J Laval

Summary

Affiliation: Institut Gustave Roussy
Country: France

Publications

  1. ncbi request reprint Antimutagenic role of base-excision repair enzymes upon free radical-induced DNA damage
    J Laval
    Groupe Reparation des lesions Radio et Chimio Induites, URA 147 CNRS, Institut Gustave Roussy, 94805 Villejuif Cedex, France
    Mutat Res 402:93-102. 1998
  2. ncbi request reprint AlkA protein is the third Escherichia coli DNA repair protein excising a ring fragmentation product of thymine
    C V Privezentzev
    Groupe Reparation des lesions Radio et Chimio Induites, UMR 8532 CNRS, Institut Gustave Roussy, 94805 Villejuif Cedex, France
    Biochemistry 39:14263-8. 2000
  3. ncbi request reprint The ring fragmentation product of thymidine C5-hydrate when present in DNA is repaired by the Escherichia coli Fpg and Nth proteins
    J Jurado
    Groupe Reparation des lesions Radio et Chimio Induites, UMR 1772 CNRS, Institut Gustave Roussy, Villejuif, France
    Biochemistry 37:7757-63. 1998
  4. ncbi request reprint Effect of single mutations on the specificity of Escherichia coli FPG protein for excision of purine lesions from DNA damaged by free radicals
    O Sidorkina
    , Institut Gustave Roussy, Villejuif, France
    Free Radic Biol Med 31:816-23. 2001
  5. ncbi request reprint Homogeneous Escherichia coli FPG protein. A DNA glycosylase which excises imidazole ring-opened purines and nicks DNA at apurinic/apyrimidinic sites
    S Boiteux
    UA147 Centre National de la Recherche Scientifique, Institut Gustave Roussy, Villejuif, France
    J Biol Chem 265:3916-22. 1990
  6. pmc Excision of hypoxanthine from DNA containing dIMP residues by the Escherichia coli, yeast, rat, and human alkylpurine DNA glycosylases
    M Saparbaev
    URA 147 Centre National de la Recherche Scientifique, Institut Gustave Roussy, Villejuif, France
    Proc Natl Acad Sci U S A 91:5873-7. 1994
  7. ncbi request reprint Substrate specificity of the Escherichia coli Fpg protein (formamidopyrimidine-DNA glycosylase): excision of purine lesions in DNA produced by ionizing radiation or photosensitization
    S Boiteux
    URA 158 CNRS, U 140 INSERM, Institut Gustave Roussy, Villejuif, France
    Biochemistry 31:106-10. 1992
  8. pmc Interactions of the human, rat, Saccharomyces cerevisiae and Escherichia coli 3-methyladenine-DNA glycosylases with DNA containing dIMP residues
    M Saparbaev
    Groupe Reparation des lesions Radio et Chimio Induites, UMR 8532 CNRS, Institut Gustave Roussy, 94805 Villejuif Cedex, France
    Nucleic Acids Res 28:1332-9. 2000
  9. ncbi request reprint The HAP1 protein stimulates the turnover of human mismatch-specific thymine-DNA-glycosylase to process 3,N(4)-ethenocytosine residues
    C V Privezentzev
    , UMR 8532 CNRS, 39 rue C. Desmoulins, Institut Gustave Roussy, 94805 Villejuif Cedex, France
    Mutat Res 480:277-84. 2001
  10. ncbi request reprint Role of the N-terminal proline residue in the catalytic activities of the Escherichia coli Fpg protein
    O M Sidorkina
    Groupe Reparation des lesions Radio et Chimio Induites, UMR 8532 Centre National de la Recherche Scientifique, Institut Gustave Roussy, 39, rue Camille Desmoulins, 94805 Villejuif Cedex, France
    J Biol Chem 275:9924-9. 2000

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Antimutagenic role of base-excision repair enzymes upon free radical-induced DNA damage
    J Laval
    Groupe Reparation des lesions Radio et Chimio Induites, URA 147 CNRS, Institut Gustave Roussy, 94805 Villejuif Cedex, France
    Mutat Res 402:93-102. 1998
    ..The mechanism of action of the Fpg and Nth proteins are discussed. The properties of the human counterpart of the Fpg and Nth proteins the hNth and OGG1 proteins, respectively are also reviewed...
