Institut Pasteur de Lille

Summary

Organization: Institut Pasteur de Lille
Country: France

Top Publications

  1. pmc Bile acid sequestrants for lipid and glucose control
    Bart Staels
    Institut Pasteur de Lille, 1 rue Calmette BP245, 59019, Lille Cedex, France
    Curr Diab Rep 10:70-7. 2010
  2. ncbi Parental longevity and 7-year changes in blood pressures in adult offspring
    Mahmoud Zureik
    Unit 508, National Institute of Health and Medical Research INSERM, Institut Pasteur de Lille, Lille, France
    Hypertension 46:287-94. 2005
  3. ncbi PPARgamma and atherosclerosis
    B Staels
    Département d Athérosclérose U 545 Inserm, Institut Pasteur de Lille, et Université de Lille2, Lille, France
    Curr Med Res Opin 21:S13-20. 2005
  4. ncbi Alcohol consumption and carotid artery structure in older French adults: the Three-City Study
    Mahmoud Zureik
    National Institute of Health and Medical Research INSERM, Unit 508, Institut Pasteur de Lille, 1 rue Calmette, BP 245 59019 Lille, France
    Stroke 35:2770-5. 2004
  5. ncbi Polymorphisms in the amino acid transporter solute carrier family 6 (neurotransmitter transporter) member 14 gene contribute to polygenic obesity in French Caucasians
    Emmanuelle Durand
    CNRS UMR8090, Institut Pasteur de Lille, 1 rue du Pr Calmette, BP 447 59021 Lille, France
    Diabetes 53:2483-6. 2004
  6. ncbi [Inflammation markers and vascular risk]
    G Luc
    Service de Medecine Interne A, CHRU de Lille, Universite de Lille II, France
    Rev Med Interne 25:S7-9. 2004
  7. ncbi 2-Hydroxy-1,4-naphthoquinone, the natural dye of Henna, is non-genotoxic in the mouse bone marrow micronucleus test and does not produce oxidative DNA damage in Chinese hamster ovary cells
    Daniel Marzin
    Laboratory of Toxicology, Institute Pasteur, 1, rue du Pr Calmette, BP 245, 59019 Lille Cedex, France
    Mutat Res 560:41-7. 2004
  8. ncbi Morphology, homogeneity and functionality of human monocytes-derived macrophages
    F Pinet
    INSERM U508, Institut Pasteur de Lille, 1 rue du Professeur Calmette, 59019 Lille Cedex, France
    Cell Mol Biol (Noisy-le-grand) 49:899-905. 2003
  9. ncbi The association of metabolic disorders with the metabolic syndrome is different in men and women
    J Dallongeville
    Service d Epidémiologie et de Santé Publique, INSERM U 508, Institut Pasteur de Lille, Lille, France
    Ann Nutr Metab 48:43-50. 2004
  10. ncbi The Gly16-->Arg16 and Gln27-->Glu27 polymorphisms of beta2-adrenergic receptor are associated with metabolic syndrome in men
    Jean Dallongeville
    Institut National de la Sante et de la Recherche Medicale, U 508, Institut Pasteur de Lille, Lille Cedex, France
    J Clin Endocrinol Metab 88:4862-6. 2003

Detail Information

Publications62

  1. pmc Bile acid sequestrants for lipid and glucose control
    Bart Staels
    Institut Pasteur de Lille, 1 rue Calmette BP245, 59019, Lille Cedex, France
    Curr Diab Rep 10:70-7. 2010
    ....
  2. ncbi Parental longevity and 7-year changes in blood pressures in adult offspring
    Mahmoud Zureik
    Unit 508, National Institute of Health and Medical Research INSERM, Institut Pasteur de Lille, Lille, France
    Hypertension 46:287-94. 2005
    ..These results indicate that there are dynamic and continuous processes linking paternal longevity to blood pressure in adults...
  3. ncbi PPARgamma and atherosclerosis
    B Staels
    Département d Athérosclérose U 545 Inserm, Institut Pasteur de Lille, et Université de Lille2, Lille, France
    Curr Med Res Opin 21:S13-20. 2005
    ..Thiazolidinediones are PPARgamma agonists that are in clinical use for the treatment of type 2 diabetes. Accumulating evidence indicates that thiazolidinediones may exert cardioprotective effects at each stage of atherogenesis...
