Herve Tilly

Summary

Affiliation: Institut Paoli-Calmettes
Country: France

Publications

  1. ncbi Intensive conventional chemotherapy (ACVBP regimen) compared with standard CHOP for poor-prognosis aggressive non-Hodgkin lymphoma
    Herve Tilly
    Department of Hematology, Centre Henri Becquerel, 76038 Rouen, France
    Blood 102:4284-9. 2003
  2. ncbi [Treatment options in non-Hodgkin lymphomas]
    Herve Tilly
    Service hématologie, Centre Henri Becquerel, 76038 Rouen
    Rev Prat 60:69-74. 2010
  3. ncbi Randomized comparison of ACVBP and m-BACOD in the treatment of patients with low-risk aggressive lymphoma: the LNH87-1 study. Groupe d'Etudes des Lymphomes de l'Adulte
    H Tilly
    Centre Henri Becquerel, Rouen, France
    J Clin Oncol 18:1309-15. 2000
  4. ncbi [Differential diagnosis of lymphomas]
    Herve Tilly
    Dépatement d hématologie Centre Henri Becquerel, 76038 Rouen
    Rev Prat 52:959-65. 2002
  5. doi Treatment of follicular lymphoma: current status
    Herve Tilly
    Centre Henri Becquerel, Rouen, France
    Leuk Lymphoma 49:7-17. 2008
  6. doi Several mechanisms lead to the inactivation of the CDKN2A (P16), P14ARF, or CDKN2B (P15) genes in the GCB and ABC molecular DLBCL subtypes
    Suzan Guney
    Inserm U918, Groupe d étude des Proliférations Lymphooedes, Institut Federatif de Recherches Multidisciplinaires sur les Peptides 23 IFRMP23, Rouen, France
    Genes Chromosomes Cancer 51:858-67. 2012
  7. doi Diffuse large B-cell lymphomas with CDKN2A deletion have a distinct gene expression signature and a poor prognosis under R-CHOP treatment: a GELA study
    Fabrice Jardin
    Service d Hématologie and INSERM UMR918, Centre Henri Becquerel, University of Rouen, Rue d Amiens, Rouen, France
    Blood 116:1092-104. 2010
  8. doi Interim positron emission tomography scan associated with international prognostic index and germinal center B cell-like signature as prognostic index in diffuse large B-cell lymphoma
    Hélène Lanic
    UMR INSERM U918, Centre Henri Becquerel, Rouen, France
    Leuk Lymphoma 53:34-42. 2012
  9. doi Detection of somatic quantitative genetic alterations by multiplex polymerase chain reaction for the prediction of outcome in diffuse large B-cell lymphomas
    Fabrice Jardin
    Department of Hematology, Centre Henri Becquerel, 76000 Rouen, France
    Haematologica 93:543-50. 2008
  10. doi Detection of gene copy number aberrations in mantle cell lymphoma by a single quantitative multiplex PCR assay: clinicopathological relevance and prognosis value
    Fabrice Jardin
    Inserm U918, Centre Henri Becquerel and European Institute of Peptide Research IFR23, Rouen, France
    Br J Haematol 146:607-18. 2009

Detail Information

Publications66

  1. ncbi Intensive conventional chemotherapy (ACVBP regimen) compared with standard CHOP for poor-prognosis aggressive non-Hodgkin lymphoma
    Herve Tilly
    Department of Hematology, Centre Henri Becquerel, 76038 Rouen, France
    Blood 102:4284-9. 2003
    ..004). Despite higher toxicity, the ACVBP regimen, used as first-line treatment for patients with poor-risk aggressive lymphoma, is superior to standard CHOP with regard to both event-free survival and overall survival...
  2. ncbi [Treatment options in non-Hodgkin lymphomas]
    Herve Tilly
    Service hématologie, Centre Henri Becquerel, 76038 Rouen
    Rev Prat 60:69-74. 2010
    ..A complete remission must be obtained in patients with aggressive lymphoma and the association of chemotherapy and rituximab, in B-cell subtype, is the standard therapeutic approach...
