Genomes and Genes
Affiliation: Institut Pasteur
- Inhibition of human immunodeficiency virus type 1 Env-mediated fusion by DC-SIGNCinzia Nobile
Virus and Immunity Group, URA CNRS 1930, Institut Pasteur, 75724 Paris Cedex 15, France
J Virol 77:5313-23. 2003..DC-SIGN facilitates capture and accumulation of viral particles in a vesicular compartment and inhibits viral fusion. Competition between CD4 and DC-SIGN for Env binding likely affects virus access to the cytosol and syncytium formation...
- Covert human immunodeficiency virus replication in dendritic cells and in DC-SIGN-expressing cells promotes long-term transmission to lymphocytesCinzia Nobile
Institut Pasteur, Groupe Virus et Immunité, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
J Virol 79:5386-99. 2005..The cell-type-dependent activity of DC-SIGN reflects the ability of HIV to replicate covertly in some cells, and not in others...
- HIV-2 infects resting CD4+ T cells but not monocyte-derived dendritic cellsLise Chauveau
Retrovirology 12:2. 2015..We propose that HIV-2, like HIV-1, does not productively infect MDDCs, possibly to avoid triggering an immune response mediated by these cells...
- SAMHD1 restricts HIV-1 reverse transcription in quiescent CD4(+) T-cellsBenjamin Descours
Institut de Genetique Humaine, CNRS UPR1142, Laboratoires de Virologie Moléculaire, Montpellier, France
Retrovirology 9:87. 2012..Quiescent CD4+ T lymphocytes are highly refractory to HIV-1 infection due to a block at reverse transcription...
- Generation and characterization of a stable cell population releasing fluorescent HIV-1-based Virus Like Particles in an inducible wayClaudia Muratori
National AIDS Center, Istituto Superiore di Sanita, Viale Regina Elena, 299, 00161 Rome, Italy
BMC Biotechnol 6:52. 2006..We sought to overcome such a limitation by using a cell line releasing HIV-1 particles in an inducible way, and by exploiting the ability of a HIV-1 Nef mutant to be incorporated in virions at quite high levels...
- Biology and pathogenesis of chikungunya virusOlivier Schwartz
Institut Pasteur, 28 rue du Dr Roux, Paris 75724 Cedex 15, France
Nat Rev Microbiol 8:491-500. 2010..This Review highlights some of the most recent advances in our understanding of the biology of CHIKV and its interactions with the host...
- Cell of the month. Dendritic cell sensing a lymphocyteOlivier Schwartz
Virus and Immunity Group, Institut Pasteur, Paris, France
Nat Rev Mol Cell Biol 5:175. 2004
- Tetherin restricts productive HIV-1 cell-to-cell transmissionNicoletta Casartelli
Institut Pasteur, Virus and Immunity Unit, URA CNRS 3015, Paris, France
PLoS Pathog 6:e1000955. 2010..Tetherin, by imprinting virions in donor cells, is the first example of a surface restriction factor limiting viral cell-to-cell spread...
- The antiviral factor APOBEC3G improves CTL recognition of cultured HIV-infected T cellsNicoletta Casartelli
Unité Virus et Immunite, Institut Pasteur, 75724 Paris Cedex 15, France
J Exp Med 207:39-49. 2010..Our results reveal a novel function for A3G, acting not only as an intrinsic antiviral factor but also as an inducer of the adaptive immune system...
- DC-SIGN facilitates fusion of dendritic cells with human T-cell leukemia virus type 1-infected cellsPierre Emmanuel Ceccaldi
Unité Epidémiologie et Physiopathologie des Virus Oncogènes, Institut Pasteur, Paris Cedex 15, France
J Virol 80:4771-80. 2006..Altogether, our results indicate that DC-SIGN facilitates HTLV-1 infection and fusion of DCs through an ICAM-dependent mechanism...
- Pediatric measles vaccine expressing a dengue antigen induces durable serotype-specific neutralizing antibodies to dengue virusSamantha Brandler
Viral Genomics and Vaccination Laboratory, Institut Pasteur, CNRS URA3015, Paris, France
PLoS Negl Trop Dis 1:e96. 2007..The protective efficacy of this vaccine should be studied in non-human primates. A combined measles-dengue vaccine might provide a one-shot approach to immunize children against both diseases where they co-exist...
