A Italiano

Summary

Affiliation: Institut Bergoni
Country: France

Publications

  1. pmc SDHA loss of function mutations in a subset of young adult wild-type gastrointestinal stromal tumors
    Antoine Italiano
    Departments of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    BMC Cancer 12:408. 2012
  2. pmc Alterations of the p53 and PIK3CA/AKT/mTOR pathways in angiosarcomas: a pattern distinct from other sarcomas with complex genomics
    Antoine Italiano
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Cancer 118:5878-87. 2012
  3. pmc Patterns of deregulation of insulin growth factor signalling pathway in paediatric and adult gastrointestinal stromal tumours
    Antoine Italiano
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Eur J Cancer 48:3215-22. 2012
  4. doi request reprint Advanced well-differentiated/dedifferentiated liposarcomas: role of chemotherapy and survival
    A Italiano
    Department of Medical Oncology, Institut Bergonie, Bordeaux, France
    Ann Oncol 23:1601-7. 2012
  5. doi request reprint Comparison of doxorubicin and weekly paclitaxel efficacy in metastatic angiosarcomas
    Antoine Italiano
    Department of Medical Oncology, Institut Bergonie, Bordeaux, France
    Cancer 118:3330-6. 2012
  6. doi request reprint Patterns of care, prognosis, and survival in patients with metastatic gastrointestinal stromal tumors (GIST) refractory to first-line imatinib and second-line sunitinib
    Antoine Italiano
    Institut Bergonie, Bordeaux, France
    Ann Surg Oncol 19:1551-9. 2012
  7. pmc The miR-17-92 cluster and its target THBS1 are differentially expressed in angiosarcomas dependent on MYC amplification
    Antoine Italiano
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Genes Chromosomes Cancer 51:569-78. 2012
  8. doi request reprint Clinical outcome of leiomyosarcomas of vascular origin: comparison with leiomyosarcomas of other origin
    A Italiano
    Department of Medical Oncology, Institut Bergonie, Bordeaux, France
    Ann Oncol 21:1915-21. 2010
  9. doi request reprint "Metronomic" chemotherapy in advanced soft tissue sarcomas
    Antoine Italiano
    Department of Medical Oncology, Institut Bergonie, 229 Cours de l Argonne, 33076 Bordeaux Cedex, France
    Cancer Chemother Pharmacol 66:197-202. 2010
  10. doi request reprint Effect of adjuvant chemotherapy on survival in FNCLCC grade 3 soft tissue sarcomas: a multivariate analysis of the French Sarcoma Group Database
    A Italiano
    Department of Medical Oncology, Institut Bergonie, Bordeaux, France
    Ann Oncol 21:2436-41. 2010

Detail Information

Publications75

  1. pmc SDHA loss of function mutations in a subset of young adult wild-type gastrointestinal stromal tumors
    Antoine Italiano
    Departments of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    BMC Cancer 12:408. 2012
    ..A recent report identified four non-syndromic, KIT/PDGFRA WT GIST harboring compound heterozygous or homozygous mutations in SDHA encoding the main subunit of the SDH complex II...
  2. pmc Alterations of the p53 and PIK3CA/AKT/mTOR pathways in angiosarcomas: a pattern distinct from other sarcomas with complex genomics
    Antoine Italiano
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Cancer 118:5878-87. 2012
    ..The scale of genetic abnormalities in these pathways remains unknown in angiosarcoma (AS)...
  3. pmc Patterns of deregulation of insulin growth factor signalling pathway in paediatric and adult gastrointestinal stromal tumours
    Antoine Italiano
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Eur J Cancer 48:3215-22. 2012
    ..Data regarding the patterns and the mechanisms of deregulation of the insulin growth factor (IGF) pathway in adult and paediatric gastrointestinal stromal tumours (GISTs) are limited...
  4. doi request reprint Advanced well-differentiated/dedifferentiated liposarcomas: role of chemotherapy and survival
    A Italiano
    Department of Medical Oncology, Institut Bergonie, Bordeaux, France
    Ann Oncol 23:1601-7. 2012
    ..Data regarding the role of systemic therapy in patients with advanced well-differentiated/dedifferentiated liposarcomas (WDLPS/DDLPS) are limited...
  5. doi request reprint Comparison of doxorubicin and weekly paclitaxel efficacy in metastatic angiosarcomas
    Antoine Italiano
    Department of Medical Oncology, Institut Bergonie, Bordeaux, France
    Cancer 118:3330-6. 2012
    ..Data regarding the role of anthracyclines and taxanes as first-line treatments of metastatic angiosarcoma are limited...
  6. doi request reprint Patterns of care, prognosis, and survival in patients with metastatic gastrointestinal stromal tumors (GIST) refractory to first-line imatinib and second-line sunitinib
    Antoine Italiano
    Institut Bergonie, Bordeaux, France
    Ann Surg Oncol 19:1551-9. 2012
    ..Data regarding the management and outcome of patients with metastatic gastrointestinal stromal tumors (GIST) refractory to 1st-line imatinib and 2nd-line sunitinib are limited...