  3. ncbi Randomized comparison of ACVBP and m-BACOD in the treatment of patients with low-risk aggressive lymphoma: the LNH87-1 study. Groupe d'Etudes des Lymphomes de l'Adulte
    H Tilly
    Centre Henri Becquerel, Rouen, France
    J Clin Oncol 18:1309-15. 2000
    ....
  4. ncbi [Differential diagnosis of lymphomas]
    Herve Tilly
    Dépatement d hématologie Centre Henri Becquerel, 76038 Rouen
    Rev Prat 52:959-65. 2002
    ..The goal of initial disease assessment is to determine prognostic factors that will guide treatment decision...
  5. doi Treatment of follicular lymphoma: current status
    Herve Tilly
    Centre Henri Becquerel, Rouen, France
    Leuk Lymphoma 49:7-17. 2008
    ..New treatment approaches for FL currently being investigated in the second-line setting include the proteasome inhibitor, bortezomib and novel anti-CD20 monoclonal antibodies...
  6. doi Several mechanisms lead to the inactivation of the CDKN2A (P16), P14ARF, or CDKN2B (P15) genes in the GCB and ABC molecular DLBCL subtypes
    Suzan Guney
    Inserm U918, Groupe d étude des Proliférations Lymphooedes, Institut Federatif de Recherches Multidisciplinaires sur les Peptides 23 IFRMP23, Rouen, France
    Genes Chromosomes Cancer 51:858-67. 2012
    ..085). Low mRNA expression levels of these genes were correlated with the ABC phenotype. Furthermore, our results show that an inactivating methylation was more frequent in the GCB phenotype...
  7. doi Diffuse large B-cell lymphomas with CDKN2A deletion have a distinct gene expression signature and a poor prognosis under R-CHOP treatment: a GELA study
    Fabrice Jardin
    Service d Hématologie and INSERM UMR918, Centre Henri Becquerel, University of Rouen, Rue d Amiens, Rouen, France
    Blood 116:1092-104. 2010
    ..Detection of TP53 and CDKN2A loss by QMPSF is a powerful tool that could be used for patient stratification in future clinical trials...
  8. doi Interim positron emission tomography scan associated with international prognostic index and germinal center B cell-like signature as prognostic index in diffuse large B-cell lymphoma
    Hélène Lanic
    UMR INSERM U918, Centre Henri Becquerel, Rouen, France
    Leuk Lymphoma 53:34-42. 2012
    ..Our study suggests that the combination of GEP, aaIPI and interim PET more accurately predicts DLBCL prognosis and is therefore suitable for tailoring therapeutic strategies...
  9. doi Detection of somatic quantitative genetic alterations by multiplex polymerase chain reaction for the prediction of outcome in diffuse large B-cell lymphomas
    Fabrice Jardin
    Department of Hematology, Centre Henri Becquerel, 76000 Rouen, France
    Haematologica 93:543-50. 2008
    ..We developed a polymerase chain reaction assay to provide information regarding gains or losses of relevant genes and prognosis in diffuse large B-cell lymphomas...
  10. doi Detection of gene copy number aberrations in mantle cell lymphoma by a single quantitative multiplex PCR assay: clinicopathological relevance and prognosis value
    Fabrice Jardin
    Inserm U918, Centre Henri Becquerel and European Institute of Peptide Research IFR23, Rouen, France
    Br J Haematol 146:607-18. 2009
    ....
  11. doi Digital PCR for quantification of recurrent and potentially actionable somatic mutations in circulating free DNA from patients with diffuse large B-cell lymphoma
    Vincent Camus
    a Department of Hematology, Centre Henri Becquerel, Rouen, France
    Leuk Lymphoma 57:2171-9. 2016
    ..05%. cfDNA somatic mutation detection by dPCR seems to be a promising technique in the management of DLBCL, in addition to NGS experiments. ..
  12. doi Next-Generation Sequencing in Diffuse Large B-Cell Lymphoma Highlights Molecular Divergence and Therapeutic Opportunities: a LYSA Study
    Sydney Dubois
    Inserm U918, Centre Henri Becquerel, Universite de Rouen, IRIB, Rouen, France
    Clin Cancer Res 22:2919-28. 2016
    ..Furthermore, for the first time, we evaluated the prognostic value of these mutations in prospective clinical trials...