- DC-SIGN promotes exogenous MHC-I-restricted HIV-1 antigen presentationArnaud Moris
Groupe Virus et Immunité, URA CNRS 1930, Institut Pasteur, Paris, France
Blood 103:2648-54. 2004..Altogether, our results highlight new aspects of DC-SIGN interactions with HIV-1. The lectin does not significantly protect captured virions against degradation and promotes MHC-I exogenous presentation of HIV-1 antigens...
- Inefficient human immunodeficiency virus replication in mobile lymphocytesMarion Sourisseau
Groupe Virus et Immunité, URA CNRS 1930, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
J Virol 81:1000-12. 2007..Altogether, these results indicate that cell-to-cell transfer is the predominant mode of HIV spread and help to explain why this virus replicates so efficiently in lymphoid organs...
- Simultaneous cell-to-cell transmission of human immunodeficiency virus to multiple targets through polysynapsesDominika Rudnicka
Department of Virology, Virus and Immunity Unit, Institut Pasteur, URA CNRS 3015, Paris Cedex 15, France
J Virol 83:6234-46. 2009..In HIV-infected individuals, these structures, by promoting concomitant infection of multiple targets in the vicinity of infected cells, may facilitate exponential viral growth and escape from immune responses...
- Partial inhibition of human immunodeficiency virus replication by type I interferons: impact of cell-to-cell viral transferDaniela Vendrame
Institut Pasteur, Virus and Immunity Unit, CNRS URA 3015, 25 28 Rue du Dr Roux, 75724 Paris, France
J Virol 83:10527-37. 2009..They help explain the incomplete protection by naturally secreted IFN during HIV infection and the unsatisfactory outcome of IFN treatment in HIV-infected patients...
- ZAP-70 kinase regulates HIV cell-to-cell spread and virological synapse formationNathalie Sol-Foulon
Groupe Virus et Immunité, Institut Pasteur, CNRS URA1930, France
EMBO J 26:516-26. 2007..These results bring novel insights into the links that exist between T-cell activation and HIV spread, and suggest that HIV usurps components of the immunological synapse machinery to ensure its own spread through cell-to-cell contacts...
- Chikungunya-induced cell death is limited by ER and oxidative stress-induced autophagyPierre Emmanuel Joubert
Unité Immunobiologie des Cellules Dendritiques, Institut Pasteur, Paris, France
Autophagy 8:1261-3. 2012....
- HIV-1 Nef inhibits ruffles, induces filopodia, and modulates migration of infected lymphocytesCinzia Nobile
Virus and Immunity Unit, Department of Virology, Institut Pasteur, URA CNRS 3015, 28 rue du Dr Roux, Paris Cedex 15, France
J Virol 84:2282-93. 2010..Therefore, Nef induces complex effects on the lymphocyte actin cytoskeleton and cellular morphology, which likely impacts the capacity of infected cells to circulate and to encounter and communicate with bystander cells...
- Type I IFN controls chikungunya virus via its action on nonhematopoietic cellsClementine Schilte
Department of Immunology, Unité Immunobiologie des Cellules Dendritiques, Institut Pasteur, 75724 Paris, Cedex 15, France
J Exp Med 207:429-42. 2010..This study defines an essential role for type I IFN, produced via cooperation between multiple host sensors and acting directly on nonhematopoietic cells, in the control of CHIKV...
- Preclinical studies of a modified vaccinia virus Ankara-based HIV candidate vaccine: antigen presentation and antiviral effectSamantha Brandler
Unité Virus et Immunite, Institut Pasteur, URA CNRS 3015, Paris, France
J Virol 84:5314-28. 2010..Deciphering the immune responses to MVA in culture experiments will help in the design of innovative vaccine strategies...
- Innate sensing of HIV-infected cellsAlice Lepelley
Institut Pasteur, Virus and Immunity Unit, URA CNRS 3015, Paris, France
PLoS Pathog 7:e1001284. 2011..Characterization of the mechanisms of innate recognition of HIV-infected cells allows a better understanding of the pathogenic and exacerbated immunologic events associated with HIV infection...
- Human immunodeficiency virus type-1 infection impairs the formation of the immunological synapseMaria Isabel Thoulouze
Unite de Biologie Cellulaire des Lymphocytes, Centre National de la Recherche Scientifique Unité de Recherche Associée 1930, Institut Pasteur, 25 28 rue Dr Roux, 75724 Paris Cedex 15, France
Immunity 24:547-61. 2006..Alteration of endocytic and signaling networks at the immunological synapse likely impacts the function and fate of HIV-1-infected cells...
