Institut Pasteur

Summary

Organization: Institut Pasteur
Country: France

Top Publications

  1. pmc Revisiting HIV-1 uncoating
    Nathalie Arhel
    Department of Virology, URA3015, Institut Pasteur, 25 28 rue du Dr, Roux, 75015 Paris, France
    Retrovirology 7:96. 2010
  2. pmc The Ferrier Lecture 1998. The molecular biology of consciousness investigated with genetically modified mice
    Jean Pierre Changeux
    Institut Pasteur and Collège de France, 25 rue du Dr Roux, 75724 Cedex 15, Paris, France
    Philos Trans R Soc Lond B Biol Sci 361:2239-59. 2006
  3. ncbi Early trafficking events of Mycobacterium ulcerans within Naucoris cimicoides
    Laurent Marsollier
    Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, Paris, France
    Cell Microbiol 9:347-55. 2007
  4. ncbi Emile Brumpt's contribution to the characterization of parasitic diseases in Brazil, 1909-1914
    A Opinel
    Centre de Recherches historiques, Institut Pasteur, Paris, France
    Parassitologia 47:299-307. 2005
  5. ncbi Biofilms and their role in the resistance of pathogenic Candida to antifungal agents
    Christophe d'Enfert
    Unité Postulante Biologie et Pathogénicité Fongiques, INRA USC 2019, Institut Pasteur, Paris, France
    Curr Drug Targets 7:465-70. 2006
  6. ncbi [Travel in tropical countries. Advice before start, diseases on return: fever, diarrhea]
    Paul Henri Consigny
    Consultation de pathologie infectieuse, Tropicale et de Médecine des voyages, Centre Médical de l Institut Pasteur, Paris
    Rev Prat 56:59-70, 94. 2006
  7. ncbi [Natural selection of DC-SIGN and its homologues L-SIGN and mSIGNR1 in pathogen recognition and innate immunity]
    Lluis Quintana-Murci
    CNRS FRE2849, Unité de prévention et thérapie moléculaires des maladies humaines, Institut Pasteur, Paris, France
    Med Sci (Paris) 22:29-32. 2006
  8. pmc A malaria vaccine that elicits in humans antibodies able to kill Plasmodium falciparum
    Pierre Druilhe
    Biomedical Parasitology Unit, Pasteur Institute, Paris, France
    PLoS Med 2:e344. 2005
  9. ncbi Identification of the critical residues involved in peptidoglycan detection by Nod1
    Stephen E Girardin
    Unite de Pathogenie Microbienne Moleculaire, INSERM U389, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Biol Chem 280:38648-56. 2005
  10. ncbi Inducible lymphoid tissues in the adult gut: recapitulation of a fetal developmental pathway?
    Gerard Eberl
    Laboratory of Lymphoid Tissue Development, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris, France
    Nat Rev Immunol 5:413-20. 2005

Research Grants

Detail Information

Publications62

  1. pmc Revisiting HIV-1 uncoating
    Nathalie Arhel
    Department of Virology, URA3015, Institut Pasteur, 25 28 rue du Dr, Roux, 75015 Paris, France
    Retrovirology 7:96. 2010
    ....
  2. pmc The Ferrier Lecture 1998. The molecular biology of consciousness investigated with genetically modified mice
    Jean Pierre Changeux
    Institut Pasteur and Collège de France, 25 rue du Dr Roux, 75724 Cedex 15, Paris, France
    Philos Trans R Soc Lond B Biol Sci 361:2239-59. 2006
    ..In addition, the contribution of defined neuronal nicotinic receptors species to some of these processes is demonstrated and the data discussed within the framework of recent neurocomputational models for access to consciousness...
  3. ncbi Early trafficking events of Mycobacterium ulcerans within Naucoris cimicoides
    Laurent Marsollier
    Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, Paris, France
    Cell Microbiol 9:347-55. 2007
    ..ulcerans into the HC, in contrast to the next step, colonization of the salivary glands; second, M. ulcerans clusters bind a member of the serpin protein family present in the salivary gland homogenate...