  13. doi Immunoglobulin heavy chain/light chain pair measurement is associated with survival in diffuse large B-cell lymphoma
    Fabrice Jardin
    Department of Hematology and INSERM U918, IRIB, Centre Henri Becquerel, Rouen, France
    Leuk Lymphoma 54:1898-907. 2013
    ..Both elevated serum FLCs and an abnormal IgMκ/IgMλ ratio are associated with unfavorable outcomes in patients with DLBCL treated by R-CHOP...
  14. pmc Detection and prognostic value of recurrent exportin 1 mutations in tumor and cell-free circulating DNA of patients with classical Hodgkin lymphoma
    Vincent Camus
    Department of Hematology, Centre Henri Becquerel, Rouen, France INSERM U918, Centre Henri Becquerel, University of Rouen, Rouen, France
    Haematologica 101:1094-101. 2016
    ..The detection of somatic mutation in the plasma cell-free DNA of patients represents a major technological advance in the context of liquid biopsies and noninvasive management of classical Hodgkin lymphoma. ..
  15. doi Oncogenic events rather than antigen selection pressure may be the main driving forces for relapse in diffuse large B-cell lymphomas
    David Rizzo
    Inserm U918, Centre Henri Becquerel, Institute for Research and Innovation in Biomedicine, University of Rouen, Rouen, France
    Am J Hematol . 2016
    ..This article is protected by copyright. All rights reserved...
  16. pmc Immunohistochemical and genomic profiles of diffuse large B-cell lymphomas: implications for targeted EZH2 inhibitor therapy?
    Sydney Dubois
    Inserm U918, Centre Henri Becquerel, Universite de Rouen, IRIB, Rouen, France
    Oncotarget 6:16712-24. 2015
    ....
  17. ncbi ¹⁸F-FDG-PET/CT Imaging in Patients with Febrile Neutropenia and Haematological Malignancies
    Vincent Camus
    Department of Haematology, Centre Henri Becquerel, Rouen, France
    Anticancer Res 35:2999-3005. 2015
    ..Our study confirmed the ability of FDG-PET/CT to diagnose infections in patients with persistent FN...
  18. doi Mutation mismatch repair gene deletions in diffuse large B-cell lymphoma
    Lucile Couronné
    UMR INSERM U918, Centre Henri Becquerel, Rouen, France
    Leuk Lymphoma 54:1079-86. 2013
    ....
  19. ncbi Recurrent disruption of the Imu splice donor site in t(14;18) positive lymphomas: a potential molecular basis for aberrant downstream class switch recombination
    Philippe Ruminy
    Groupe d étude des Proliférations Lymphoïdes, Centre Henri Becquerel, INSERM U614, IFR23, 76000 Rouen, France
    Genes Chromosomes Cancer 46:735-44. 2007
    ..In conclusion, our data suggest that an acquired mutation at the splicing donor site of the Smu transcripts may participate in the selection of lymphoma cells and play a significant role during the onset of the disease...
  20. ncbi Follicular lymphoma without t(14;18) and with BCL-6 rearrangement: a lymphoma subtype with distinct pathological, molecular and clinical characteristics
    F Jardin
    Department of Haematology and EMI 9906 IRFMP No 23, Centre Henri Becquerel, Rouen, France
    Leukemia 16:2309-17. 2002
    ..This study indicates that 3q27(+) FL without t(14;18) translocation have peculiar clinico-pathologic features and may correspond to a rare and distinct subtype of lymphoma originating from the germinal center...
  21. ncbi Incidence and risk factors for central nervous system occurrence in elderly patients with diffuse large-B-cell lymphoma: influence of rituximab
    P Feugier
    Service hématologie, Service Informatique Médicale, Hopitaux de Brabois, Nancy, France
    Ann Oncol 15:129-33. 2004
    ..The addition of rituximab increases the complete response rate and prolongs event-free and overall survival in elderly patients with such lymphoma...
  22. doi Molecular Profile and FDG-PET/CT Total Metabolic Tumor Volume Improve Risk Classification at Diagnosis for Patients with Diffuse Large B-Cell Lymphoma
    Anne Ségolène Cottereau
    Nuclear Medicine Department, Henri Becquerel Cancer Center and Rouen University Hospital, Rouen, France QuantIF LITIS EA 4108 FR CNRS 3638, Faculty of Medicine, University of Rouen, Rouen, France
    Clin Cancer Res 22:3801-9. 2016
    ..The prognostic impact of total metabolic tumor volume (TMTV) measured on pretreatment (18)F-FDG PET/CT and its added value to molecular characteristics was investigated in patients with diffuse large B-cell lymphoma (DLBCL)...