  2. ncbi request reprint AlkA protein is the third Escherichia coli DNA repair protein excising a ring fragmentation product of thymine
    C V Privezentzev
    Groupe Reparation des lesions Radio et Chimio Induites, UMR 8532 CNRS, Institut Gustave Roussy, 94805 Villejuif Cedex, France
    Biochemistry 39:14263-8. 2000
    ..The present results suggest possible structural similarity of the active site between E. coli AlkA, Fpg, and Nth proteins...
  3. ncbi request reprint The ring fragmentation product of thymidine C5-hydrate when present in DNA is repaired by the Escherichia coli Fpg and Nth proteins
    J Jurado
    Groupe Reparation des lesions Radio et Chimio Induites, UMR 1772 CNRS, Institut Gustave Roussy, Villejuif, France
    Biochemistry 37:7757-63. 1998
    ..dA. Moreover, we show that human cell extract exhibits an activity that excises alphaRT from an oligonucleotide, suggesting that human homologues of the Nth and/or Fpg proteins could be involved in repair of this lesion in human cells...
  4. ncbi request reprint Effect of single mutations on the specificity of Escherichia coli FPG protein for excision of purine lesions from DNA damaged by free radicals
    O Sidorkina
    , Institut Gustave Roussy, Villejuif, France
    Free Radic Biol Med 31:816-23. 2001
    ..The results show that point mutations significantly change the specificity of Fpg protein and suggest that point mutations are also expected to change specificities of other DNA repair enzymes...
  5. ncbi request reprint Homogeneous Escherichia coli FPG protein. A DNA glycosylase which excises imidazole ring-opened purines and nicks DNA at apurinic/apyrimidinic sites
    S Boiteux
    UA147 Centre National de la Recherche Scientifique, Institut Gustave Roussy, Villejuif, France
    J Biol Chem 265:3916-22. 1990
    ..coli. The contribution of the AP-nicking activity associated with the FPG protein represents 10-20% of the total EDTA-resistant AP-nicking activities in E. coli...
  6. pmc Excision of hypoxanthine from DNA containing dIMP residues by the Escherichia coli, yeast, rat, and human alkylpurine DNA glycosylases
    M Saparbaev
    URA 147 Centre National de la Recherche Scientifique, Institut Gustave Roussy, Villejuif, France
    Proc Natl Acad Sci U S A 91:5873-7. 1994
    ..The mammalian enzyme is by far the most efficient hypoxanthine DNA glycosylase of all the enzymes tested...
  7. ncbi request reprint Substrate specificity of the Escherichia coli Fpg protein (formamidopyrimidine-DNA glycosylase): excision of purine lesions in DNA produced by ionizing radiation or photosensitization
    S Boiteux
    URA 158 CNRS, U 140 INSERM, Institut Gustave Roussy, Villejuif, France
    Biochemistry 31:106-10. 1992
    ..The Fpg protein also excised FapyGua and 8-OH-Gua from visible light/MB-treated DNA. The presence of these products in the supernatant fractions confirmed their excision.(ABSTRACT TRUNCATED AT 250 WORDS)..
  8. pmc Interactions of the human, rat, Saccharomyces cerevisiae and Escherichia coli 3-methyladenine-DNA glycosylases with DNA containing dIMP residues
    M Saparbaev
    Groupe Reparation des lesions Radio et Chimio Induites, UMR 8532 CNRS, Institut Gustave Roussy, 94805 Villejuif Cedex, France
    Nucleic Acids Res 28:1332-9. 2000
    ..coli (AlkA) proteins. At variance, the yeast MAG protein removed more efficiently HX from a dI:dG over dI:dC, dI:T and dI:dA mismatches...
