Nicholas D Huntington

Summary

Affiliation: Institut Pasteur
Country: France

Publications

  1. pmc Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim sustains B lymphopoiesis in the absence of IL-7
    Nicholas D Huntington
    Cytokines and Lymphoid Development Unit, Institut Pasteur, 25 rue du Docteur Roux, Paris, France
    Int Immunol 21:715-25. 2009
  2. pmc IL-15 trans-presentation promotes human NK cell development and differentiation in vivo
    Nicholas D Huntington
    Immunology Department, 2 Institut National de la Santé et de la Recherche Médicale U668, 3 INSERM U883, Unite de Regulation Immunitaire et Vaccinologie, Institut Pasteur, Paris 75724, France
    J Exp Med 206:25-34. 2009
  3. doi Autonomous and extrinsic regulation of thymopoiesis in human immune system (HIS) mice
    Nicholas D Huntington
    Innate Immunity Unit, Immunology Department, Institut Pasteur, Paris, France
    Eur J Immunol 41:2883-93. 2011
  4. ncbi 10th Meeting of the Society for Natural Immunity, Cambridge, UK, 11-14 April 2007
    Nicholas D Huntington
    Cytokines and Lymphoid Development Unit, Institut Pasteur, Inserm U668, Paris, France
    Immunol Cell Biol 85:508-10. 2007
  5. pmc IL-15 transpresentation promotes both human T-cell reconstitution and T-cell-dependent antibody responses in vivo
    Nicholas D Huntington
    Innate Immunity Unit, Immunology Department, Institut Pasteur, 75724 Paris, France
    Proc Natl Acad Sci U S A 108:6217-22. 2011
  6. pmc Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1
    Nicholas D Huntington
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Nat Immunol 8:856-63. 2007
  7. ncbi NK cell maturation and peripheral homeostasis is associated with KLRG1 up-regulation
    Nicholas D Huntington
    Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    J Immunol 178:4764-70. 2007
  8. doi Cutting Edge: a thymocyte-thymic epithelial cell cross-talk dynamically regulates intrathymic IL-7 expression in vivo
    Nuno L Alves
    Cytokines and Lymphoid Development Unit, Institut Pasteur, Paris, France
    J Immunol 184:5949-53. 2010
  9. pmc A requirement for CD45 distinguishes Ly49D-mediated cytokine and chemokine production from killing in primary natural killer cells
    Nicholas D Huntington
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    J Exp Med 201:1421-33. 2005
  10. doi CpG inhibits pro-B cell expansion through a cathepsin B-dependent mechanism
    Ana Inés Lalanne
    Unité du Développement des Lymphocytes, Departement d Immunologie, Institut Pasteur, Paris, France
    J Immunol 184:5678-85. 2010

