Sylvie Robine

Summary

Affiliation: Institut Curie
Country: France

Publications

  1. pmc Wnt/beta-catenin is essential for intestinal homeostasis and maintenance of intestinal stem cells
    Tea Fevr
    Ecole Polytechnique Federale de Lausanne, ISREC Swiss Institute for Experimental Cancer Research, Chemin des Boveresses 155, 1066 Epalinges, Switzerland
    Mol Cell Biol 27:7551-9. 2007
  2. ncbi request reprint The epithelial cell cytoskeleton and intracellular trafficking. III. How is villin involved in the actin cytoskeleton dynamics in intestinal cells?
    Rafika Athman
    Laboratoire de Morphogenèse et Signalisation Cellulaires, Institut Curie UMR 144, 75248 Paris Cedex 05, France
    Am J Physiol Gastrointest Liver Physiol 283:G496-502. 2002
  3. pmc Krüppel-like factor 5 mediates cellular transformation during oncogenic KRAS-induced intestinal tumorigenesis
    Mandayam O Nandan
    Division of Digestive Diseases, Department of Medicine, Emory University, Atlanta, Georgia, USA
    Gastroenterology 134:120-30. 2008
  4. ncbi request reprint Heterogeneous metastasis efficiency of isogenic orthotopic colon cancer xenografts reveals distinctive gene expression profiles
    Miguel Abal
    Transfer Laboratory, Institut Curie CNRS, Paris, France
    Tumour Biol 28:139-50. 2007
  5. ncbi request reprint [Notch signals control the fate of immature progenitor cells in the intestine]
    Sylvie Robine
    Morphogenèse et signalisation intracellulaires, Institut Curie, CNRS UMR 144, 26 Rue d Ulm, 75248 Paris, France
    Med Sci (Paris) 21:780-2. 2005
  6. pmc Krüppel-like factor 5 is a crucial mediator of intestinal tumorigenesis in mice harboring combined ApcMin and KRASV12 mutations
    Mandayam O Nandan
    Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, 201 Whitehead Research Building, 615 Michael Street, Atlanta, GA 30322, USA
    Mol Cancer 9:63. 2010
  7. pmc In vivo, villin is required for Ca(2+)-dependent F-actin disruption in intestinal brush borders
    E Ferrary
    Institut Curie, UMR 144, 75248 Paris, France
    J Cell Biol 146:819-30. 1999
  8. ncbi request reprint Fascin, a novel target of beta-catenin-TCF signaling, is expressed at the invasive front of human colon cancer
    Danijela Vignjevic
    UMR 144 Centre National de la Recherche Scientifique and Department of Pathology, Institut Curie, 25 rue d Ulm, 75248 Paris Cedex 05, France
    Cancer Res 67:6844-53. 2007
  9. pmc Villin enhances hepatocyte growth factor-induced actin cytoskeleton remodeling in epithelial cells
    Rafika Athman
    Laboratoire de Morphogenèse et Signalisation Cellulaires, Institut Curie Unité Mixte Recherche 144, 75248 Paris, France
    Mol Biol Cell 14:4641-53. 2003
  10. ncbi request reprint Mouse models of K-ras-initiated carcinogenesis
    Klaus Peter Janssen
    Morphogenesis and intracellular signalling, UMR 144, Institut Curie CNRS, 26 rue d Ulm 75248 Paris Cedex 05, France
    Biochim Biophys Acta 1756:145-54. 2005

