence of HCC in areas where genotype D is highly prevalent...
  2. pmc Extremely high Tp53 mutation load in esophageal squamous cell carcinoma in Golestan Province, Iran
    Behnoush Abedi-Ardekani
    Digestive Disease Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
    PLoS ONE 6:e29488. 2011
    ..We have analyzed TP53 mutation patterns in tumors from this high-risk geographic area in search of clues to the mutagenic processes involved in causing ESCC...
  3. pmc Mutations in TP53 and CTNNB1 in Relation to Hepatitis B and C Infections in Hepatocellular Carcinomas from Thailand
    Olivier Galy
    INSERM U1052, 151 Cours Albert Thomas, 69003 Lyon, France
    Hepat Res Treat 2011:697162. 2011
    ..TP53 and CTNNB1 mutations were not mutually exclusive, and most of TP53 mutations were R249S, suggesting a significant impact of aflatoxin-induced mutagenesis in HCC development...
  4. pmc The role of the pathologist in tissue banking: European Consensus Expert Group Report
    Generoso Bevilacqua
    Division of Surgical, Molecular and Ultrastructural Pathology, University of Pisa and Pisa University Hospital, Medical School, Via Roma 57, 56126 Pisa, Italy
    Virchows Arch 456:449-54. 2010
    ....
  5. pmc Biological characterization of two xenografts derived from human CUPs (carcinomas of unknown primary)
    Delphine Lequin
    Universite Paris Sud, CNRS UMR 8126 and Institut Gustave Roussy, 39 rue Camille Desmoulins, F 94805 Villejuif, France
    BMC Cancer 7:225. 2007
    ..Although they often adopt an aggressive clinical pattern, their basic biology remains poorly understood. Laboratory research on their biology have been hampered so far by the absence of cell lines representative of CUPs...
  6. doi 30 years and a long way into p53 research
    Pierre Hainaut
    International Agency for Research on Cancer, Lyon, France
    Lancet Oncol 10:913-9. 2009
    ....
  7. doi The European Prospective Investigation into Cancer and Nutrition biobank
    Pierre Hainaut
    International Agency for Research on Cancer, Lyon, France
    Methods Mol Biol 675:179-91. 2011
    ..This chapter describes the building up of the EPIC central biobank and the mechanisms that have been developed to manage the access to specimens by a large number of different users...
  8. ncbi Zinc binding and redox control of p53 structure and function
    P Hainaut
    Group of Molecular Carcinogenesis, International Agency for Research on Cancer, Lyon, France
    Antioxid Redox Signal 3:611-23. 2001
    ..This redox sensitivity may be one of the biochemical mechanisms by which p53 acts as a "sensor" of multiple forms of stress...
  9. ncbi Patterns of p53 G-->T transversions in lung cancers reflect the primary mutagenic signature of DNA-damage by tobacco smoke
    P Hainaut
    International Agency for Research on Cancer WHO, 150 cours Albert Thomas, 69372 Lyon Cedex, France
    Carcinogenesis 22:367-74. 2001
    ..Our data reinforce the notion that p53 mutations in lung cancers can be attributed to direct DNA damage from cigarette smoke carcinogens rather than to selection of pre-existing endogenous mutations...
  10. pmc IARC Database of p53 gene mutations in human tumors and cell lines: updated compilation, revised formats and new visualisation tools
    P Hainaut
    International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
    Nucleic Acids Res 26:205-13. 1998
    ..In this report, we describe the criteria for inclusion of data, the revised format and the new visualisation tools. We also briefly discuss the relevance of p 53 mutations to clinical and biological questions...
  11. doi Association between HBX status, aflatoxin-induced R249S TP53 mutation and risk of hepatocellular carcinoma in a case-control study from Thailand
    Sandra Ortiz-Cuaran
    International Agency for Research on Cancer, Lyon, France
    Cancer Lett 331:46-51. 2013
    ..Thus, R249S may specifically cooperate with HBX in a pathway to HCC that bypasses cirrhosis...
  12. pmc Aberrant DNA methylation links cancer susceptibility locus 15q25.1 to apoptotic regulation and lung cancer
    Anupam Paliwal
    International Agency for Research on Cancer, Lyon, France
    Cancer Res 70:2779-88. 2010
    ..1 and lung cancer, and suggest nAChRs to be theranostic targets for cancer detection and chemoprevention...
  13. pmc TP53 R249S mutation, genetic variations in HBX and risk of hepatocellular carcinoma in The Gambia
    Doriane A Gouas
    International Agency for Research on Cancer, Molecular Carcinogenesis Group, Lyon, France
    Carcinogenesis 33:1219-24. 2012
    ..50 [95% confidence interval (CI) 1.50-60.11]; HCC: OR: 11.29 [95% CI 2.07-61.47]}. These findings suggest that in HCC from The Gambia, complete HBX sequences are often associated with the presence of TP53 R249S mutation...