  4. ncbi Emile Brumpt's contribution to the characterization of parasitic diseases in Brazil, 1909-1914
    A Opinel
    Centre de Recherches historiques, Institut Pasteur, Paris, France
    Parassitologia 47:299-307. 2005
    ..We will set the paper on a part of Brumpt's photographic archives which he constitued during his missions to South America between 1913 and 1914...
  5. ncbi Biofilms and their role in the resistance of pathogenic Candida to antifungal agents
    Christophe d'Enfert
    Unité Postulante Biologie et Pathogénicité Fongiques, INRA USC 2019, Institut Pasteur, Paris, France
    Curr Drug Targets 7:465-70. 2006
    ..The original physiology of mature Candida biofilms is mirrored by specific gene expression patterns that may pinpoint genes important for the acquisition of pleiotropic antifungal resistance...
  6. ncbi [Travel in tropical countries. Advice before start, diseases on return: fever, diarrhea]
    Paul Henri Consigny
    Consultation de pathologie infectieuse, Tropicale et de Médecine des voyages, Centre Médical de l Institut Pasteur, Paris
    Rev Prat 56:59-70, 94. 2006
  7. ncbi [Natural selection of DC-SIGN and its homologues L-SIGN and mSIGNR1 in pathogen recognition and innate immunity]
    Lluis Quintana-Murci
    CNRS FRE2849, Unité de prévention et thérapie moléculaires des maladies humaines, Institut Pasteur, Paris, France
    Med Sci (Paris) 22:29-32. 2006
  8. pmc A malaria vaccine that elicits in humans antibodies able to kill Plasmodium falciparum
    Pierre Druilhe
    Biomedical Parasitology Unit, Pasteur Institute, Paris, France
    PLoS Med 2:e344. 2005
    ..The corresponding long synthetic peptide was administered to 36 volunteers, with either alum or Montanide ISA720 as adjuvant...
  9. ncbi Identification of the critical residues involved in peptidoglycan detection by Nod1
    Stephen E Girardin
    Unite de Pathogenie Microbienne Moleculaire, INSERM U389, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Biol Chem 280:38648-56. 2005
    ....
  10. ncbi Inducible lymphoid tissues in the adult gut: recapitulation of a fetal developmental pathway?
    Gerard Eberl
    Laboratory of Lymphoid Tissue Development, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris, France
    Nat Rev Immunol 5:413-20. 2005
    ..I propose that this network is induced by cryptopatches, which are small clusters of dendritic cells and lymphoid cells that are identical to fetal inducers of lymph-node and Peyer's-patch development...
  11. ncbi Phase-response curves give the responses of neurons to transient inputs
    Boris S Gutkin
    Receptors and Cognition, Department of Neuroscience, Institut Pasteur, 75015 Paris, France
    J Neurophysiol 94:1623-35. 2005
    ..This implies that the neuron is more of a coincidence detector at low firing frequencies and more of an integrator at high frequencies. The steady-state theory is shown to also hold for slowly varying inputs...
  12. pmc Covert human immunodeficiency virus replication in dendritic cells and in DC-SIGN-expressing cells promotes long-term transmission to lymphocytes
    Cinzia Nobile
    Institut Pasteur, Groupe Virus et Immunité, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Virol 79:5386-99. 2005
    ..The cell-type-dependent activity of DC-SIGN reflects the ability of HIV to replicate covertly in some cells, and not in others...
  13. ncbi Identification of multiple chondroitin sulfate A (CSA)-binding domains in the var2CSA gene transcribed in CSA-binding parasites
    Benoit Gamain
    Unité de Biologie des Interactions Hôte Parasite, URA 2581, Institut Pasteur, Paris, France
    J Infect Dis 191:1010-3. 2005
    ..The identification of multiple binding domains in var2CSA strengthens the evidence for their involvement in malaria during pregnancy and may have applications for the development of a vaccine against malaria in pregnancy...