  7. pmc The miR-17-92 cluster and its target THBS1 are differentially expressed in angiosarcomas dependent on MYC amplification
    Antoine Italiano
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Genes Chromosomes Cancer 51:569-78. 2012
    ..Thus, MYC amplification may play a crucial role in the angiogenic phenotype of AS through upregulation of the miR-17-92 cluster, which subsequently downregulates THBS1, a potent endogenous inhibitor of angiogenesis...
  8. doi request reprint Clinical outcome of leiomyosarcomas of vascular origin: comparison with leiomyosarcomas of other origin
    A Italiano
    Department of Medical Oncology, Institut Bergonie, Bordeaux, France
    Ann Oncol 21:1915-21. 2010
    ..There are no data about the natural history of leiomyosarcoma of vascular origin (vLMS) in comparison with leiomyosarcoma (LMS) of other origin and about the management of advanced disease...
  9. doi request reprint "Metronomic" chemotherapy in advanced soft tissue sarcomas
    Antoine Italiano
    Department of Medical Oncology, Institut Bergonie, 229 Cours de l Argonne, 33076 Bordeaux Cedex, France
    Cancer Chemother Pharmacol 66:197-202. 2010
    ..Endothelial cells are the primary target of metronomic chemotherapy. We report the safety and the efficacy of metronomic chemotherapy in metastatic STS patients...
  10. doi request reprint Effect of adjuvant chemotherapy on survival in FNCLCC grade 3 soft tissue sarcomas: a multivariate analysis of the French Sarcoma Group Database
    A Italiano
    Department of Medical Oncology, Institut Bergonie, Bordeaux, France
    Ann Oncol 21:2436-41. 2010
    ..The predictive value of grade for benefit from adjuvant chemotherapy (AC) in soft tissue sarcoma (STS) patients has never been explored...
  11. doi request reprint [Chemotherapy options for patients with advanced soft-tissue sarcoma beyond anthracyclines]
    A Italiano
    Institut Bergonie, Departement d Oncologie Medicale, 229, cours de l Argonne, 33076 Bordeaux Cedex, France
    Bull Cancer 97:679-86. 2010
    ..Further studies are needed in order to identify predictive factors of clinical benefit in advanced soft-tissue sarcoma patients treated with cytotoxic agents in combination or not with targeted therapies...
  12. doi request reprint Trends in survival for patients with metastatic soft-tissue sarcoma
    Antoine Italiano
    Department of Medical Oncology, Bergonie Institute, Bordeaux, France
    Cancer 117:1049-54. 2011
    ..The objective of this study was to determine whether the overall survival of patients with metastatic soft tissue sarcoma (STS) has improved over the last 20 years...
  13. doi request reprint Temsirolimus in advanced leiomyosarcomas: patterns of response and correlation with the activation of the mammalian target of rapamycin pathway
    Antoine Italiano
    Department of Medical Oncology, Institut Bergonie, Bordeaux, Cedex, France
    Anticancer Drugs 22:463-7. 2011
    ..Further investigations of the phosphoinositide 3-kinases/PTEN/Akt/mTOR pathway are needed to explore the role of mTOR inhibitors, either alone or in combination, in patients with advanced sarcoma...
  14. doi request reprint Clinical and biological significance of CDK4 amplification in well-differentiated and dedifferentiated liposarcomas
    Antoine Italiano
    Laboratory of Solid Tumors Genetics and Department of Pathology, Nice University Hospital, Nice, France
    Clin Cancer Res 15:5696-703. 2009
    ..Our goal was to determine whether the absence of CDK4 amplification was (a) correlated to a specific clinico-histopathologic profile; and (b) compensated by another genomic anomaly involving the CCND1/CDK4/P16INK4a/RB1/E2F pathway...
  15. doi request reprint KRAS and BRAF mutational status in primary colorectal tumors and related metastatic sites: biological and clinical implications
    Antoine Italiano
    Laboratory of Solid Tumors Genetics, Nice University Hospital, Nice, France
    Ann Surg Oncol 17:1429-34. 2010
    ..The question of primary resistance to anti-EGFR treatment as a result of the presence of KRAS or BRAF mutations only in metastases has been raised but not resolved...
  16. doi request reprint Neo/adjuvant chemotherapy does not improve outcome in resected primary synovial sarcoma: a study of the French Sarcoma Group
    A Italiano
    Department of Medical Oncology, Institut Bergonie, Bordeaux, France
    Ann Oncol 20:425-30. 2009
    ..There are only scarce data about the benefit of adjunctive chemotherapy in patients with localized synovial sarcoma (SS)...
  17. doi request reprint High-dose chemotherapy consolidation for chemosensitive advanced soft tissue sarcoma patients: an open-label, randomized controlled trial
    B Bui-Nguyen
    Department of Medical Oncology, Institut Bergonie, Bordeaux, France
    Ann Oncol 23:777-84. 2012
    ..This randomized open phase III study examines whether high-dose (HD) chemotherapy with peripheral blood stem cells (PBSCs) could improve overall survival (OS) of chemosensitive patients...