  14. doi Aberrant DNA methylation distinguishes hepatocellular carcinoma associated with HBV and HCV infection and alcohol intake
    Marie Pierre Lambert
    Epigenetics Group, International Agency for Research on Cancer, Lyon, France
    J Hepatol 54:705-15. 2011
    ..Herein, we sought to establish DNA methylation patterns in HCC and corresponding cirrhotic tissues and to identify DNA methylation changes associated with major risk factors...
  15. ncbi Patterns of EGFR, HER2, TP53, and KRAS mutations of p14arf expression in non-small cell lung cancers in relation to smoking history
    Mounia Mounawar
    IARC, Lyon, France
    Cancer Res 67:5667-72. 2007
    ....
  16. ncbi TP53 and KRAS2 mutations in plasma DNA of healthy subjects and subsequent cancer occurrence: a prospective study
    Emmanuelle Gormally
    IARC, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
    Cancer Res 66:6871-6. 2006
    ..TP53 mutation may be associated with environmental exposures. These observations have implications for monitoring early steps of carcinogenesis...
  17. doi 20 years into the Gambia Hepatitis Intervention Study: assessment of initial hypotheses and prospects for evaluation of protective effectiveness against liver cancer
    Simonetta Viviani
    IARC, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
    Cancer Epidemiol Biomarkers Prev 17:3216-23. 2008
    ....
  18. pmc Aflatoxin-induced TP53 R249S mutation in hepatocellular carcinoma in Thailand: association with tumors developing in the absence of liver cirrhosis
    Stephanie Villar
    International Agency for Research on Cancer, Lyon, France
    PLoS ONE 7:e37707. 2012
    ..027). Overall, these results support the preferential occurrence of R249S-mutated DNA in HCC developing in the absence of cirrhosis in a context of HBV chronic infection...
  19. doi Intraepithelial p63-dependent expression of distinct components of cell adhesion complexes in normal esophageal mucosa and squamous cell carcinoma
    Amélie Thépot
    Molecular Carcinogenesis Group and Epigenetics Group, IARC, Lyon, France
    Int J Cancer 127:2051-62. 2010
    ..These results indicate that DeltaNp63 may contribute to esophageal squamous carcinogenesis by maintaining cell adhesion patterns compatible with cell proliferation...
  20. doi p53-Dependent repression of focal adhesion kinase in response to estradiol in breast cancer cell-lines
    Suresh Anaganti
    International Agency for Research on Cancer, Lyon, France
    Cancer Lett 300:215-24. 2011
    ....
  21. ncbi Somatic mutations in human cancer: applications in molecular epidemiology
    E Le Roux
    Molecular Carcinogenesis Group, International Agency for Research on Cancer, 150, cours Albert Thomas, 69372 Lyon Cedex 08
    Rev Epidemiol Sante Publique 53:257-66. 2005
    ..Thus, TP53 mutations have multiple applications as markers of mutagenic exposures, or as intermediate end-points in assessment of cancer occurrence and progression...
  22. pmc Quantitative analysis of DNA methylation profiles in lung cancer identifies aberrant DNA methylation of specific genes and its association with gender and cancer risk factors
    Thomas Vaissière
    Epigenetics Group, IARC, 150 cours Albert Thomas, Lyon Cedex 08, France
    Cancer Res 69:243-52. 2009
    ..Together, this study identifies aberrant DNA methylation patterns in lung cancer and thus exemplifies the mechanism by which environmental factors may interact with key genes involved in tumor suppression and contribute to lung cancer...
  23. doi DNA methylation of hepatitis B virus (HBV) genome associated with the development of hepatocellular carcinoma and occult HBV infection
    Pushpinder Kaur
    International Agency for Research on Cancer, 150 cours Albert Thomas, Lyon, France
    J Infect Dis 202:700-4. 2010
    ....
  24. doi Association between TP53 R249S mutation and polymorphisms in TP53 intron 1 in hepatocellular carcinoma
    Sandra Ortiz-Cuaran
    International Agency for Research on Cancer, Lyon, France
    Genes Chromosomes Cancer 52:912-9. 2013
    ..This domain contains two coding sequences overlapping with TP53 (WRAP53 and Hp53int1) suggesting that sequences in TP53 intron 1 encode transcripts that may modulate R249S mutation rate in HCC...
  25. doi The aflatoxin-induced TP53 mutation at codon 249 (R249S): biomarker of exposure, early detection and target for therapy
    Doriane Gouas
    International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
    Cancer Lett 286:29-37. 2009
    ..R249S protein in HCC pathogenesis. Next, we discuss the significance of R249S as a biomarker to study the natural history of HCC and as a target for therapeutic approaches aimed at restoring wild-type p53 activity...
  26. doi Epigenetic silencing of sFRP1 activates the canonical Wnt pathway and contributes to increased cell growth and proliferation in hepatocellular carcinoma
    Pushpinder Kaur
    Epigenetics Group, International Agency for Research on Cancer IARC, 150 cours Albert Thomas, 69008, Lyon, France
    Tumour Biol 33:325-36. 2012
    ....