  14. ncbi Pharmacological properties of homomeric and heteromeric pannexin hemichannels expressed in Xenopus oocytes
    Roberto Bruzzone
    Department of Neuroscience, Institut Pasteur, Paris, France
    J Neurochem 92:1033-43. 2005
    ..The opposite was true in the case of connexin46 (Cx46), thus indicating that gap junction blockers are able to selectively modulate pannexin and connexin channels...
  15. ncbi Quality assessed nonculture techniques for detection and typing of meningococci
    Muhamed Kheir Taha
    Neisseria Unit and National Reference Center for Meningococci, Institut Pasteur, Paris, France
    FEMS Microbiol Rev 31:37-42. 2007
    ..The European Monitoring Group on Meningococci has provided a good forum to conduct such studies through the development and distribution of samples and protocols for nonculture detection and typing of N. meningitidis...
  16. ncbi Antibiotic resistance: the pros and cons of probiotics
    Patrice Courvalin
    Unite des Agents Antibacteriens, Institut Pasteur, 25 28 Rue du Docteur Roux, 75724 Paris Cedex 15, France
    Dig Liver Dis 38:S261-5. 2006
    ..This article reviews the experiments to be performed and the criteria for assessment of safety of antibiotic resistant probiotics...
  17. pmc Persistence drives gene clustering in bacterial genomes
    Gang Fang
    Génétique des Génomes Bactériens, Institut Pasteur, 28 rue du Dr, Roux, 75724 Paris Cedex 15, France
    BMC Genomics 9:4. 2008
    ..However, genomes harbor two very different categories of genes: those genes present in a majority of organisms - persistent genes - and those present in very few organisms - rare genes...
  18. pmc Immune status in sepsis: the bug, the site of infection and the severity can make the difference
    Jean Marc Cavaillon
    Département Infection et Epidémiologie, Unité Cytokines and Inflammation, Institut Pasteur, 28 rue Dr, Roux F 75015 Paris, France
    Crit Care 14:167. 2010
    ..Their study illustrates the heterogeneity of patients with sepsis and points out that numerous key parameters of severe infection influence immune status...
  19. ncbi Entomology in translation: interpreting French medical entomological knowledge in colonial Mali
    T Giles-Vernick
    Unité d Epidémiologie des Maladies Emergentes, Institut Pasteur, Paris, France
    Parassitologia 50:281-90. 2008
    ....
  20. doi Rac1 inactivation by lethal toxin from Clostridium sordellii modifies focal adhesions upstream of actin depolymerization
    Blandine Geny
    Unité des Bactéries anaérobies et Toxines, Department of Microbiology, Institut Pasteur, 25 rue du Docteur Roux, Paris Cedex 15, France
    Cell Microbiol 12:217-32. 2010
    ..Therefore, we proposed that Rac inactivation by LT-82 alters phosphoinositide metabolism leading to FA and AJ complex disorganization and actin depolymerization...
  21. doi Transposition of fly mariner elements into bacteria as a genetic tool for mutagenesis
    Mathieu Picardeau
    Unité de Biologie des Spirochètes, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Genetica 138:551-8. 2010
    ..Transposon-based approaches greatly facilitate studies of bacterial biology. We summarize the current mariner-based transposon tools and techniques for conducting genetic studies in bacteria...
  22. doi Learning tolerance while fighting ignorance
    Philippe J Sansonetti
    Unite de Pathogenie Microbienne Moleculaire, Institut Pasteur, 75724 Paris Cedex 15, France Microbiologie et Maladies Infectieuses, College de France, 75231 Paris Cedex 05, France
    Cell 138:416-20. 2009
    ..It is becoming clear that the host immune system must reach a delicate balance between destroying dangerous bacterial pathogens while preserving the beneficial gut microbiota...
  23. ncbi ADAM9 as a potential target molecule in cancer
    Lucie Peduto
    Institut Pasteur, Laboratory of Lymphoid Tissue Development, CNRS URA1961, Paris, France
    Curr Pharm Des 15:2282-7. 2009
    ..Its role in the shedding of cell surface molecules will be discussed along with emerging aspects of regulation and possible functions in cancer development...
