David Dombrowicz

Summary

Affiliation: Institut Pasteur de Lille
Country: France

Publications

  1. ncbi request reprint Exploiting the innate immune system to control allergic asthma
    David Dombrowicz
    INSERM U547, Institut Pasteur de Lille, France
    Eur J Immunol 35:2786-8. 2005
  2. pmc Peroxisome proliferator-activated receptors alpha and gamma down-regulate allergic inflammation and eosinophil activation
    Gaetane Woerly
    Institut National de la Sante et de la Recherche Medicale INSERM, U547 IFR17, Institut Pasteur de Lille, France
    J Exp Med 198:411-21. 2003
  3. pmc GW501516-activated PPARβ/δ promotes liver fibrosis via p38-JNK MAPK-induced hepatic stellate cell proliferation
    Radina Kostadinova
    Center for Integrative Genomics, National Research Center Frontiers in Genetics, University of Lausanne, Genopode Building, 1015, Lausanne, Switzerland
    Cell Biosci 2:34. 2012
  4. doi request reprint Fc(epsilon)RI and FcgammaRIII/CD16 differentially regulate atopic dermatitis in mice
    Georges Abboud
    Institut National de la Santé et de la Recherche Médicale Unité 547, Institut Pasteur de Lille, and Université Lille 2, Lille, France
    J Immunol 182:6517-26. 2009
  5. ncbi request reprint Peroxisome proliferator-activated receptor gamma is expressed in airways and inhibits features of airway remodeling in a mouse asthma model
    Kohei Honda
    Inserm U547 IFR17, Institut Pasteur de Lille, 1 rue du Professeur Calmette, BP 245, 59019 Lille Cedex, France
    J Allergy Clin Immunol 113:882-8. 2004
  6. doi request reprint Eosinophil-derived IFN-gamma induces airway hyperresponsiveness and lung inflammation in the absence of lymphocytes
    Akira Kanda
    INSERM U547, Lille, France Institut Pasteur de Lille, Lille, France
    J Allergy Clin Immunol 124:573-82, 582.e1-9. 2009
  7. doi request reprint TLR2-dependent eosinophil interactions with mycobacteria: role of alpha-defensins
    Virginie Driss
    INSERM U547, Universite Lille 2, IFR142, Institut Pasteur de Lille, Lille, France
    Blood 113:3235-44. 2009
  8. ncbi request reprint Heterogeneity of expression of IgA receptors by human, mouse, and rat eosinophils
    Véronique Decot
    Institut National de la Santé et de la Recherche Médicale Unité 547 Institut Fédératif de Recherche 17, Institut Pasteur de Lille, France
    J Immunol 174:628-35. 2005
  9. doi request reprint Peroxisome proliferator-activated receptor alpha regulates skin inflammation and humoral response in atopic dermatitis
    Delphine Staumont-Sallé
    INSERM U547, Lille, France
    J Allergy Clin Immunol 121:962-8.e6. 2008
  10. ncbi request reprint Activation of the D prostanoid receptor 1 regulates immune and skin allergic responses
    Veronique Angeli
    Unite 547, Institut National de la Sante et de la Recherche Medicale, Institut Fédératif de Recherche 17, Institut Pasteur de Lille, Lille, France
    J Immunol 172:3822-9. 2004