  27. doi Methylation patterns in sentinel genes in peripheral blood cells of heavy smokers: Influence of cruciferous vegetables in an intervention study
    Chiara Scoccianti
    International Agency for Research on Cancer, Lyon, France
    Epigenetics 6:1114-9. 2011
    ....
  28. doi PRIMA-1 reactivates mutant p53 by covalent binding to the core domain
    Jeremy M R Lambert
    Department of Oncology Pathology, Cancer Center Karolinska, Karolinska Institutet, SE 171 76 Stockholm, Sweden International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
    Cancer Cell 15:376-88. 2009
    ..Covalent modification of mutant p53 per se is sufficient to induce apoptosis in tumor cells. These findings might facilitate the design of more potent and specific mutant p53-targeting anticancer drugs...
  29. ncbi Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database
    Audrey Petitjean
    Group of Molecular Carcinogenesis and Biomarkers, International Agency for Research on Cancer IARC, World Health Organization, Lyon, France
    Hum Mutat 28:622-9. 2007
    ..These results provide new insights into the factors that shape mutation patterns and influence mutation phenotype, which may have clinical interest...
  30. doi Prognostic value of TP53, KRAS and EGFR mutations in nonsmall cell lung cancer: the EUELC cohort
    Chiara Scoccianti
    International Prevention Research Institute, Lyon, France
    Eur Respir J 40:177-84. 2012
    ..These results suggest that mutations are good markers of different aetiologies and histopathological forms of lung cancers but have little prognostic value, with the exception of KRAS mutation, which may have a prognostic value in ADC...
  31. pmc DNA methylation changes associated with risk factors in tumors of the upper aerodigestive tract
    Samson Mani
    International Agency for Research on Cancer IARC, Lyon, France
    Epigenetics 7:270-7. 2012
    ..This study identifies aberrant DNA methylation patterns in UADT cancers and suggests a potential mechanism by which environmental factors may deregulate key cellular genes involved in tumor suppression and contribute to UADT cancers...
  32. doi p53 status influences response to tamoxifen but not to fulvestrant in breast cancer cell lines
    Lynnette Fernández-Cuesta
    International Agency for Research on Cancer, Lyon, France
    Int J Cancer 128:1813-21. 2011
    ..These results bring new insights into the prognostic role of p53 in breast cancer and into possible mechanisms underlying tamoxifen resistance...
  33. ncbi In vitro and in vivo cytotoxic effects of PRIMA-1 on hepatocellular carcinoma cells expressing mutant p53ser249
    Hong Shi
    International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
    Carcinogenesis 29:1428-34. 2008
    ..Thus, both inhibition of this effect by PRIMA-1 and removal of the mutant by siRNA can lead to the decrease of survival capacity of HCC cells...
  34. ncbi TP63 gene in stress response and carcinogenesis: a broader role than expected
    Audrey Petitjean
    International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
    Bull Cancer 93:E126-35. 2006
    ....
  35. ncbi The cytoprotective aminothiol WR1065 activates p53 through a non-genotoxic signaling pathway involving c-Jun N-terminal kinase
    Olivier Pluquet
    Unit of Molecular Carcinogenesis, International Agency for Research on Cancer, 69372 Lyon Cedex 08, France
    J Biol Chem 278:11879-87. 2003
    ..Thus, WR1065 activates p53 through a JNK-dependent signaling pathway. This pathway may prove useful for pharmacological modulation of p53 activity through non-genotoxic mechanisms...
  36. pmc Seasonal variation in TP53 R249S-mutated serum DNA with aflatoxin exposure and hepatitis B virus infection
    Stephanie Villar
    Molecular Carcinogenesis Group, International Agency for Research on Cancer, Lyon, France
    Environ Health Perspect 119:1635-40. 2011
    ..In chronic carriers, 1762T/1764A mutations in the HBV X gene are associated with increased HCC risk. Both mutations have been detected in circulating cell-free DNA (CFDNA) from asymptomatic HBV carriers...
  37. doi Interactions between hepatitis B virus and aflatoxin B(1): effects on p53 induction in HepaRG cells
    Myriam Lereau
    INSERM U1052, 151 Cours Albert Thomas, 69424 Lyon Cedex 03, France
    J Gen Virol 93:640-50. 2012
    ..Thus, in HepaRG cell line, AFB(1) and HBV do not cooperate to increase DNA damage by AFB(1). Further studies on the effects of both factors in a context of chronicity are needed to better understand synergistic effects...
  38. doi Population-based breast (female) and cervix cancer rates in the Gambia: evidence of ethnicity-related variations
    Dominique Sighoko
    International Agency for Research on Cancer, 150 cours Albert Thomas, Lyon, France
    Int J Cancer 127:2248-56. 2010
    ..It points to the need for further studies on cancer determinants to improve prevention, early detection and therapeutic management of these diseases in a low-resource setting in West Africa...
  39. ncbi The expression of TA and DeltaNp63 are regulated by different mechanisms in liver cells
    Audrey Petitjean
    International Agency for Research on Cancer, 150 cours A Thomas, 69372 Lyon Cedex 08, France
    Oncogene 24:512-9. 2005
    ..Furthermore, our results suggest that p63 may partially substitute for wild-type p53, in counteracting uncontrolled liver cell proliferation in response to certain forms of DNA-damage...