  23. doi Activating somatic mutations in diffuse large B-cell lymphomas: lessons from next generation sequencing and key elements in the precision medicine era
    Elodie Bohers
    Inserm U918, Centre Henri Becquerel, Rouen University and IRIB, Rouen, France
    Leuk Lymphoma 56:1213-22. 2015
    ....
  24. doi Whole exome sequencing of relapsed/refractory patients expands the repertoire of somatic mutations in diffuse large B-cell lymphoma
    Sylvain Mareschal
    Inserm U918, Centre Henri Becquerel, Rouen, France
    Genes Chromosomes Cancer 55:251-67. 2016
    ..Among these analyses, somatic events in the NF-κB pathway were found preponderant in the three DLBCL subtypes, confirming its major implication in DLBCL aggressiveness and pinpointing several new candidate genes...
  25. doi Molecular characterization of 9p21 deletions shows a minimal common deleted region removing CDKN2A exon 1 and CDKN2B exon 2 in diffuse large B-cell lymphomas
    Suzan Guney
    Inserm U918, Groupe d étude des Proliférations Lymphodes, Institut Federatif de Recherches Multidisciplinaires sur les Peptides 23 IFRMP23, Rouen, France
    Genes Chromosomes Cancer 50:715-25. 2011
    ....
  26. ncbi Intravascular large B-Cell lymphoma with bone marrow involvement and superior sagittal sinus thrombosis: report of a case successfully treated with a CHOP/rituximab combination regimen
    Fabrice Jardin
    Department of Hematology, Centre Henri Becquerel and Charles Nicolle University Hospital, Rouen, France
    Clin Lymphoma 6:46-9. 2005
    ..This observation highlights an unusual vascular aspect of ILBCL and the efficacy of the current standard treatment for this age group (CHOP/rituximab) in this particularly aggressive lymphoma subtype...
  27. ncbi Follicle center lymphoma is associated with significantly elevated levels of BCL-6 expression among lymphoma subtypes, independent of chromosome 3q27 rearrangements
    F Jardin
    Department of Haematology and EMI 9906 IRFMP No 23, Centre Henri Becquerel, Rouen, France
    Leukemia 16:2318-25. 2002
    ..Clinical implication and alternative deregulation pathways of BCL-6 expression remain to be determined...
  28. doi Targetable activating mutations are very frequent in GCB and ABC diffuse large B-cell lymphoma
    Elodie Bohers
    Inserm U918, Centre Henri Becquerel, Institute for Research and Innovation in Biomedicine, University of Rouen, Rouen, France
    Genes Chromosomes Cancer 53:144-53. 2014
    ....
  29. ncbi [Acute respiratory distress syndrome due to pneumonitis following intrathecal methotrexate administration]
    F Le Guillou
    Clinique Pneumologique, CHU, Rouen, France
    Rev Mal Respir 20:273-7. 2003
    ..Methotrexate, given orally or systemically, is associated with pneumonitis in 7% of cases...
  30. ncbi Allogeneic stem cell transplantation in second rather than first complete remission in selected patients with good-risk acute myeloid leukemia
    A De Labarthe
    Department of Hematology, Hopital Saint Louis, Paris, France
    Bone Marrow Transplant 35:767-73. 2005
    ..In NN patients, FLT3-ITD was the main bad-prognosis factor for second CR achievement and survival, leading to consider SCT earlier, at least in FLT3-ITD patients with a donor...
  31. doi Prognostic impact of fat tissue loss and cachexia assessed by computed tomography scan in elderly patients with diffuse large B-cell lymphoma treated with immunochemotherapy
    Vincent Camus
    Department of Haematology, Centre Henri Becquerel, Rouen, France Centre Henri Becquerel, Inserm U918, IRIB, Rouen, France
    Eur J Haematol 93:9-18. 2014
    ..This study evaluated the prognostic impact of a cachexia score (CS) including fat tissue loss (adipopenia) and sarcopenia as assessed by computed tomography (CT scan) in elderly DLBCL patients treated with chemotherapy and rituximab (R)...
