Shahragim Tajbakhsh

Summary

Affiliation: Institut Pasteur
Country: France

Publications

  1. doi request reprint Ballroom dancing with stem cells: placement and displacement in the intestinal crypt
    Shahragim Tajbakhsh
    Stem Cells and Development, Department of Developmental and Stem Cell Biology, CNRS URA 2578, Institut Pasteur, 25 rue du Dr Roux, 75015 Paris, France Electronic address
    Cell Stem Cell 14:271-3. 2014
  2. pmc Distinct contextual roles for Notch signalling in skeletal muscle stem cells
    Philippos Mourikis
    Stem Cells and Development, CNRS URA 2578, Department of Developmental and Stem Cell Biology, Institut Pasteur, 25 rue du Dr, Roux, 75015 Paris, France
    BMC Dev Biol 14:2. 2014
  3. doi request reprint Embryonic founders of adult muscle stem cells are primed by the determination gene Mrf4
    Ramkumar Sambasivan
    Institut Pasteur, Stem Cells and Development, CNRS URA 2578, 25 rue du Dr Roux, 75724, Paris Cedex 15, France
    Dev Biol 381:241-55. 2013
  4. doi request reprint Distinct regulatory cascades govern extraocular and pharyngeal arch muscle progenitor cell fates
    Ramkumar Sambasivan
    Institut Pasteur, Stem Cells and Development, CNRS URA 2578, Universite de la Mediterranee, Campus de Luminy, Marseille, France
    Dev Cell 16:810-21. 2009
  5. doi request reprint A Cranial Mesoderm Origin for Esophagus Striated Muscles
    Swetha Gopalakrishnan
    Department of Developmental and Stem Cell Biology, Institut Pasteur, Stem Cells and Development, CNRS URA 2578, 25 rue du Dr Roux, 75015 Paris, France
    Dev Cell 34:694-704. 2015
  6. doi request reprint Myf5 haploinsufficiency reveals distinct cell fate potentials for adult skeletal muscle stem cells
    Barbara Gayraud-Morel
    Stem Cells and Development, Department of Developmental Biology, Institut Pasteur, CNRS URA 2578, Paris, France
    J Cell Sci 125:1738-49. 2012
  7. doi request reprint Cell-autonomous Notch activity maintains the temporal specification potential of skeletal muscle stem cells
    Philippos Mourikis
    Stem Cells and Development, Department of Developmental Biology, CNRS URA 2578, Institut Pasteur, 25 rue du Dr Roux, 75105 Paris, France
    Development 139:4536-48. 2012
  8. doi request reprint Numb promotes an increase in skeletal muscle progenitor cells in the embryonic somite
    Aurélie Jory
    Stem Cells and Development, Department of Developmental Biology Pasteur Institute, Centre National de la Recherche Scientifique CNRS URA 2578, 75724 Paris Cedex 15, France
    Stem Cells 27:2769-80. 2009
  9. doi request reprint A critical requirement for notch signaling in maintenance of the quiescent skeletal muscle stem cell state
    Philippos Mourikis
    Stem Cells and Development, Department of Developmental Biology, Institut Pasteur, CNRS URA 2578, Paris, France
    Stem Cells 30:243-52. 2012
  10. doi request reprint [Immortal DNA or epigenetic signature ?]
    Pierre Rocheteau
    Cellules Souches et Développement, Departement de Biologie du Developpement, Institut Pasteur, CNRS URA 2578, 25, rue du Docteur Roux, 75724 Paris Cedex 15, France
    Med Sci (Paris) 24:847-52. 2008