  40. ncbi TP53 R249S mutation, genetic variations in HBX and risk of hepatocellular carcinoma in The Gambia
    Doriane A Gouas
    International Agency for Research on Cancer, Molecular Carcinogenesis Group, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
    Carcinogenesis 33:1-6. 2012
    ..50 [95% confidence interval (CI) 1.50-60.11]; HCC: OR: 11.29 [95% CI 2.07-61.47]}. These findings suggest that in HCC from The Gambia, complete HBX sequences are often associated with the presence of TP53 R249S mutation...
  41. ncbi Roles of thioredoxin reductase 1 and APE/Ref-1 in the control of basal p53 stability and activity
    Severine Seemann
    Group of Molecular Carcinogenesis, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon, France
    Oncogene 24:3853-63. 2005
    ..When both factors were inhibited, basal levels of p53 were restored. These results suggest that TRR-Trx and APE/Ref-1 cooperate in the control of basal p53 activity, but not in its induction by DNA-damage...
  42. pmc Increase in female liver cancer in the Gambia, West Africa: evidence from 19 years of population-based cancer registration (1988-2006)
    Dominique Sighoko
    International Agency for Research on Cancer, Lyon, France
    PLoS ONE 6:e18415. 2011
    ..We have used data from the Gambian National Cancer Registry to compare trends in incidence of HCC in both genders...
  43. pmc Epidermal growth factor receptor (EGFR) mutations and expression in squamous cell carcinoma of the esophagus in central Asia
    Behnoush Abedi-Ardekani
    International Agency for Research on Cancer, Lyon, France
    BMC Cancer 12:602. 2012
    ..In lung adenocarcinoma, activating mutations in the gene encoding epidermal growth factor receptor (EGFR) are frequent in tumors of never smokers of Asian origin, predicting therapeutic sensitivity to Egfr-targeting drugs...
  44. pmc Prognostic and predictive value of TP53 mutations in node-positive breast cancer patients treated with anthracycline- or anthracycline/taxane-based adjuvant therapy: results from the BIG 02-98 phase III trial
    Lynnette Fernández-Cuesta
    Molecular Carcinogenesis Group, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 8, France
    Breast Cancer Res 14:R70. 2012
    ....
  45. doi Characterisation of human fibroblasts as keratinocyte feeder layer using p63 isoforms status
    Celine Auxenfans
    Banque de Tissus et Cellules des Hospices Civils de Lyon, Lyon, France
    Biomed Mater Eng 19:365-72. 2009
    ..These results indicate that human fibroblasts represent an adequate feeder layer system to support the culture of primary human keratinocytes...
  46. ncbi Activation of p53 by the cytoprotective aminothiol WR1065: DNA-damage-independent pathway and redox-dependent modulation of p53 DNA-binding activity
    Olivier Pluquet
    Unit of Molecular Carcinogenesis, International Agency for Research on Cancer, 69372 Lyon Cedex 08, France
    Biochem Pharmacol 65:1129-37. 2003
    ..Direct reduction by WR1065 of key cysteines in p53 may play an important role in this alternative pathway, as shown by the fact that WR1065 activated the redox-dependent, DNA-binding activity of p53 in vitro...
  47. ncbi Arrayed primer extension resequencing of mutations in the TP53 tumor suppressor gene: comparison with denaturing HPLC and direct sequencing
    Florence Le Calvez
    International Agency for Research on Cancer, Lyon, France
    Clin Chem 51:1284-7. 2005
  48. pmc Skin human papillomavirus type 38 alters p53 functions by accumulation of deltaNp73
    Rosita Accardi
    Infections and Cancer Biology Group, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon, France
    EMBO Rep 7:334-40. 2006
    ..Our findings illustrate a novel mechanism of the alteration of p53 function that is mediated by a cutaneous HPV type and support the role of HPV38 and deltaNp73 in human carcinogenesis...
  49. doi KRAS mutation status in primary nonsmall cell lung cancer and matched metastases
    Alexis B Cortot
    Department of Pulmonary Diseases, Lyon Sud Hospital Center, Claude Bernard University, Lyon, France
    Cancer 116:2682-7. 2010
    ....
  50. pmc TP53 mutations in human cancers: origins, consequences, and clinical use
    Magali Olivier
    Group of Molecular Carcinogenesis, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
    Cold Spring Harb Perspect Biol 2:a001008. 2010
    ..Here, we summarize current knowledge on TP53 gene variations observed in human cancers and populations, and current clinical applications derived from this knowledge...
  51. pmc Osteopontin and latent-TGF β binding-protein 2 as potential diagnostic markers for HBV-related hepatocellular carcinoma
    André Nogueira da Costa
    International Agency for Research on Cancer, Lyon, France
    Int J Cancer 136:172-81. 2015
    ..Thus, the combination of LTBP2 and OPN outperformed AFP for diagnosis and prediction of HCC and may therefore improve biomarker-based detection of HBV-related HCC. ..