- Restriction of foamy viruses by APOBEC cytidine deaminasesFrédéric Delebecque
Virus and Immunity Group, URA CNRS 1930, Institut Pasteur, 75724 Paris Cedex 15, France
J Virol 80:605-14. 2006..In infected hosts, the persistence strategy employed by FV might be based on low levels of replication, as well as avoidance of cells expressing large amounts of active cytidine deaminases...
- SAMHD1 restricts HIV-1 cell-to-cell transmission and limits immune detection in monocyte-derived dendritic cellsIsabel Puigdomènech
Institut Pasteur, Unité Virus et Immunite, Departement de Virologie, and CNRS, URA3015, Paris, France
J Virol 87:2846-56. 2013..Therefore, SAMHD1, by controlling the sensitivity of MDDCs to HIV-1 infection during intercellular contacts, impacts their ability to sense the virus and to trigger an innate immune response...
- HIV-1 Nef promotes the localization of Gag to the cell membrane and facilitates viral cell-to-cell transferMarine Malbec
Departement de Virologie, Institut Pasteur, Unité Virus et Immunite, 28 rue du Docteur Roux, Paris F 75015, France
Retrovirology 10:80. 2013..Whether Nef modulates Gag and/or GagPol localization and assembly at the membrane and facilitates viral cell-to-cell transfer has not been extensively characterized so far...
- Transcytosis of HTLV-1 across a tight human epithelial barrier and infection of subepithelial dendritic cellsSandra Martin-Latil
Unité Epidémiologie et Physiopathologie des Virus Oncogènes, URA Centre National de la Recherche Scientifique 3015, Institut Pasteur, Paris, France
Blood 120:572-80. 2012..The present study provides the first data pertaining to the mode of HTLV-1 transport across a tight epithelial barrier, as can occur during mother-to-child HTLV-1 transmission during breastfeeding...
- Characterization of reemerging chikungunya virusMarion Sourisseau
Department of Virology, Unité Virus et Immunite, Institut Pasteur, Paris, France
PLoS Pathog 3:e89. 2007..CHIKV was highly sensitive to the antiviral activity of type I and II interferons. These results provide a general insight into the interaction between CHIKV and its mammalian host...
- HIV-1 Nef-induced upregulation of DC-SIGN in dendritic cells promotes lymphocyte clustering and viral spreadNathalie Sol-Foulon
Unité Rétrovirus et Transfert Génétique, URA CNRS 1930, Institut Pasteur, 28 rue du Docteur Roux, 75724 Cedex 15, Paris, France
Immunity 16:145-55. 2002..These results provide new insights into how HIV-1 spreads from DCs to T lymphocytes and manipulates immune responses. They help explain how Nef may act as a virulence factor in vivo...
- Broadly neutralizing antibodies that inhibit HIV-1 cell to cell transmissionMarine Malbec
Virus and Immunity Unit, Department of Virology and 2 Laboratory of Humoral Response to Pathogens, Department of Immunology Institut Pasteur, 75015 Paris, France
J Exp Med 210:2813-21. 2013..Thus, only a subset of bNAbs can efficiently prevent HIV-1 cell to cell transmission, and this property should be considered an important characteristic defining antibody potency for therapeutic or prophylactic antiviral strategies. ..
- Cutting edge: independent roles for IRF-3 and IRF-7 in hematopoietic and nonhematopoietic cells during host response to Chikungunya infectionClementine Schilte
Unité d Immunobiologie des Cellules Dendritiques, Departement d Immunologie, Institut Pasteur, Paris 75724, France
J Immunol 188:2967-71. 2012..These results highlight the interplay between nonimmune and immune cells during Chikungunya virus infection and suggest an important role for nonhematopoietic cells as a critical source of IFN-α/β...
- Large-scale nucleotide optimization of simian immunodeficiency virus reduces its capacity to stimulate type I interferon in vitroNicolas Vabret
Unité de Génomique Virale et Vaccination, CNRS UMR 3569, Institut Pasteur, Paris, France
J Virol 88:4161-72. 2014..No reversion of introduced mutations was observed for either of the optimized viruses after 10 serial passages. In conclusion, we have designed large-scale nucleotide-modified SIVs that may display attenuated pathogenic potential...
- DC-SIGN from African green monkeys is expressed in lymph nodes and mediates infection in trans of simian immunodeficiency virus SIVagmMickaël J Y Ploquin
Unité de Biologie des Rétrovirus, Institut Pasteur, Paris, France
J Virol 78:798-810. 2004....