  9. ncbi request reprint The HAP1 protein stimulates the turnover of human mismatch-specific thymine-DNA-glycosylase to process 3,N(4)-ethenocytosine residues
    C V Privezentzev
    , UMR 8532 CNRS, 39 rue C. Desmoulins, Institut Gustave Roussy, 94805 Villejuif Cedex, France
    Mutat Res 480:277-84. 2001
    ..However, using a variety of techniques including gel retardation assay, surface plasmon resonance and two-hybrid system, it was not possible to detect evidence for a complex including the substrate, the hTDG and HAP1 proteins...
  10. ncbi request reprint Role of the N-terminal proline residue in the catalytic activities of the Escherichia coli Fpg protein
    O M Sidorkina
    Groupe Reparation des lesions Radio et Chimio Induites, UMR 8532 Centre National de la Recherche Scientifique, Institut Gustave Roussy, 39, rue Camille Desmoulins, 94805 Villejuif Cedex, France
    J Biol Chem 275:9924-9. 2000
    ....
  11. pmc 3,N4-ethenocytosine, a highly mutagenic adduct, is a primary substrate for Escherichia coli double-stranded uracil-DNA glycosylase and human mismatch-specific thymine-DNA glycosylase
    M Saparbaev
    Groupe Reparation des lesions Radio et Chimio Induites, UMR 1772, Centre National de la Recherche Scientifique, Institut Gustave Roussy, 94805 Villejuif Cedex, France
    Proc Natl Acad Sci U S A 95:8508-13. 1998
    ..coli dsUDG and hTDG proteins in vitro suggests that these enzymes may be responsible for the repair of this mutagenic lesion in vivo and be important contributors to genetic stability...
  12. pmc Escherichia coli Fpg protein and UvrABC endonuclease repair DNA damage induced by methylene blue plus visible light in vivo and in vitro
    H Czeczot
    Groupe Réparation des lésions radio chimioinduites, UA158 CNRS, U140 INSERM, Institut Gustave Roussy, Villejuif, France
    J Bacteriol 173:3419-24. 1991
    ..Therefore, one of the physiological functions of Fpg protein might be to repair DNA base damage induced by photosensitizers and light...
  13. pmc Role of lysine-57 in the catalytic activities of Escherichia coli formamidopyrimidine-DNA glycosylase (Fpg protein)
    O M Sidorkina
    Groupe Reparation des lesions Radio et Chimio Induites, UMR 1772 CNRS, Institut Gustave Roussy, 94805 Villejuif Cedex, France
    Nucleic Acids Res 26:5351-7. 1998
    ..coli BH990 ( fpg mutY ) cells. These results suggest an important role for Lys-57 in the 8-oxoG-DNA glycosylase activity of the Fpg protein in vitro and in vivo...
  14. pmc Formamidopyrimidine-DNA glycosylase of Escherichia coli: cloning and sequencing of the fpg structural gene and overproduction of the protein
    S Boiteux
    UA 147 CNRS, Institut Gustave Roussy, Villejuif, France
    EMBO J 6:3177-83. 1987
    ..The nucleotide sequence of the fpg gene is composed of 809 base pairs and codes for a protein of 269 amino acids with a calculated mol. wt of 30.2 kd...
  15. ncbi request reprint Fpg protein of Escherichia coli is a zinc finger protein whose cysteine residues have a structural and/or functional role
    T R O'Connor
    Groupe Reparation des lesions Radio et Chimio Induites, Centre National de la Recherche Scientifique URA147 Institut National de la Santé et de la Recherche Médicale U140, Institut Gustave Roussy, Villejuif, France
    J Biol Chem 268:9063-70. 1993
    ..Therefore, the disruption of zinc coordination in the zinc finger of the Fpg protein is associated with decreased binding capacity to DNA as well as decreased enzymatic activities...