  52. ncbi Ser-249TP53 mutation in tumour and plasma DNA of hepatocellular carcinoma patients from a high incidence area in the Gambia, West Africa
    Katarzyna Szymanska
    International Agency for Research on Cancer and Gambia Hepatitis Intervention Study, Lyon, France
    Int J Cancer 110:374-9. 2004
    ..g., eastern China: >50%). Moreover, our studies indicate that plasma is a convenient source of liver tumour-derived DNA, thus holding promise for earlier detection and diagnosis of cancer...
  53. doi Detailed haplotype analysis at the TP53 locus in p.R337H mutation carriers in the population of Southern Brazil: evidence for a founder effect
    Sonia Garritano
    International Agency for Research on Cancer IARC, Lyon, Rhone, France
    Hum Mutat 31:143-50. 2010
    ..This historical circumstance and the relatively low penetrance before the age of 30 may have contributed to the maintenance of this pathogenic mutation in a large, open population...
  54. pmc Subcellular distribution of human RDM1 protein isoforms and their nucleolar accumulation in response to heat shock and proteotoxic stress
    Lydia Messaoudi
    International Agency for Research on Cancer IARC, 150 cours Albert Thomas, 69372 Lyon, France
    Nucleic Acids Res 35:6571-87. 2007
    ..Finally, RDM1 null chicken DT40 cells displayed an increased sensitivity to heat shock, compared to wild-type (wt) cells, suggesting a function for RDM1 in the heat-shock response...
  55. ncbi TP53 and KRAS mutation load and types in lung cancers in relation to tobacco smoke: distinct patterns in never, former, and current smokers
    Florence Le Calvez
    IARC, Lyon, France
    Cancer Res 65:5076-83. 2005
    ..6-50). These results support the notion that lung tumorigenesis proceeds through different molecular mechanisms according to smoking status. In never smokers, accumulation of N-Tyr suggests an etiology involving severe inflammation...
  56. pmc Sources of pre-analytical variations in yield of DNA extracted from blood samples: analysis of 50,000 DNA samples in EPIC
    Elodie Caboux
    International Agency for Research on Cancer, Lyon, France
    PLoS ONE 7:e39821. 2012
    ..The results provide a strong evidence-based rationale for standardized recommendations on blood collection and processing protocols for large-scale genetic studies...
  57. doi G-quadruplex structures in TP53 intron 3: role in alternative splicing and in production of p53 mRNA isoforms
    Virginie Marcel
    Group of Molecular Carcinogenesis, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372, Lyon Cedex 08, France
    Carcinogenesis 32:271-8. 2011
    ..These results indicate that G4 structures in intron 3 regulate the splicing of intron 2, leading to differential expression of transcripts encoding distinct p53 isoforms...
  58. pmc Computational approaches for predicting the biological effect of p53 missense mutations: a comparison of three sequence analysis based methods
    Ewy Mathe
    International Agency for Research on Cancer, Lyon, France
    Nucleic Acids Res 34:1317-25. 2006
    ..9% specificity and sensitivity, respectively). These results further demonstrate the utility of the Align-GVGD method, which was previously applied to BRCA1. Align-GVGD is available online at http://agvgd.iarc.fr...
  59. doi Tumor protein 53 mutations and inherited cancer: beyond Li-Fraumeni syndrome
    Edenir I Palmero
    International Agency for Research on Cancer, Group of Molecular Carcinogenesis, Lyon, France
    Curr Opin Oncol 22:64-9. 2010
    ....
  60. ncbi Distinct pattern of TP53 mutations in squamous cell carcinoma of the esophagus in Iran
    A Sepehr
    Group of Molecular Carcinogenesis, International Agency for Research on Cancer (IARC, 150, cours Albert-Thomas, Lyon 69008, France
    Oncogene 20:7368-74. 2001
    ..These factors include a baseline of chronic inflammatory stress, which may have a multiplicative impact on the sensitivity of esophageal cells to exogenous factors of risk...
  61. doi Downregulation of transcription factor E4F1 in hepatocarcinoma cells: HBV-dependent effects on autophagy, proliferation and metabolism
    Yayun Dai
    Molecular Carcinogenesis, International Agency for Research on Cancer, 150 cours Albert Thomas, Lyon 69372, France
    Carcinogenesis 35:635-50. 2014
    ....
  62. doi Breast cancer in pre-menopausal women in West Africa: analysis of temporal trends and evaluation of risk factors associated with reproductive life
    Dominique Sighoko
    International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France Laboratory of Sciences Complex Decision and in Health Policy, University Lyon 1, Lyon, France
    Breast 22:828-35. 2013
    ..In West Africa, trends and risk factors for breast cancer (BC) have been rarely studied...
  63. pmc Effects of Δ40p53, an isoform of p53 lacking the N-terminus, on transactivation capacity of the tumor suppressor protein p53
    Hind Hafsi
    International Agency for Research on Cancer, Lyon, France
    BMC Cancer 13:134. 2013
    ..Overexpression of Δ40p53 antagonizes wild-type p53 in vitro. However, animal models of Δ40p53 in mouse or Zebrafish have shown complex phenotypes suggestive of p53-dependent growth suppressive effects...