  32. ncbi Low-grade stage III-IV follicular lymphoma: multivariate analysis of prognostic factors in 484 patients--a study of the groupe d'Etude des lymphomes de l'Adulte
    D Decaudin
    Groupe d Etude des Lymphomes de l Adulte, Creteil, Paris, Nantes, Rouen, Caen, Lyon, and Le Mans, France, and Yvoir, Belgium
    J Clin Oncol 17:2499-505. 1999
    ..To identify the prognostic factors that influence overall survival (OS) in patients with stage III-IV follicular lymphomas and evaluate the clinical usefulness and the prognostic value of the International Prognostic Index (IPI)...
  33. doi Recurrent mutations of the exportin 1 gene (XPO1) and their impact on selective inhibitor of nuclear export compounds sensitivity in primary mediastinal B-cell lymphoma
    Fabrice Jardin
    Departement of Hematology, Inserm U918, Centre Henri Becquerel, Rouen, France
    Am J Hematol 91:923-30. 2016
    ..SINE compounds appear active for both mutated and wild-type protein. Am. J. Hematol. 91:923-930, 2016. © 2016 Wiley Periodicals, Inc. ..
  34. doi Invasive aspergillosis in neutropenic patients during hospital renovation: effectiveness of mechanical preventive measures in a prospective cohort of 438 patients
    Michael Loschi
    Department of Hematology, Centre Henri Becquerel, 1 rue d Amiens, 76000, Rouen, France
    Mycopathologia 179:337-45. 2015
    ..Aspergillus species are the main cause of invasive fungal disease for patients with severe and prolonged neutropenia. Building or renovation works have been shown as one of the major causes of outbreaks of aspergillosis...
  35. doi Outcome of patients older than 60 years with classical Hodgkin lymphoma treated with front line ABVD chemotherapy: frequent pulmonary events suggest limiting the use of bleomycin in the elderly
    Aspasia Stamatoullas
    Henri Becquerel Centre, Rouen University, Rouen, France
    Br J Haematol 170:179-84. 2015
    ..ABVD can be proposed as front-line chemotherapy in selected elderly cHL patients. The frequency of pulmonary events leads us to propose to either reduce the dose of bleomycin or to remove it from the regimen. ..
  36. doi Complex karyotype in mantle cell lymphoma is a strong prognostic factor for the time to treatment and overall survival, independent of the MCL international prognostic index
    Clémentine Sarkozy
    Department of Hematology, Centre Hospitalier de Versailles, Le Chesnay, Universite de Versailles Saint Quentin, Versailles, France
    Genes Chromosomes Cancer 53:106-16. 2014
    ..In conclusion, in this multicentric cohort of MCL patients, a complex karyotype was associated with a shorter survival time and allowed for the identification of iMCL at the time of diagnosis...
  37. ncbi Concomitant eosinophilia, fasciitis, and mycosis fungoides-like reaction with antinuclear autoantibodies in chronic myeloid leukaemia: role of a T-cell clone induced by imatinib
    Fabrice Jardin
    Department of Haematology, Centre Henri Becquerel, Rouen, France
    Lancet Oncol 6:728-9. 2005
  38. ncbi Secondary Philadelphia chromosome in a patient with acute lymphoblastic leukemia
    Lin Chen
    Department of Hematology, Cytogenetic Department, Centre Henri Becquerel, 1 rue d Amiens, Rouen, France
    Cancer Genet Cytogenet 152:132-5. 2004
    ..This anomaly is usually related to the initiation of the disease, but can be a late event related to progression. We discuss these hypotheses and review the literature...
  39. ncbi The BCL6 proto-oncogene: a leading role during germinal center development and lymphomagenesis
    Fabrice Jardin
    Département d hématologie clinique, Centre Henri Becquerel, Rouen, France
    Pathol Biol (Paris) 55:73-83. 2007
    ....