  24. pmc Mitochondrial and Y-chromosome diversity of the Tharus (Nepal): a reservoir of genetic variation
    Simona Fornarino
    Dipartimento di Genetica e Microbiologia, Universita di Pavia, Pavia, Italy
    BMC Evol Biol 9:154. 2009
    ..Until now, however, investigations on their genetic structure have been scarce mainly identifying East Asian signatures...
  25. doi [The immune system of teleost fish]
    Jean Pierre Levraud
    Unité Macrophages et Développement de l Immunité, Institut Pasteur, CNRS URA2578, 75015 Paris, France
    Med Sci (Paris) 25:405-11. 2009
    ....
  26. ncbi Patterns and rates of nucleotide substitution, insertion and deletion in the endosymbiont of ants Blochmannia floridanus
    L Gomez-Valero
    Biologie des Bactéries Intracellulaires, Institute Pasteur, 28 rue du Dr Roux, 75724 Paris, France
    Mol Ecol 17:4382-92. 2008
    ..Accordingly, we found intrapopulational polymorphisms for the detected microsatellites in contrast to the stability associated with these in free-living bacteria such as Escherichia coli...
  27. doi Shigella type III secretion effectors: how, where, when, for what purposes?
    Claude Parsot
    Institut Pasteur, Unite de Pathogenie Microbienne Moleculaire, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Curr Opin Microbiol 12:110-6. 2009
    ..Schematically, effectors involved in entry are produced independently of the T3SA activity, whereas effectors involved in controlling the cell responses are produced upon activation of the T3SA...
  28. doi Epidemiological analysis of Salmonella enterica from beef sampled in the slaughterhouse and retailers in Dakar (Senegal) using pulsed-field gel electrophoresis and antibiotic susceptibility testing
    Antoine Stevens
    Institut Pasteur de Dakar, 36 Avenue Pasteur, BP 220, Dakar, Senegal
    Int J Food Microbiol 123:191-7. 2008
    ....
  29. doi Nicotinic receptors, allosteric proteins and medicine
    Jean Pierre Changeux
    Research Unit, National Center of Scientific Research 2182, Department of Neuroscience, Pasteur Institute, Paris, France
    Trends Mol Med 14:93-102. 2008
    ....
  30. doi [The experimental populations of genetic mapping]
    Xavier Montagutelli
    Unité postulante de Génétique fonctionnelle de la Souris, CNRS URA 2578, Institut Pasteur, 25 rue du Docteur Roux, Paris Cedex 15, France
    Med Sci (Paris) 24:77-80. 2008
  31. ncbi Death-defying immunity: do apoptotic cells influence antigen processing and presentation?
    Matthew L Albert
    INSERM AVEN0201, Laboratoire d Immunobiologie des Cellules Dendritiques, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Nat Rev Immunol 4:223-31. 2004
  32. ncbi CAAT-Box, Contigs-Assembly and Annotation Tool-Box for genome sequencing projects
    L Frangeul
    Genopole, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris 15, France
    Bioinformatics 20:790-7. 2004
    ..Using this strategy, the user works with a group of IPFs independently of the closure phase progression. The IPFs are accessible by a web server and can therefore be modified and commented by different groups...
  33. ncbi Prochlorococcus marinus Chisholm et al. 1992 subsp. pastoris subsp. nov. strain PCC 9511, the first axenic chlorophyll a2/b2-containing cyanobacterium (Oxyphotobacteria)
    R Rippka
    CNRS URA 1129, Département de Biochimie et Génétique moléculaire, Institut Pasteur, Paris, France
    Int J Syst Evol Microbiol 50:1833-47. 2000
    ..In order to distinguish strain PCC 9511 from the nomenclatural type, a new subspecies is proposed, Prochlorococcus marinus Chisholm et al. 1992 subsp. pastoris subsp. nov...
  34. ncbi Comparison of conserved structural and regulatory domains within divergent 16S rRNA-23S rRNA spacer sequences of cyanobacteria
    I Iteman
    Unité de Physiologie Microbienne CNRS URA 1129, Département de Biochimie et Génétique moléculaire, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    Microbiology 146:1275-86. 2000
    ..The conserved and variable regions of the cyanobacterial ITS are potential targets of PCR primers and oligonucleotide probes for detection and identification of cyanobacteria at different taxonomic levels...