  4. ncbi Alcohol consumption and carotid artery structure in older French adults: the Three-City Study
    Mahmoud Zureik
    National Institute of Health and Medical Research INSERM, Unit 508, Institut Pasteur de Lille, 1 rue Calmette, BP 245 59019 Lille, France
    Stroke 35:2770-5. 2004
    ..Several epidemiological studies have suggested a U-shaped association between alcohol consumption and cardiovascular risk. However, the modifications of vascular structure associated with alcohol consumption are largely unknown...
  5. ncbi Polymorphisms in the amino acid transporter solute carrier family 6 (neurotransmitter transporter) member 14 gene contribute to polygenic obesity in French Caucasians
    Emmanuelle Durand
    CNRS UMR8090, Institut Pasteur de Lille, 1 rue du Pr Calmette, BP 447 59021 Lille, France
    Diabetes 53:2483-6. 2004
    ..003 < P < 0.06). In conclusion, these data confirm an association of the SLC6A14 gene locus with obesity...
  6. ncbi [Inflammation markers and vascular risk]
    G Luc
    Service de Medecine Interne A, CHRU de Lille, Universite de Lille II, France
    Rev Med Interne 25:S7-9. 2004
  7. ncbi 2-Hydroxy-1,4-naphthoquinone, the natural dye of Henna, is non-genotoxic in the mouse bone marrow micronucleus test and does not produce oxidative DNA damage in Chinese hamster ovary cells
    Daniel Marzin
    Laboratory of Toxicology, Institute Pasteur, 1, rue du Pr Calmette, BP 245, 59019 Lille Cedex, France
    Mutat Res 560:41-7. 2004
    ..These results confirm that HNQ poses no or negligible genotoxic risk...
  8. ncbi Morphology, homogeneity and functionality of human monocytes-derived macrophages
    F Pinet
    INSERM U508, Institut Pasteur de Lille, 1 rue du Professeur Calmette, 59019 Lille Cedex, France
    Cell Mol Biol (Noisy-le-grand) 49:899-905. 2003
    ..Cultures meeting these criteria will be used for the proteomic analysis and the establishment of the reference map...
  9. ncbi The association of metabolic disorders with the metabolic syndrome is different in men and women
    J Dallongeville
    Service d Epidémiologie et de Santé Publique, INSERM U 508, Institut Pasteur de Lille, Lille, France
    Ann Nutr Metab 48:43-50. 2004
    ..Metabolic disorders depend on genetic, hormonal and environmental factors, whose relations may differ between genders. Therefore, we compared the contribution of metabolic disorders to the metabolic syndrome in women and men...
  10. ncbi The Gly16-->Arg16 and Gln27-->Glu27 polymorphisms of beta2-adrenergic receptor are associated with metabolic syndrome in men
    Jean Dallongeville
    Institut National de la Sante et de la Recherche Medicale, U 508, Institut Pasteur de Lille, Lille Cedex, France
    J Clin Endocrinol Metab 88:4862-6. 2003
    ..In conclusion, these data suggest that the Arg(16) and Gln(27) variants of the beta(2)-adrenergic receptor gene contribute to metabolic syndrome susceptibility in men...
  11. ncbi Circulating soluble adhesion molecules ICAM-1 and VCAM-1 and incident coronary heart disease: the PRIME Study
    Gerald Luc
    Department of Atherosclerosis, SERLIA INSERM UR325, Institut Pasteur de Lille, 1, rue du Professeur Calmette, 59019 Lille, France
    Atherosclerosis 170:169-76. 2003
    ....
  12. ncbi Peroxisome proliferator activated receptors and stroke
    Jean Charles Fruchart
    Unité de Recherche sur les Lipoprotéines et l Athérosclérose, UR 545 INSERM and Université de Lille 2, Institut Pasteur, 1 rue du Pr Calmette, 59019 Lille, France
    Curr Atheroscler Rep 5:331-2. 2003
  13. ncbi [Evaluation of discomfort and complications in a population of 18,102 patients overweight or obese patients]
    J M Lecerf
    Service de Nutrition, Institut Pasteur de Lille, Lille 59
    Presse Med 32:689-95. 2003
    ..The burden of disorders associated with overweight and obesity is a major public health problem. It is therefore important to better identify these concomitant disorders and how their frequencies vary with sex and age...