Collaborators

Detail Information

Publications30

  1. doi request reprint Ballroom dancing with stem cells: placement and displacement in the intestinal crypt
    Shahragim Tajbakhsh
    Stem Cells and Development, Department of Developmental and Stem Cell Biology, CNRS URA 2578, Institut Pasteur, 25 rue du Dr Roux, 75015 Paris, France Electronic address
    Cell Stem Cell 14:271-3. 2014
    ..Ritsma et al. (2014) recently reported temporal live imaging of mouse intestinal stem cells and their progeny, providing insights into spatial dynamics underlying stem cell behavior. ..
  2. pmc Distinct contextual roles for Notch signalling in skeletal muscle stem cells
    Philippos Mourikis
    Stem Cells and Development, CNRS URA 2578, Department of Developmental and Stem Cell Biology, Institut Pasteur, 25 rue du Dr, Roux, 75015 Paris, France
    BMC Dev Biol 14:2. 2014
    ..This review will provide an overview of Notch signalling during myogenic development and postnatally, and underscore the seemingly opposing contextual activities of Notch that have lead to a reassessment of its role in myogenesis. ..
  3. doi request reprint Embryonic founders of adult muscle stem cells are primed by the determination gene Mrf4
    Ramkumar Sambasivan
    Institut Pasteur, Stem Cells and Development, CNRS URA 2578, 25 rue du Dr Roux, 75724, Paris Cedex 15, France
    Dev Biol 381:241-55. 2013
    ..We propose that embryonic myogenic cells and the majority of adult muscle stem cells form a lineage continuum...
  4. doi request reprint Distinct regulatory cascades govern extraocular and pharyngeal arch muscle progenitor cell fates
    Ramkumar Sambasivan
    Institut Pasteur, Stem Cells and Development, CNRS URA 2578, Universite de la Mediterranee, Campus de Luminy, Marseille, France
    Dev Cell 16:810-21. 2009
    ..These findings identify novel genetic networks that may provide insights into myopathies which often affect only subsets of muscles...
  5. doi request reprint A Cranial Mesoderm Origin for Esophagus Striated Muscles
    Swetha Gopalakrishnan
    Department of Developmental and Stem Cell Biology, Institut Pasteur, Stem Cells and Development, CNRS URA 2578, 25 rue du Dr Roux, 75015 Paris, France
    Dev Cell 34:694-704. 2015
    ..These findings have important implications in understanding esophageal dysfunctions, including dysphagia, and congenital disorders, such as DiGeorge syndrome...
  6. doi request reprint Myf5 haploinsufficiency reveals distinct cell fate potentials for adult skeletal muscle stem cells
    Barbara Gayraud-Morel
    Stem Cells and Development, Department of Developmental Biology, Institut Pasteur, CNRS URA 2578, Paris, France
    J Cell Sci 125:1738-49. 2012
    ..These findings have important implications for how stem cell fates can be modulated by crucial transcription factors while generating a pool of responsive heterogeneous cells...
  7. doi request reprint Cell-autonomous Notch activity maintains the temporal specification potential of skeletal muscle stem cells
    Philippos Mourikis
    Stem Cells and Development, Department of Developmental Biology, CNRS URA 2578, Institut Pasteur, 25 rue du Dr Roux, 75105 Paris, France
    Development 139:4536-48. 2012
    ..Significantly, Notch does not override other signals that promote temporal myogenic cell fates during ontology where spatiotemporal developmental cues produce distinct phenotypic classes of myoblasts...
  8. doi request reprint Numb promotes an increase in skeletal muscle progenitor cells in the embryonic somite
    Aurélie Jory
    Stem Cells and Development, Department of Developmental Biology Pasteur Institute, Centre National de la Recherche Scientifique CNRS URA 2578, 75724 Paris Cedex 15, France
    Stem Cells 27:2769-80. 2009
    ..Thus, we propose that Numb can regulate the self-renewal of dermal and muscle progenitors during a lineage progression...
  9. doi request reprint A critical requirement for notch signaling in maintenance of the quiescent skeletal muscle stem cell state
    Philippos Mourikis
    Stem Cells and Development, Department of Developmental Biology, Institut Pasteur, CNRS URA 2578, Paris, France
    Stem Cells 30:243-52. 2012
    ..This study establishes Notch signaling pathway as the first regulator of cellular quiescence in adult muscle stem cells...
  10. doi request reprint [Immortal DNA or epigenetic signature ?]
    Pierre Rocheteau
    Cellules Souches et Développement, Departement de Biologie du Developpement, Institut Pasteur, CNRS URA 2578, 25, rue du Docteur Roux, 75724 Paris Cedex 15, France
    Med Sci (Paris) 24:847-52. 2008
    ....
  11. doi request reprint Pax7-expressing satellite cells are indispensable for adult skeletal muscle regeneration
    Ramkumar Sambasivan
    Institut Pasteur, Stem Cells and Development, CNRS URA 2578, 25 rue du Dr Roux, Paris, F 75015, France