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Exploiting the innate immune system to control allergic asthma
    David Dombrowicz
    INSERM U547, Institut Pasteur de Lille, France
    Eur J Immunol 35:2786-8. 2005
    ..Increased IFN-gamma synthesis, rather than regulatory IL-10, accounts for this paradoxical effect...
  2. pmc Peroxisome proliferator-activated receptors alpha and gamma down-regulate allergic inflammation and eosinophil activation
    Gaetane Woerly
    Institut National de la Sante et de la Recherche Medicale INSERM, U547 IFR17, Institut Pasteur de Lille, France
    J Exp Med 198:411-21. 2003
    ..Thus, PPAR-alpha and -gamma (co)agonists might be of therapeutic interest for the regulation of allergic or inflammatory reactions by targeting both regulatory and effector cells involved in the immune response...
  3. pmc GW501516-activated PPARβ/δ promotes liver fibrosis via p38-JNK MAPK-induced hepatic stellate cell proliferation
    Radina Kostadinova
    Center for Integrative Genomics, National Research Center Frontiers in Genetics, University of Lausanne, Genopode Building, 1015, Lausanne, Switzerland
    Cell Biosci 2:34. 2012
    ..abstract:..
  4. doi request reprint Fc(epsilon)RI and FcgammaRIII/CD16 differentially regulate atopic dermatitis in mice
    Georges Abboud
    Institut National de la Santé et de la Recherche Médicale Unité 547, Institut Pasteur de Lille, and Université Lille 2, Lille, France
    J Immunol 182:6517-26. 2009
    ..Targeting both IgE/Fc(epsilon)RI and IgG/CD16 interactions might represent an efficient therapeutic strategy for allergic diseases...
  5. ncbi request reprint Peroxisome proliferator-activated receptor gamma is expressed in airways and inhibits features of airway remodeling in a mouse asthma model
    Kohei Honda
    Inserm U547 IFR17, Institut Pasteur de Lille, 1 rue du Professeur Calmette, BP 245, 59019 Lille Cedex, France
    J Allergy Clin Immunol 113:882-8. 2004
    ..Recently, PPAR-gamma has been shown to play an important role in the control of inflammatory responses, including within the lung, acting on both immune and nonimmune cells...
  6. doi request reprint Eosinophil-derived IFN-gamma induces airway hyperresponsiveness and lung inflammation in the absence of lymphocytes
    Akira Kanda
    INSERM U547, Lille, France Institut Pasteur de Lille, Lille, France
    J Allergy Clin Immunol 124:573-82, 582.e1-9. 2009
    ..Likewise, lung fibrosis is abrogated in 2 strains of eosinophil-deficient mice, whereas AHR is inhibited in only one of them. Finally, eosinophils have been shown to attract T(H)2 lymphocytes at the inflammatory site...
  7. doi request reprint TLR2-dependent eosinophil interactions with mycobacteria: role of alpha-defensins
    Virginie Driss
    INSERM U547, Universite Lille 2, IFR142, Institut Pasteur de Lille, Lille, France
    Blood 113:3235-44. 2009
    ....
  8. ncbi request reprint Heterogeneity of expression of IgA receptors by human, mouse, and rat eosinophils
    Véronique Decot
    Institut National de la Santé et de la Recherche Médicale Unité 547 Institut Fédératif de Recherche 17, Institut Pasteur de Lille, France
    J Immunol 174:628-35. 2005
    ..Indeed, mouse eosinophils expressed only TfR, whereas rat eosinophils expressed ASGP-R and CD89 mRNA. These results provide a molecular basis for the differences observed between human, rat, and mouse regarding IgA-mediated immunity...
  9. doi request reprint Peroxisome proliferator-activated receptor alpha regulates skin inflammation and humoral response in atopic dermatitis
    Delphine Staumont-Sallé
    INSERM U547, Lille, France
    J Allergy Clin Immunol 121:962-8.e6. 2008
    ..In skin both PPAR-alpha and PPAR-beta/delta regulate keratinocyte proliferation/differentiation and contribute to wound healing. The 3 PPAR isoforms are expressed by several cell types recruited into the dermis during inflammation...
  10. ncbi request reprint Activation of the D prostanoid receptor 1 regulates immune and skin allergic responses
    Veronique Angeli
    Unite 547, Institut National de la Sante et de la Recherche Medicale, Institut Fédératif de Recherche 17, Institut Pasteur de Lille, Lille, France
    J Immunol 172:3822-9. 2004