  40. ncbi PVRL2 is translocated to the TRA@ locus in t(14;19)(q11;q13)-positive peripheral T-cell lymphomas
    Carole Almire
    Groupe d Etude des Proliférations Lymphoides GPL, European Institute for Peptides Research IFRMP23, Centre Henri Becquerel, Rouen, France
    Genes Chromosomes Cancer 46:1011-8. 2007
    ..These results suggest that both BCL3 and PVRL2 may participate in the pathogenesis of these PTCLs, but further studies should be undertaken to investigate the precise role of these genes...
  41. doi Attenuated immunochemotherapy regimen (R-miniCHOP) in elderly patients older than 80 years with diffuse large B-cell lymphoma: a multicentre, single-arm, phase 2 trial
    Frederic Peyrade
    Department of Onco Hematology, Centre régional de lutte contre le cancer de Nice, Nice, France
    Lancet Oncol 12:460-8. 2011
    ....
  42. ncbi Expression of HYAL2 mRNA, hyaluronan and hyaluronidase in B-cell non-Hodgkin lymphoma: relationship with tumor aggressiveness
    Philippe Bertrand
    INSERM EMI 9906 IFR23, Molecular Biology Laboratory, Department of Hematology, Centre Henri Becquerel, Rue d Amiens, 76038 Rouen Cedex, France
    Int J Cancer 113:207-12. 2005
    ..Conversely, HA overexpression in high-grade lymphomas is in favor of its involvement in tumor development and could provide a useful target for lymphoma therapy using HA-binding peptides...
  43. doi S(mu) mutation patterns suggest different progression pathways in follicular lymphoma: early direct or late from FL progenitor cells
    Philippe Ruminy
    Inserm U918, Groupe d étude des Proliférations Lymphoïdes, Institut Federatif de Recherches Multidisciplinaires sur les Peptides 23 IFRMP23, France
    Blood 112:1951-9. 2008
    ..The second was indirect, arising from earlier subclones usually after years of remission. A better understanding of these mechanisms might influence the future choice of treatment strategies...
  44. ncbi Intronic BCL-6 mutations are preferentially targeted to the translocated allele in t(3;14)(q27;q32) non-Hodgkin B-cell lymphoma
    Fabrice Jardin
    Department of Haematology, Centre Henri Becquerel, 76000 Rouen, France
    Blood 102:1872-6. 2003
    ..Junctional sequences indicate translocation origins from earlier BCL-6 mutations and switch recombinase events...
  45. ncbi Human monocytes synthesize hyaluronidase
    Nicole Girard
    Laboratory of Molecular Oncology, Centre Henri Becquerel, Rouen, France
    Br J Haematol 119:199-203. 2002
    ..Hence, monocytes have one or more hyaluronidases that can generate a pool of active HA fragments within tissues. Hyaluronidase activity was also found in 3/3 myelomonocytic lineage leukaemias but not in 3/3 lymphoblastic leukaemias...
  46. ncbi Eosinophilic leukemia associated with t(2;5)(p23;q31)
    Stephane Lepretre
    Department of Haematology, Centre Henri Becquerel, Rue d Amiens, 76038 Rouen Cedex, France
    Cancer Genet Cytogenet 133:164-7. 2002
    ..Initial data could suggest a clonal eosinophilia, with an hepatosplenomegaly, severe pancytopenia, and a high level of blood and medullar eosinophilia...
  47. ncbi Standard chemotherapy with interferon compared with CHOP followed by high-dose therapy with autologous stem cell transplantation in untreated patients with advanced follicular lymphoma: the GELF-94 randomized study from the Groupe d'Etude des Lymphomes de
    Catherine Sebban
    Centre Leon Berard, 28 rue Laennec, 69008 Lyon, France
    Blood 108:2540-4. 2006
    ..After long-term follow-up, our study showed that there was no statistically significant benefit in favor of first-line high-dose therapy in patients with follicular lymphoma. High-dose therapy should be reserved for relapsing patients...
  48. ncbi Transient anti rhesus alloantibody produced by graft after non-myeloablative allogeneic stem cell transplant
    N Contentin
    Department of Hematology, Centre Henri Becquerel, 1, Rue d Amiens, 76038 Rouen Cedex, France
    Transfus Apher Sci 31:191-7. 2004
    ..We report the case of a patient who received an allogeneic transplant with peripheral blood compatible ABO, Rhesus mismatched progenitor cells and who developed an asymptomatic transient anti Rhesus alloimmunisation...