  14. ncbi Prostaglandin D2 affects the maturation of human monocyte-derived dendritic cells: consequence on the polarization of naive Th cells
    Philippe Gosset
    Institut National de la Sante et de la Recherche Medicale, Unité 416 and Institut Fédératif de Recherche 17, Institut Pasteur de Lille, Lille, France
    J Immunol 170:4943-52. 2003
    ..Finally, in a model of Th CD45RA(+) differentiation induced by allergen- and superantigen-pulsed DC, PGD(2) impacts on the orientation of the immune response by favoring a Th2 response...
  15. pmc Rapid method for enumeration of viable Legionella pneumophila and other Legionella spp. in water
    Pilar Delgado-Viscogliosi
    Département Eaux et Environnement, Institut Pasteur de Lille, F 59019 Lille cedex, France
    Appl Environ Microbiol 71:4086-96. 2005
    ....
  16. ncbi Molecular diagnosis of Pneumocystis pneumonia
    Isabelle Durand-Joly
    Parasitology Mycology EA 3609, Lille 2 University Hospital Centre, France
    FEMS Immunol Med Microbiol 45:405-10. 2005
    ..This non-invasive procedure may reach 90%-sensitivity and has been used for monitoring the response to treatment in AIDS patients and for typing Pneumocystis isolates...
  17. ncbi Association between peroxisome proliferator-activated receptor gamma haplotypes and the metabolic syndrome in French men and women
    Aline Meirhaeghe
    INSERM, U508, Institut Pasteur de Lille, 59019 Lille Cedex, France
    Diabetes 54:3043-8. 2005
    ..In conclusion, a specific haplotype of PPARgamma polymorphisms is associated with an increased risk of the metabolic syndrome in a French general population...
  18. doi Association of plasma amyloid beta with risk of dementia: the prospective Three-City Study
    J C Lambert
    Unité INSERM 744, Institut Pasteur de Lille, BP 245, 1, rue du Professeur Calmette, F 59019 Lille cedex, France
    Neurology 73:847-53. 2009
    ..We also assessed the association between plasma concentrations of truncated Abeta (Abeta(n-40) and Abeta(n-42)) and the risk of dementia...
  19. ncbi Efficacy of peroxisome proliferator-activated receptor agonists in diabetes and coronary artery disease
    Catherine Fievet
    Institut Pasteur, Lille, France
    Curr Atheroscler Rep 11:281-8. 2009
    ..This review discusses our current knowledge of the effectiveness of PPAR-based therapeutics, focusing exclusively on cardiovascular disease in type 2 diabetes mellitus and the future prospects for novel generation of PPAR agonists...
  20. doi A review of bile acid sequestrants: potential mechanism(s) for glucose-lowering effects in type 2 diabetes mellitus
    Bart Staels
    Universite Lille Nord de France, INSERM U545, UDSL, Lille, France
    Postgrad Med 121:25-30. 2009
    ..This article reviews the role for bile acids in glucose regulation and discusses the potential mechanism(s) of action for the glycemic effects of bile acid sequestrants...
  21. doi Small, qualitative changes in fatty acid intake decrease plasma low-density lipoprotein-cholesterol levels in mildly hypercholesterolemic outpatients on their usual high-fat diets
    Jean Michel Lecerf
    Nutrition Department, Pasteur Institute, Lille, France
    Int J Food Sci Nutr 60:151-63. 2009
    ..The diet is the first step in managing hypercholesterolemia. The objective of the present study is to assess whether moderate changes in dietary fatty acids improve plasma lipid parameters in mildly hypercholesterolemic outpatients...
  22. doi Abdominal obesity is associated with ineffective control of cardiovascular risk factors in primary care in France
    J Dallongeville
    Service d Epidémiologie et Santé Publique, INSERM U744, Institut Pasteur de Lille, 1, rue du Professeur Calmette, 59019 Lille, France
    Diabetes Metab 34:606-11. 2008
    ..The goal of the present study was to evaluate the association of abdominal obesity with achievement of treatment targets for HbA(1c), LDL cholesterol, triglycerides, HDL cholesterol and blood pressure in primary care...