- Subcapsular sinus macrophages promote NK cell accumulation and activation in response to lymph-borne viral particlesZacarias Garcia
Institut Pasteur, Dynamics of Immune Responses Unit, Paris, France
Blood 120:4744-50. 2012..Our results identify SCS macrophages as primary mediators of NK cell activation in response to lymph-borne viral particles suggesting that they act as early sensors of local infection or delivery of viral-based vaccines...
- HIV cell-to-cell transmission requires the production of infectious virus particles and does not proceed through env-mediated fusion poresBlandine Monel
INSERM U941, Hopital Saint Louis, Paris, France
J Virol 86:3924-33. 2012..The increased efficiency of this infection route may thus be attributed to the high local concentrations of virus particles at sites of cellular contacts rather than to a qualitatively different transmission process...
- A novel pathway down-modulating T cell activation involves HPK-1-dependent recruitment of 14-3-3 proteins on SLP-76Vincenzo Di Bartolo
Molecular Immunology Unit, Centre National de la Recherche Scientifique CNRS URA 1961, Institut Pasteur, 75724 Paris, Cedex 15, France
J Exp Med 204:681-91. 2007..These data reveal a novel negative feedback loop involving HPK-1-dependent serine phosphorylation of SLP-76 and 14-3-3 protein recruitment, which tunes T cell activation...
- Lack of ADCC breadth of human non-neutralizing anti-HIV-1 antibodiesTimothée Bruel
Virus and Immunity Unit, Department of Virology, Institut Pasteur, Paris, France
J Virol . 2017..Overall, our data reveal important qualitative and quantitative differences between nnAbs and bNAbs in their ADCC capacity and strongly suggest that the breadth of recognition of HIV-1 by nnAbs is narrow...
- The effects of HIV-1 Nef on CD4 surface expression and viral infectivity in lymphoid cells are independent of raftsNathalie Sol-Foulon
Virus and Immunity Group, URA CNRS 1930, Paris, France
J Biol Chem 279:31398-408. 2004..Altogether, these results strongly suggest that rafts are not a key element involved in the effects of Nef on trafficking of cellular proteins and on viral replication...
- Contrasted innate responses to two viruses in zebrafish: insights into the ancestral repertoire of vertebrate IFN-stimulated genesValérie Briolat
Macrophages et Développement de l Immunité, Institut Pasteur, 75015 Paris, France
J Immunol 192:4328-41. 2014..This study provides a useful reference set for the analysis of host-virus interactions in zebrafish and highlights the differences between protective and nonprotective antiviral innate responses. ..
- Dendritic cells and HIV-specific CD4+ T cells: HIV antigen presentation, T-cell activation, and viral transferArnaud Moris
Groupe Virus et Immunité, Unité de Recherche Associée URA Centre National de la Recherche Scientifique CNRS 1930, Paris, France
Blood 108:1643-51. 2006..Our results unravel the mechanisms of MHC-II-restricted HIV antigen presentation by DCs and describe how HIV gains access to the very cells designed by the immune system to counteract this pathogen...
- Hyperthermia stimulates HIV-1 replicationFerdinand Roesch
Institut Pasteur, Unité Virus et Immunite, Departement de Virologie, Paris, France
PLoS Pathog 8:e1002792. 2012..Altogether, our results indicate that fever may directly stimulate HIV-1 replication, in a process involving Hsp90 and facilitation of Tat-mediated LTR activity...
- The Siva protein is a novel intracellular ligand of the CD4 receptor that promotes HIV-1 envelope-induced apoptosis in T-lymphoid cellsBénédicte Py
Institut Cochin, CNRS UMR 8104, Universite Paris Descartes, 27 rue du Faubourg Saint Jacques, 75014, Paris, France
Apoptosis 12:1879-92. 2007..Altogether, these results suggest that Siva-1 might participate in the CD4-initiated signaling apoptotic pathway induced by the HIV-1 envelope in T-lymphoid cells...
- Real-time whole-body visualization of Chikungunya Virus infection and host interferon response in zebrafishNuno Palha
Institut Pasteur, Macrophages et Développement de l Immunité, Department of Developmental and Stem Cells Biology, Paris, France CNRS URA2578, Paris, France Université Pierre et Marie Curie, Paris, France
PLoS Pathog 9:e1003619. 2013..Altogether, our results show that the zebrafish represents a novel valuable model to dynamically visualize replication, pathogenesis and host responses to a human virus. ..