    Development 138:3647-56. 2011
    ....
  12. doi request reprint Skeletal muscle as a paradigm for regenerative biology and medicine
    Barbara Gayraud-Morel
    Stem Cells and Development, Department of Developmental Biology, Pasteur Institute, CNRS URA 2578, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Regen Med 4:293-319. 2009
    ..This review addresses these issues, focusing on muscle regeneration and how different factors, including genes, cells and the environment, impinge on this process...
  13. doi request reprint Variations in the efficiency of lineage marking and ablation confound distinctions between myogenic cell populations
    Glenda Comai
    Stem Cells and Development, Department of Developmental and Stem Cell Biology, URA CNRS 2578, Institut Pasteur, 25 rue du Dr Roux, 75015 Paris, France
    Dev Cell 31:654-67. 2014
    ..Therefore, these observations are incompatible with a previously proposed functional two-lineage model. These findings will have an impact on the interpretation of phenotypes obtained using similar strategies in other tissues. ..
  14. doi request reprint DNA asymmetry and cell fate regulation in stem cells
    Siham Yennek
    Institut Pasteur, Stem Cells and Development, Department of Developmental and Stem Cell Biology, CNRS URA 2578, 25 rue du Dr Roux, Paris F 75015, France
    Semin Cell Dev Biol 24:627-42. 2013
    ..We propose that cellular asymmetry is inherently present during each cell division, and that it provides an opportunity during each cell cycle for moderating cell fates. ..
  15. doi request reprint Template DNA-strand co-segregation and asymmetric cell division in skeletal muscle stem cells
    Vasily Shinin
    Stem Cells and Development, Department of Developmental Biology, Pasteur Institute, Paris, France
    Methods Mol Biol 482:295-317. 2009
    ..In addition, asymmetric segregation of template DNA and the cytoplasmic protein Numb provides a landmark to define cell behaviour as self-renewal and differentiation decisions are being executed...
  16. doi request reprint Sorting DNA with asymmetry: a new player in gene regulation?
    Brendan Evano
    Institut Pasteur, Stem Cells and Development, Department of Developmental and Stem Cell Biology, CNRS URA 2578, 25 rue du Dr Roux, Paris 75015, France
    Chromosome Res 21:225-42. 2013
    ..Here, we review the evidence for asymmetric or template DNA strand segregation in mammals with a focus on skeletal muscle...
  17. doi request reprint A subpopulation of adult skeletal muscle stem cells retains all template DNA strands after cell division
    Pierre Rocheteau
    Institut Pasteur, Stem Cells and Development, Department of Developmental Biology, CNRS URA 2578, 25 rue du Dr Roux, Paris 75015, France
    Cell 148:112-25. 2012
    ..These findings provide major insights into the biology of stem cells that segregate DNA asymmetrically...
  18. doi request reprint Asymmetric cell divisions and asymmetric cell fates
    Shahragim Tajbakhsh
    Stem Cells and Development, CNRS URA 2578, Department of Developmental Biology, Institut Pasteur, 75724 Paris Cedex 15, France
    Annu Rev Cell Dev Biol 25:671-99. 2009
    ..This review addresses some of these points and considers different developmental model systems that attempt to investigate how cell fate decisions are determined, as well as the molecules that guide these choices...
  19. doi request reprint Skeletal muscle stem cells adopt a dormant cell state post mortem and retain regenerative capacity
    Mathilde Latil
    Human Histopathology and Animal Models, Infection and Epidemiology Departement, Institut Pasteur, 25 rue du Dr Roux, Paris 75015, France
    Nat Commun 3:903. 2012
    ..Finally, severe hypoxia, or anoxia is critical for maintaining stem cell viability and regenerative capacity. Thus, these cells provide a useful resource for studying stem cell biology...
  20. pmc Numb is required to prevent p53-dependent senescence following skeletal muscle injury
    Isabelle Le Roux
    Department of Developmental and Stem Cell Biology, Stem Cells and Development, CNRS URA 2578, Institut Pasteur, 25 rue du Dr Roux, Paris 75015, France
    Nat Commun 6:8528. 2015
    ..These findings provide insights into previously reported developmental and oncogenic senescence that are also differentially regulated by p53. ..
  21. doi request reprint More efficient repair of DNA double-strand breaks in skeletal muscle stem cells compared to their committed progeny
    Leyla Vahidi Ferdousi
    Institut Pasteur, Yeast Molecular Genetics, Dept of Genomes and Genetics, 25 rue du Dr Roux, 75724 Paris Cedex 15, France CNRS UMR 3525, Team Stability of Nuclear and Mitochondrial DNA, Paris, France Sorbonne Universités, UPMC, University of Paris 06, IFD ED 515, place Jussieu, Paris, 72252, France
