Francoise Jacob-Dubuisson

Summary

Affiliation: Institut Pasteur de Lille
Country: France

Publications

  1. pmc Role of adhesin release for mucosal colonization by a bacterial pathogen
    Loic Coutte
    INSERM U447, Institut National de Sante et la Recherche Medical Institut de Biologie de Lille, Institut Pasteur de Lille, 1 rue Calmette, 59019 Lille Cedex, France
    J Exp Med 197:735-42. 2003
  2. ncbi request reprint Channel formation by FhaC, the outer membrane protein involved in the secretion of the Bordetella pertussis filamentous hemagglutinin
    F Jacob-Dubuisson
    INSERM U447, Institut de Biologie de Lille, Institut Pasteur de Lille, 1 rue Calmette, 59019 Lille Cedex, France
    J Biol Chem 274:37731-5. 1999
  3. ncbi request reprint Protein secretion through autotransporter and two-partner pathways
    Francoise Jacob-Dubuisson
    INSERM U629, Institut de Biologie de Lille, Institut Pasteur de Lille, 1 rue Calmette, 59019 Lille Cedex, France
    Biochim Biophys Acta 1694:235-57. 2004
  4. ncbi request reprint Structure of the membrane protein FhaC: a member of the Omp85-TpsB transporter superfamily
    Bernard Clantin
    UMR8161 CNRS, Institut de Biologie de Lille, Universite de Lille 1, Universite de Lille 2, 1 rue du Prof Calmette, F 59021 Lille cedex, France
    Science 317:957-61. 2007
  5. ncbi request reprint Surface anchoring of bacterial subtilisin important for maturation function
    Loic Coutte
    INSERM U44, Institut de Biologie de Lille, Institut Pasteur de Lille, 1 rue Calmette, 59019 Lille Cedex, France
    Mol Microbiol 49:529-39. 2003
  6. ncbi request reprint Structural analysis of Bordetella pertussis BugE solute receptor in a bound conformation
    Isabelle Huvent
    UMR8161 CNRS, Institut de Biologie de Lille, Institute Pasteur de Lille, 1 rue du Professeur Calmette, BP245, 59021 Lille Cedex, France
    Acta Crystallogr D Biol Crystallogr 62:1375-81. 2006
  7. ncbi request reprint Secretion signal of the filamentous haemagglutinin, a model two-partner secretion substrate
    Hélène Hodak
    INSERM U629, 1 rue Calmette, F 59019 Lille cedex, France
    Mol Microbiol 61:368-82. 2006
  8. doi request reprint The peptidyl-prolyl isomerase and chaperone Par27 of Bordetella pertussis as the prototype for a new group of parvulins
    Hélène Hodak
    INSERM U629, Lille, France
    J Mol Biol 376:414-26. 2008
  9. ncbi request reprint Crystal structure of Bordetella pertussis BugD solute receptor unveils the basis of ligand binding in a new family of periplasmic binding proteins
    Isabelle Huvent
    CNRS UMR8117 Institut de Biologie de Lille, Institut Pasteur de Lille, 1 rue du Professeur Calmette, BP245 59021 Lille cedex, France
    J Mol Biol 356:1014-26. 2006
  10. ncbi request reprint The periplasmic binding protein of a tripartite tricarboxylate transporter is involved in signal transduction
    Rudy Antoine
    INSERM U629, Institut de Biologie de Lille, Institut Pasteur de Lille, 1 rue Calmette, 59019 Lille Cedex, France
    J Mol Biol 351:799-809. 2005