- CTL escape mediated by proteasomal destruction of an HIV-1 cryptic epitopeSylvain Cardinaud
INSERM, UMR S945, Université Pierre et Marie Curie UPMC, Paris, France
PLoS Pathog 7:e1002049. 2011..Our results strongly suggest that HIV-1 escapes CTL surveillance by introducing mutations leading to HIV ARF-epitope destruction by proteasomes...
- Innate sensing of foamy viruses by human hematopoietic cellsRejane Rua
Institut Pasteur, Virus and Immunity Unit, URA CNRS 3015, Paris, France
J Virol 86:909-18. 2012..Therefore, FV are potent inducers of type I IFN by pDCs and by PBMCs. This previously underestimated activation of the innate immune response may be involved in the control of viral replication in humans...
- Chikungunya virus-induced autophagy delays caspase-dependent cell deathPierre Emmanuel Joubert
Unité Immunobiologie des Cellules Dendritiques, Department of Immunology, Institut Pasteur, Paris, France
J Exp Med 209:1029-47. 2012..Our study suggests that inducers of autophagy may limit the pathogenesis of acute Chikungunya disease...
- Antigen crosspresentation by human plasmacytoid dendritic cellsGuillaume Hoeffel
Departement d Immunologie, Institut Cochin, Paris, F 75014, France
Immunity 27:481-92. 2007....
- Vpr Enhances Tumor Necrosis Factor Production by HIV-1-Infected T CellsFerdinand Roesch
Institut Pasteur, Virus and Immunity Unit, Virology Department, Paris, France CNRS, URA3015, Paris, France Université Paris Diderot, Sorbonne Paris Cité, Cellule Pasteur, Paris, France
J Virol 89:12118-30. 2015..Thus, the stimulation of the proinflammatory pathway by Vpr may impact HIV-1 replication in vivo...
- Restricting HIV the SAMHD1 way: through nucleotide starvationDiana Ayinde
Institut Pasteur, Unité Virus et Immunite, Departement de Virologie, Centre National de la Recherche Scientifique, Unité de Recherche Associée 3015, Paris, France
Nat Rev Microbiol 10:675-80. 2012..In this Progress article, we describe how SAMHD1 regulates the pool of intracellular nucleotides to control HIV replication and the innate immune response...
- Identification of cryptic MHC I-restricted epitopes encoded by HIV-1 alternative reading framesSylvain Cardinaud
Unité Cellulaire Antivirale, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
J Exp Med 199:1053-63. 2004..This should be taken into account when designing vaccine strategies aimed at activating these responses...
- DC-SIGN and L-SIGN are high affinity binding receptors for hepatitis C virus glycoprotein E2Pierre Yves Lozach
Unite d Immunologie Virale, Institut Pasteur, 28, rue du Dr Roux, 75015 Paris, France
J Biol Chem 278:20358-66. 2003..High affinity interaction of viral glycoproteins with oligomeric lectins might represent a strategy by which HCV targets to and concentrates in the liver and infects dendritic cells...
- Live attenuated measles vaccine expressing HIV-1 Gag virus like particles covered with gp160DeltaV1V2 is strongly immunogenicMathilde Guerbois
Laboratoire de Génomique Virale et Vaccination, CNRS URA 3015, Institut Pasteur, Paris Cedex 15, France
Virology 388:191-203. 2009..This candidate vaccine will be next tested in non-human primates. As a pediatric vaccine, it might protect children and adolescents simultaneously from measles and HIV...
- Neonatal plasmacytoid dendritic cells (pDCs) display subset variation but can elicit potent anti-viral innate responsesXiaoming Zhang
Régulation Immunitaire et Vaccinologie, Institut Pasteur, Paris, France
PLoS ONE 8:e52003. 2013..Therefore, neonatal pDCs clearly display variation in phenotype and subset composition, but without major consequences for their antiviral responses...
- HIV escape from natural killer cytotoxicity: nef inhibits NKp44L expression on CD4+ T cellsHugues Fausther-Bovendo
INSERM UMR945, Hopital Pitie Salpetriere, Paris, France
AIDS 23:1077-87. 2009..NKp44LCD4 T cells are highly sensitive to the NK lysis activity. In contrast, HIV-infected CD4 T cells are resistant to NK killing, suggesting that HIV-1 developed strategies to avoid detection by the host cell immunity...