  18. ncbi request reprint Advanced well-differentiated/dedifferentiated liposarcomas: Role of chemotherapy and survival
    M Toulmonde
    Institut Bergonie, Bordeaux, France Centre Oscar Lambret, Lille, France Institut Gustave Roussy, Villejuif, France Centre Georges François Leclerc, Dijon, France Centre René Gauducheau, Nantes, France La Timone University Hospital, Marseille, France Memorial Sloan Kettering Cancer Center, New York, NY Centre Léon Bérard, Lyon, France
    J Clin Oncol 29:10071. 2011
    ..10071 Background: Data regarding the role of systemic therapy in patients (pts) with advanced well-differentiated/dedifferentiated liposarcomas (WLPS/DDLPS) are limited...
  19. doi request reprint Chemotherapy in patients with desmoid tumors: a study from the French Sarcoma Group (FSG)
    D Garbay
    Department of Medical Oncology, Institut Bergonie, Bordeaux, France
    Ann Oncol 23:182-6. 2012
    ..Data regarding the role of chemotherapy (CT) in patients with recurrent and/or unresectable desmoid tumors (DTs) are scarce...
  20. doi request reprint [Helical tomotherapy for axial and paraspinal tumours: experience of Institut Bergonié (14 cases)]
    H Haddad
    Departement de Radiotherapie, Institut Bergonie, Centre Régional de Lutte Contre le Cancer de Bordeaux et du Sud Ouest, 229 Cours de l Argonne, Bordeaux Cedex, France
    Cancer Radiother 15:404-12. 2011
    ..To evaluate the feasibility of helical tomotherapy intensity-modulated radiotherapy for the treatment of axial and paraspinal tumours...
  21. ncbi request reprint Outcomes for patients with advanced GIST achieving a complete remission (CR) with imatinib (IM): Results from the prospective randomized phase III trial of the French Sarcoma Group
    A Cioffi
    Institut Gustave Roussy, Villejuif, France Centre Leon Berard, Lyon, France Institut Bergonié, Bordeaux, France Centre Alexis Vautrin, Nancy, France La Timone, Marseille, France Institut Paoli Calmettes, Marseille, France Centre Oscar Lambret, Lille, France
    J Clin Oncol 26:10550. 2008
    ..The pattern of response to IM is heterogeneous. Patient (pt) characteristics and outcome of pts experiencing a CR under IM are unknown...
  22. pmc Advanced chondrosarcomas: role of chemotherapy and survival
    A Italiano
    Department of Medical Oncology, Institut Bergonie, Bordeaux
    Ann Oncol 24:2916-22. 2013
    ..There are limited data about the role of chemotherapy in patients with advanced chondrosarcomas...
  23. ncbi request reprint Metastatic epitheloid hemangioendothelioma (EHE): Role of systemic therapy and survival
    A Cioffi
    Institut Gustave Roussy, Villejuif, France Institut Bergonié, Bordeaux, France Centre Oscar Lambret, Lille, France Institut Claudius Regaud, Toulouse, France APHM, Marseille, France La Timone University Hospital, Marseille, France Memorial Sloan Kettering Cancer Center, New York, NY Mount Sinai School of Medicine, New York, NY
    J Clin Oncol 29:10079. 2011
    ..10079 Background: Data regarding the management of patients with metastatic EHE are almost nonexistent...
  24. ncbi request reprint Patterns of care, prognosis, and survival of patients with metastatic gastrointestinal stromal tumors (GIST) refractory to first-line imatinib and second-line sunitinib
    A Italiano
    Institut Bergonie, Bordeaux, France Institut Gustave Roussy, Villejuif, France Memorial Sloan Kettering Cancer Center, New York, NY University Hospitals Leuven, Leuven, Belgium Maria Sklodowska Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland La Timone University Hospital, Marseille, France Centre Oscar Lambret, Lille, France Centre Georges François Leclerc, Dijon, France Centre René Gauducheau, Nantes, France Centre Leon Berard, Lyon, France Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy Katholieke Universiteit Leuven, Leuven, Belgium
    J Clin Oncol 29:10044. 2011
    ..10044 Background: Data regarding the management and outcome of metastatic GIST patients (pts) refractory to 1st line imatinib (I) and 2nd sunitinib (S) are limited...
  25. ncbi request reprint Head and neck squamous cell carcinoma in patients over 80 years old: patterns of care and survival
    C Ortholan
    Centre Antoine Lacassagne, Nice, France
    J Clin Oncol 26:6050. 2008
    ..6050 Background: Scarce data exist concerning the outcome of elderly patients (pts) diagnosed with head and neck squamous cell carcinoma (HNSCC)...
  26. pmc Aplidin in patients with advanced dedifferentiated liposarcomas: a French Sarcoma Group Single-Arm Phase II study
    M Toulmonde
    Department of Medical Oncology, Institut Bergonie, Bordeaux
    Ann Oncol 26:1465-70. 2015
    ..Preclinical data have suggested a therapeutic role of JUN pathway activation in dedifferentiated liposarcoma (DDLPS) tumorigenesis. Aplidin is a drug inducing apoptosis through a strong, sustained activation of c-Jun NH2-terminal kinase...
  27. pmc GDC-0449 in patients with advanced chondrosarcomas: a French Sarcoma Group/US and French National Cancer Institute Single-Arm Phase II Collaborative Study
    A Italiano
    Department of Medical Oncology, Institut Bergonie, Bordeaux
    Ann Oncol 24:2922-6. 2013
    ..Pre-clinical data have suggested a therapeutic role of Hedgehog (Hh) pathway inhibitors in chondrosarcoma...
