Agnès Bernet

Summary

Affiliation: Institut Paoli-Calmettes
Country: France

Publications

  1. ncbi request reprint Netrin-1 and its receptors in tumour growth promotion
    Agnès Bernet
    Universite de Lyon, Apoptosis, Cancer and Development Laboratory, Equipe Labellisée La Ligue, CNRS UMR5238, Centre Leon Berard, 69008 Lyon, France
    Expert Opin Ther Targets 12:995-1007. 2008
  2. doi request reprint Interference with netrin-1 and tumor cell death in non-small cell lung cancer
    Céline Delloye-Bourgeois
    Apoptosis, Cancer and Development Laboratory Equipe labellisée La Ligue, CNRS UMR5238, Universite de Lyon, Centre Leon Berard, Lyon, France
    J Natl Cancer Inst 101:237-47. 2009
  3. doi request reprint Nucleolar localization of a netrin-1 isoform enhances tumor cell proliferation
    Céline Delloye-Bourgeois
    Apoptosis, Cancer and Development Laboratory Equipe labellisée La Ligue, LabEx DEVweCAN, Centre de Cancérologie de Lyon, INSERM U1052 CNRS UMR5286, Universite de Lyon, Centre Leon Berard, 69008 Lyon, France
    Sci Signal 5:ra57. 2012
  4. doi request reprint NF-kappaB regulates netrin-1 expression and affects the conditional tumor suppressive activity of the netrin-1 receptors
    Andrea Paradisi
    Apoptosis, Cancer and Development Laboratory Equipe labellisée La Ligue, CNRS UMR 5238, Universite de Lyon, Centre Leon Berard, Lyon, France
    Gastroenterology 135:1248-57. 2008
  5. doi request reprint DCC constrains tumour progression via its dependence receptor activity
    Marie Castets
    Apoptosis, Cancer and Development Laboratory Equipe labellisée La Ligue, LabEx DEVweCAN, Centre de Cancérologie de Lyon, INSERM U1052 CNRS UMR5286, Universite de Lyon, Centre Leon Berard, 69008 Lyon, France
    Nature 482:534-7. 2011
  6. pmc Netrin-1 acts as a survival factor for aggressive neuroblastoma
    Céline Delloye-Bourgeois
    Centre National de la Recherche Scientifique UMR, Universite de Lyon, France
    J Exp Med 206:833-47. 2009
  7. pmc Combining chemotherapeutic agents and netrin-1 interference potentiates cancer cell death
    Andrea Paradisi
    Apoptosis, Cancer and Development Laboratory Equipe labellisée La Ligue, LabEx DEVweCAN, Centre de Cancérologie de Lyon, INSERM U1052 CNRS UMR5286, Universite de Lyon, Centre Leon Berard, Lyon, France
    EMBO Mol Med 5:1821-34. 2013
  8. pmc Netrin-1 expression confers a selective advantage for tumor cell survival in metastatic breast cancer
    Julien Fitamant
    Apoptosis, Cancer, and Development Laboratory Equipe Labellisée La Ligue, Centre National de la Recherche Scientifique, Unite Mixte de Recherche 5238, Centre Leon Berard, Université de Lyon 69008 Lyon, France
    Proc Natl Acad Sci U S A 105:4850-5. 2008
  9. pmc Sonic Hedgehog promotes tumor cell survival by inhibiting CDON pro-apoptotic activity
    Céline Delloye-Bourgeois
    Apoptosis, Cancer and Development Laboratory Equipe labellisée La Ligue, LabEx DEVweCAN, Centre de Cancérologie de Lyon, Institut National de la Santé et de la Recherche Médicale INSERM U1052 Centre National de la Recherche Scientifique CNRS Unité Mixte de Recherche UMR5286, Universite de Lyon, Centre Leon Berard, 69008 Lyon, France
    PLoS Biol 11:e1001623. 2013
  10. doi request reprint Inhibition of endothelial cell apoptosis by netrin-1 during angiogenesis
    Marie Castets
    Apoptosis, Cancer, and Development Laboratory, Equipe Labellisée La Ligue, CNRS UMR5238, Universite de Lyon, Centre Leon Berard, Lyon, France
    Dev Cell 16:614-20. 2009