- Ultrasensitive HIV-1 p24 detects single infected cells and differences in reservoir induction by latency-reversal agentsCaroline Pereira Bittencourt Passaes
Institut Pasteur, Unité HIV, Inflammation et Persistance, Départements de Virologie et Immunologie, Paris, France
J Virol . 2017....
- SUN2 Overexpression Deforms Nuclear Shape and Inhibits HIVDaniel A Donahue
Institut Pasteur, Department of Virology, Virus and Immunity Unit, Paris, France CNRS URA 3015, Paris, France
J Virol 90:4199-214. 2016..Our results demonstrate that SUN2 overexpression perturbs both nuclear shape and early events of HIV infection...
- Elimination of HIV-1-infected cells by broadly neutralizing antibodiesTimothée Bruel
Virus and Immunity Unit, Department of Virology, Institut Pasteur, Paris 75015, France
Nat Commun 7:10844. 2016..Our study delineates the parameters controlling ADCC activity of bNAbs, and supports the use of the most potent antibodies to clear the viral reservoir. ..
- Inhibition of mTORC1 Enhances the Translation of Chikungunya Proteins via the Activation of the MnK/eIF4E PathwayPierre Emmanuel Joubert
Unité Immunobiologie des Cellules Dendritiques, Departement d Immunologie, Institut Pasteur, Paris, Cedex 15, France Inserm U818, Paris, France
PLoS Pathog 11:e1005091. 2015..Our study reveals an unexpected bypass pathway by which CHIKV protein translation overcomes viral induced mTORC1 inhibition. ..
- Low SAMHD1 expression following T-cell activation and proliferation renders CD4+ T cells susceptible to HIV-1Nicolas Ruffin
aINSERM, U955, Equipe 16 bFaculté de médecine, Université Paris Est cVaccine Research Institute VRI, Créteil dUnité Virus et Immunité, Departement de Virologie, Institut Pasteur, Paris, France eInfectious Diseases Unit, Department of Internal Medicine, University Medical Center, Hamburg Eppendorf and Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg fGeneral, Visceral and Thoracic Surgery Department, University Medical Center Hamburg, Eppendorf, Germany gAP HP, Hôpital H Mondor A Chenevier, Service d immunologie clinique et maladies infectieuses, Creteil, France hThe Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, USA
AIDS 29:519-30. 2015..The modulation of SAMHD1 expression during T-cell activation and proliferation, however, remains unclear, as well as a role for SAMHD1 during HIV-1 pathogenesis...
- DC-SIGN induction in alveolar macrophages defines privileged target host cells for mycobacteria in patients with tuberculosisLudovic Tailleux
Institut Pasteur, Unite de Genetique Mycobacterienne, Paris, France
PLoS Med 2:e381. 2005....
- SUN2 silencing impairs CD4 T cell proliferation and alters sensitivity to HIV-1 infection independently of Cyclophilin ADaniel A Donahue
Institut Pasteur, Department of Virology, Virus and Immunity Unit, Paris 75015, France
J Virol . 2017....
- Natural mutations in IFITM3 modulate post-translational regulation and toggle antiviral specificityAlex A Compton
Virus and Immunity Unit, Institut Pasteur, Paris, France
EMBO Rep 17:1657-1671. 2016..Overall, we provide the first experimental evidence that diversification of IFITM3 genes may boost the antiviral coverage of host cells and provide selective functional advantages...
- Distinct characteristics of endometrial and decidual macrophages and regulation of their permissivity to HIV-1 infection by SAMHD1Heloise Quillay
Unité de Régulation des Infections Rétrovirales, Institut Pasteur, Paris, France Université Paris Diderot, Sorbonne Paris Cité, Cellule Pasteur, Paris, France
J Virol 89:1329-39. 2015..This study and further comparisons of the decidua with FRT mucosae in nonpregnant women should help to identify mechanisms of mucosal protection against HIV-1 infection...
- Human muscle satellite cells as targets of Chikungunya virus infectionSimona Ozden
Unité Epidémiologie et Physiopathologie des Virus Oncogènes CNRS URA1930, Institut Pasteur, Paris, France
PLoS ONE 2:e527. 2007..7% of cases. Since the cellular targets of CHIK virus in humans are unknown, we studied the pathogenic events and targets of CHIK infection in skeletal muscle...