  16. pmc Physical association of the 2,6-diamino-4-hydroxy-5N-formamidopyrimidine-DNA glycosylase of Escherichia coli and an activity nicking DNA at apurinic/apyrimidinic sites
    T R O'Connor
    Unité de Recherche Associee 158, Centre National de la Recherche Scientifique, Institut Gustave Roussy, Villejuif, France
    Proc Natl Acad Sci U S A 86:5222-6. 1989
    ..coli exonuclease III. These data suggest that the repair of the Fapy lesion at least to some extent results in the formation of both 5'- and 3'-phosphomonoester nucleotides and the release of the deoxyribose...
  17. pmc Escherichia coli, Saccharomyces cerevisiae, rat and human 3-methyladenine DNA glycosylases repair 1,N6-ethenoadenine when present in DNA
    M Saparbaev
    Groupe Reparation des lesions Radio et Chimio Induites, URA 147 CNRS, Institut Gustave Roussy, Villejuif, France
    Nucleic Acids Res 23:3750-5. 1995
    ..These three proteins efficiently cleave duplex oligonucleotides containing epsilon A positioned opposite T, G, C or epsilon A. However the MAG protein excises A opposite cytosine much faster than opposite thymine, guanine or adenine...
  18. ncbi request reprint Ultraviolet-B-induced damage to Escherichia coli Fpg protein
    O M Sidorkina
    Groupe Reparation des lesions Radio et Chimio Induites, Institut Gustave Roussy, Villejuif, France
    Photochem Photobiol 69:658-63. 1999
    ..Theses polypeptides are most probably formed by the photolytic cleavage of Fpg protein induced by light absorption by the adjacent Trp-34 residue...
  19. ncbi request reprint Role of DNA repair enzymes in the cellular resistance to oxidative stress
    J Laval
    Groupe de Réparation des lésions radio et chimio induites, URA 147 CNRS, Institut Gustave Roussy, Villejuif, France
    Pathol Biol (Paris) 44:14-24. 1996
    ..Mammalian cells have similar DNA repair proteins and it should be emphazized that there is conservation of the different functions and in most cases a remarquable homology of the amino acids sequences from E. coli to man...
  20. ncbi request reprint HU protein of Escherichia coli binds specifically to DNA that contains single-strand breaks or gaps
    B Castaing
    Groupe Reparation des lesions Radio et Chimio Induites, URA 147, CNRS, Institut Gustave Roussy, Villejuif, France
    J Biol Chem 270:10291-6. 1995
    ..Due to specific binding to DNA strand breaks, HU may play a role in replication, recombination, and repair...
  21. pmc Identification of the radC102 mutation. Order of the genes in the 81.5-82.0 min region of the Escherichia coli chromosome
    I Felzenszwalb
    Groupe Réparation des Lésions Chimio et Radioinduites, UA158 CNRS, U140 INSERM, Institut Gustave Roussy, Villejuif, France
    Nucleic Acids Res 20:366. 1992
  22. ncbi request reprint Enzymology of the repair of etheno adducts in mammalian cells and in Escherichia coli
    M Saparbaev
    Groupe Reparation des lesions Radio et Chimio Induites, UMR 1772 CNRS Institut Gustave Roussy, Villejuif, France
    IARC Sci Publ . 1999
    ....
  23. ncbi request reprint Excision of 5'-terminal deoxyribose phosphate from damaged DNA is catalyzed by the Fpg protein of Escherichia coli
    R J Graves
    Groupe Reparation des lesions Radio et Chimio Induites, Centre National de la Recherche Scientifique URA147, Institut Gustave Roussy, Villejuif, France
    J Biol Chem 267:14429-35. 1992
    ..The release of 5'-terminal dRp by crude extracts of E. coli from wild type and fpg-mutant strains shows that the Fpg protein is one of the major EDTA-resistant activities catalyzing this reaction...