Collaborators

Detail Information

Publications35

  1. pmc Wnt/beta-catenin is essential for intestinal homeostasis and maintenance of intestinal stem cells
    Tea Fevr
    Ecole Polytechnique Federale de Lausanne, ISREC Swiss Institute for Experimental Cancer Research, Chemin des Boveresses 155, 1066 Epalinges, Switzerland
    Mol Cell Biol 27:7551-9. 2007
    ..This challenges attempts to target aberrant Wnt signaling as a new therapeutic strategy to treat colorectal cancer...
  2. ncbi request reprint The epithelial cell cytoskeleton and intracellular trafficking. III. How is villin involved in the actin cytoskeleton dynamics in intestinal cells?
    Rafika Athman
    Laboratoire de Morphogenèse et Signalisation Cellulaires, Institut Curie UMR 144, 75248 Paris Cedex 05, France
    Am J Physiol Gastrointest Liver Physiol 283:G496-502. 2002
    ..Our data suggest that villin is involved in actin remodeling necessary for many cellular processes requiring the actin cytoskeleton plasticity...
  3. pmc Krüppel-like factor 5 mediates cellular transformation during oncogenic KRAS-induced intestinal tumorigenesis
    Mandayam O Nandan
    Division of Digestive Diseases, Department of Medicine, Emory University, Atlanta, Georgia, USA
    Gastroenterology 134:120-30. 2008
    ..Oncogenic KRAS mutations are commonly found in colorectal cancers. We aimed to determine whether KLF5 mediates KRAS functions during intestinal tumorigenesis...
  4. ncbi request reprint Heterogeneous metastasis efficiency of isogenic orthotopic colon cancer xenografts reveals distinctive gene expression profiles
    Miguel Abal
    Transfer Laboratory, Institut Curie CNRS, Paris, France
    Tumour Biol 28:139-50. 2007
    ..This dynamic process might determine tumor progression, namely the metastasis dissemination...
  5. ncbi request reprint [Notch signals control the fate of immature progenitor cells in the intestine]
    Sylvie Robine
    Morphogenèse et signalisation intracellulaires, Institut Curie, CNRS UMR 144, 26 Rue d Ulm, 75248 Paris, France
    Med Sci (Paris) 21:780-2. 2005
  6. pmc Krüppel-like factor 5 is a crucial mediator of intestinal tumorigenesis in mice harboring combined ApcMin and KRASV12 mutations
    Mandayam O Nandan
    Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, 201 Whitehead Research Building, 615 Michael Street, Atlanta, GA 30322, USA
    Mol Cancer 9:63. 2010
    ..Here we investigated the in vivo effect of Klf5 heterozygosity on the propensity of ApcMin/KRASV12 double transgenic mice to develop intestinal tumors...
  7. pmc In vivo, villin is required for Ca(2+)-dependent F-actin disruption in intestinal brush borders
    E Ferrary
    Institut Curie, UMR 144, 75248 Paris, France
    J Cell Biol 146:819-30. 1999
    ..We postulate that this property might be involved in cellular plasticity related to cell injury...
  8. ncbi request reprint Fascin, a novel target of beta-catenin-TCF signaling, is expressed at the invasive front of human colon cancer
    Danijela Vignjevic
    UMR 144 Centre National de la Recherche Scientifique and Department of Pathology, Institut Curie, 25 rue d Ulm, 75248 Paris Cedex 05, France
    Cancer Res 67:6844-53. 2007
    ..We propose that genes involved in cell migration and invasion, such as fascin1, could serve as novel targets for metastasis prevention...
  9. pmc Villin enhances hepatocyte growth factor-induced actin cytoskeleton remodeling in epithelial cells
    Rafika Athman
    Laboratoire de Morphogenèse et Signalisation Cellulaires, Institut Curie Unité Mixte Recherche 144, 75248 Paris, France
    Mol Biol Cell 14:4641-53. 2003
    ..Collectively, these data demonstrate that villin acts as a regulator of HGF-induced actin dynamics...
  10. ncbi request reprint Mouse models of K-ras-initiated carcinogenesis
    Klaus Peter Janssen
    Morphogenesis and intracellular signalling, UMR 144, Institut Curie CNRS, 26 rue d Ulm 75248 Paris Cedex 05, France
    Biochim Biophys Acta 1756:145-54. 2005
    ..from these sophisticated models, a common picture emerges: The effects of K-ras on tumor initiation depend strongly on the cellular context, and different tissues vary in their susceptibility to K-ras transformation...
  11. ncbi request reprint APC inactivation associates with abnormal mitosis completion and concomitant BUB1B/MAD2L1 up-regulation
    Miguel Abal
    Morphogenesis and intracellular signalling, UMR 144, Institut Curie CNRS, Paris, France
    Gastroenterology 132:2448-58. 2007
    ..Here, we tackled the genetic basis for the contribution of APC to chromosomal instability in familial adenomatous polyposis and sporadic colorectal cancer...
  12. pmc A new role for the architecture of microvillar actin bundles in apical retention of membrane proteins