  28. pmc Retroperitoneal sarcomas: patterns of care at diagnosis, prognostic factors and focus on main histological subtypes: a multicenter analysis of the French Sarcoma Group
    M Toulmonde
    Department of Medical Oncology, Institut Bergonie, Bordeaux
    Ann Oncol 25:735-42. 2014
    ..This study addresses these specific points in a homogeneous cohort of patients with completely resected primary RPS...
  29. pmc Retroperitoneal sarcomas: patterns of care in advanced stages, prognostic factors and focus on main histological subtypes: a multicenter analysis of the French Sarcoma Group
    M Toulmonde
    Department of Medical Oncology, Institut Bergonie, Bordeaux
    Ann Oncol 25:730-4. 2014
    ..There is no available report assessing palliative chemotherapy in advanced RPS. This study analyzes management and outcome in a large cohort of patients with advanced RPS, considering main histological subtypes separately...
  30. doi request reprint Advanced soft-tissue sarcoma in elderly patients: patterns of care and survival
    D Garbay
    Department of Medical Oncology, Institut Bergonie, Bordeaux, France
    Ann Oncol 24:1924-30. 2013
    ..There are no data regarding the management of advanced soft-tissue sarcoma (STS) in elderly patients...
  31. ncbi request reprint Consolidation with high-dose chemotherapy for responding patients to standard chemotherapy in advanced, metastatic soft tissue sarcoma (STS): A randomized trial from FNCLCC-French Sarcoma Group
    N N Binh
    PALSAR02 Clinical Trial Group Institut Bergonié, Bordeaux, France Institut Claudius Regaud, Toulouse, France Centre Oscar Lambret, Lille, France Centre Jean Perrin, Clermont Ferrand, France Centre Leon Berard, Lyon, France FNCLCC, Paris, France
    J Clin Oncol 27:10505. 2009
    ..This randomized, open, phase III study was designed to assess whether or not an HD chemotherapy with peripheral blood stem cells (PBSC) would improve OS in patients with advanced or metastatic STS responding to MAID chemotherapy...
  32. ncbi request reprint Adjuvant (A) and neoadjuvant (NeoA) chemotherapy (C) in resected synovial sarcoma (SS): A study of the French Sarcoma Group (GSF-GETO)
    A Italiano
    Centre Antoine Lacassagne, Nice, France Centre Hospitalier Universitaire de Lyon, Lyon, France Institut Bergonié, Bordeaux, France Institut Gustave Roussy, Villejuif, France Centre Leon Berard, Lyon, France Centre Oscar Lambret, Lille, France Institut Curie, Paris, France Centre René Huguenin, Saint Cloud, France
    J Clin Oncol 26:10527. 2008
    ..We report here a database study assessing the role of AC and NeoAC in patients with SS...
  33. ncbi request reprint Outcome of 157 adult rhabdomyosarcoma (RMS) patients: A retrospective study from the French Group Sarcoma (GSF-GETO)
    E Bompas
    Centre Rene Gauducheau, Nantes, France Centre René Gauducheau, Saint Herblain, France Institut Bergonié, Bordeaux, France Department of Medical Oncology, Institut Gustave Roussy, Villejuif, France IGR, Villejuif, France Institut Claudius Regaud, Toulouse, France Institut Curie, Paris, France Centre Georges François Leclerc, Dijon, France Medical Oncology, Centre Antoine Lacassagne, Nice, France Centre Alexis Vautrin, Nancy, France CHU, Strasbourg, France Centre François Baclesse, Caen, France Centre Jean Perrin, Clermont Ferrand, France La Timone University Hospital, Marseille, France Centre Paul Papin, Angers, France Centre Leon Berard, Lyon, France
    J Clin Oncol 29:10070. 2011
    ..10070 Background: Five-year overall survival (OS) of localized RMS of children < 18 exceeds 70%, while OS in adult pts is poor. We report a retrospective experience from centers of GSF-GETO...
  34. doi request reprint Aromatase inhibition in male breast cancer patients: biological and clinical implications
    J Doyen
    Department of Medical Oncology, Centre Antoine Lacassagne, Nice, France
    Ann Oncol 21:1243-5. 2010
    ..The role of aromatase inhibitors (AIs) and their impact on estradiol (E(2)) levels remain unknown in male breast cancer (MBC) patients...
  35. doi request reprint [Surgical margins in soft tissue sarcoma]
    E Stoeckle
    Institut Bergonie, Centre Regional de Lutte Contre le Cancer, Bordeaux, France
    Bull Cancer 95:1199-204. 2008
    ..To state about adequacy of surgery margins in soft tissue sarcoma (STS)...
  36. ncbi request reprint Metastatic angiosarcomas (mAS): Identification of treatments that significantly improve the outcome
    E Amela
    Centre Oscar Lambret, Lille, France Institut Bergonié, Bordeaux, France Centre Leon Berard, Lyon, France CHU, Besancon, France Centre François Baclesse, Caen, France Institut Paoli Calmettes, Marseille, France Centre Georges François Leclerc, Dijon, France Centre Val d Aurelle, Montpellier, France Centre René Gauducheau, Nantes, France Centre Jean Perrin and Centre Hospitalier Universitaire Clermont Ferrand, Clermont Ferrand, France La Timone University Hospital, Marseille, France Centre Henri Becquerel, Rouen, France CHU, Nantes, France The Royal Marsden Hospital, Sutton, United Kingdom Institut Claudius Regaud, Toulouse, France
    J Clin Oncol 29:10085. 2011
    ..10085 Background: AS represent about 1% of all soft tissue sarcomas. Few literature data are available and the impact role of the different treatments is debated...