  64. ncbi p53 protein variants: structural and functional similarities with p63 and p73 isoforms
    Stéphanie Courtois
    Unit of Molecular Carcinogenesis, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
    Oncogene 23:631-8. 2004
    ....
  65. pmc TP53 mutation p.R337H in gastric cancer tissues of a 12-year-old male child: evidence for chimerism involving a common mutant founder haplotype: case report
    Edaise M da Silva
    International Agency for Research on Cancer, Lyon, France
    BMC Cancer 11:449. 2011
    ..We report a case of invasive well-differentiated metastatic gastric cancer in a Brazilian 12-year-old boy without documented familial history of cancer...
  66. pmc Hepatitis B virus impairs TLR9 expression and function in plasmacytoid dendritic cells
    Isabelle E Vincent
    INSERM, U871, Lyon, France
    PLoS ONE 6:e26315. 2011
    ..Thus HBV has developed several escape mechanisms to avoid TLR9 activation in both pDCs and B lymphocytes, which may in turn contribute to the establishment and/or persistence of chronic infection...
  67. doi Interferon-inducible guanylate binding protein (GBP)-2: a novel p53-regulated tumor marker in esophageal squamous cell carcinomas
    Denise P Guimarães
    Molecular Carcinogenesis and Biomarkers Group, International Agency for Research on Cancer, Lyon Cedex 08, France
    Int J Cancer 124:272-9. 2009
    ..Our results suggest that p53 up-regulates GBP-2 by cooperating with IRF-1. The association of GBP-2 expression with proliferative squamous cells suggests that GBP-2 may represent a marker of interest in esophageal SCC...
  68. ncbi Li-Fraumeni and related syndromes: correlation between tumor type, family structure, and TP53 genotype
    Magali Olivier
    IARC, Lyon, Cedex 8, France
    Cancer Res 63:6643-50. 2003
    ..004). These observations have clinical implications for genetic testing and tumor surveillance in LFS/LFL families...
  69. doi Genetics of lung-cancer susceptibility
    Paul Brennan
    Section of Genetics, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
    Lancet Oncol 12:399-408. 2011
    ..There is also a need for studies that investigate how genetic susceptibility is associated with clinical outcome measures, including treatment response and tumour relapse...
  70. ncbi The tumor suppressor gene TP53: implications for cancer management and therapy
    Severine Seemann
    International Agency for Research on Cancer, Lyon, France
    Crit Rev Clin Lab Sci 41:551-83. 2004
    ..In addition, detection of mutant TP53 may also serve as a marker for early cancer detection, prediction, and prognosis. In this review, we discuss the mechanisms underlying these approaches and their perspectives for cancer therapy...
  71. doi Biobanking in a fast moving world: an international perspective
    Robert Hewitt
    Biopreservation and Biobanking, Aix en Provence, France
    J Natl Cancer Inst Monogr 2011:50-1. 2011
    ....
  72. ncbi Amifostine (WR2721) restores transcriptional activity of specific p53 mutant proteins in a yeast functional assay
    D Maurici
    Group of Molecular Carcinogenesis, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon, France
    Oncogene 20:3533-40. 2001
    ..The results indicate that the yeast functional assay may be used to identify compounds that modulate p53 activity, with potential therapeutic implications...
  73. doi Aberrant DNA methylation of cancer-associated genes in gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST)
    Karen Balassiano
    International Agency for Research on Cancer IARC, 150 cours Albert Thomas, 69008 Lyon, France
    Cancer Lett 311:85-95. 2011
    ..This study identifies aberrant methylation patters in specific genes in GC thus providing information that could be exploited as novel biomarkers in clinics and molecular epidemiology of GC...
  74. ncbi Amount of DNA in plasma and cancer risk: a prospective study
    Emmanuelle Gormally
    International Agency for Research on Cancer, Lyon, France
    Int J Cancer 111:746-9. 2004
    ..e., a time elapsed between blood drawing and disease onset lower than 36 months. This was particularly true for COPD deaths (OR = 12.7; 95% CI = 1.57-103) and leukemia (OR = 2.37; 95% CI = 1.20-4.67)...
  75. pmc Impact of delay to cryopreservation on RNA integrity and genome-wide expression profiles in resected tumor samples
    Elodie Caboux
    Laboratory Services and Biobank, International Agency for Research on Cancer, Lyon, France
    PLoS ONE 8:e79826. 2013
    ....
  76. doi Estrogen levels act as a rheostat on p53 levels and modulate p53-dependent responses in breast cancer cell lines
    Lynnette Fernández-Cuesta
    Molecular Carcinogenesis Group, International Agency for Research on Cancer, Lyon, France
    Breast Cancer Res Treat 125:35-42. 2011
    ..It would thus be important to further characterize the influence of ERα pathway on the predictive value of TP53 mutation status in specifically designed clinical trials, as it may open perspectives for improving breast cancer treatment...