- The Phosphatidylserine and Phosphatidylethanolamine Receptor CD300a Binds Dengue Virus and Enhances InfectionXavier Carnec
INSERM U944 CNRS 7212, Laboratoire de Pathologie et Virologie Moléculaire, Hopital Saint Louis, Paris, France Institut Universitaire d Hématologie, Hopital Saint Louis, Paris, France Université Paris Diderot, Sorbonne Paris Cité, Hopital St Louis, Paris, France
J Virol 90:92-102. 2015..Overall, these data indicate that CD300a is a novel DENV binding receptor that recognizes PtdEth and PtdSer present on virions and enhance infection...
- Plasmacytoid Dendritic Cell Infection and Sensing Capacity during Pathogenic and Nonpathogenic Simian Immunodeficiency Virus InfectionSimon P Jochems
Institut Pasteur, Unité HIPER, Paris, France Université Paris Diderot, Sorbonne Paris Cité, Paris, France
J Virol 89:6918-27. 2015..The high level of pDC infection by SIVagm suggests that if CCR5 paucity on immune cells is important for nonpathogenesis of natural hosts, it is possibly not due to its role as a coreceptor...
- A new role for the HTLV-1 p8 protein: increasing intercellular conduits and viral cell-to-cell transmissionMarine Malbec
Virus and Immunity Unit, Institut Pasteur, URA CNRS 3015, 28 rue du Dr Roux, 75724 Paris, France
Viruses 3:254-9. 2011..So far, only synapses and biofilms have been described for HTLV-1 transmission. Recently, Van Prooyen et al.  identified an additional mode of HTLV-1 transmission through cellular conduits induced by the viral accessory protein p8...
- Extensive editing of a small fraction of human T-cell leukemia virus type 1 genomes by four APOBEC3 cytidine deaminasesRenaud Mahieux
Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
J Gen Virol 86:2489-94. 2005..Thus, although HTLV-1 DNA can indeed be edited by at least four APOBEC3 cytidine deaminases in vitro, they are conspicuously absent in vivo...
- HIV-1 Virological Synapse: Live Imaging of TransmissionJerome Feldmann
Institut Pasteur, Virus and Immunity Unit, URA CNRS 3015, 28 rue du Dr Roux, 75724 Paris, France
Viruses 2:1666-80. 2010..This review will recapitulate current knowledge with a particular emphasis on the questions live microscopy has raised...
- DC-SIGN is the major Mycobacterium tuberculosis receptor on human dendritic cellsLudovic Tailleux
INSERM EMI 0013 Institut Universitaire d Hématologie, Assistance Publique Hopitaux de Paris, France
J Exp Med 197:121-7. 2003..Thus, as for human immunodeficiency virus (HIV), which is captured by the same receptor, DC-SIGN-mediated entry of M. tuberculosis in DCs in vivo is likely to influence bacterial persistence and host immunity...
- Human dendritic cell-specific intercellular adhesion molecule-grabbing nonintegrin (CD209) is a receptor for Yersinia pestis that promotes phagocytosis by dendritic cellsPei Zhang
Department of Biomedical Sciences, College of Medicine, University of Illinois at Chicago UIC, 1601 Parkview Avenue, Rockford, IL 61107, USA
Infect Immun 76:2070-9. 2008..pestis and human DCs can be reduced by a combination treatment with anti-CD209 and anti-CD207 antibodies. This study shows that human DC-SIGN is a receptor for Y. pestis that promotes phagocytosis by DCs in vitro...
- HIV-1 buds and accumulates in "nonacidic" endosomes of macrophagesMabel Jouve
Institut Curie, INSERM U653, 26 rue d Ulm 75248 Paris Cedex 05, France
Cell Host Microbe 2:85-95. 2007..Thus, HIV-1 has developed a strategy for survival within infected macrophages involving prevention of acidification within a devoted endocytic virus assembly compartment...
- Deciphering the molecular bases of Mycobacterium tuberculosis binding to the lectin DC-SIGN reveals an underestimated complexitySylvain Pitarque
Institut de Pharmacologie et de Biologie Structurale, Département Mécanismes Moléculaires des Infections Mycobactériennes, CNRS UMR 5089, 205 route de Narbonne, 31077 Toulouse Cedex 4, France
Biochem J 392:615-24. 2005..tuberculosis binding to DC-SIGN is more complicated than previously thought and provides further insight into the mechanisms of M. tuberculosis recognition by the immune system...