  37. ncbi request reprint Effect of adjuvant chemotherapy on survival in FNCLCC grade 3 soft tissue sarcomas: A multivariate analysis of the French Sarcoma Group database
    A Italiano
    French Sarcoma Group GSF GETO Institut Bergonie, Bordeaux, France Institut Gustave Roussy, Villejuif, France Centre René Huguenin, Saint Cloud, France Centre François Baclesse, Caen, France Centre George François Leclerc, Dijon, France Centre Leon Berard, Lyon, France
    J Clin Oncol 27:10504. 2009
    ..We report here the analysis of the impact of AC in the population of STS patients included in the prospective database of the French Sarcoma Group...
  38. ncbi request reprint Who are the long responders to imatinib (IM) in patients with advanced GIST? Results of the BFR14 prospective French Sarcoma Group randomized phase III trial
    A Blesius
    Medical Oncology Department, Institut Gustave Roussy, Villejuif, France The Royal Marsden Hospital, Sutton, United Kingdom Centre Léon Bérard, Lyon, France Institut Bergonié, Bordeaux, France Centre Oscar Lambret, Lille, France Centre Alexis Vautrin, Nancy, France Institut Paoli Calmettes, Marseille, France University Hospital La Timone, Marseille, France Centre Val d Aurelle, Montpellier, France Institut Claudius Regaud, Toulouse, France Centre René Gauducheau, Nantes, France Department of Pathology, Ambroise Pare Hospital, Boulogne, France Institut Gustave Roussy, Villejuif, France
    J Clin Oncol 29:10048. 2011
    ..10048 Background: The aim of this work was to characterize patient (pts) characteristics and the mutational status of GIST who benefit the most from IM in term of prolonged response and overall survival...
  39. doi request reprint Standardization of selection criteria for percutaneous image-guided cryoablation of recurrent soft-tissue sarcomas
    N Lippa
    Department of Radiology, Institute Bergonie, 229, cours de l Argonne, 33076 Bordeaux, France
    Diagn Interv Imaging 95:1071-7. 2014
    ..This study aims to identify selection criteria for cryoablation in order to standardize indications of this treatment...
  40. doi request reprint [Adjuvant chemotherapy of adults soft tissue sarcomas]
    B Bui-Nguyen
    Institut Bergonie, Departement d Oncologie Medicale, 229, cours de l Argonne, 33076 Bordeaux Cedex, France
    Bull Cancer 97:673-8. 2010
    ..This needs a better understanding of the biology of those tumors, of metastases risk factors and of the determinants of systemic therapies efficacy in these tumors...
  41. doi request reprint Quality of randomized controlled trials reporting in the treatment of sarcomas
    Maud Toulmonde
    Institut Bergonie, Bordeaux, France
    J Clin Oncol 29:1204-9. 2011
    ..Randomized controlled trials (RCTs) represent the best evidence in oncology practice. The aim of this study was to assess the reporting quality of sarcoma RCTs and to identify significant predictors of quality...
  42. ncbi request reprint Primary osteosarcomas of the mandible: Joint study of the Groupe Sarcome Francais (GSF), Rare Cancer Network, and Groupe d'Etude des Tumeurs de la Tete et du Cou (GETTEC)
    J Thariat
    Centre Antoine Lacassagne, Nice, France Centre Leon Berard, Lyon, France Medical Oncology, Centre Antoine Lacassagne, Nice, France Institut Bergonié, Bordeaux, France Institute Claudius Regaud, Toulouse, France Mayo Clinic, Rochester, MN Centre René Gauducheau, Nantes, France CHU, Toulouse, France APHM, Marseille, France Department of Radiation Oncology, Centre Georges Francois Leclerc, Dijon, France CHU, Strasbourg, France Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Brussels, Belgium Medical Oncology Department, AP HP, Salpetriere Hospital, University Paris VI, Paris, France Centre Val d Aurelle, Montpellier, France CHU, Limoges, France Centre Eugène Marquis, Rennes, France CHU Tenon, Paris, Scottish National Blood Transfusion Service (SNBTS
    J Clin Oncol 29:10036. 2011
    ..The prognosis mainly depends on local control. Indications of radiotherapy (RT) for R1 disease (dz) or chemotherapy (chemo) vary among centers. This study focused on the impact of surgery and perioperative management toward outcome...
  43. ncbi request reprint Definition of an imatinib trough concentration threshold in the treatment of advanced gastrointestinal stromal tumors (GIST)
    M Molimard
    Groupe Hospitalier Pellegrin, Bordeaux, France Department of Pharmacology Universitary Hospital of Bordeaux, University of Bordeaux, INSERM U657, Bordeaux, France Universite V Segalen Service de Pharmacologie, Bordeaux, France Institut Bergonié, Bordeaux, France Institut Claudius Regaud, Toulouse, France La Timone University Hospital, Marseille, France Centre Alexis Vautrin, Nancy, France Centre Val d Aurelle, Montpellier, France Centre Oscar Lambret, Lille, France Centre Leon Berard, Lyon, France University Hospital Robert Debre, Reims, France Institut Gustave Roussy, Villejuif, France
    J Clin Oncol 29:10013. 2011
    ..We prospectively performed routine analysis of I in advanced GIST pts in which we investigated the relationships between Cmin and progression-free survival (PFS)...