  77. pmc Dual function of MyD88 in RAS signaling and inflammation, leading to mouse and human cell transformation
    Isabelle Coste
    CNRS UMR5201, University of Lyon, Centre Leon Berard, Lyon, France
    J Clin Invest 120:3663-7. 2010
    ..Collectively, these results show that in addition to its role in inflammation, MyD88 plays what we believe to be a crucial direct role in RAS signaling, cell-cycle control, and cell transformation...
  78. doi Exposure to hazardous substances in a standard molecular biology laboratory environment: evaluation of exposures in IARC laboratories
    Brigitte Chapot
    International Agency for Research on Cancer, 69372 Lyon Cedex 08, France
    Ann Occup Hyg 53:485-90. 2009
    ..The results enabled the staff physician to develop an individual approach to medical surveillance and to draw a personal history of occupational exposures for laboratory staff...
  79. doi Infection with hepatitis B and C viruses and risk of lymphoid malignancies in the European Prospective Investigation into Cancer and Nutrition (EPIC)
    Silvia Franceschi
    International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon, Cedex 08, France
    Cancer Epidemiol Biomarkers Prev 20:208-14. 2011
    ..More limited data suggested that hepatitis B virus (HBV) infection might also be associated with NHL. However, prospective studies on the topic are few...
  80. doi A sample storage management system for biobanks
    C Voegele
    Genetic Cancer Susceptibility Group, International Agency for Research on Cancer IARC, Lyon, France
    Bioinformatics 26:2798-800. 2010
    ..Both the database and the interface have been modeled to be compatible with and adaptable to almost all types of biobanks...
  81. ncbi Hepatocellular carcinoma: from gene to public health
    R Montesano
    Unit of Mechanisms of Carcinogenesis, International Agency for Research on Cancer, Lyon, France
    J Natl Cancer Inst 89:1844-51. 1997
    ....
  82. ncbi The multidisciplinary management of gastrointestinal cancer. Epidemiology of oesophagogastric cancer
    R Lambert
    International Agency for Research on Cancer, Group of Screening, 150 cours Albert Thomas, Lyon 69372 Cedex 08, France
    Best Pract Res Clin Gastroenterol 21:921-45. 2007
    ..Preneoplastic conditions of the oesophagogastric mucosa include erosive oesophagitis in alcoholics, columnar lined oesophagus as a complication of gastro-oesophageal reflux disease, and atrophic gastritis following H. pylori infection...
  83. doi Recent advances in p53 research: an interdisciplinary perspective
    M Olivier
    1Group of Molecular Carcinogenesis and Biomarkers, International Agency for Research on Cancer, World Health Organization, Lyon, France
    Cancer Gene Ther 16:1-12. 2009
    ..New opportunities for translational research for improving cancer detection, prognosis, prevention and therapy based upon the integration of this knowledge are described...
  84. doi Somatic mutation databases as tools for molecular epidemiology and molecular pathology of cancer: proposed guidelines for improving data collection, distribution, and integration
    M Olivier
    Group of Molecular Carcinogenesis and Biomarkers, International Agency for Research on Cancer, World Health Organization, Lyon, France
    Hum Mutat 30:275-82. 2009
    ..This initiative is meant to promote collaboration and discussion on these issues and the development of adequate resources that would avoid the loss of extremely valuable information generated by years of basic and clinical research...
  85. ncbi Esophageal cancer: cases and causes (part I)
    R Lambert
    Screening Group, International Agency for Research on Cancer, Lyon, France
    Endoscopy 39:550-5. 2007
  86. ncbi Esophageal cancer: the precursors (Part II)
    R Lambert
    Screening and Molecular Carcinogenesis and Biomarkers Groups, International Agency for Research on Cancer, Lyon, France
    Endoscopy 39:659-64. 2007
  87. pmc TP53 mutations, amplification of P63 and expression of cell cycle proteins in squamous cell carcinoma of the oesophagus from a low incidence area in Western Europe
    P Taniere
    Molecular Carcinogenesis, International Agency for Research on Cancer, 150 cours Albert Thomas, Lyon Cedex, 69372 08, France
    Br J Cancer 85:721-6. 2001
    ..Overall, these results indicate that in Europe, SCCE from areas of high and low incidence present a similar pattern of molecular alterations but differ by the type of TP53 mutations...
  88. ncbi Absence of association between HPV DNA, TP53 codon 72 polymorphism, and risk of oesophageal cancer in a high-risk area of China
    D Peixoto Guimaraes
    Unit of Mechanisms of Carcinogenesis, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon 08, Cedex, France
    Cancer Lett 162:231-5. 2001
    ..Our findings do not support the association between risk of oesophageal cancer, human papilloma virus infection, and TP53 codon 72 polymorphism in a Chinese population at high risk of oesophageal cancer...