  35. ncbi Myf5 is a novel early axonal marker in the mouse brain and is subjected to post-transcriptional regulation in neurons
    P Daubas
    CNRS URA 1947, Department de Biologie Moleculaire, Institut Pasteur, 75724 Paris Cedex 15, France
    Development 127:319-31. 2000
    ..This phenomenon may be widespread and it remains to be seen how many other potentially potent regulatory genes, in addition to Myf5, when activated do not accumulate protein at inappropriate sites in the embryo...
  36. ncbi Entry of human cytomegalovirus into retinal pigment epithelial and endothelial cells by endocytosis
    B Bodaghi
    Unite d Immunologie Virale, Institut Pasteur, Paris, France
    Invest Ophthalmol Vis Sci 40:2598-607. 1999
    ..This study analyzes the kinetics and mechanisms of HCMV entry into both cell types...
  37. ncbi Intranasal murine model of Bordetella pertussis infection. I. Prediction of protection in human infants by acellular vaccines
    N Guiso
    Laboratoire des Bordetella, Institut Pasteur, Paris, France
    Vaccine 17:2366-76. 1999
    ..Pertactin had a synergistic effect with bicomponent DTPa. Intranasal challenge may be useful as part of the preclinical evaluation of new acellular pertussis formulations or DTPa-based combinations...
  38. ncbi Immunochemical, structural and translocating properties of anti-DNA antibodies from (NZBxNZW)F1 mice
    T Ternynck
    Unités d Immunocytochimie, Departement d Immunologie, Institut Pasteur, Paris, 75015, France
    J Autoimmun 11:511-21. 1998
    ..Although all CDR2-3 reacted with dsDNA and other self antigens, each one exhibited a distinct polyreactivity profile...
  39. pmc The introduction into bacillus sphaericus of the Bacillus thuringiensis subsp. medellin Cyt1Ab1 gene results in higher susceptibility of resistant mosquito larva populations to B. sphaericus
    I Thiery
    Unité des Bactéries Entomopathogènes, Institut Pasteur, 75724 Paris Cedex 15, France
    Appl Environ Microbiol 64:3910-6. 1998
    ..sphaericus recombinant strain...
  40. ncbi Mechanisms for positional signalling by morphogen transport: a theoretical study
    M Kerszberg
    Neurobiologie moleculaire, Institut Pasteur, 25 rue du Docteur Roux, Paris Cedex 15, F 75724, France
    J Theor Biol 191:103-14. 1998
    ....
  41. ncbi A recombinant virus-like particle system derived from parvovirus as an efficient antigen carrier to elicit a polarized Th1 immune response without adjuvant
    R Lo-Man
    Unité de Biologie des Régulations Immunitaires, Institut Pasteur, Paris, France
    Eur J Immunol 28:1401-7. 1998
    ..These results give some indication of how PPV:VLP can be presented by MHC class I and class II molecules, and underscore the wide potency of such VLP system to deliver foreign antigens for vaccine design...
  42. ncbi A genetic system that reports transient activation of genes in Bacillus
    S Salamitou
    Unité de Biochimie Microbienne, Institut Pasteur, Paris, France
    Gene 202:121-6. 1997
    ..Thus, this system can be used to identify genes which are transiently or conditionally expressed...
  43. pmc Interaction between Entamoeba histolytica and intestinal epithelial cells involves a CD44 cross-reactive protein expressed on the parasite surface
    P Renesto
    Unite de Pathogenie Microbienne Moleculaire, Institut National de la Sante et de la Recherche Medicale U389, Institut Pasteur, Paris, France
    Infect Immun 65:4330-3. 1997
    ..The binding molecule was identified as an 80-kDa membrane protein and was recognized by anti-CD44 monoclonal antibodies. These data indicate that a CD44 cross-reacting adherence molecule is expressed on E. histolytica...
  44. ncbi IL-10: a potential therapy for allergic inflammation?