  23. doi The Residual Risk Reduction Initiative: a call to action to reduce residual vascular risk in dyslipidaemic patient
    Jean Charles Fruchart
    INSERM UR 545, Universite Lille 2, Lille, France
    Diab Vasc Dis Res 5:319-35. 2008
    ..In conclusion, the R3I highlights the need to address with lifestyle and/or pharmacotherapy the high level of residual vascular risk among dyslipidaemic patients who are treated in accordance with current standards of care...
  24. ncbi Parental longevity, carotid atherosclerosis, and aortic arterial stiffness in adult offspring
    Mahmoud Zureik
    National Institute of Health and Medical Research INSERM, Unit 744, Lille, France
    Stroke 37:2702-7. 2006
    ..We examined the associations of parental longevity with carotid intima-media thickness, carotid plaques, and aortic arterial stiffness in adult offspring...
  25. ncbi Association study of the PIN1 gene with Alzheimer's disease
    Jean Charles Lambert
    INSERM U744, Institut Pasteur de Lille, Universite de Lille 2, France
    Neurosci Lett 402:259-61. 2006
    ..No association of these polymorphisms or haplotypes with the disease was observed in a large French case-control population. Our data suggest that these genetic variants in PIN1 do not make a significant contribution to AD risk...
  26. ncbi Growth factor receptors in helminth parasites: signalling and host-parasite relationships
    Colette Dissous
    Unité INSERM 547, Institut Pasteur de Lille, 1 rue du Pr Calmette, 59019 Lille Cedex, France
    FEBS Lett 580:2968-75. 2006
    ....
  27. ncbi Mode of action of fibrates in the regulation of triglyceride and HDL-cholesterol metabolism
    Jean Charles Fruchart
    Lipoprotein and Atherosclerosis Research Unit, INSERM Unité de Recherche sur l Arthérosclérose and Lille University 2 U545, Pasteur Institute of Lille, Lille, France
    Drugs Today (Barc) 42:39-64. 2006
    ..PPARs are also expressed in atherosclerotic lesions...
  28. ncbi [The best of fundamental research in 2005]
    F Pinet
    Groupe de reflexion sur la recherche cardiovasculaire, INSERM U508 IPL, 1, rue du Professeur Calmette, 59019 Lille
    Arch Mal Coeur Vaiss 99:91-3. 2006
    ..Six voyage grants for the American Heart Association Meeting were given to students who had their summaries accepted, in the expectation of upcoming publications by young French workers in the best journals...
  29. ncbi [Contribution of proteomic analysis to study cardiovascular physiopathology]
    A Dupont
    Unité INSERM 508, Institut Pasteur de Lille
    Ann Biol Clin (Paris) 63:611-7. 2005
    ..This impact is being generally only detectable at protein level. These works are only at the beginning and these approaches applied in cardiovascular field will meet a large success in the immediate future and should be promising...
  30. ncbi Serum tissue inhibitors of metalloproteinases 1 (TIMP-1) and carotid atherosclerosis and aortic arterial stiffness
    Mahmoud Zureik
    National Institute of Health and Medical Research INSERM, Unit 508, Lille, France
    J Hypertens 23:2263-8. 2005
    ..In a population-based study, we report the relationships of serum TIMP-1 with carotid intima-media thickness, carotid plaques and aortic arterial stiffness...
  31. pmc Discordant effects of interleukin-2 on viral and immune parameters in human immunodeficiency virus-1-infected monocyte-derived mature dendritic cells
    G M Bahr
    Laboratoire d Immunologie Moleculaire de l Infection et de l Inflammation, Institut Pasteur de Lille, Lille, France
    Clin Exp Immunol 132:289-96. 2003
    ..Taken together, these findings point to a role for IL-2 in inducing virus purging from dendritic cell reservoirs but indicate no relevant potential of the cytokine in restoring defective elements of innate immunity in HIV infection...
  32. ncbi Apolipoprotein A5, a crucial determinant of plasma triglyceride levels, is highly responsive to peroxisome proliferator-activated receptor alpha activators
    Ngoc Vu-Dac
    Departement d Atherosclerose, U 545 INSERM, Institut Pasteur de Lille and Faculté de Pharmacie de Lille, 1 rue Calmette BP 245, 59019 Lille Cedex, France
    J Biol Chem 278:17982-5. 2003
    ..These findings demonstrate that APOA5 is a highly responsive peroxisome proliferator-activated receptor alpha target gene and support its role as a major mediator for how fibrates reduce plasma triglycerides in humans...