Collaborators

Detail Information

Publications34

  1. pmc Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim sustains B lymphopoiesis in the absence of IL-7
    Nicholas D Huntington
    Cytokines and Lymphoid Development Unit, Institut Pasteur, 25 rue du Docteur Roux, Paris, France
    Int Immunol 21:715-25. 2009
    ..Our data highlight the role of Bim as a key regulator of cell survival during B lymphocyte development in vivo...
  2. pmc IL-15 trans-presentation promotes human NK cell development and differentiation in vivo
    Nicholas D Huntington
    Immunology Department, 2 Institut National de la Santé et de la Recherche Médicale U668, 3 INSERM U883, Unite de Regulation Immunitaire et Vaccinologie, Institut Pasteur, Paris 75724, France
    J Exp Med 206:25-34. 2009
    ....
  3. doi Autonomous and extrinsic regulation of thymopoiesis in human immune system (HIS) mice
    Nicholas D Huntington
    Innate Immunity Unit, Immunology Department, Institut Pasteur, Paris, France
    Eur J Immunol 41:2883-93. 2011
    ..As IL-15 immunotherapy promotes early thymopoiesis, this novel approach could be used to reduce the period of T-cell immunodeficiency in the post-transplant clinical setting...
  4. ncbi 10th Meeting of the Society for Natural Immunity, Cambridge, UK, 11-14 April 2007
    Nicholas D Huntington
    Cytokines and Lymphoid Development Unit, Institut Pasteur, Inserm U668, Paris, France
    Immunol Cell Biol 85:508-10. 2007
    ....
  5. pmc IL-15 transpresentation promotes both human T-cell reconstitution and T-cell-dependent antibody responses in vivo
    Nicholas D Huntington
    Innate Immunity Unit, Immunology Department, Institut Pasteur, 75724 Paris, France
    Proc Natl Acad Sci U S A 108:6217-22. 2011
    ....
  6. pmc Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1
    Nicholas D Huntington
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Nat Immunol 8:856-63. 2007
    ..Thus, IL-15 regulates the survival of NK cells at multiple steps, with Bim and Noxa being key antagonists of Mcl-1, the critical survivor factor in this process...
  7. ncbi NK cell maturation and peripheral homeostasis is associated with KLRG1 up-regulation
    Nicholas D Huntington
    Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    J Immunol 178:4764-70. 2007
    ..These data indicate that NK cells acquire KLRG1 on their surface during development, and this expression correlates with functional distinctions from other peripheral NK cells in vivo...
  8. doi Cutting Edge: a thymocyte-thymic epithelial cell cross-talk dynamically regulates intrathymic IL-7 expression in vivo
    Nuno L Alves
    Cytokines and Lymphoid Development Unit, Institut Pasteur, Paris, France
    J Immunol 184:5949-53. 2010
    ..Although thymocyte-derived signals are often considered stimulatory for TEC maturation, our findings identify a negative feedback mechanism in which signals derived from TCRbeta-selected thymocytes modulate TEC-dependent IL-7 expression...
  9. pmc A requirement for CD45 distinguishes Ly49D-mediated cytokine and chemokine production from killing in primary natural killer cells
    Nicholas D Huntington
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    J Exp Med 201:1421-33. 2005
    ..Thus we identify CD45 as a pivotal enzyme in eliciting a precise subset of NK cell responses...
  10. doi CpG inhibits pro-B cell expansion through a cathepsin B-dependent mechanism
    Ana Inés Lalanne
    Unité du Développement des Lymphocytes, Departement d Immunologie, Institut Pasteur, Paris, France
    J Immunol 184:5678-85. 2010
    ..Thus, TLR9 signals can regulate B lymphopoiesis in vivo...
  11. doi A role for Blimp1 in the transcriptional network controlling natural killer cell maturation
    Axel Kallies
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Blood 117:1869-79. 2011
    ..We have identified NK cells as the first hematopoietic cell type in which the IRF4-Blimp1-Bcl6 regulatory axis is not in operation, highlighting the distinct nature of the NK-cell gene-regulatory network...
  12. ncbi CD45 links the B cell receptor with cell survival and is required for the persistence of germinal centers
    Nicholas D Huntington
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Nat Immunol 7:190-8. 2006
    ..These results show mechanistic differences in B cell survival during germinal center initiation and propagation; CD40 signaling is sufficient for the former, whereas the latter requires signaling from the BCR...
  13. ncbi ER stress triggers apoptosis by activating BH3-only protein Bim
    Hamsa Puthalakath
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Cell 129:1337-49. 2007
    ..These results define the molecular mechanisms of ER stress-induced apoptosis and identify targets for therapeutic intervention in ER stress-related diseases...
  14. doi Phosphatidylinositol-3 kinase activity in B cells is negatively regulated by Lyn tyrosine kinase
    Yuekang Xu
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
    Immunol Cell Biol 90:903-11. 2012
    ..Regulating SFK activity may thus be a central mechanism by which Lyn regulates PI3K activity in B cells. This study defines the molecular connection between the BCR and PI3K and reveals this to be a point of Lyn-mediated regulation...
  15. pmc Characterization of the thymic IL-7 niche in vivo
    Nuno L Alves
    Cytokines and Lymphoid Development Unit, Lymphocyte Development Unit, Plate Forme Technologique Centre d Ingénierie Génétique Murine, and Laboratory of Lymphoid Tissue Development, Institut Pasteur, Paris, France
    Proc Natl Acad Sci U S A 106:1512-7. 2009
    ..This IL-7 reporter mouse provides a valuable tool to further dissect the mechanisms that govern thymic IL-7 expression in vivo...
  16. pmc Peripheral natural killer cell maturation depends on the transcription factor Aiolos
    Melissa L Holmes
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Vic, Australia
    EMBO J 33:2721-34. 2014
    ..These data place Aiolos in the emerging gene regulatory network controlling NK-cell maturation and function...
  17. doi Differential requirement for Nfil3 during NK cell development
    Cyril Seillet
    Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
    J Immunol 192:2667-76. 2014
    ..Collectively, these findings demonstrate that Nfil3 drives the formation of mature NK cells by inducing Eomes expression and reveal the differential requirements of NK cell subsets for Nfil3. ..
  18. ncbi Different kinetics of blimp-1 induction in B cell subsets revealed by reporter gene
    Kirsten A Fairfax
    Immunology Division, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria, Australia