- Dendritic-cell-specific ICAM3-grabbing non-integrin is essential for the productive infection of human dendritic cells by mosquito-cell-derived dengue virusesErika Navarro-Sanchez
Interactions Moléculaires Flavivirus Hôtes, 25 rue du Dr Roux, 75724 Paris, France
EMBO Rep 4:723-8. 2003..Mosquito-cell-derived DVs may have differential infectivity for DC-SIGN-expressing cells. We suggest that the differential use of DC-SIGN by viral envelope glycoproteins may account for the immunopathogenesis of DVs...
- Functional characterization of HIV-1 Nef mutants in the context of viral infectionOliver T Fackler
Department of Virology, University of Heidelberg, INF 324, D 69120 Heidelberg, Germany
Virology 351:322-39. 2006..The results emphasize that multiple activities govern Nef's effects on HIV replication and argue against a role of virion incorporation for Nef's activity as pathogenicity factor...
- DC-SIGN (CD209) recognition of Neisseria gonorrhoeae is circumvented by lipooligosaccharide variationPei Zhang
Department of Biomedical Sciences, College of Medicine, University of Illinois at Chicago, USA
J Leukoc Biol 79:731-8. 2006..The experiments suggest that LOS variation may have evolved as a mechanism for GC to avoid phagocytosis by DCs...
- Activation of the lectin DC-SIGN induces an immature dendritic cell phenotype triggering Rho-GTPase activity required for HIV-1 replicationAshleigh Hodges
Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK
Nat Immunol 8:569-77. 2007..Activation of LARG in DCs exposed to HIV was required for the formation of virus-T cell synapses. Thus, HIV sequestration by and stimulation of DC-SIGN helps HIV evade immune responses and spread to cells...
- The core lipopolysaccharide of Escherichia coli is a ligand for the dendritic-cell-specific intercellular adhesion molecule nonintegrin CD209 receptorJohn Klena
School of Molecular Biosciences, Washington State University, Pullman, Washington, USA
J Bacteriol 187:1710-5. 2005..coli in part by interacting with the complete core region of the LPS molecule. These results provide a mechanism for how O antigen acts as an antiphagocytic factor...
- Modulation of the immunological synapse: a key to HIV-1 pathogenesis?Oliver T Fackler
Oliver T Fackler is at the Department of Virology, University of Heidelberg, D 69120 Heidelberg, Germany
Nat Rev Immunol 7:310-7. 2007..We propose that modulating lymphocyte signalling, apoptosis and intracellular trafficking ensures efficient spread of the virus in the hostile environment of the immune system...
- [HIV-1, a very Vif virus]Olivier Schwartz
Med Sci (Paris) 20:139-41. 2004
- Dual inhibitory effects of APOBEC family proteins on retrotransposition of mammalian endogenous retrovirusesCécile Esnault
Unité des rétrovirus endogènes et éléments rétroïdes des eucaryotes supérieurs, CNRS UMR 8122 Institut, Gustave Roussy, 94805 Villejuif, France
Nucleic Acids Res 34:1522-31. 2006..This dual, two-step effect likely participates in the efficient defense of the cell genome against invading endogenous retroelements...
- Processing of the bovine spongiform encephalopathy-specific prion protein by dendritic cellsCatherine Rybner-Barnier
Neurovirologie et Régénération du Système Nerveux, Department de Neurosciences, Repliement et Modélisation des Protéines, Dpt Biologie Structurale et Chimie, Biologie des Régulations Immunaires, INSERM E352, 75015 Paris, France
J Virol 80:4656-63. 2006....
- The human polycomb group EED protein interacts with the integrase of human immunodeficiency virus type 1Sebastien Violot
Laboratoire de Virologie and Pathogénèse Virale, Faculté de médecine RTH Laennec, CNRS UMR 5537, France
J Virol 77:12507-22. 2003..i., suggesting the ocurrence of multiprotein complexes involving these three proteins at early steps of the HIV-1 virus life cycle. Such IEM patterns were not observed with a noninfectious, envelope deletion mutant of HIV-1...
- HIV-1 Nef protein expression in human CD34+ progenitors impairs the differentiation of an early T/NK cell precursorCéline Dorival
INSERM U 841, Faculte de Medecine, Creteil, France
Virology 377:207-15. 2008..Altogether, these data demonstrate that Nef interferes with the differentiation of a primitive lymphoid human precursor with a T/NK potential...
- Langerhans cells lap up HIV-1Olivier Schwartz
Nat Med 13:245-6. 2007