  33. ncbi Peroxisome proliferator-activated receptor alpha is not rate-limiting for the lipoprotein-lowering action of fish oil
    J Dallongeville
    Departement d Atherosclerose, INSERM U 508, and INSERM U 325, Institut Pasteur de Lille, 59019 Lille, France
    J Biol Chem 276:4634-9. 2001
    ..Altogether, these results show major molecular differences in action between fibrates and fish oil providing a molecular rationale for combination treatment with these compounds...
  34. ncbi p13(SUC1) and the WW domain of PIN1 bind to the same phosphothreonine-proline epitope
    I Landrieu
    CNRS UMR 8525, Institut de Biologie de Lille Pasteur Institute of Lille, 59019 Lille Cedex, France
    J Biol Chem 276:1434-8. 2001
    ....
  35. ncbi Molecular aspects of Bordetella pertussis pathogenesis
    C Locht
    Laboratoire de Microbiologie Génétique et Moléculaire, INSERM, Institut Pasteur de Lille, France
    Int Microbiol 2:137-44. 1999
    ..pertussis strains to be used as recombinant live bacterial vaccine vectors for homologous and heterologous protection...
  36. ncbi Hormones and nuclear receptors in schistosome development
    R L de Mendonça
    INSERM U 167, Institut Pasteur de Lille, 1 rue du Professeur A Calmette, 59019 Lille Cedex, France
    Parasitol Today 16:233-40. 2000
    ..However, the probability that schistosome nuclear receptors exist for a variety of unique ligands opens up exciting possibilities for targeted drug development...
  37. ncbi Sex-dependent neutralizing humoral response to Schistosoma mansoni 28GST antigen in infected human populations
    F Remoue
    Unit e INSERM U167, Institut Pasteur de Lille, 59019 Lille Cedex, France
    J Infect Dis 181:1855-9. 2000
    ..These results strongly support the hypothesis that GST-neutralizing IgG3 and IgA isotypes are sex dependent. The relationship of this specific acquired immune response with the level of intensity of infection is discussed...
  38. ncbi Genetics of obesity: towards the understanding of a complex syndrome
    P Froguel
    Département de Génétique humaine de l Institut de Biologie de Lille
    Presse Med 29:564-71. 2000
    ..Identification of these genes with positional cloning and functional genomic techniques will be helpful in better understanding the molecular determinants of obesity and better defining targets for new therapies...
  39. ncbi Schistosoma mansoni schistosomula reduce E-selectin and VCAM-1 expression in TNF-alpha-stimulated lung microvascular endothelial cells by interfering with the NF-kappaB pathway
    F Trottein
    Centre d Immunologie et de Biologie, Parasitaire INSERM U167, Institut Pasteur de Lille, Lille, France
    Eur J Immunol 29:3691-701. 1999
    ..We speculate that this mechanism could represent a new stratagem that parasites may use to escape the immune system by controlling leukocyte recruitment to the lungs...
  40. pmc Schistosoma mansoni activates host microvascular endothelial cells to acquire an anti-inflammatory phenotype
    F Trottein
    Unite INSERM U167, Institut Pasteur de Lille, Lille, France
    Infect Immun 67:3403-9. 1999
    ..These combined findings suggest that the secretory/excretory products from schistosomula possess anti-inflammatory factor(s) that signal host microvascular endothelium. The immunological consequences of such activation are discussed...
  41. ncbi Preclinical evaluation of radiopharmaceutical toxicological prerequisites
    D Marzin
    Institut Pasteur De Lille Laboratoire De Toxicologie 1, France
    Nucl Med Biol 25:733-6. 1998
    ....
  42. ncbi Animal models of pneumocystosis
    E Dei-Cas
    Faculty of Medicine and Regional University Hospital Centre, Lille, France
    FEMS Immunol Med Microbiol 22:163-8. 1998
    ..They were also used to test the anti-Pneumocystis activity of antimicrobial molecules...
  43. ncbi Activation of human aortic smooth-muscle cells is inhibited by PPARalpha but not by PPARgamma activators
    B Staels
    U325 INSERM, Departement d Atherosclerose, Institut Pasteur, Lille, France
    Nature 393:790-3. 1998
    ....