    M Pretolani
    Unite de Pharmacologie Cellulaire, Unité Associée Institut Pasteur INSERM U285, Institut Pasteur, Paris, France
    Immunol Today 18:277-80. 1997
  45. pmc A recombinant Bacillus anthracis strain producing the Clostridium perfringens Ib component induces protection against iota toxins
    J C Sirard
    Unité des Toxines et Pathogénie Bactériennes, URA1858, Centre National de la Recherche Scientifique, Institut Pasteur, Paris
    Infect Immun 65:2029-33. 1997
    ..perfringens iota toxin or with the homologous Clostridium spiroforme toxin. The protective immunity was mediated by neutralizing antibodies. In conclusion, B. anthracis is promising for the development of live veterinary vaccines...
  46. ncbi Molecular characterization and phylogenetic analyses of a new simian T cell lymphotropic virus type 1 in a wild-caught african baboon (Papio anubis) with an indeterminate STLV type 2-like serology
    R Mahieux
    Unité d Oncologie Virale, Institut Pasteur, 75724 Paris Cedex 15, France
    AIDS Res Hum Retroviruses 16:2043-8. 2000
    ..The complete p19 sequence reveals amino acid changes at critical positions. This is the first report of an African STLV-1 virus leading to an STLV-2-like serological profile in its host...
  47. ncbi Retroviral recombination: what drives the switch?
    M Negroni
    Department of Molecular Biology, Institut Pasteur, 75724 Paris 15, France
    Nat Rev Mol Cell Biol 2:151-5. 2001
    ..Although the mechanism that leads to this switch is still a matter of debate, there is increasing evidence that specific RNA structures are involved. And the implications might go beyond retroviral genetic variability...
  48. ncbi Cultured myf5 null and myoD null muscle precursor cells display distinct growth defects
    D Montarras
    Laboratoire de développement cellulaire URA 1947, Institut Pasteur, Paris, France
    Biol Cell 92:565-72. 2000
    ..That a null mutation in either gene reduces the proliferative potential of cultured myoblasts raises the possibility that Myf-5 and MyoD serve proliferation of muscle precursor cells...
  49. ncbi Immunoproliferative small intestinal disease associated with Campylobacter jejuni
    Marc Lecuit
    Hopital Avicenne, Paris, France
    N Engl J Med 350:239-48. 2004
    ..Early-stage disease responds to antibiotics, suggesting a bacterial origin. We attempted to identify a causative agent...
  50. ncbi The spirochetal chpK-chromosomal toxin-antitoxin locus induces growth inhibition of yeast and mycobacteria
    Mathieu Picardeau
    Unité de bactériologie moléculaire et médicale, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris15, France
    FEMS Microbiol Lett 229:277-81. 2003
    ..These results show that ChpK possesses a broad activity against both prokaryotes and eukaryotes, suggesting that the cellular target of the toxin is conserved in these organisms...
  51. ncbi Genetic evidence for the existence of two pathways for the biosynthesis of methionine in the Leptospira spp
    Mathieu Picardeau
    Unité de bactériologie moléculaire et médicale, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
    FEMS Microbiol Lett 225:257-62. 2003
    ..In addition, a L. interrogans gene, called metZ, was found to complement an Escherichia coli metB mutant, further suggesting that the transsulfuration pathway is also present in Leptospira spp...
  52. ncbi [The mouse as a model for heart morphogenesis in mammals: the origin of myocytes and studies with cardiac explants]
    Stephane Zaffran
    CNRS URA 2578, Departement de Biologie du Developpement, Institut Pasteur, 25, rue du Dr Roux, Paris, 75015 France
    J Soc Biol 197:187-94. 2003
    ..The Mlc3f-nlacZ-2 line, which marks the right atrium, allowed us to determine the time window during which left-right signaling confers left-right atrial identity...
  53. ncbi A highly efficient, stable, and rapid approach for ex vivo human liver gene therapy via a FLAP lentiviral vector
    Carlo Giannini
    PASTEUR INSERM Unité 370, Necker Institute, Paris, France
    Hepatology 38:114-22. 2003
    ..This work therefore opens new perspectives for the development of human clinical trials based on liver-directed ex vivo gene therapy...