    Celine Revenu
    Unite Mixte de Recherche 144, Centre National de la Recherche Scientifique, Institut Curie, 75248 Paris, Cedex 05, France
    Mol Biol Cell 23:324-36. 2012
    ....
  13. ncbi request reprint APC and oncogenic KRAS are synergistic in enhancing Wnt signaling in intestinal tumor formation and progression
    Klaus Peter Janssen
    UMR144 Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Gastroenterology 131:1096-109. 2006
    ..Synchronous activation of the Wnt signaling pathway, mostly because of loss of function of the APC tumor suppressor, and of the oncogenic KRAS-signaling pathway is very frequent in colorectal cancer and is associated with poor prognosis...
  14. ncbi request reprint In vivo tumor targeting using a novel intestinal pathogen-based delivery approach
    Klaus Peter Janssen
    UMR144 Curie Centre National de la Recherche Scientifique, Institut Curie, Paris, France
    Cancer Res 66:7230-6. 2006
    ....
  15. ncbi request reprint In vivo absorption of water and electrolytes in mouse intestine. Application to villin -/- mice
    Rafika Athman
    Institut Curie, UMR 144, 75248 Paris Cedex 05, France
    Am J Physiol Gastrointest Liver Physiol 282:G634-9. 2002
    ....
  16. doi request reprint Notch signaling in intestinal homeostasis across species: the cases of Drosophila, Zebrafish and the mouse
    Silvia Fre
    Morphogenesis and Intracellular Signaling, Institut Curie, UMR 144 CNRS, Paris, France
    Exp Cell Res 317:2740-7. 2011
    ....
  17. doi request reprint Conditional expression of fascin increases tumor progression in a mouse model of intestinal cancer
    Marie Schoumacher
    Institut Curie, Research Center, 25 rue d Ulm, 75248 Paris Cedex 05, France
    Eur J Cell Biol 93:388-95. 2014
    ..Altogether, our study shows that fascin can promote tumor progression in vivo, but also unravels an unexpected role of fascin in tumor initiation. ..
  18. doi request reprint Preclinical study of the DNA repair inhibitor Dbait in combination with chemotherapy in colorectal cancer
    Flavien Devun
    Institut Curie, Equipe Dutreix, Bat 110, Research Centre, Centre Universitaire, 91405 Paris Orsay, France
    J Gastroenterol 47:266-75. 2012
    ..Dbait has already been shown to be effective in combination with radiotherapy. The aim of this study was to assess the adjuvant impact of Dbait on chemotherapy in vitro and in mouse models of colorectal cancer...
  19. pmc Enterocyte loss of polarity and gut wound healing rely upon the F-actin-severing function of villin
    Florent Ubelmann
    Unite Mixte de Recherche 144, Centre National de la Recherche Scientifique, Institut Curie, 75248 Paris Cedex 05, France
    Proc Natl Acad Sci U S A 110:E1380-9. 2013
    ..This work highlights the importance of specialized apical pole disassembly for the repolarization of epithelial cells initiating migration...
  20. doi request reprint The power of one
    Daniel Louvard
    Centre National de la Recherche Scientifique, Institut Curie, 75248 Paris, Cedex 05, France
    Sci Transl Med 4:130fs7. 2012
    ..A single mouse Lgr5-positive colon stem cell can be expanded into a three-dimensional organoid that, after transplant, contributes to the repair of injured colon epithelia in a mouse model of colitis...
  21. ncbi request reprint Targeted expression of oncogenic K-ras in intestinal epithelium causes spontaneous tumorigenesis in mice
    Klaus Peter Janssen
    Cellular Morphogenesis and Signalisation, UMR144, Institut Curie, Paris, France
    Gastroenterology 123:492-504. 2002
    ..Ras oncoproteins are mutated in about 50% of human colorectal cancers, but their precise role in tumor initiation or progression is still unclear...
  22. doi request reprint Epithelial morphogenesis and intestinal cancer: new insights in signaling mechanisms
    Silvia Fre
    UMR144 Curie CNRS, Institut Curie, Paris, France
    Adv Cancer Res 100:85-111. 2008
    ..This multistep process is highly complex and still far from being understood while being of major importance for the survival of patients with digestive cancer...
  23. doi request reprint Human colorectal tumors and metastases express Gb3 and can be targeted by an intestinal pathogen-based delivery tool
    Thomas Falguières
    Department of Surgery, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Strasse 22, Munich, Germany
    Mol Cancer Ther 7:2498-508. 2008
    ....
  24. ncbi request reprint Tissue-specific and inducible Cre-mediated recombination in the gut epithelium
    Fatima el Marjou
    Morphogenesis and intracellular signalling, Institut Curie CNRS, Paris, France
    Genesis 39:186-93. 2004
    ..The villin-Cre and villin-Cre-ERT2 mice provide valuable tools for studies of cell lineage allocation and gene function in the developing and adult intestine...