  49. ncbi [Auto-immune manifestations in Non-Hodgkin's lymphoma]
    F Jardin
    Département d hématologie clinique et groupe d étude des syndromes lymphoprolifératifs, Inserm U164, Centre Henri Becquerel, 76000 Rouen, France
    Rev Med Interne 26:557-71. 2005
    ..The purpose of the review is to describe the immune manifestations observed in NHL, according to their histological subtype and to discuss the current physiopathological hypothesis with their therapeutic relevance...
  50. ncbi Clinical and biological relevance of single-nucleotide polymorphisms and acquired somatic mutations of the BCL6 first intron in follicular lymphoma
    F Jardin
    Department of Clinical Hematology, Centre Henri Becquerel, Rouen, France
    Leukemia 19:1824-30. 2005
    ..This study demonstrates that the first BCL6 intron is a highly variable region as a consequence of both SNP and SM, which may contribute to biology and outcome of FL...
  51. ncbi Comparison of a quantitative PCR method with FISH for the assessment of the four aneuploidies commonly evaluated in CLL patients
    C Bastard
    Groupe d étude des Proliférations Lymphoïdes, Centre Henri Becquerel, Rouen, France
    Leukemia 21:1460-3. 2007
    ..However, although QMPSF is perfectly adapted to the detection of primary defects, care should be taken when searching for clonal evolutions present in a small proportion of tumor cells...
  52. doi Recurrent genomic aberrations combined with deletions of various tumour suppressor genes may deregulate the G1/S transition in CD4+CD56+ haematodermic neoplasms and contribute to the aggressiveness of the disease
    F Jardin
    INSERM, U918, European Institute of Peptide Research IFR23, Centre Henri Becquerel, Rouen, France
    Leukemia 23:698-707. 2009
    ..Taken together, these results indicate that in addition to frequent G1/S checkpoint alterations, various genetic events could contribute to the chemoresistance of the tumour...
  53. ncbi Mapping of MYC breakpoints in 8q24 rearrangements involving non-immunoglobulin partners in B-cell lymphomas
    P Bertrand
    Groupe d étude des Proliférations Lymphoïdes, Centre Henri Becquerel, INSERM U614, IFRMP23, Rouen, France
    Leukemia 21:515-23. 2007
    ..006). These results suggest that these rearrangements are the consequence of a non-random process targeting MYC together with non-IG genes involved in lymphocyte differentiation and lymphoma progression...
  54. doi Long-term follow-up of an age-adapted C5R protocol followed by radiotherapy in 99 newly diagnosed primary CNS lymphomas: a prospective multicentric phase II study of the Groupe d'Etude des Lymphomes de l'Adulte (GELA)
    H Ghesquieres
    Department of Hematology, Centre Leon Berard, Universite de Lyon, 28 rue Laennec, Lyon, France
    Ann Oncol 21:842-50. 2010
    ..This prospective multicentric phase II study aimed to confirm the results of the C5R protocol of high-dose methotrexate (MTX)-based chemotherapy (CT) for immunocompetent primary central nervous system lymphoma...
  55. doi Body mass index and other anthropometric parameters in patients with diffuse large B-cell lymphoma: physiopathological significance and predictive value in the immunochemotherapy era
    Clémentine Sarkozy
    Department of Hematology, Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Universite Claude Bernard, Pierre Benite, France
    Leuk Lymphoma 56:1959-68. 2015
    ..We also discuss their relationship with other nutritional parameters and their potential role in the management of patients with DLBCL. ..
  56. doi Comparison between 2D and 3D dosimetry protocols in 90Y-ibritumomab tiuxetan radioimmunotherapy of patients with non-Hodgkin's lymphoma
    Karine Assié
    Laboratoire LITIS EA 4108, Universite de Rouen, Rouen, France
    Cancer Biother Radiopharm 23:53-64. 2008
    ....
  57. ncbi Distribution of BCL2 breakpoints in follicular lymphoma and correlation with clinical features: specific subtypes or same disease?
