Pierre Bruhns

Summary

Affiliation: Institut Pasteur
Country: France

Publications

  1. doi request reprint Inhibitory IgG Receptor-Expressing Cells: The Must-Have Accessory for Anti-CD40 Immunomodulatory mAb Efficacy
    Pierre Bruhns
    Unit of Antibodies in Therapy and Pathology, Department of Immunology, Institut Pasteur, Paris 75015, France INSERM, U1222, Paris 75015, France Electronic address
    Cancer Cell 29:771-3. 2016
  2. doi request reprint Properties of mouse and human IgG receptors and their contribution to disease models
    Pierre Bruhns
    Institut Pasteur, Unité d Allergologie Moléculaire et Cellulaire, Departement d Immunologie, Paris, France
    Blood 119:5640-9. 2012
  3. doi request reprint Specificity and affinity of human Fcgamma receptors and their polymorphic variants for human IgG subclasses
    Pierre Bruhns
    Institut Pasteur, Departement d Immunologie, Unité d Allergologie Moléculaire et Cellulaire, Paris, France
    Blood 113:3716-25. 2009
  4. pmc Human FcγRIIA induces anaphylactic and allergic reactions
    Friederike Jönsson
    Institut Pasteur, Departement d Immunologie, Unité d Allergologie Moléculaire et Cellulaire, Paris, France
    Blood 119:2533-44. 2012
  5. doi request reprint Cutting edge: FcγRIII (CD16) and FcγRI (CD64) are responsible for anti-glycoprotein 75 monoclonal antibody TA99 therapy for experimental metastatic B16 melanoma
    Marcello Albanesi
    Institut Pasteur, corrected Département d Immunologie, Unité d Allergologie Moléculaire et Cellulaire, corrected 75015 Paris, France
    J Immunol 189:5513-7. 2012
  6. doi request reprint The high-affinity human IgG receptor FcγRI (CD64) promotes IgG-mediated inflammation, anaphylaxis, and antitumor immunotherapy
    David A Mancardi
    Institut Pasteur, Departement d Immunologie, Laboratoire Anticorps en Thérapie et Pathologie, Paris, France
    Blood 121:1563-73. 2013
  7. doi request reprint Cutting Edge: The murine high-affinity IgG receptor FcγRIV is sufficient for autoantibody-induced arthritis
    David A Mancardi
    Departement d Immunologie, Institut Pasteur, Unité d Allergologie Moléculaire et Cellulaire, F 75015 Paris, France
    J Immunol 186:1899-903. 2011
  8. doi request reprint Mechanisms of anaphylaxis in human low-affinity IgG receptor locus knock-in mice
    Caitlin M Gillis
    Institut Pasteur, Department of Immunology, Unit of Antibodies in Therapy and Pathology, Paris, France INSERM, U1222, Paris, France Université Pierre et Marie Curie, Paris, France Electronic address
    J Allergy Clin Immunol . 2016
  9. pmc Mouse and human neutrophils induce anaphylaxis
    Friederike Jönsson
    Institut Pasteur, Unité d Allergologie Moléculaire et Cellulaire, Departement d Immunologie, Paris, France
    J Clin Invest 121:1484-96. 2011
  10. doi request reprint A strain of Lactobacillus casei inhibits the effector phase of immune inflammation
    Cecile Schiffer
    Institut Pasteur, Departement d Immunologie, Unité d Allergologie Moléculaire et Cellulaire, 75015 Paris, France
    J Immunol 187:2646-55. 2011

Collaborators

  • Marc Daëron
  • Nico Van Rooijen
  • Patrick England
  • Lynn E Macdonald
  • Andrew J Murphy
  • Hajime Karasuyama
  • Stephen J Galli
  • Philippe Bousso
  • Jean Luc Teillaud
  • Clifford A Lowell
  • James P Di Santo
  • Wolf H Fridman
  • Laurence Zitvogel
  • Gerard Eberl
  • David A Mancardi
  • Friederike Jönsson
  • Bruno Iannascoli
  • Caitlin M Gillis
  • Marcello Albanesi
  • Héloïse Beutier
  • Bianca Balbino
  • Laurent L Reber
  • Riccardo Sibilano
  • Laure Guenin-Macé
  • Laurence Fiette
  • Caroline Montaudouin
  • Huot Khun
  • Takao Shimizu
  • Yoshihiro Kita
  • Cecile Schiffer
  • Matthias Lochner
  • Georges Bismuth
  • Isabelle Isnardi
  • Thomas Marichal
  • Susanna Celli
  • Naxin Tu
  • Priscila P Zenatti
  • Ophélie Godon
  • Nicolas Gaudenzio
  • Mindy Tsai
  • Mark S Cragg
  • Philipp Starkl
  • Fabien Le Chevalier
  • Cédric Tresse
  • Caroline Demangel
  • Ludivine Baron
  • Sarah Saint-Auret
  • Nicolas Blanchard
  • Jean François Bisson
  • Sophie Hidalgo-Lucas
  • Anne Caroline Chany
  • Emmanuelle Gaudin
  • William G Kerr
  • Tahia Fernandez
  • Susanne V Duncker
  • Antonio A Freitas
  • Michael Ehrenstein
  • Jean Hervé Colle
  • Marie Anson
  • Yi Hao
  • Xiaoqiang Kang
  • Lawrence B Schwartz
  • Wei Zhao
  • Jeanette H Leusen
  • Laura Presley
  • Fariel Dif
  • Lydie Cassard
  • Michel Huerre
  • Mustapha Si-Tahar
  • Ana Inés Lalanne
  • Shinichiro Sawa
  • Odile Malbec
  • Caspar Ohnmacht
  • Sylviane Hoos

