Alain R Baulard

Summary

Affiliation: Institut Pasteur de Lille
Country: France

Publications

  1. ncbi request reprint In vivo interaction between the polyprenol phosphate mannose synthase Ppm1 and the integral membrane protein Ppm2 from Mycobacterium smegmatis revealed by a bacterial two-hybrid system
    Alain R Baulard
    INSERM U447, Institut Pasteur de Lille Institut de Biologie de Lille, France
    J Biol Chem 278:2242-8. 2003
  2. pmc Structural activation of the transcriptional repressor EthR from Mycobacterium tuberculosis by single amino acid change mimicking natural and synthetic ligands
    Xavier Carette
    Center for Infection and Immunity of Lille, F 59019 Lille, France
    Nucleic Acids Res 40:3018-30. 2012
  3. ncbi request reprint EthR, a repressor of the TetR/CamR family implicated in ethionamide resistance in mycobacteria, octamerizes cooperatively on its operator
    Jean Engohang-Ndong
    INSERM U447, Institut de Biologie de Lille Institut Pasteur de Lille, 1 rue du Professeur Calmette, BP 245, 59019 Lille Cedex, France
    Mol Microbiol 51:175-88. 2004
  4. ncbi request reprint Unconventional surface plasmon resonance signals reveal quantitative inhibition of transcriptional repressor EthR by synthetic ligands
    Céline Crauste
    Biostructures and Drug Discovery, INSERM U761, F 59000 Lille, France Faculté de Pharmacie de Lille, University of Lille Nord de France, F 59000 Lille, France Institut Pasteur de Lille, F 59019 Lille, France IFR 142, Molecular and Cellular Medicine, F 59021 Lille, France PRIM, F 59019 Lille, France
    Anal Biochem 452:54-66. 2014
  5. ncbi request reprint Direct measurement of hydrophobic forces on cell surfaces using AFM
    David Alsteens
    Unite de Chimie des Interfaces, Universite Catholique de Louvain, Croix du Sud 2 18, Louvain la Neuve, Belgium
    Langmuir 23:11977-9. 2007
  6. ncbi request reprint Antibody response in pulmonary tuberculosis against recombinant 27kDa (MPT51, Rv3803c) protein of Mycobacterium tuberculosis
    Ramalingam Bethunaickan
    Department of Immunology, Tuberculosis Research Centre ICMR, Chetput, Chennai, India
    Scand J Infect Dis 39:867-74. 2007
  7. ncbi request reprint Selective intracellular accumulation of the major metabolite issued from the activation of the prodrug ethionamide in mycobacteria
    Xavier Hanoulle
    UMR 8525 CNRS Universíté de Lille 2 Lille, F 59021, France
    J Antimicrob Chemother 58:768-72. 2006
  8. ncbi request reprint Insights into mechanisms of induction and ligands recognition in the transcriptional repressor EthR from Mycobacterium tuberculosis
    Frédéric Frénois
    CNRS UMR8525, Institut de Biologie de Lille Institut Pasteur de Lille, 1 rue du Professeur Calmette, BP245 59019 Lille cedex, France
    Tuberculosis (Edinb) 86:110-4. 2006
  9. ncbi request reprint Structure of EthR in a ligand bound conformation reveals therapeutic perspectives against tuberculosis
    Frédéric Frénois
    CNRS UMR8525, 1 rue du Professeur Calmette, BP245 59019 Lille cedex, France
    Mol Cell 16:301-7. 2004
  10. ncbi request reprint Cloning, expression, and purification of the 27 kDa (MPT51, Rv3803c) protein of Mycobacterium tuberculosis
    B Ramalingam
    Department of Immunology, Tuberculosis Research Centre ICMR, Mayor V R Ramanathan Road, Chetput, Chennai 600 031, India
    Protein Expr Purif 36:53-60. 2004

Collaborators

  • Gurdyal S Besra
  • Jean Engohang-Ndong
  • C Locht
  • DAVID BRANCH MOODY
  • Laurent Kremer
  • G Lippens
  • I Landrieu
  • Frédéric Frénois
  • Xavier Carette
  • Vincent Villeret
  • Céline Crauste
  • Eve Willery
  • Nicolas Willand
  • Benoit Deprez
  • Ramalingam Bethunaickan
  • David Alsteens
  • Xavier Hanoulle
  • Alamelu Raja
  • B Ramalingam
  • Benjawan Phetsuksiri
  • Patrick J Brennan
  • Dean C Crick
  • Martin Moune Dimala
  • Pierre Marie Danze
  • Marion Flipo
  • Baptiste Villemagne
  • Anne Sophie Drucbert
  • Sudagar S Gurcha
  • Nicolas Blondiaux
  • Patrick England
  • Nathalie Lecat-Guillet
  • Alexandre Wohlkonig
  • Bertrand Dirié
  • Sameh H Soror
  • Sylviane Hoos
  • René Wintjens
  • Zoé Lens
  • Paul G Rouxhet
  • Etienne Dague
  • Yves F Dufrêne
  • Jean Michel Wieruszeski
  • Pierre Rousselot-Pailley
  • P R Narayanan
  • Mark S Baird
  • Mary Jackson
  • Michael McNeil
  • Clifton E Barry
  • Hataichanok Scherman
  • Andrea E DeBarber
  • Richard A Slayden
  • Catherine E Costello
  • Walter Muhlecker