Collaborators

  • Alexandre Wohlkonig
  • Caroline Smet
  • Marc Jamin
  • Jerome de Ruyck
  • N Saint
  • Isabelle Landrieu
  • C Locht
  • Marc F Lensink
  • G Molle
  • Rudy Antoine
  • Elian Dupré
  • Jérémy Guérin
  • Hélène Hodak
  • Catherine Baud
  • Vincent Villeret
  • Bernard Clantin
  • Isabelle Huvent
  • Eve Willery
  • Hervé Vezin
  • Loic Coutte
  • Elodie Lesne
  • Julien Herrou
  • Hervé Drobecq
  • Albano C Meli
  • Hassan Belrhali
  • Coralie Bompard
  • Sean Crosson
  • Alexey Vagin
  • Alexis Verger
  • Guillaume Brysbaert
  • Andrey Lebedev
  • Emilien Etienne
  • René Wintjens
  • Nadia Touati
  • Emmanuelle Petit
  • Cédric Leyrat
  • Nicolas Martinez
  • Euripedes de Almeida Ribeiro
  • Jean Michel Wieruszeski
  • Magalie Senechal
  • Anne Sophie Delattre
  • Prakash Rucktooa
  • Dominique Raze
  • Isabelle Deray
  • Karim Chemlal
  • Brigitte Quatannens
  • Sylvie Alonso
  • Nathalie Reveneau
  • Sarah Lesjean