Detail Information

Publications20

  1. doi request reprint Inhibitory IgG Receptor-Expressing Cells: The Must-Have Accessory for Anti-CD40 Immunomodulatory mAb Efficacy
    Pierre Bruhns
    Unit of Antibodies in Therapy and Pathology, Department of Immunology, Institut Pasteur, Paris 75015, France INSERM, U1222, Paris 75015, France Electronic address
    Cancer Cell 29:771-3. 2016
    ..This study also highlights the fine balance between increased treatment efficacy and secondary side effects. ..
  2. doi request reprint Properties of mouse and human IgG receptors and their contribution to disease models
    Pierre Bruhns
    Institut Pasteur, Unité d Allergologie Moléculaire et Cellulaire, Departement d Immunologie, Paris, France
    Blood 119:5640-9. 2012
    ....
  3. doi request reprint Specificity and affinity of human Fcgamma receptors and their polymorphic variants for human IgG subclasses
    Pierre Bruhns
    Institut Pasteur, Departement d Immunologie, Unité d Allergologie Moléculaire et Cellulaire, Paris, France
    Blood 113:3716-25. 2009
    ..They therefore highlight the role of specific hFcgammaRs in the therapeutic and pathogenic effects of antibodies in disease...
  4. pmc Human FcγRIIA induces anaphylactic and allergic reactions
    Friederike Jönsson
    Institut Pasteur, Departement d Immunologie, Unité d Allergologie Moléculaire et Cellulaire, Paris, France
    Blood 119:2533-44. 2012
    ..Supporting these findings, human mast cells, monocytes and neutrophils produced anaphylactogenic mediators after FcγRIIA engagement. IgG and FcγRIIA may therefore contribute to allergic and anaphylactic reactions in humans...
  5. doi request reprint Cutting edge: FcγRIII (CD16) and FcγRI (CD64) are responsible for anti-glycoprotein 75 monoclonal antibody TA99 therapy for experimental metastatic B16 melanoma
    Marcello Albanesi
    Institut Pasteur, corrected Département d Immunologie, Unité d Allergologie Moléculaire et Cellulaire, corrected 75015 Paris, France
    J Immunol 189:5513-7. 2012
    ..Our finding that mouse FcγRIII contributes to Ab-induced tumor reduction correlates with clinical data on its human functional equivalent human FcγRIIIA (CD16A)...
  6. doi request reprint The high-affinity human IgG receptor FcγRI (CD64) promotes IgG-mediated inflammation, anaphylaxis, and antitumor immunotherapy
    David A Mancardi
    Institut Pasteur, Departement d Immunologie, Laboratoire Anticorps en Thérapie et Pathologie, Paris, France
    Blood 121:1563-73. 2013
    ..Finally, hFcγRI was capable of mediating antibody-induced immunotherapy of metastatic melanoma. Our results unravel novel capabilities of human FcγRI that confirm the role of high-affinity IgG receptors in vivo...
  7. doi request reprint Cutting Edge: The murine high-affinity IgG receptor FcγRIV is sufficient for autoantibody-induced arthritis
    David A Mancardi
    Departement d Immunologie, Institut Pasteur, Unité d Allergologie Moléculaire et Cellulaire, F 75015 Paris, France
    J Immunol 186:1899-903. 2011
    ....
  8. doi request reprint Mechanisms of anaphylaxis in human low-affinity IgG receptor locus knock-in mice
    Caitlin M Gillis
    Institut Pasteur, Department of Immunology, Unit of Antibodies in Therapy and Pathology, Paris, France INSERM, U1222, Paris, France Université Pierre et Marie Curie, Paris, France Electronic address
    J Allergy Clin Immunol . 2016
    ....
  9. pmc Mouse and human neutrophils induce anaphylaxis
    Friederike Jönsson
    Institut Pasteur, Unité d Allergologie Moléculaire et Cellulaire, Departement d Immunologie, Paris, France
    J Clin Invest 121:1484-96. 2011
    ..These molecules and cells could be potential new targets for the development of anaphylaxis therapeutics if the same mechanism is responsible for anaphylaxis in humans...
  10. doi request reprint A strain of Lactobacillus casei inhibits the effector phase of immune inflammation
    Cecile Schiffer
    Institut Pasteur, Departement d Immunologie, Unité d Allergologie Moléculaire et Cellulaire, 75015 Paris, France
    J Immunol 187:2646-55. 2011
    ..They might, therefore, prevent inflammation in patients who have already synthesized specific IgE or autoantibodies...
  11. doi request reprint In vivo effector functions of high-affinity mouse IgG receptor FcγRI in disease and therapy models
    Caitlin M Gillis