  89. pmc Molecular and clinical differences between adenocarcinomas of the esophagus and of the gastric cardia
    P Taniere
    International Agency for Research on Cancer the Fédération des Spécialités Digestives and the Laboratoire d Anatomie Pathologique, Hopital Edouard Herriot, Lyon, France
    Am J Pathol 158:33-40. 2001
    ..These results support the notion that ADCC and ADCE are distinct pathological entities...
  90. ncbi Human papillomavirus type 16 and TP53 mutation in oral cancer: matched analysis of the IARC multicenter study
    Min Dai
    IARC, Lyon, France
    Cancer Res 64:468-71. 2004
    ..0; 95% confidence interval, 0.2-5.4). TP53 inactivation is a major mechanism of HPV-related carcinogenesis in the oral cavity and oropharynx. The role of HPV in cancers also containing TP53 mutations remains to be clarified...
  91. doi Genetic and epigenetic alterations as biomarkers for cancer detection, diagnosis and prognosis
    Zdenko Herceg
    Group of Molecular Carcinogenesis and Biomarkers, International Agency for Research on Cancer, 150 cours Albert Thomas, Lyon Cedex F 69008, Rhone Alpes, France
    Mol Oncol 1:26-41. 2007
    ..Such functional alterations may represent candidates for targeted therapeutic approaches...
  92. doi Curbing the liver cancer epidemic in Africa
    Pierre Hainaut
    International Agency for Research on Cancer, 69372 Lyon, France
    Lancet 371:367-8. 2008
  93. doi Redox control and interplay between p53 isoforms: roles in the regulation of basal p53 levels, cell fate, and senescence
    Hind Hafsi
    International Agency for Research on Cancer, 150 cours Albert Thomas, Lyon, France
    Antioxid Redox Signal 15:1655-67. 2011
    ..Together, these mechanisms suggest that p53 acts not only as a "guardian of the genome" against DNA damage but also as a finely-tuned regulator of redox-dependent physiological processes...
  94. ncbi The clinical value of somatic TP53 gene mutations in 1,794 patients with breast cancer
    Magali Olivier
    IARC, Lyon, France
    Clin Cancer Res 12:1157-67. 2006
    ..These results, obtained on the largest series analyzed thus far, show that TP53 mutations identified by gene sequencing have an independent prognostic value in breast cancer and could have potential uses in clinical practice...
  95. ncbi DeltaN-p53, a natural isoform of p53 lacking the first transactivation domain, counteracts growth suppression by wild-type p53
    Stéphanie Courtois
    Group of Molecular Carcinogenesis, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
    Oncogene 21:6722-8. 2002
    ..These results suggest that DeltaN-p53 may play a role as a transient, negative regulator of p53 during cell cycle progression...
  96. doi p53 regulates the transcription of its Delta133p53 isoform through specific response elements contained within the TP53 P2 internal promoter
    V Marcel
    Molecular Carcinogenesis Group, International Agency for Research on Cancer, Lyon, Cedex, France
    Oncogene 29:2691-700. 2010
    ..These observations indicate that Delta133p53 is a novel target of p53 that may participate in a negative feedback loop controlling p53 function...
  97. ncbi Premalignant lesions of the esophagogastric mucosa
    R Lambert
    International Agency for Research on Cancer, Lyon, France
    Semin Oncol 31:498-512. 2004
    ..The trend to early detection of premalignant lesions justifies the development of mini-invasive endoscopic procedures of treatment...
  98. doi TP53 and EGFR mutations in combination with lifestyle risk factors in tumours of the upper aerodigestive tract from South America
    K Szymanska
    International Agency for Research on Cancer, 150 cours Albert Thomas, F 69008 Lyon, France
    Carcinogenesis 31:1054-9. 2010
    ..EGFR mutations do not appear to be a common event in UADT carcinogenesis in this population...
  99. pmc TP53 mutations, human papilloma virus DNA and inflammation markers in esophageal squamous cell carcinoma from the Rift Valley, a high-incidence area in Kenya
    Kirtika Patel
    Group of Molecular Carcinogenesis, International Agency for Research on Cancer, Lyon, France
    BMC Res Notes 4:469. 2011
    ..In Kenya, clinical observations suggest that this cancer is frequent in the Rift Valley area. However, so far, there has been no report on the molecular characteristics of esophageal squamous cell carcinoma (ESCC) in this area...
  100. pmc Association between pre-diagnostic circulating vitamin D concentration and risk of colorectal cancer in European populations:a nested case-control study
    Mazda Jenab
    International Agency for Research on Cancer IARC WHO, Lyon, France
    BMJ 340:b5500. 2010
    ..To examine the association between pre-diagnostic circulating vitamin D concentration, dietary intake of vitamin D and calcium, and the risk of colorectal cancer in European populations...
  101. ncbi The IARC TP53 database: new online mutation analysis and recommendations to users
    Magali Olivier
    Molecular Carcinogenesis Group, International Agency for Research on Cancer, World Health Organization, Lyon, France
    Hum Mutat 19:607-14. 2002
    ..In addition, a new on-line application to retrieve somatic mutation data and analyze mutation patterns is now available. We also discuss limitations on the use of the database and provide recommendations to users...