Detail Information

Publications12

  1. ncbi request reprint In vivo interaction between the polyprenol phosphate mannose synthase Ppm1 and the integral membrane protein Ppm2 from Mycobacterium smegmatis revealed by a bacterial two-hybrid system
    Alain R Baulard
    INSERM U447, Institut Pasteur de Lille Institut de Biologie de Lille, France
    J Biol Chem 278:2242-8. 2003
    ..This interaction is reminiscent of that of mammalian Dpm1 with Dpm3 and mimics the structure of MtPpm1 as demonstrated by the capacity of the two domains of MtPpm1 to spontaneously interact when co-expressed in E. coli...
  2. pmc Structural activation of the transcriptional repressor EthR from Mycobacterium tuberculosis by single amino acid change mimicking natural and synthetic ligands
    Xavier Carette
    Center for Infection and Immunity of Lille, F 59019 Lille, France
    Nucleic Acids Res 40:3018-30. 2012
    ..These results also shed light on the mechanistic of ligand-induced allosterism controlling the DNA binding properties of TetR family repressors...
  3. ncbi request reprint EthR, a repressor of the TetR/CamR family implicated in ethionamide resistance in mycobacteria, octamerizes cooperatively on its operator
    Jean Engohang-Ndong
    INSERM U447, Institut de Biologie de Lille Institut Pasteur de Lille, 1 rue du Professeur Calmette, BP 245, 59019 Lille Cedex, France
    Mol Microbiol 51:175-88. 2004
    ..In contrast, surface plasmon resonance analyses showed that eight EthR molecules bind cooperatively to the 55 bp operator, which represents a novel repression mechanism for a TetR/CamR member...
  4. ncbi request reprint Unconventional surface plasmon resonance signals reveal quantitative inhibition of transcriptional repressor EthR by synthetic ligands
    Céline Crauste
    Biostructures and Drug Discovery, INSERM U761, F 59000 Lille, France Faculté de Pharmacie de Lille, University of Lille Nord de France, F 59000 Lille, France Institut Pasteur de Lille, F 59019 Lille, France IFR 142, Molecular and Cellular Medicine, F 59021 Lille, France PRIM, F 59019 Lille, France
    Anal Biochem 452:54-66. 2014
    ....
  5. ncbi request reprint Direct measurement of hydrophobic forces on cell surfaces using AFM
    David Alsteens
    Unite de Chimie des Interfaces, Universite Catholique de Louvain, Croix du Sud 2 18, Louvain la Neuve, Belgium
    Langmuir 23:11977-9. 2007
    ..Then, we measured hydrophobic forces associated with mycolic acids on the surface of mycobacteria, supporting the notion that these hydrophobic compounds represent an important permeation barrier to drugs...
  6. ncbi request reprint Antibody response in pulmonary tuberculosis against recombinant 27kDa (MPT51, Rv3803c) protein of Mycobacterium tuberculosis
    Ramalingam Bethunaickan
    Department of Immunology, Tuberculosis Research Centre ICMR, Chetput, Chennai, India
    Scand J Infect Dis 39:867-74. 2007
    ..Measuring the IgG+IgA combination positivities of the CIC-bound antibodies gave a poor sensitivity of 21%, 18% and 10%, respectively. The specificity of the assay by these combinations was maintained at 94%...
  7. ncbi request reprint Selective intracellular accumulation of the major metabolite issued from the activation of the prodrug ethionamide in mycobacteria
    Xavier Hanoulle
    UMR 8525 CNRS Universíté de Lille 2 Lille, F 59021, France
    J Antimicrob Chemother 58:768-72. 2006
    ..Activation pathways of prodrugs are generally problematic to uncover as they produce intermediates potentially difficult to characterize, to purify and that might prove unstable outside of their cellular context...
  8. ncbi request reprint Insights into mechanisms of induction and ligands recognition in the transcriptional repressor EthR from Mycobacterium tuberculosis
    Frédéric Frénois
    CNRS UMR8525, Institut de Biologie de Lille Institut Pasteur de Lille, 1 rue du Professeur Calmette, BP245 59019 Lille cedex, France
    Tuberculosis (Edinb) 86:110-4. 2006
    ..This observation paves the way to the design of specific drugs that could increase the sensitivity of M. tuberculosis to ethionamide...
  9. ncbi request reprint Structure of EthR in a ligand bound conformation reveals therapeutic perspectives against tuberculosis
    Frédéric Frénois
    CNRS UMR8525, 1 rue du Professeur Calmette, BP245 59019 Lille cedex, France
    Mol Cell 16:301-7. 2004
    ....
  10. ncbi request reprint Cloning, expression, and purification of the 27 kDa (MPT51, Rv3803c) protein of Mycobacterium tuberculosis
    B Ramalingam
    Department of Immunology, Tuberculosis Research Centre ICMR, Mayor V R Ramanathan Road, Chetput, Chennai 600 031, India
    Protein Expr Purif 36:53-60. 2004
    ..The purified proteins were found to be immunogenic and useful for immunodiagnostic studies of tuberculosis by enzyme linked immunosorbent assay (ELISA), with a sensitivity of 71% and specificity of 95%...
  11. ncbi request reprint Unique mechanism of action of the thiourea drug isoxyl on Mycobacterium tuberculosis
    Benjawan Phetsuksiri
    Department of Microbiology, Pathology, and Immunology, Colorado State University, Fort Collins, Colorado 80523 1682, USA
    J Biol Chem 278:53123-30. 2003
    ..These results validate membrane-bound Delta9-desaturase, DesA3, as a new therapeutic target, and the thioureas as anti-tuberculosis drugs worthy of further development...
  12. pmc Ppm1, a novel polyprenol monophosphomannose synthase from Mycobacterium tuberculosis
    Sudagar S Gurcha
    Department of Microbiology and Immunology, The Medical School, The University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, UK
    Biochem J 365:441-50. 2002
    ..PPM synthase can also be exploited as a target for specific inhibitors of M. tuberculosis...