    Institut Pasteur, Department of Immunology, Unit of Antibodies in Therapy and Pathology, Paris, France INSERM U1222, Paris, France Université Pierre et Marie Curie, Paris, France
    J Autoimmun . 2016
    ..Our results show that the in vivo roles of FcγRI are more restricted than initially reported using FcγRI-/- mice, but confirm effector capabilities for this high-affinity IgG receptor in vivo...
  12. pmc Neutrophils mediate antibody-induced antitumor effects in mice
    Marcello Albanesi
    Departement d Immunologie, Laboratoire Anticorps en Thérapie et Pathologie, Institut Pasteur, Paris, France
    Blood 122:3160-4. 2013
    ....
  13. pmc IgG subclasses determine pathways of anaphylaxis in mice
    Héloïse Beutier
    Department of Immunology, Unit of Antibodies in Therapy and Pathology, Institut Pasteur, Paris, France INSERM, U1222, Paris, France Université Pierre et Marie Curie, Paris, France
    J Allergy Clin Immunol . 2016
    ..Although these interactions are of strikingly different affinities, these 3 IgG subclasses have been shown to enable induction of systemic anaphylaxis...
  14. pmc Quorum sensing contributes to activated IgM-secreting B cell homeostasis
    Caroline Montaudouin
    Unité de Biologie des Populations Lymphocytaires, Department d Immunologie, Institut Pasteur, Paris 75015, France
    J Immunol 190:106-14. 2013
    ..We hypothesize that malfunction of this quorum-sensing mechanism may lead to uncontrolled B cell activation and autoimmunity...
  15. pmc FcgammaRIV is a mouse IgE receptor that resembles macrophage FcepsilonRI in humans and promotes IgE-induced lung inflammation
    David A Mancardi
    Departement d Immunologie, Unité d Allergologie Moléculaire et Cellulaire, Paris, France
    J Clin Invest 118:3738-50. 2008
    ..We therefore suggest that a similar cooperation may occur between mast cells and hFceRI-expressing lung cells in human allergic asthma...
  16. doi request reprint Shaping mycolactone for therapeutic use against inflammatory disorders
    Laure Guenin-Macé
    Institut Pasteur, Unité d Immunobiologie de l Infection, Paris 75015, France CNRS URA 1961, Paris 75015, France
    Sci Transl Med 7:289ra85. 2015
    ..In addition to establishing the anti-inflammatory potency of mycolactone in vivo, our study therefore highlights the translational potential of mycolactone core-derived structures as prospective immunosuppressants. ..
  17. pmc Pathways of immediate hypothermia and leukocyte infiltration in an adjuvant-free mouse model of anaphylaxis
    Bianca Balbino
    Institut Pasteur, Department of Immunology, Unit of Antibodies in Therapy and Pathology, Paris, France INSERM, U1222, Paris, France Université Pierre et Marie Curie, Paris, France
    J Allergy Clin Immunol . 2016
    ..In part, this might reflect the choice of adjuvant used during sensitization because various adjuvants might differentially influence the production of particular antibody isotypes...
  18. doi request reprint Mouse and human FcR effector functions
    Pierre Bruhns
    Unité des Anticorps en Thérapie et Pathologie, Departement d Immunologie, Institut Pasteur, Paris, France
    Immunol Rev 268:25-51. 2015
    ..A particular focus will be made on the (mis)concepts on the role of high-affinity IgG receptors in vivo and on results from antibody engineering to enhance or abrogate antibody effector functions mediated by FcRs...
  19. pmc Microbiota-induced tertiary lymphoid tissues aggravate inflammatory disease in the absence of RORgamma t and LTi cells
    Matthias Lochner
    Lymphoid Tissue Development Unit, Institut Pasteur, 75724 Paris, France
    J Exp Med 208:125-34. 2011
    ..However, this comes at a high cost for the host and can lead to a deregulated B cell response and aggravated inflammatory pathology...
  20. ncbi request reprint The SH2 domain-containing inositol 5-phosphatase SHIP1 is recruited to the intracytoplasmic domain of human FcgammaRIIB and is mandatory for negative regulation of B cell activation
    Isabelle Isnardi
    Unité d Allergologie Moléculaire et Cellulaire, Departement d Immunologie, Institut Pasteur, 75015 Paris, France
    Immunol Lett 104:156-65. 2006
    ..This segment, however, did not recruit the adapters Grb2/Grap which were demonstrated to stabilize the recruitment of SHIP1 to the ITIM in murine FcgammaRIIB...