  44. pmc Tuberculin-induced delayed-type hypersensitivity reaction in a model of hu-PBMC-SCID mice grafted with autologous skin
    A Tsicopoulos
    Institut Pasteur de Lille, France
    Am J Pathol 152:1681-8. 1998
    ..These results are similar to those reported after tuberculin-induced delayed-type hypersensitivity in humans, suggesting that this model might be useful to study cutaneous inflammatory reaction...
  45. ncbi Confronting the degeneracy of convergent combinatorial immunogens, or 'mixotopes', with the specificity of recognition of the target sequences
    H Gras-Masse
    Faculté de Pharmacie URA CNRS 1309, Institut Pasteur de Lille, France
    Vaccine 15:1568-78. 1997
    ..These results suggest that serological cross-reactivity depends on the sequential similarity of the antigen with the parent immunogen. Such 'mixotopes' could represent a useful approach to vaccination against hypervariable pathogens...
  46. ncbi Functionalization of peptides and proteins by aldehyde or keto groups
    O Melnyk
    UMR 8525 Institut de Biologie et Institut Pasteur de Lille, Universite de Lille 2, 1 rue du Pr Calmette, 59021 Lille, France
    Biopolymers 55:165-86. 2000
    ..The second part describes the utility of the aldehyde or keto functionalities for the site-specific modification of peptides or proteins...
  47. ncbi Mechanisms of resistance to S. mansoni infection: the rat model
    J Khalife
    Institut Pasteur de Lille, 1 rue du Pr Calmette, 59019 Lille Cedex, France
    Parasitol Int 49:339-45. 2000
    ..This review will consider the relevance of extrapolating studies of immune responses from experimentally infected rats a semi-permissive host, to studies on S. mansoni infected humans...
  48. pmc Mucosal immune responses and protection against tetanus toxin after intranasal immunization with recombinant Lactobacillus plantarum
    C Grangette
    Département de Microbiologie des Ecosystèmes, Institut Pasteur de Lille, 59019 Lille Cedex, France
    Infect Immun 69:1547-53. 2001
    ..These results demonstrate that recombinant lactobacilli can induce specific humoral (protective) and mucosal antibodies and cellular immune response against protective antigens upon nasal administration...
  49. ncbi In vivo interaction between the polyprenol phosphate mannose synthase Ppm1 and the integral membrane protein Ppm2 from Mycobacterium smegmatis revealed by a bacterial two-hybrid system
    Alain R Baulard
    INSERM U447, Institut Pasteur de Lille Institut de Biologie de Lille, France
    J Biol Chem 278:2242-8. 2003
    ..This interaction is reminiscent of that of mammalian Dpm1 with Dpm3 and mimics the structure of MtPpm1 as demonstrated by the capacity of the two domains of MtPpm1 to spontaneously interact when co-expressed in E. coli...
  50. ncbi [Statins for cardiovascular prevention. Lowering LDL cholesterol, the primary objective]
    Jean Charles Fruchart
    Departement de Recherche sur les Lipoproteines et l Atherosclerose, UR 545 Inserm et Université de Lille 2, Institut Pasteur 1, rue du Professeur Calmette 59019 Lille
    Presse Med 31:1428-33. 2002
    ..Nonetheless, the other risk factors must also be treated in order to reduce the patients' global cardiovascular risk score...
  51. ncbi Genetic susceptibility to ageing-associated diseases
    Philippe Amouyel
    INSERM U508, Institut Pasteur de Lille, 1, rue Calmette, 59019 Lille, France
    C R Biol 325:741-5. 2002
    ..This determination will offer new clues for a better-targeted disease management...
  52. ncbi Solution structure of the single-domain prolyl cis/trans isomerase PIN1At from Arabidopsis thaliana
    Isabelle Landrieu
    UMR 8525 CNRS Lille2, Institut de Biologie de Lille Pasteur Institute of Lille, 59019 Lille Cedex, France
    J Mol Biol 320:321-32. 2002
    ..Based on our experimental results and the molecular specificities of the PIN1At enzyme, functional implications of the lack of WW domains in this plant PIN-type PPIase will be discussed...
  53. ncbi Enhanced bacterial virulence through exploitation of host glycosaminoglycans
    Franco D Menozzi
    INSERM IPL U 447, Institut Pasteur de Lille, France
    Mol Microbiol 43:1379-86. 2002
    ..The exploitation of PGs by pathogenic bacteria is thus a multifaceted mechanistic process directly related to the potential virulence of a number of microorganisms...