    ..We propose that DP1 activation by specific agonists may represent a strategy to control cutaneous inflammatory Th2-associated diseases...
  11. pmc EMBO workshop on immunology and metabolism
    Bart Staels
    INSERM U1011, University of Lille Nord de France and Institut Pasteur de Lille, Lille, France
    EMBO Rep 12:386-8. 2011
    ..The meeting brought together approximately 100 scientists to discuss interactions between metabolism and inflammation...
  12. pmc A functional gammadeltaTCR/CD3 complex distinct from gammadeltaT cells is expressed by human eosinophils
    Fanny Legrand
    INSERM U547, Lille, France
    PLoS ONE 4:e5926. 2009
    ..Eosinophils are effector cells during parasitic infections and allergic responses. However, their contribution to innate immunity has been only recently unravelled...
  13. ncbi request reprint Acute antiinflammatory properties of statins involve peroxisome proliferator-activated receptor-alpha via inhibition of the protein kinase C signaling pathway
    Rejane Paumelle
    Institut Pasteur de Lille, Departement d Atherosclerose, INSERM, U545, Lille, France
    Circ Res 98:361-9. 2006
    ..These data indicate that the acute antiinflammatory effect of simvastatin occurs via PPARalpha by a mechanism involving inhibition of PKCalpha inactivation of PPARalpha transrepression activity...
  14. doi request reprint Pathogen induced regulatory cell populations preventing allergy through the Th1/Th2 paradigm point of view
    Thomas Roumier
    INSERM U547, Univ Lille 2, Institut Pasteur de Lille, 1, rue du Professeur Calmette, Lille, France
    Immunol Res 40:1-17. 2008
    ..We will emphasize the key role of various regulatory cell populations associated to the immune responses toward pathogen...
  15. ncbi request reprint [Eosinophils, parasites and allergy: from the biological to the clinical]
    Monique Capron
    U547 INSERM, Institut Pasteur de Lille, 1 rue du Professeur Calmette, BP 245, Lille, France
    J Soc Biol 196:23-8. 2002
    ..The results of clinical trials aiming at increasing or decreasing respectively their effects are discussed...
  16. ncbi request reprint Helminth infections and allergic diseases: from the Th2 paradigm to regulatory networks
    Andre Capron
    INSERM U547, IFR 17, Institut Pasteur de Lille, France
    Clin Rev Allergy Immunol 26:25-34. 2004
    ..This mechanism could provide a new vision of the so-called "hygiene hypothesis"...
  17. ncbi request reprint Eosinophils and urticaria
    Delphine Staumont-Sallé
    Department of Dermatology, CHRU, Hospital Claude Huriez, and Institut National de la Sante et de la Recherche Medicale, Unite 547, Institut Fédératif de Recherche 17, Institut Pasteur de Lille, Lille, France
    Clin Rev Allergy Immunol 30:13-8. 2006
    ..Recent advances in the knowledge of eosinophils will certainly help toward developing new strategies for the management of antihistamines resistant to urticaria...
  18. ncbi request reprint Activation of the prostaglandin D2 receptor DP2/CRTH2 increases allergic inflammation in mouse
    Isabelle Spik
    Unite 547, Institut National de la Sante et de la Recherche Medicale, Institut Fédératif de Recherche 17, Institut Pasteur de Lille, Lille, France
    J Immunol 174:3703-8. 2005
    ..Taken together, these results support the hypothesis that DP2 might play a critical role in allergic diseases and underline the interest of DP2 antagonists in human therapy...
  19. doi request reprint Breast milk-mediated transfer of an antigen induces tolerance and protection from allergic asthma
    Valerie Verhasselt
    Institut National de la Sante et de la Recherche Medicale, U924, Universite de Nice Sophia Antipolis, Valbonne, France
    Nat Med 14:170-5. 2008
    ..This study may pave the way for the design of new strategies to prevent the development of allergic diseases...
  20. ncbi request reprint Receptors and signaling mechanisms required for prostaglandin E2-mediated regulation of mast cell degranulation and IL-6 production
    MyTrang Nguyen
    Department of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    J Immunol 169:4586-93. 2002
    ..Accordingly, these studies identify PGE(2)/EP(3) as a proinflammatory signaling pathway that promotes mast cell activation...