  44. ncbi request reprint Effect of metastasectomy and doxorubicin dose on the outcome of patients with metastastic leiomyosarcoma: A multicenter study
    N Penel
    Oscar Lambret Cancer Center, Lille, France Institut Bergonié, Bordeaux, France Centre George François Leclerc, Dijon, France Centre René Gauducheau, Saint Herblain, France Hôpital Saint Louis, Paris, France Hopital la Timone, Marseille, France
    J Clin Oncol 27:10580. 2009
    ..10580 Background: The role of metastasectomy and front-line chemotherapy modalities remain debated in the metastastatic soft tissue sarcoma setting...
  45. ncbi request reprint Aromatase inhibition in male breast cancer patients: Biological and clinical implications
    J Doyen
    Centre Antoine Lacassagne, Nice, France
    J Clin Oncol 27:1130. 2009
    ..We report here the largest experience about the efficacy of AI in MBC pts with advanced disease and their impact on estradiol (E) levels...
  46. ncbi request reprint Correlation of global expresssion of ERCC1 in head and neck squamous cell carcinoma with prognosis
    E Saada
    Centre Antoine Lacassagne, Nice, France Institut Bergonié, Bordeaux, France CHU Poitiers, Poitiers, France
    J Clin Oncol 27:e17016. 2009
    ....
  47. doi request reprint The introduction of early patient rehabilitation in surgery of soft tissue sarcoma and its impact on post-operative outcome
    A Michot
    Department of Surgery, Institut Bergonie, 229 Cours de l Argonne, F 33076 Bordeaux, France
    Eur J Surg Oncol 41:1678-84. 2015
    ..We wondered whether its introduction into STS surgery might have impacted postoperative outcome...
  48. pmc Adherence to consensus-based diagnosis and treatment guidelines in adult soft-tissue sarcoma patients: a French prospective population-based study
    S Mathoulin-Pelissier
    Clinical and Epidemiological Research Unit, Institut Bergonie, Comprehensive Cancer Centre, Bordeaux
    Ann Oncol 25:225-31. 2014
    ..Management and treatment are thus complex, but crucial for patient outcomes. We assess adherence to adult STS management guidelines across two French regions (10% of the French population). We also report standardized incidence...
  49. doi request reprint [Normal tissue tolerance to external beam radiation therapy: adult bone]
    P Sargos
    Departement de Radiotherapie, Centre Regional de Lutte Contre le Cancer, Institut Bergonie, 229 Cours de l Argonne, 33076 Bordeaux Cedex, France
    Cancer Radiother 14:386-91. 2010
    ..Dose-effect relations are difficult to qualify in older series. Recent models evaluating radiations toxicity on diaphysa suggest an important risk after 60 Gy, for high dose-fraction and for a large volume...
  50. ncbi request reprint Trough imatinib plasma levels in patients treated for advanced gastrointestinal stromal tumors evidence of large interpatient variations under treatment with standard doses
    B N Bui
    Institut Bergonie, Bordeaux, France Institut Bergonié, Bordeaux, France Université de Bordeaux 2, Bordeaux, France
    J Clin Oncol 26:10564. 2008
    ..10564 Background: Large interpatient variations of trough imatinib level have been reported in patients with CML given imatinib 400- 600 mg/d; moreover, the 24h residual plasma level of imatinib was found correlated with imatinib efficacy...
  51. ncbi request reprint Docetaxel-based chemotherapy in elderly patients (≥ 75 years) with castration resistant prostate cancer (CRPC): A French National study of 175 patients
    E Bompas
    Centre Rene Gauducheau, Saint Herblain, France Institut Gustave Roussy, Villejuif, France Centre Antoine Lacassagne, Nice, France Hôpital européen Georges Pompidou, Paris, France Centre Val d Aurelle, Marseille, France Institut Paoli Calmettes, Marseille, France Institut Curie, Paris, France Centre Leon Berard, Lyon, France Centre François Baclesse, Rouen, France
    J Clin Oncol 26:5145. 2008
    ..5145 Background: Although docetaxel-based chemotherapy is a standard in CRPC, only limited data is available in elderly patients (pts) with CRPC treated with chemotherapy...
  52. ncbi request reprint Oral cavity squamous cell carcinoma in patients aged 80 or older: Risk factors, treatment, and outcome
    C Ortholan
    Centre Antoine Lacassagne, Nice, France Centre Hospitalier Universitaire de Poitiers, Poitiers, France Institut Bergonié, Bordeau, France Institut Gustave Roussy, Villejuif, France
    J Clin Oncol 27:6064. 2009
    ..There are no specific data on this cancer location outcome in elderly patients. Therefore, we report here the experience of two French cancer centers in the treatment of oral cavity SCC in patients aged ≥ 80 years...