  25. ncbi request reprint Non-apoptotic concentrations of prodigiosin (H+/Cl- symporter) inhibit the acidification of lysosomes and induce cell cycle blockage in colon cancer cells
    Wilmar Castillo-Avila
    Department of Pathology and Experimental Therapy, CCBR Group, Pavelló Central, 5a planta, LR 5101 C Feixa Llarga s n, E 08907, L Hospitalet Barcelona, Spain
    Life Sci 78:121-7. 2005
    ..The effect of intracellular acidification on cell cycle arrest must be analysed more exactly...
  26. pmc Raf protects against colitis by promoting mouse colon epithelial cell survival through NF-kappaB
    Karen L Edelblum
    Department of Cell and Developmental Biology, Vanderbilt University, Nashville, Tennessee, USA
    Gastroenterology 135:539-51. 2008
    ..This study addresses the role of Raf in epithelial cell survival in response to dextran sulfate sodium (DSS)-induced injury and inflammation...
  27. pmc Nox1 is over-expressed in human colon cancers and correlates with activating mutations in K-Ras
    Eunice Laurent
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Int J Cancer 123:100-7. 2008
    ..We conclude that Nox1 mRNA and protein are overexpressed in colon cancer and are strongly correlated with activating mutations in K-Ras...
  28. ncbi request reprint Compensatory increase in hepatic lipogenesis in mice with conditional intestine-specific Mttp deficiency
    Yan Xie
    Division of Gastroenterology, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 281:4075-86. 2006
    ..These findings establish distinctive features for MTTP involvement in intestinal chylomicron assembly and secretion and suggest that hepatic lipogenesis undergoes compensatory induction in the face of defective intestinal TG secretion...
  29. pmc c-Myc is required for the formation of intestinal crypts but dispensable for homeostasis of the adult intestinal epithelium
    Michael D Bettess
    Genetics and Stem Cell Laboratory, Swiss Institute for Experimental Cancer Research, Epalinges
    Mol Cell Biol 25:7868-78. 2005
    ..This study provides genetic and molecular evidence that proliferation and expansion of progenitors necessary to maintain the adult intestinal epithelium can unexpectedly occur in a Myc-independent manner...
  30. ncbi request reprint Shigella flexneri infection is dependent on villin in the mouse intestine and in primary cultures of intestinal epithelial cells
    Rafika Athman
    Institut Curie UMR 144, 75248 Paris Cedex 05, France
    Cell Microbiol 7:1109-16. 2005
    ..flexneri entry and cell-to-cell dissemination. Villin expression is thus critical for Shigella infection through its ability to remodel the actin cytoskeleton...
  31. ncbi request reprint Notch signals control the fate of immature progenitor cells in the intestine
    Silvia Fre
    Department of Cell Biology, Harvard Medical School, Massachusetts General Hospital Cancer Center, Charlestown, Massachusetts 02129, USA
    Nature 435:964-8. 2005
    ..We conclude that Notch activity is required for the maintenance of proliferating crypt cells in the intestinal epithelium...
  32. ncbi request reprint Crypt-restricted proliferation and commitment to the Paneth cell lineage following Apc loss in the mouse intestine
    Pauline Andreu
    Institut Cochin, INSERM U567, CNRS UMR8104, Universite Paris V, 24 rue du Fb St Jacques, 75014 Paris, France
    Development 132:1443-51. 2005
    ....
  33. ncbi request reprint The co-workers of actin filaments: from cell structures to signals
    Celine Revenu
    UMR144 Centre National de la Recherche Scientifique Institut Curie, Paris, France
    Nat Rev Mol Cell Biol 5:635-46. 2004
    ..This phenomenon is achieved through a tight coupling between cell structure and signal transduction, a process that is modulated by the regulation of actin-binding proteins...
  34. pmc Sox9 regulates cell proliferation and is required for Paneth cell differentiation in the intestinal epithelium
    Pauline Bastide
    INSERM U661, Department of Cellular and Molecular Oncology, Centre National de la Recherche Scientifique UMR5203, Université de Montpellier I and Service d Anatomie Pathologie, Centre Hospitalier Universitaire Caremeau, Nimes, France
    J Cell Biol 178:635-48. 2007
    ..These results highlight the central position of Sox9 as both a transcriptional target and a regulator of the Wnt pathway in the regulation of intestinal epithelium homeostasis...
  35. pmc Villin severing activity enhances actin-based motility in vivo
    Celine Revenu
    Laboratoire de Morphogenèse et Signalisation Cellulaires, Unite Mixte de Recherche 144, Centre National de la Recherche Scientifique Institut Curie, 75248 Paris Cedex 05, France
    Mol Biol Cell 18:827-38. 2007
    ....