    G Buchonnet
    INSERM, EMI 9906, IFRMP No 23, Centre Henri Becquerel, Rouen, France
    Leukemia 16:1852-6. 2002
    ..It was not possible, in this series, to demonstrate any correlation between breakpoint location and either initial characteristics of the disease or survival of the patients...
  58. ncbi Unusual complex hyperdiploid karyotypes in myelodysplastic syndromes
    Aspasia Stamatoullas
    Groupe d étude des Proliférations Lymphoïdes, Centre Henri Becquerel, Département d Hématologie INSERM U 614, IFR 23, Rouen, France
    Cancer Genet Cytogenet 170:129-32. 2006
    ..Notably, trisomy 8 and monosomy 7 were rare in that group of patients. Three of four patients with marked dyserythropoiesis shared abnormalities of both chromosomes 13 and 17...
  59. doi Brain perfusion in adult patients with acute myeloblastic leukemia before and after cytosine arabinoside
    Romain Modzelewski
    Department of Nuclear Medicine, Rouen University Hospital, University of Rouen, Rouen, France
    Mol Imaging Biol 13:747-53. 2011
    ..We conducted a prospective study to evaluate brain perfusion with single-photon emission computed tomography (SPECT) in adult patients before and after receiving ara-C...
  60. ncbi Intense paraneoplastic neutrophilic leukemoid reaction related to a G-CSF-secreting lung sarcoma
    Fabrice Jardin
    Department of Haematology and EMI 9906, IFRMP 23, Centre Henri Becquerel, Rouen, France
    Am J Hematol 80:243-5. 2005
    ..Adjunction of the patient's serum to CD34+ cell cultures induced a 12.3-fold increase in CD15+ cells, demonstrating the serum's capacity to induce myeloid differentiation...
  61. ncbi Does chemotherapy influence the quantification of SUV when contrast-enhanced CT is used in PET/CT in lymphoma?
    Pierre Vera
    Department of Nuclear Medicine, Henri Becquerel Centre and Rouen University Hospital, 1 rue d Amiens, Rouen, France
    Eur J Nucl Med Mol Imaging 34:1943-52. 2007
    ..In patients with lymphoma, we investigated the impact of contrast-enhanced CT on PET attenuation correction in lesions and normal tissues, particularly when PET/CT was performed after chemotherapy...
  62. ncbi Managing early failures with R-CHOP in patients with diffuse large B-cell lymphoma
    Vincent Camus
    a Department of Hematology, Centre Henri Becquerel, Universite de Rouen, IRIB, Rouen, France
    Expert Rev Hematol . 2016
    ....
  63. doi PET/CT before autologous stem cell transplantation predicts outcome in refractory/relapsed follicular lymphoma
    Marion Alcantara
    Service d Hematologie, Centre Henri Becquerel, Universite de Rouen, Rue d Amiens, Rouen, Cedex 760381, France
    Eur J Nucl Med Mol Imaging 42:215-21. 2015
    ..Previous studies dealing with relapsed Hodgkin lymphoma have shown the prognostic value of PET/CT prior to ASCT...
  64. doi Invasive Geotrichum clavatum fungal infection in an acute myeloid leukaemia patient: a case report and review
    Vincent Camus
    Department of Hematology, Centre Henri Becquerel, Rue d Amiens, 76038, Rouen, France
    Mycopathologia 177:319-24. 2014
    ..He was treated with voriconazole and is still alive 1 year after with controlled disease. We then discuss the epidemiological, clinical, and therapeutic features of these serious fungal infections compared to the published data. ..
  65. ncbi Two patterns of chromosomal breakpoint locations on the immunoglobulin heavy-chain locus in B-cell lymphomas with t(3;14)(q27;q32): relevance to histology
    P Ruminy
    1Groupe d Etude des Proliférations Lymphoïdes, Centre Henri Becquerel, INSERM U614, IFR23, Rouen, France
    Oncogene 25:4947-54. 2006
    ....
  66. ncbi [Primary pleural lymphoma after collapse therapy: modern aspects of an historic disease]
    F Jardin
    Service d Hematologie Clinique, centre de lutte contre le cancer Henri Becquerel, Rouen, France
    Rev Med Interne 20:985-91. 1999
    ..Most cases have been described by Japanese investigators and it seems rare or unrecognised in Western countries. We report the study of six cases observed in a single institution...