  53. doi request reprint Guidelines for time-to-event end point definitions in sarcomas and gastrointestinal stromal tumors (GIST) trials: results of the DATECAN initiative (Definition for the Assessment of Time-to-event Endpoints in CANcer trials)†
    C A Bellera
    Clinical and Epidemiological Research Unit, Institut Bergonie, Comprehensive Cancer Centre, Bordeaux Clinical Epidemiology Unit, INSERM CIC 14 01 Clinical Epidemiology, Bordeaux
    Ann Oncol 26:865-72. 2015
    ..We report guidelines for RCT in sarcomas and gastrointestinal stromal tumors (GIST)...
  54. doi request reprint Percutaneous image-guided cryoablation in inoperable extra-abdominal desmoid tumors: a study of tolerability and efficacy
    M Havez
    Department of Radiology, Hopital Pellegrin, CHU de Bordeaux, Place Amelie Raba Leon, 33076, Bordeaux, France
    Cardiovasc Intervent Radiol 37:1500-6. 2014
    ..To determine the tolerability, effectiveness and outcomes of percutaneous image-guided cryoablation on inoperable extra-abdominal desmoid tumors...
  55. doi request reprint Treatment of advanced gastrointestinal stromal tumors in patients over 75 years old: clinical and pharmacological implications
    A Italiano
    Department of Medical Oncology, Institut Bergonie, 229 Cours de l Argonne, 33076, Bordeaux Cedex, France
    Target Oncol 8:295-300. 2013
    ..Overall survival is similar to that of younger patients. Comorbidities did not result in increased incidence of toxicity. Careful follow-up regarding tolerance issues should be considered in elderly patients with poor PS...
  56. doi request reprint Sarcoma lung metastases treated with percutaneous radiofrequency ablation: results from 29 patients
    J Palussiere
    Department of Radiology, Institut Bergonie, Regional Cancer Center, Bordeaux, France
    Ann Surg Oncol 18:3771-7. 2011
    ..We aimed to determine safety and efficacy of radiofrequency ablation (RFA) in the treatment of lung metastases arising from sarcoma...
  57. ncbi request reprint Comparison of the epidermal growth factor receptor gene and protein in primary non-small-cell-lung cancer and metastatic sites: implications for treatment with EGFR-inhibitors
    A Italiano
    Department of Medical Oncology, Centre Antoine Lacassagne, Nice, France
    Ann Oncol 17:981-5. 2006
    ..However, it is still not known whether EGFR expression differs in metastases compared to primary non-small cell lung cancer (NSCLC)...
  58. doi request reprint EGFR and KRAS status of primary sarcomatoid carcinomas of the lung: implications for anti-EGFR treatment of a rare lung malignancy
    Antoine Italiano
    Laboratory of Solid Tumors Genetics, Nice University Hospital, Nice, France
    Int J Cancer 125:2479-82. 2009
    ..The rare incidence of increased EGFR gene copy number, the lack of EGFR mutation and the high rate of KRAS mutation observed in our series also suggest that most patients with lung SC are not likely to benefit from anti-EGFR therapies...
  59. ncbi request reprint Targeting the epidermal growth factor receptor in colorectal cancer: advances and controversies
    Antoine Italiano
    Department of Medical Oncology, Centre Regional de Lutte Contre le Cancer Antoine Lacassagne, Canceropôle PACA, Nice, France
    Oncology 70:161-7. 2006
    ..However, expression of EGFR did not correlate with clinical benefit. Clearly, the search for markers of response to treatment against EGFR must go on...
  60. doi request reprint Effect on survival of local ablative treatment of metastases from sarcomas: a study of the French sarcoma group
    A T Falk
    Centre Antoine Lacassagne, Nice, France
    Clin Oncol (R Coll Radiol) 27:48-55. 2015
    ..The purpose of this study was to assess the efficacy of local ablative treatment on the survival of patients with oligometastases (one to five lesions, any metastatic site, any grade/histology) from sarcomas...
  61. doi request reprint Bone marrow metastases in a patient with primary mediastinal non-seminomatous germ cell tumor - an unusual pattern of relapse
    Delphine Garbay
    Department of Medical Oncology, Institut Bergonie, Bordeaux, France
    Onkologie 35:40-2. 2012
    ..Bone marrow is a very unusual site of metastasis for germ cell tumors...
  62. ncbi request reprint Linea alba tumoral (sarcomatous) hernia
    P Y Marcy
    Radiology Department, Centre Antoine Lacassagne, Nice, France
    JBR-BTR 89:103. 2006
  63. ncbi request reprint Home infusions of biphosphonate in cancer patients: a prospective study
    A Italiano
    Centre Regional de Lutte Contre le Cancer Antoine Lacassagne Canceropôle PACA, Nice, France
    J Chemother 18:217-20. 2006
    ....
  64. doi request reprint [Multifocal Langerhans cell histiocytosis of bone: indications for radiotherapy]
    G L Gaundong Mbéthé
    Service de Radiotherapie, Centre Regional de Lutte Contre le Cancer, Institut Bergonie, 229, cours de l Argonne, 33076 Bordeaux Cedex, France
    Cancer Radiother 14:759-62. 2010
    ..The decision of radiotherapy must be weighed against the risk of the disease. Caution should be the rule in this non-malignant tumour pathology...