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Netrin-1 and its receptors in tumour growth promotion
    Agnès Bernet
    Universite de Lyon, Apoptosis, Cancer and Development Laboratory, Equipe Labellisée La Ligue, CNRS UMR5238, Centre Leon Berard, 69008 Lyon, France
    Expert Opin Ther Targets 12:995-1007. 2008
    ..Rather, such a receptor can mediate two signalling pathways, depending on whether it is bound to its ligand or not. In the absence of ligand, an active signalling pathway results in cell death through apoptosis...
  2. doi request reprint Interference with netrin-1 and tumor cell death in non-small cell lung cancer
    Céline Delloye-Bourgeois
    Apoptosis, Cancer and Development Laboratory Equipe labellisée La Ligue, CNRS UMR5238, Universite de Lyon, Centre Leon Berard, Lyon, France
    J Natl Cancer Inst 101:237-47. 2009
    ..The status of netrin-1 and its receptors in non-small cell lung cancer (NSCLC) was unknown...
  3. doi request reprint Nucleolar localization of a netrin-1 isoform enhances tumor cell proliferation
    Céline Delloye-Bourgeois
    Apoptosis, Cancer and Development Laboratory Equipe labellisée La Ligue, LabEx DEVweCAN, Centre de Cancérologie de Lyon, INSERM U1052 CNRS UMR5286, Universite de Lyon, Centre Leon Berard, 69008 Lyon, France
    Sci Signal 5:ra57. 2012
    ..Thus, some cancer cells produce not only a full-length, secreted form of netrin-1 that promotes cell survival but also a truncated netrin-1 that stimulates cell proliferation, potentially by enhancing ribosome biogenesis...
  4. doi request reprint NF-kappaB regulates netrin-1 expression and affects the conditional tumor suppressive activity of the netrin-1 receptors
    Andrea Paradisi
    Apoptosis, Cancer and Development Laboratory Equipe labellisée La Ligue, CNRS UMR 5238, Universite de Lyon, Centre Leon Berard, Lyon, France
    Gastroenterology 135:1248-57. 2008
    ..We have investigated whether netrin-1 is up-regulated in colorectal cancer and have searched for a link between NF-kappaB activation and netrin-1 up-regulation...
  5. doi request reprint DCC constrains tumour progression via its dependence receptor activity
    Marie Castets
    Apoptosis, Cancer and Development Laboratory Equipe labellisée La Ligue, LabEx DEVweCAN, Centre de Cancérologie de Lyon, INSERM U1052 CNRS UMR5286, Universite de Lyon, Centre Leon Berard, 69008 Lyon, France
    Nature 482:534-7. 2011
    ..These results demonstrate that DCC functions as a tumour suppressor via its ability to trigger tumour cell apoptosis...
  6. pmc Netrin-1 acts as a survival factor for aggressive neuroblastoma
    Céline Delloye-Bourgeois
    Centre National de la Recherche Scientifique UMR, Universite de Lyon, France
    J Exp Med 206:833-47. 2009
    ....
  7. pmc Combining chemotherapeutic agents and netrin-1 interference potentiates cancer cell death
    Andrea Paradisi
    Apoptosis, Cancer and Development Laboratory Equipe labellisée La Ligue, LabEx DEVweCAN, Centre de Cancérologie de Lyon, INSERM U1052 CNRS UMR5286, Universite de Lyon, Centre Leon Berard, Lyon, France
    EMBO Mol Med 5:1821-34. 2013
    ..Together these data suggest that combining conventional chemotherapies with netrin-1 interference could be a promising therapeutic approach. ..
  8. pmc Netrin-1 expression confers a selective advantage for tumor cell survival in metastatic breast cancer
    Julien Fitamant
    Apoptosis, Cancer, and Development Laboratory Equipe Labellisée La Ligue, Centre National de la Recherche Scientifique, Unite Mixte de Recherche 5238, Centre Leon Berard, Université de Lyon 69008 Lyon, France
    Proc Natl Acad Sci U S A 105:4850-5. 2008
    ....
  9. pmc Sonic Hedgehog promotes tumor cell survival by inhibiting CDON pro-apoptotic activity
    Céline Delloye-Bourgeois
    Apoptosis, Cancer and Development Laboratory Equipe labellisée La Ligue, LabEx DEVweCAN, Centre de Cancérologie de Lyon, Institut National de la Santé et de la Recherche Médicale INSERM U1052 Centre National de la Recherche Scientifique CNRS Unité Mixte de Recherche UMR5286, Universite de Lyon, Centre Leon Berard, 69008 Lyon, France