    J Immunol 178:4104-11. 2007
    ..Transferred naive Blimp-1(GFP/+) B1 and B2 cells both gave rise to ASCs in the bone marrow, suggesting no intrinsic barriers to B1 cell entry into the long-lived ASC compartment...
  19. doi The Helix-Loop-Helix Protein ID2 Governs NK Cell Fate by Tuning Their Sensitivity to Interleukin-15
    Rebecca B Delconte
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia Department of Medical Biology, University of Melbourne, VIC 3010 Australia
    Immunity 44:103-15. 2016
    ....
  20. pmc A novel mouse model for stable engraftment of a human immune system and human hepatocytes
    Helene Strick-Marchand
    Innate Immunity Unit, Department of Immunology, Institut Pasteur, Paris, France Institut National de la Santé et de la Recherche Médicale INSERM U668, Paris, France
    PLoS ONE 10:e0119820. 2015
    ..This novel HIS-HUHEP model provides a platform to investigate human immune responses against hepatotropic pathogens and to test novel drug strategies or vaccine candidates. ..
  21. ncbi Developmental pathways that generate natural-killer-cell diversity in mice and humans
    Nicholas D Huntington
    Cytokines and Lymphoid Development Unit and Inserm Unit 668, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris, Cedex 15, France
    Nat Rev Immunol 7:703-14. 2007
    ....
  22. ncbi Lyn tyrosine kinase: accentuating the positive and the negative
    Yuekang Xu
    The Walter and Eliza Hall Institute of Medical Research, Melbourne 3050, Australia
    Immunity 22:9-18. 2005
    ..Here, we review the outcomes of altered Lyn activity within the framework of B cell development and differentiation and the circumstances that appear to dictate the outcome...
  23. doi Thymic epithelial cells: the multi-tasking framework of the T cell "cradle"
    Nuno L Alves
    Cytokines and Lymphoid Development Unit, Institut Pasteur, Paris, France
    Trends Immunol 30:468-74. 2009
    ..Thus, the division of labour among TECs may be coordinated directly by local cellular feedback mechanisms operating within distinct thymic niches...
  24. doi CD19 differentially regulates BCR signalling through the recruitment of PI3K
    Yuekang Xu
    The Walter and Eliza Hall Institute of Medical Research, Department of Medical Biology, The University of Melbourne, Australia
    Autoimmunity 47:430-7. 2014
    ..Thus, we propose that CD19 can modulate BCR signalling in both a positive and negative manner depending on the receptor/ligand interaction in vivo...
  25. pmc Nfil3 is required for the development of all innate lymphoid cell subsets
    Cyril Seillet
    Division of Molecular Immunology, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3052, Australia Department of Medical Biology, University of Melbourne, Melbourne, Victoria 3010, Australia
    J Exp Med 211:1733-40. 2014
    ..Thus, we demonstrate that Nfil3 is a key regulator of the development of ILC subsets essential for immune protection in the lung and gut. ..
  26. ncbi Functional subsets of mouse natural killer cells
    Yoshihiro Hayakawa
    Cancer Immunology Program, Sir Donald and Lady Trescowick Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    Immunol Rev 214:47-55. 2006
    ..Extending our knowledge of mature NK cell heterogeneity between the species will be critical to further our understanding of the pathological role of NK cells in immune responses...
  27. doi Deciphering the Innate Lymphoid Cell Transcriptional Program
    Cyril Seillet
    The Walter and Eliza Hall Institute of Medical Research and Department of Medical Biology, University of Melbourne, Parkville, VIC 3052, Australia Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia Electronic address
    Cell Rep 17:436-447. 2016
    ....
  28. doi CIS is a potent checkpoint in NK cell-mediated tumor immunity
    Rebecca B Delconte
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Nat Immunol 17:816-24. 2016
    ..Our data uncover a potent intracellular checkpoint in NK cell-mediated tumor immunity and suggest possibilities for new cancer immunotherapies directed at blocking CIS function. ..
  29. doi Innate Allorecognition Results in Rapid Accumulation of Monocyte-Derived Dendritic Cells
    Kevin V Chow
    Immunology Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia Department of Nephrology, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    J Immunol 197:2000-8. 2016
    ..A major component of this moDC accumulation appears to be recruitment. Our findings provide new insights into how the innate and adaptive immune system may interact during allogeneic encounters and thus transplant rejection. ..
  30. pmc Complementarity and redundancy of IL-22-producing innate lymphoid cells
    Lucille C Rankin
    The Walter and Eliza Hall Institute of Medical Research, and Department of Medical Biology, University of Melbourne, Parkville, Australia
    Nat Immunol 17:179-86. 2016
    ..However, NCR(+) ILC3 cells were essential for cecal homeostasis. Our data show that interplay between intestinal ILC3 cells and adaptive lymphocytes results in robust complementary failsafe mechanisms that ensure gut homeostasis. ..
  31. doi Development, Homeostasis, and Heterogeneity of NK Cells and ILC1
    Cyril Seillet
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Vic, 3052, Australia
    Curr Top Microbiol Immunol 395:37-61. 2016
    ..Here, we review recent advances in our understanding of peripheral cNK cell and ILC1 heterogeneity in terms of their development, phenotype, homeostasis, and effector functions. ..
  32. pmc Rapid Inflammation in Mice Lacking Both SOCS1 and SOCS3 in Hematopoietic Cells
    Takashi Ushiki
    Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    PLoS ONE 11:e0162111. 2016
    ..We propose a model in which SOCS1 and SOCS3 operate independently to control specific cytokine responses and together modulate the proliferation and activation of lymphoid and myeloid cells to prevent rapid inflammatory disease. ..
  33. ncbi CD45: direct and indirect government of immune regulation
    Nicholas D Huntington
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3050, Australia
    Immunol Lett 94:167-74. 2004
    ....
  34. ncbi GVHD prevents NK-cell-dependent leukemia and virus-specific innate immunity
    Mark D Bunting
    Bone Marrow Transplantation Laboratory, Immunology Department, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia
    Blood . 2016
    ..Thus, during GVHD, donor T-cells compete with NK-cells for IL-15 thereby inducing profound defects in NK-cell reconstitution that compromise both leukemia and pathogen-specific immunity...