  65. doi request reprint HMGA2 is the partner of MDM2 in well-differentiated and dedifferentiated liposarcomas whereas CDK4 belongs to a distinct inconsistent amplicon
    Antoine Italiano
    Laboratory of Solid Tumors Genetics, Nice University Hospital, and CNRS, UMR 6543, Faculty of Medicine, Nice, France
    Int J Cancer 122:2233-41. 2008
    ..We also found a frequent amplification and overexpression of YEATS4, an oncogene that inactivates P53, suggesting that YEATS4 might play an important role together with MDM2 in WDLPS/DDLPS oncogenesis...
  66. ncbi request reprint Molecular cytogenetic characterization of a metastatic lung sarcomatoid carcinoma: 9p23 neocentromere and 9p23-p24 amplification including JAK2 and JMJD2C
    Antoine Italiano
    Laboratory of Solid Tumors Genetics, Centre Hospitalier Universitaire de Nice and CNRS UMR 6543, Faculte de Medecine, 28 Avenue de Valombrose, 06107 Nice, France
    Cancer Genet Cytogenet 167:122-30. 2006
    ..The frequency of neocentromere formation in solid tumors may indeed be underestimated and may have a significant implication in chromosomal instability in tumor cells...
  67. ncbi request reprint Cetuximab shows activity in colorectal cancer patients with tumors for which FISH analysis does not detect an increase in EGFR gene copy number
    Antoine Italiano
    Department of Medical Oncology, Centre Antoine Lacassagne, Canceropôle PACA, Nice, France
    Ann Surg Oncol 15:649-54. 2008
    ..The aim or our study was to relate the EGFR gene copy number to therapeutic results in patients with metastatic colorectal cancer (CRC) treated with a cetuximab-containing regimen...
  68. pmc BRCA1 haplotype and clinical benefit of trabectedin in soft-tissue sarcoma patients
    A Laroche-Clary
    1 INSERM U916 and University of Bordeaux, Bordeaux, France 2 Institut Bergonié, Bordeaux, France
    Br J Cancer 112:688-92. 2015
    ..This study aimed to determine whether the BRCA1 haplotype was associated with trabectedin efficacy in soft-tissue sarcoma (STS) patients...
  69. doi request reprint Quality of reporting of phase II trials: a focus on highly ranked oncology journals
    T Grellety
    Department of Medical Oncology, Institut Bergonie, Regional Comprehensive Cancer Centre, Bordeaux
    Ann Oncol 25:536-41. 2014
    ..This study assesses the quality of their reporting in highly ranked oncology journals, investigates predictive factors of quality, and proposes reporting guidelines...
  70. ncbi request reprint Dedifferentiated liposarcoma of the pleura mimicking a malignant solitary fibrous tumor and associated with dedifferentiated liposarcoma of the mediastinum: usefulness of cytogenetic and molecular genetic analyses
    Maxime Benchetritt
    Laboratory of Clinical and Experimental Pathology, 30 Avenue de la Voie Romaine, Louis Pasteur Hospital, 06002, Nice, France
    Cancer Genet Cytogenet 179:150-5. 2007
    ..Array comparative genomic hybridization showed amplifications of chromosome arms 6q, 12q, and 15q, shared by both tumors and strongly pointing to a common origin...
  71. doi request reprint Monosomy 7 and absence of 12q amplification in two cases of spindle cell liposarcomas
    Antoine Italiano
    Laboratory of Solid Tumors Genetics, Faculty of Medicine, Nice University Hospital, 28 Avenue de Valombrose, 06107 Nice, France
    Cancer Genet Cytogenet 184:99-104. 2008
    ..On the basis of cytogenetic and molecular findings, some SCL may constitute an independent entity rather than being regarded as variants of WDLPS...
  72. doi request reprint Variability of origin for the neocentromeric sequences in analphoid supernumerary marker chromosomes of well-differentiated liposarcomas
    Antoine Italiano
    Laboratory of Solid Tumors Genetics, Nice University Hospital and CNRS UMR 6543, Faculty of Medicine, 28 Avenue de Valombrose, 06107 Nice, France
    Cancer Lett 273:323-30. 2009
    ..These sequences might be activated for centromeric function by epigenetic mechanisms...
  73. ncbi request reprint Tumour response to paclitaxel in an adult with relapsed nephroblastoma
    Antoine Italiano
    Antoine Lacassagne Centre, Department of Medical Oncology, Nice, France
    Lancet Oncol 6:252-3. 2005
  74. ncbi request reprint Gains and complex rearrangements of the 12q13-15 chromosomal region in ordinary lipomas: the "missing link" between lipomas and liposarcomas?
    Antoine Italiano
    Faculty of Medicine, Laboratory of Solid Tumors Genetics, Nice University Hospital and CNRS UMR 6543, Nice, France
    Int J Cancer 121:308-15. 2007
    ..Some of these intermediary forms may correspond to a genomic premalignant condition while some may have no malignant potential...
  75. doi request reprint [Gastrointestinal stromal tumors: molecular aspects and therapeutic implications]
    Antoine Italiano
    Centre Antoine Lacassagne, Departement d Oncologie Medicale, Nice, France
    Bull Cancer 95:107-16. 2008
    ....