Genomes and Genes
Guillaume van Niel
Affiliation: Institut Curie
- Endosomal sorting of MHC class II determines antigen presentation by dendritic cellsGuillaume van Niel
Institut Curie, Centre National de la Recherche Scientifique Unité Mixte de Recherche 144, Paris 75248, France
Curr Opin Cell Biol 20:437-44. 2008..MHC II-p is inefficiently ubiquitinated in DCs that are activated by pathogens or inflammatory stimuli, thus allowing its transfer to and stable expression at the plasma membrane...
- [Biogenesis of melanosomes - the chessboard of pigmentation]Cedric Delevoye
Institut Curie, Centre de Recherche, CNRS UMR144, 26, rue d Ulm, 75248 Paris, France
Med Sci (Paris) 27:153-62. 2011..Further dissection of the melanosomal system will likely shed light not only on the biogenesis of lysosome-related organelles but also on general aspects of vesicular transport in the endosomal system...
- Study of Exosomes Shed New Light on Physiology of AmyloidogenesisGuillaume van Niel
Institut Curie, PSL Research University, UMR144, Centre de Recherche, 26 Rue d Ulm, 75231, Paris, France
Cell Mol Neurobiol 36:327-42. 2016..This physiological model of amyloidogenesis could shed new light on the roles of MVEs and exosomes in conditions with pathological amyloid metabolism, such as Alzheimer's disease. ..
- Apolipoprotein E Regulates Amyloid Formation within Endosomes of Pigment CellsGuillaume van Niel
Institut Curie, PSL Research University, UMR144, Centre de Recherche, 26 Rue d Ulm, Paris 75231, France Centre National de la Recherche Scientifique, UMR144, Paris 75248, France Cell and Tissue Imaging Core Facility PICT IBiSA, Institut Curie, Paris 75248, France Electronic address
Cell Rep 13:43-51. 2015..This process secures the physiological formation of amyloid fibrils by exploiting ILVs as amyloid nucleating platforms...
- The tetraspanin CD63 regulates ESCRT-independent and -dependent endosomal sorting during melanogenesisGuillaume van Niel
Institut Curie, Centre de Recherche, F 75248 Paris, France
Dev Cell 21:708-21. 2011..Our data thus reveal a tight interplay regulated by CD63 between two distinct endosomal ILV sorting processes for a single cargo during LRO biogenesis...
- BACE2 processes PMEL to form the melanosome amyloid matrix in pigment cellsLeila Rochin
Institut Curie, and Unité Mixte de Recherche 144, Centre National de la Recherche Scientifique, F 75248 Paris, France
Proc Natl Acad Sci U S A 110:10658-63. 2013....
- T84-intestinal epithelial exosomes bear MHC class II/peptide complexes potentiating antigen presentation by dendritic cellsJulia Mallegol
INSERM U793, Paris, France
Gastroenterology 132:1866-76. 2007..To characterize further the role of human epithelial exosomes in antigen presentation, their capacity to load antigenic peptides, bind immune target cells, and induce T-cell activation was analyzed in vitro...
- Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesiclesMarina Colombo
Institut Curie Section Recherche, 26 Rue d Ulm, 75248 Paris Cedex 05, France
J Cell Sci 126:5553-65. 2013..The results reveal a role for selected ESCRT components and accessory proteins in exosome secretion and composition by HeLa-CIITA. They also highlight biogenetic differences in vesicles secreted by a tumour cell line and primary DCs...
- Exosomes released by keratinocytes modulate melanocyte pigmentationAlessandra Lo Cicero
1 Institut Curie, PSL Research University, UMR144, CNRS, F 75248 Paris, France 2 Structure and Membrane Compartments, Centre National de la Recherche Scientifique, UMR144, Paris F 75248, France 3 Cell and Tissue Imaging Facility, Infrastructures en Biologie Santé et Agronomie IBiSA, Paris F 75248, France
Nat Commun 6:7506. 2015....
- Exosomes: a common pathway for a specialized functionGuillaume van Niel
Institut Curie, CNRS UMR144, 75248 Paris Cedex, France
J Biochem 140:13-21. 2006..These findings open up new therapeutic and diagnostic strategies...
- PMEL Amyloid Fibril Formation: The Bright Steps of PigmentationChristin Bissig
Institut Curie, Paris Sciences et Lettres Research University, UMR144, Centre de Recherche, 26 Rue d Ulm, Paris F 75231, France
Int J Mol Sci 17:. 2016..In this review we summarize the known mechanisms of PMEL fibrillation and discuss how the recent understanding of physiological PMEL amyloid formation may help to shed light on processes involved in pathological amyloid formation. ..
- Dendritic cells regulate exposure of MHC class II at their plasma membrane by oligoubiquitinationGuillaume van Niel
Faculty of Veterinary Medicine, Department of Biochemistry and Cell Biology, Utrecht University, P O Box 80 176, NL 3508 TD, Utrecht, The Netherlands
Immunity 25:885-94. 2006..Together, these data provide a molecular basis for the regulation of MHC class II-mediated antigen presentation by DCs...
- Gastric Helicobacter infection inhibits development of oral tolerance to food antigens in miceTamara Matysiak-Budnik
INSERM EMI 0212, Faculte de Medecine Necker Enfants Malades, Paris, France
Infect Immun 71:5219-24. 2003..We conclude that H. felis can inhibit the development of oral tolerance to OVA in mice and that this inhibition is prevented by rebamipide...