Detail Information

Publications21

  1. pmc Role of adhesin release for mucosal colonization by a bacterial pathogen
    Loic Coutte
    INSERM U447, Institut National de Sante et la Recherche Medical Institut de Biologie de Lille, Institut Pasteur de Lille, 1 rue Calmette, 59019 Lille Cedex, France
    J Exp Med 197:735-42. 2003
    ..These results indicate that the release of FHA is important for colonization, as it may facilitate the dispersal of bacteria from microcolonies and the binding to new sites in the respiratory tract...
  2. ncbi request reprint Channel formation by FhaC, the outer membrane protein involved in the secretion of the Bordetella pertussis filamentous hemagglutinin
    F Jacob-Dubuisson
    INSERM U447, Institut de Biologie de Lille, Institut Pasteur de Lille, 1 rue Calmette, 59019 Lille Cedex, France
    J Biol Chem 274:37731-5. 1999
    ..We thus propose that FhaC forms a specific beta-barrel channel in the outer membrane for the outward translocation of FHA...
  3. ncbi request reprint Protein secretion through autotransporter and two-partner pathways
    Francoise Jacob-Dubuisson
    INSERM U629, Institut de Biologie de Lille, Institut Pasteur de Lille, 1 rue Calmette, 59019 Lille Cedex, France
    Biochim Biophys Acta 1694:235-57. 2004
    ....
  4. ncbi request reprint Structure of the membrane protein FhaC: a member of the Omp85-TpsB transporter superfamily
    Bernard Clantin
    UMR8161 CNRS, Institut de Biologie de Lille, Universite de Lille 1, Universite de Lille 2, 1 rue du Prof Calmette, F 59021 Lille cedex, France
    Science 317:957-61. 2007
    ..General features of the mechanism obtained here are likely to apply throughout the superfamily...
  5. ncbi request reprint Surface anchoring of bacterial subtilisin important for maturation function
    Loic Coutte
    INSERM U44, Institut de Biologie de Lille, Institut Pasteur de Lille, 1 rue Calmette, 59019 Lille Cedex, France
    Mol Microbiol 49:529-39. 2003
    ..The tethered protease appears to be stabilized by unusual Gly- and Pro-rich motifs at the N-terminus of the protein. This represents a new mode of localization for a protease involved in protein secretion...
  6. ncbi request reprint Structural analysis of Bordetella pertussis BugE solute receptor in a bound conformation
    Isabelle Huvent
    UMR8161 CNRS, Institut de Biologie de Lille, Institute Pasteur de Lille, 1 rue du Professeur Calmette, BP245, 59021 Lille Cedex, France
    Acta Crystallogr D Biol Crystallogr 62:1375-81. 2006
    ..No charged residues are involved in glutamate binding by BugE, unlike what has been described for all glutamate receptors reported so far...
  7. ncbi request reprint Secretion signal of the filamentous haemagglutinin, a model two-partner secretion substrate
    Hélène Hodak
    INSERM U629, 1 rue Calmette, F 59019 Lille cedex, France
    Mol Microbiol 61:368-82. 2006
    ..The N-terminal domain of FhaC is involved in the FHA-FhaC interaction, in agreement with its proposed function and periplasmic localization...
  8. doi request reprint The peptidyl-prolyl isomerase and chaperone Par27 of Bordetella pertussis as the prototype for a new group of parvulins
    Hélène Hodak
    INSERM U629, Lille, France
    J Mol Biol 376:414-26. 2008
    ..Par27 displays both PPIase and chaperone activities in vitro. In vivo, Par27 might function as a general periplasmic chaperone in B. pertussis...
  9. ncbi request reprint Crystal structure of Bordetella pertussis BugD solute receptor unveils the basis of ligand binding in a new family of periplasmic binding proteins
    Isabelle Huvent
    CNRS UMR8117 Institut de Biologie de Lille, Institut Pasteur de Lille, 1 rue du Professeur Calmette, BP245 59021 Lille cedex, France
    J Mol Biol 356:1014-26. 2006
    ..The present structure thus unveils the bases of ligand binding in this large family of periplasmic binding proteins, several hundred members of which have been identified in various bacterial species...
  10. ncbi request reprint The periplasmic binding protein of a tripartite tricarboxylate transporter is involved in signal transduction
    Rudy Antoine
    INSERM U629, Institut de Biologie de Lille, Institut Pasteur de Lille, 1 rue Calmette, 59019 Lille Cedex, France
    J Mol Biol 351:799-809. 2005
    ..Thus, BctC is part of the signalling cascade leading to upregulation of the transporter operon in the presence of its solute, a new function for periplasmic binding proteins of TT transporters...
  11. doi request reprint Structure and plasticity of the peptidyl-prolyl isomerase Par27 of Bordetella pertussis revealed by X-ray diffraction and small-angle X-ray scattering
    Bernard Clantin
    UMR8161 CNRS, Institut de Biologie de Lille, Institut Pasteur de Lille, Université de Lille 1 Université de Lille 2, 1 rue Calmette, 59021 Lille Cedex, France
    J Struct Biol 169:253-65. 2010
    ....
  12. pmc Overrepresentation of a gene family encoding extracytoplasmic solute receptors in Bordetella
    Rudy Antoine
    INSERM U447 CNRS UMR 8525, Institut de Biologie de Lille, Institut Pasteur de Lille, 59019 Lille Cedex, France