    Stem Cell Res 13:492-507. 2014
    ..Finally, we show that repair of DSB substrates is not only very efficient but, surprisingly, also very accurate in satellite cells and that accurate repair depends on the key non-homologous end-joining factor DNA-PKcs. ..
  22. doi request reprint Stem cell identity and template DNA strand segregation
    Shahragim Tajbakhsh
    Institut Pasteur, Stem Cells and Development, CNRS URA 2578, Department of Developmental Biology, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Curr Opin Cell Biol 20:716-22. 2008
    ..Although initially postulated as a mechanism to avoid DNA replication errors, alternative views including epigenetic regulation and sister chromatid silencing may provide insights into this process...
  23. doi request reprint An eye on the head: the development and evolution of craniofacial muscles
    Ramkumar Sambasivan
    Institut Pasteur, Stem Cells and Development, Paris, F 75015, France
    Development 138:2401-15. 2011
    ..Through evolutionary comparisons of primitive chordates (such as amphioxus) and jawless vertebrates (such as lampreys) with jawed vertebrates, we also provide some clues as to how this dichotomy arose...
  24. pmc Comparative Study of Injury Models for Studying Muscle Regeneration in Mice
    David Hardy
    Institut Pasteur, Human Histopathology and Animal Models Unit, Infection and Epidemiology Department, Paris, France
    PLoS ONE 11:e0147198. 2016
    ..Specifically, for skeletal muscle regeneration several models are reported in the literature, yet the relative impact on muscle physiology and the distinct cells types have not been extensively characterised...
  25. doi request reprint Engulfment of the midbody remnant after cytokinesis in mammalian cells
    Elizabeth Faris Crowell
    Institut Pasteur, Membrane Traffic and Cell Division Lab, Department of Cell Biology and Infection, 25 rue du Dr Roux, 75015 Paris, France CNRS URA 2582, F 75015 Paris, France
    J Cell Sci 127:3840-51. 2014
    ..This study changes our understanding of how MBRs are inherited and degraded in mammalian cells and suggests a mechanism by which MBRs might signal over long distances between cells. ..
  26. doi request reprint Molecular and cellular regulation of skeletal myogenesis
    Glenda Comai
    Stem Cells and Development, CNRS URA 2578, Department of Developmental and Stem Cell Biology, Institut Pasteur, Paris, France
    Curr Top Dev Biol 110:1-73. 2014
    ..This apparent nonspecificity can be reconciled in part by the permissivity of the cell for myogenic commitment, and also by new roles for some of these regulators as pioneer transcription factors acting on chromatin state. ..
  27. doi request reprint Cell adhesion geometry regulates non-random DNA segregation and asymmetric cell fates in mouse skeletal muscle stem cells
    Siham Yennek
    Institut Pasteur, Stem Cells and Development, Department of Developmental and Stem Cell Biology, CNRS URA 2578, 25 rue du Dr Roux, Paris F 75015, France Sorbonne Universités, UPMC, University of Paris 06, IFD ED 515, 4 place Jussieu, Paris 75252, France
    Cell Rep 7:961-70. 2014
    ..Furthermore, regulation of DNA segregation by cell adhesion occurs within a defined time interval. Thus, cell adhesion cues have a major impact on determining both DNA segregation patterns and cell fates...
  28. pmc Losing stem cells in the aged skeletal muscle niche
    Shahragim Tajbakhsh
    Stem Cells and Development, Department of Developmental and Stem Cell Biology, CNRS URA 2578, Pasteur Institute, 25 rue du Dr Roux, 75015, Paris, France
    Cell Res 23:455-7. 2013
    ..Recently, genetic and cell marking strategies were used to uncover a new and causal relationship between muscle stem cells and differentiated fibers that constitute their niche and provoke their loss...
  29. ncbi request reprint Skeletal muscle stem cell birth and properties
    Ramkumar Sambasivan
    Stem Cells and Development, Department of Developmental Biology, Pasteur Institute, CNRS URA 2578, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Semin Cell Dev Biol 18:870-82. 2007
    ..These properties include markers that influence cell behaviour and mode of division during normal development, after trauma and cell transplantations. This review addresses these issues from a developmental perspective...
  30. ncbi request reprint A role for the myogenic determination gene Myf5 in adult regenerative myogenesis
    Barbara Gayraud-Morel
    Stem Cells and Development, Dept of Developmental Biology, Pasteur Institute, CNRS URA 2578, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Dev Biol 312:13-28. 2007
    ..Therefore, we show that Myf5 is a regulator of regenerative myogenesis and homeostasis, with functions distinct from those of Myod and Mrf4...