  54. ncbi Interaction of human Tamm-Horsfall glycoprotein with Bordetella pertussis toxin
    Franco D Menozzi
    Institut Pasteur de Lille, INSERM U447, Mécanismes Moléculaires de la Pathogénie Microbienne, 1 rue du Professeur Calmette, 59019 Lille Cedex, France
    Microbiology 148:1193-201. 2002
    ..These observations suggest that besides its anti-adherence activity, THP may also trap toxins produced by pathogenic bacteria that colonize mucosal surfaces...
  55. ncbi [Human nasal myiasis due to Oestrus ovis]
    L Delhaes
    Service de Parasitologie Mycologie, Faculte de Medecine, 1, Place de Verdun, 59045 Lille, France
    Parasite 8:289-96. 2001
    ..The authors examine the oestrosis pathogenesis in the usual host (sheep) or in humans, and analyse the epidemiology, the symptomatology and the treatment of human oestrosis...
  56. ncbi The relationship between faecal egg counts, worm burden and tissue egg counts in early Schistosoma mattheei infections in cattle
    J De Bont
    Centre d Immunologie et de Biologie Parasitaire, Inserm IPL U547, Institut Pasteur de Lille, 1, rue du Professeur Calmette, BP 245, 59019 Cedex, Lille, France
    Acta Trop 81:63-76. 2002
    ..For all three sets of comparisons the predictability of one parameter based on another was poor for a single sample...
  57. pmc Automated high-throughput genotyping for study of global epidemiology of Mycobacterium tuberculosis based on mycobacterial interspersed repetitive units
    P Supply
    Laboratoire des Mécanismes Moléculaires de la Pathogenèse Bactérienne, INSERM U447, Institut Pasteur de Lille, F 59019 Lille cedex, France
    J Clin Microbiol 39:3563-71. 2001
    ..tuberculosis MIRU-VNTR genotypes via the Internet. This opens the way for global epidemiological surveillance of tuberculosis and should lead to novel insights into the evolutionary and population genetics of this major pathogen...
  58. pmc Molecular characterization of Cryptosporidium isolates obtained from humans in France
    K Guyot
    Ecologie du Parasitisme, Institut Pasteur de Lille, BP 245, 59019 Lille, France
    J Clin Microbiol 39:3472-80. 2001
    ..This is the first report of the last three species of Cryptosporidium in humans in France. These results indicate that immunocompromised individuals are susceptible to a wide range of Cryptosporidium species and genotypes...
  59. ncbi High resolution magic angle spinning NMR in combinatorial chemistry
    G Lippens
    UMR CNRS 8525, IBL, Pasteur Institute of Lille, 1, rue du Professeur Calmette, 59019 Lille Cedex, France
    Comb Chem High Throughput Screen 4:333-51. 2001
    ..The applications of HRMAS NMR to different solid supports that are used in combinatorial chemistry will be described in terms of rapidity, robustness and sensitivity...
  60. ncbi Peroxisome proliferator-activated receptors (PPARs): nuclear receptors with functions in the vascular wall
    G Chinetti
    U 325 INSERM, Institut Pasteur de Lille 1, rue Calmette BP245, 59019 Lille, France
    Z Kardiol 90:125-32. 2001
    ..In this review, we summarize the evidence indicating that PPAR alpha and PPAR gamma directly modulate vessel wall functions, and its consequences in the control of cardiovascular disease...
  61. ncbi Fh-Souassi: a founder frameshift mutation in exon 10 of the LDL-receptor gene, associated with a mild phenotype in Tunisian families
    M N Slimane
    Laboratoire de Biochimie, Faculte de medecine de Monastir, 5019, Monastir, Tunisia
    Atherosclerosis 154:557-65. 2001
    ..7+/-1.3 mmol/l) without taking any lipid-lowering medication. This mild clinical phenotype which contrasted with the severity of the mutation, could not be explained by specific apolipoprotein E or lipoprotein lipase alleles...
  62. ncbi A virtual screening approach applied to the search for trypanothione reductase inhibitors
    D Horvath
    CEREP Lille, France
    J Med Chem 40:2412-23. 1997
    ..The docking model has also been used to obtain hints about the binding modes of TR ligands...