    J Bacteriol 185:1470-4. 2003
    ..pertussis, and one is involved in citrate uptake. The bug genes probably form an ancient family that has been subjected to a large expansion in a restricted phylogenic group...
  13. doi request reprint Dynamic interplay of membrane-proximal POTRA domain and conserved loop L6 in Omp85 transporter FhaC
    Jérémy Guérin
    Institut Pasteur de Lille, CIIL, 1 rue Calmette, 59019, Lille Cedex, France
    Mol Microbiol 98:490-501. 2015
    ..Our findings thus link all three essential components of Omp85 transporters and indicate that they operate in a concerted fashion in the transport cycle. ..
  14. pmc Signal Transduction by BvgS Sensor Kinase: BINDING OF MODULATOR NICOTINATE AFFECTS THE CONFORMATION AND DYNAMICS OF THE ENTIRE PERIPLASMIC MOIETY
    Elian Dupré
    From the Institut Pasteur de Lille, Center for Infection and Immunity of Lille, 59019 Lille Cedex, France, the Université Lille Nord de France, 59000 Lille, France, the CNRS, Unité Mixte de Recherche UMR 8204, 59046 Lille, France, the Inserm, U1019, 59045 Lille, France
    J Biol Chem 290:23307-19. 2015
    ..This mechanism may be relevant to the other VFT-containing sensor kinases homologous to BvgS. ..
  15. pmc Characterization of the PAS domain in the sensor-kinase BvgS: mechanical role in signal transmission
    Elian Dupré
    Institut Pasteur de Lille, Center for Infection and Immunity, Lille, France
    BMC Microbiol 13:172. 2013
    ..PAS domains are small, ubiquitous sensing or regulatory domains. The function of the PAS domain in BvgS remains unknown...
  16. ncbi request reprint Current challenges in autotransport and two-partner protein secretion pathways
    Hélène Hodak
    INSERM U629, Institut Pasteur de Lille, IFR142, 1 rue du Professeur Calmette, 59019 Lille Cedex, France
    Res Microbiol 158:631-7. 2007
    ..Both mediate the translocation of large proteins across the outer membrane. Deciphering the molecular mechanisms of secretion machineries as well as folding of exoproteins in the course of translocation represents a current challenge...
  17. doi request reprint Translocation path of a substrate protein through its Omp85 transporter
    Catherine Baud
    1 Center for Infection and Immunity of Lille, Institut Pasteur de Lille, 1 rue Calmette, Lille 59021, France 2 CNRS UMR8204, Lille 59021, France 3 INSERM U1019, Lille 59045, France 4 University of Lille Nord de France, Lille 59044, France
    Nat Commun 5:5271. 2014
    ..This sheet of FhaC guides the secretion domain of FHA along discrete steps of translocation and folding. This work demonstrates that the Omp85 barrel serves as a channel for translocation of substrate proteins. ..
  18. pmc Virulence regulation with Venus flytrap domains: structure and function of the periplasmic moiety of the sensor-kinase BvgS
    Elian Dupré
    Center for Infection and Immunity CIIL, Institut Pasteur de Lille, Lille, France Center for Infection and Immunity CIIL, University Lille North of France, Lille, France UMR 8204, Centre National de la Recherche Scientifique CNRS, Lille, France U1019, Institut National de la Sante et de la Recherche Medicale INSERM, Lille, France
    PLoS Pathog 11:e1004700. 2015
    ..As homologous sensor-kinases control virulence features of diverse bacterial pathogens, the BvgS structure and mechanism may pave the way for new modes of targeted therapeutic interventions. ..
  19. doi request reprint Conformational dynamics of protein transporter FhaC: large-scale motions of plug helix
    Jérémy Guérin
    Institut Pasteur de Lille, Center for Infection and Immunity, Lille, France CNRS UMR8204, Lille, France Inserm U1019, Lille, France Univ Lille Nord de France, Lille, France
    Mol Microbiol 92:1164-76. 2014
    ..The open conformation of FhaC implies a large displacement from the channel of the N-terminal 'plug' helix, which remains in the periplasm during FHA secretion. The membrane environment favours the dynamics of the TpsB transporter. ..
  20. pmc Crystallization and preliminary X-ray diffraction analysis of the peptidylprolyl isomerase Par27 of Bordetella pertussis
    Alexandre Wohlkonig
    Approches Structurales et Fonctionnelles de Pathogenèse, Institut de Biologie de Lille, Institut Pasteur de Lille, Universite de Lille 1, Universite de Lille 2, IFR142, 1 rue du Professeur Calmette, BP245 Lille 59021 CEDEX, France
    Acta Crystallogr Sect F Struct Biol Cryst Commun 64:809-12. 2008
    ..6, b = 214.1, c = 57.8 A), diffracts to 2.2 A resolution. Preliminary diffraction data analysis agreed with the presence of one monomer in the asymmetric unit of the orthorhombic crystal form and two in the monoclinic form...
  21. doi request reprint First structural insights into the TpsB/Omp85 superfamily
    Francoise Jacob-Dubuisson
    INSERM U629, Institut Pasteur de Lille, 1 rue Calmette, F 59019 Lille cedex, France
    Biol Chem 390:675-84. 2009
    ..With two POTRA domains in the periplasm, a transmembrane beta barrel and a large loop harboring a functionally important motif, FhaC epitomizes the conserved features of the super-family...