    PLoS Biol 11:e1001623. 2013
    ..The latter observation qualifies CDON as a relevant alternative target for anticancer therapy in SHH-expressing tumors. ..
  10. doi request reprint Inhibition of endothelial cell apoptosis by netrin-1 during angiogenesis
    Marie Castets
    Apoptosis, Cancer, and Development Laboratory, Equipe Labellisée La Ligue, CNRS UMR5238, Universite de Lyon, Centre Leon Berard, Lyon, France
    Dev Cell 16:614-20. 2009
    ..Thus, the proapoptotic effect of unbound UNC5B and the survival effect of netrin-1 on endothelial cells finely tune the angiogenic process...
  11. doi request reprint The dependence receptor UNC5H2/B triggers apoptosis via PP2A-mediated dephosphorylation of DAP kinase
    Céline Guenebeaud
    Apoptosis, Cancer and Development Laboratory Equipe labellisée La Ligue, CNRS UMR5238, Universite de Lyon, Centre Leon Berard, 69008 Lyon, France
    Mol Cell 40:863-76. 2010
    ..Thus we show here that, in the absence of netrin-1, recruitment of PP2A to UNC5H2/B allows the activation of DAPk via a PP2A-mediated dephosphorylation and that this mechanism is involved in angiogenesis regulation...
  12. pmc Inactivation of the UNC5C Netrin-1 receptor is associated with tumor progression in colorectal malignancies
    Agnès Bernet
    Apoptosis, Cancer and Development Laboratory Equipe labellisée La Ligue, Centre National de la Recherche Scientifique, CNRS UMR5238, University of Lyon, Centre Leon Berard, Lyon, France
    Gastroenterology 133:1840-8. 2007
    ..We investigate here whether UNC5C acts as a tumor suppressor in colorectal malignancies...
  13. doi request reprint Structural Decoding of the Netrin-1/UNC5 Interaction and its Therapeutical Implications in Cancers
    Mélodie Grandin
    Apoptosis, Cancer and Development Laboratory, Equipe Labellisée La Ligue, LabEx DEVweCAN, Centre de Recherche en Cancérologie de Lyon, INSERM U1052 CNRS UMR5286, Universite de Lyon, Centre Leon Berard, 69008 Lyon, France
    Cancer Cell 29:173-85. 2016
    ..These results support that this antibody is a promising drug candidate. ..
  14. pmc Variants in the netrin-1 receptor UNC5C prevent apoptosis and increase risk of familial colorectal cancer
    Marie May Coissieux
    Apoptosis, Cancer and Development Laboratory Equipe labellisée La Ligue, UMR INSERM 1052 CNRS 5286, University of Lyon, Lyon, France
    Gastroenterology 141:2039-46. 2011
    ..We investigated whether specific variants in UNC5C increase risk of colorectal cancer (CRC)...
  15. ncbi request reprint Dependence receptors: when apoptosis controls tumor progression
    Agnès Bernet
    Apoptosis, Cancer and Development Laboratory, Laboratoire labellisé La Ligue, CNRS FRE2870, Centre Leon Berard, 69008 Lyon, France
    Bull Cancer 94:E12-7. 2007
    ..In this review, we will describe the implication of the netrin-1/receptor pairs as novel negative regulators of tumor development...
  16. doi request reprint Unraveling the Role of Huntingtin in Breast Cancer Metastasis
    Morgane S Thion
    Institut Curie, Paris, France MST, JRM, CMS, LF, SL, SV, IB, AVS, SH CNRS UMR 3306, Orsay, France MST, JRM, CMS, SL, SH INSERM U1005, Orsay, France MST, JRM, CMS, SL, SH University Paris Sud 11, Orsay, France MST Apoptosis, Cancer and Development Laboratory, Equipe Labellisée La Ligue, Centre National de la Recherche Scientifique UMR5238, Universite de Lyon, Lyon, France JF, AB, PM Department of Biostatistics and Medical Informatics, Assistance Publique Hôpitaux de Paris STdM Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1136
    J Natl Cancer Inst 107:. 2015
    ..Huntingtin (HTT) is mutated in Huntington's disease but is ubiquitously expressed, and mutant HTT influences cancer progression. We investigated wild-type HTT function during breast cancer...
  17. pmc Netrin-1 regulates somatic cell reprogramming and pluripotency maintenance
    Duygu Ozmadenci
    Apoptosis, Cancer and Development Laboratory Equipe labellisée La Ligue, LabEx DEVweCAN, Centre de Recherche en Cancérologie de Lyon, INSERM U1052 CNRS UMR5286, Universite de Lyon, Centre Leon Berard, 69008 Lyon, France
    Nat Commun 6:7398. 2015
    ....