  54. ncbi Genes, neurons and codes: remarks on biological communication
    Michel Kerszberg
    Recepteurs et Cognition, Institut Pasteur, 25 rue du Docteur Roux, F 75724 Paris Cedex 15, France
    Bioessays 25:699-708. 2003
    ..I suggest that collective oscillatory modes may play a role in solving this addressing problem, in the same way that the clock signal gates the operation of man-made computers...
  55. ncbi Folding and aggregation of export-defective mutants of the maltose-binding protein
    Jean Michel Betton
    Unité de Repliement et de Modélisation des Protéines, Institut Pasteur, CNRS URA 2185, Paris, France
    Res Microbiol 153:399-404. 2002
    ..Our results are most easily interpreted by a kinetic competition between exportation, folding, and degradation...
  56. ncbi Phylogenetic and functional classification of ATP-binding cassette (ABC) systems
    Philippe Bouige
    Unite de Programmation Moleculaire et Toxicologie Genetique, CNRS URA 1444, Institut Pasteur, 25, rue du Dr Roux, 7572, Paris, Cedex 15, France
    Curr Protein Pept Sci 3:541-59. 2002
    ..This analysis will be helpful to accurately annotate ABC systems discovered during the sequencing of the genome of living organisms and to identify the partners of the ABC ATPases...
  57. ncbi Evolution of the gyrB gene and the molecular phylogeny of Enterobacteriaceae: a model molecule for molecular systematic studies
    Catherine Dauga
    Unité INSERM 389, Institut Pasteur, Paris, France
    Int J Syst Evol Microbiol 52:531-47. 2002
    ....
  58. ncbi Efficient in vivo priming of specific cytotoxic T cell responses by neonatal dendritic cells
    Gilles Dadaglio
    Unit of Biology of Immune Regulations, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Immunol 168:2219-24. 2002
    ..Although a reduced number of these cells was observed in the spleen of neonatal mice as compared with adults, this study clearly shows that neonatal DC have full functional capacity and may well prime Ag-specific naive T cells in vivo...
  59. ncbi Epaxial-adaxial-hypaxial regionalisation of the vertebrate somite: evidence for a somitic organiser and a mirror-image duplication
    R Spörle
    Institute of Mammalian Genetics, GSF Research Center for Environment and Health, Ingolstadter Landstrasse 1, 85764 Neuherberg, Germany
    Dev Genes Evol 211:198-217. 2001
    ....
  60. ncbi Kallmann syndrome: towards molecular pathogenesis
    J P Hardelin
    Unité de Génétique des Déficits Sensoriels, CNRS URA 1968, Institut Pasteur, 25, rue du Dr Roux, 75724 Paris Cedex 15, France
    Mol Cell Endocrinol 179:75-81. 2001
    ..Based on the distribution of anosmin-1 in the early olfactory system, the pathogenesis of the olfactory loss and GnRH deficiency in X-linked Kallmann syndrome is discussed...
  61. ncbi Scale invariance in biology: coincidence or footprint of a universal mechanism?
    T Gisiger
    Groupe de Physique des Particules, Universite de Montreal, Quebec, Canada
    Biol Rev Camb Philos Soc 76:161-209. 2001
    ..This article also discusses how the notion of scale invariance can give important insights into the workings of biological systems...
  62. ncbi The pilA regulatory gene modulates the pilus-mediated adhesion of Neisseria meningitidis by controlling the transcription of pilC1
    M K Taha
    unité des Neisseria, Institut Pasteur, Paris, France
    Mol Microbiol 19:1073-84. 1996
    ..Thus, in addition to phase variation, a more co-ordinate and responsive system may allow a fine adaptation of adhesiveness of meningococci to various environmental signals...

Research Grants2

  1. Conformational changes in the ACh binding protein
    BRIAN MOLLES; Fiscal Year: 2005
    ..The experiments proposed will determine if the the AchBP provides a model for receptor function as well as its structure, and may provide insights into the shape of the binding site of this large and important receptor family. ..