- Liver cell transformation in chronic HBV infectionShirine Benhenda
Oncogenesis and Molecular Virology Unit, Institut Pasteur, INSERM U579, 28 rue du Dr Roux, 75724 Paris Cedex 15, France E Mails S B D C C N
Viruses 1:630-46. 2009..These studies might help identifying the cellular effectors connecting HBV infection and liver cell transformation...
- Inhibition of PP1 phosphatase activity by HBx: a mechanism for the activation of hepatitis B virus transcriptionDelphine Cougot
Oncogenèse et Virologie Moléculaire, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
Sci Signal 5:ra1. 2012..Our results illustrate a previously unknown mechanism of HBV transcriptional activation by HBx in which HBx interferes with the inactivation of CREB by the PP1 and HDAC1 complex...
- Hepatitis B virus X protein molecular functions and its role in virus life cycle and pathogenesisShirine Benhenda
Unité d Oncogenèse et Virologie Moléculaire INSERM U579, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
Adv Cancer Res 103:75-109. 2009..HBx has been shown to modulate a myriad of viral and cellular functions, yet its role in virus replication and pathogenesis in infected individuals remains far from being completely understood...