Institut de Recherches Servier

Summary

Organization: Institut de Recherches Servier
Country: France

Top Publications

  1. doi DRUG FOCUS: S 18986: A positive allosteric modulator of AMPA-type glutamate receptors pharmacological profile of a novel cognitive enhancer
    Katy Bernard
    Institut de Recherches Internationales Servier, Courbevoie, France
    CNS Neurosci Ther 16:e193-212. 2010
  2. ncbi Discriminative stimulus properties of the selective and highly potent alpha2-adrenoceptor agonist, S18616, in rats: mediation by the alpha2A subtype, and blockade by the atypical antidepressants, mirtazapine and mianserin
    Anne Dekeyne
    Institut de Recherches Servier, Centre de Recherches de Croissy, Psychopharmacology Department, 125, Chemin de Ronde, 78290 Croissy sur Seine, Paris, France
    Neuropharmacology 51:718-26. 2006
  3. ncbi Therapeutic potential of melatonin ligands
    Philippe Delagrange
    Département des Sciences Expérimentales, Institut de Recherches Servier, Suresnes, France
    Chronobiol Int 23:413-8. 2006
  4. pmc Assessment of some tools for the characterization of the human osteoarthritic cartilage proteome
    Frederic De Ceuninck
    Institut de Recherches Servier, Division de Rhumatologie, 11 rue des Moulineaux, 92150 Suresnes, France
    J Biomol Tech 16:256-65. 2005
  5. ncbi Serotonin 5-HT2C receptors as a target for the treatment of depressive and anxious states: focus on novel therapeutic strategies
    Mark John Millan
    Institut de Recherches Servier, Croissy sur Seine, France
    Therapie 60:441-60. 2005
  6. ncbi [The discovery of the selective If current inhibitor ivabradine (Procoralan): a new therapeutic approach to ischemic heart disease]
    Jean Paul Vilaine
    Institut de Recherches Servier, Division Pathologies Cardiaques et Vasculaires, Suresnes, France
    Med Sci (Paris) 22:87-94. 2006
  7. ncbi In vivo neuroprotective effects of the novel imidazolyl nitrone free-radical scavenger (Z)-alpha-[2-thiazol-2-yl)imidazol-4-yl]-N-tert-butylnitrone (S34176)
    Brian Lockhart
    Division of Cerebral Pathology, 125, Chemin de Ronde, 78290 Croissy sur Seine, France
    Eur J Pharmacol 511:127-36. 2005
  8. ncbi [Selection and pharmacological characterisation of Procoralan, a selective inhibitor of the pacemaker If current]
    Jean Paul Vilaine
    Institut de Recherches Servier, Division Pathologies Cardiaques et Vasculaires, Suresnes, France
    Therapie 59:495-505. 2004
  9. ncbi Cdk1 and Cdk2 complexes (cyclin dependent kinases) in apoptosis: a role beyond the cell cycle
    Roy M Golsteyn
    Cancer Research Division, Institut de Recherches Servier, 125 ch de Ronde, Croissy sur Seine, Paris F 78290, France
    Cancer Lett 217:129-38. 2005
  10. ncbi Quantification and pharmacological characterization of dialysate levels of noradrenaline in the striatum of freely-moving rats: release from adrenergic terminals and modulation by alpha2-autoreceptors
    Alain Gobert
    Psychopharmacology Department, Institut de Recherches Servier, Centre de Recherches de Croissy, 125 Chemin de Ronde, Croissy Seine 78290, France
    J Neurosci Methods 140:141-52. 2004

Detail Information

Publications62

  1. doi DRUG FOCUS: S 18986: A positive allosteric modulator of AMPA-type glutamate receptors pharmacological profile of a novel cognitive enhancer
    Katy Bernard
    Institut de Recherches Internationales Servier, Courbevoie, France
    CNS Neurosci Ther 16:e193-212. 2010
    ..From these results, S 18986 is expected to treat memory deficits associated with early cerebral aging and neurological diseases in elderly people...
  2. ncbi Discriminative stimulus properties of the selective and highly potent alpha2-adrenoceptor agonist, S18616, in rats: mediation by the alpha2A subtype, and blockade by the atypical antidepressants, mirtazapine and mianserin
    Anne Dekeyne
    Institut de Recherches Servier, Centre de Recherches de Croissy, Psychopharmacology Department, 125, Chemin de Ronde, 78290 Croissy sur Seine, Paris, France
    Neuropharmacology 51:718-26. 2006
    ..In conclusion, S18616 elicits a robust DS in rats that principally reflects engagement of alpha2A-ARs. This novel procedure should prove useful in the characterisation of psychoactive drugs which interact with alpha2-ARs...
  3. ncbi Therapeutic potential of melatonin ligands
    Philippe Delagrange
    Département des Sciences Expérimentales, Institut de Recherches Servier, Suresnes, France
    Chronobiol Int 23:413-8. 2006
    ..The development of specific ligands for each of these melatonin binding sites is necessary to link physiological and/or therapeutic effects...
  4. pmc Assessment of some tools for the characterization of the human osteoarthritic cartilage proteome
    Frederic De Ceuninck
    Institut de Recherches Servier, Division de Rhumatologie, 11 rue des Moulineaux, 92150 Suresnes, France
    J Biomol Tech 16:256-65. 2005
    ....
  5. ncbi Serotonin 5-HT2C receptors as a target for the treatment of depressive and anxious states: focus on novel therapeutic strategies
    Mark John Millan
    Institut de Recherches Servier, Croissy sur Seine, France
    Therapie 60:441-60. 2005
    ....
  6. ncbi [The discovery of the selective If current inhibitor ivabradine (Procoralan): a new therapeutic approach to ischemic heart disease]
    Jean Paul Vilaine
    Institut de Recherches Servier, Division Pathologies Cardiaques et Vasculaires, Suresnes, France
    Med Sci (Paris) 22:87-94. 2006
    ....
  7. ncbi In vivo neuroprotective effects of the novel imidazolyl nitrone free-radical scavenger (Z)-alpha-[2-thiazol-2-yl)imidazol-4-yl]-N-tert-butylnitrone (S34176)
    Brian Lockhart
    Division of Cerebral Pathology, 125, Chemin de Ronde, 78290 Croissy sur Seine, France
    Eur J Pharmacol 511:127-36. 2005
    ....
  8. ncbi [Selection and pharmacological characterisation of Procoralan, a selective inhibitor of the pacemaker If current]
    Jean Paul Vilaine
    Institut de Recherches Servier, Division Pathologies Cardiaques et Vasculaires, Suresnes, France
    Therapie 59:495-505. 2004
    ..Ivabradine exerts a similar anti-ischaemic activity in exercise-induced myocardial ischaemia in pigs to that of a beta-blocker and, furthermore, it limits to a greater extent ischaemic myocardial contractile dysfunction...
  9. ncbi Cdk1 and Cdk2 complexes (cyclin dependent kinases) in apoptosis: a role beyond the cell cycle
    Roy M Golsteyn
    Cancer Research Division, Institut de Recherches Servier, 125 ch de Ronde, Croissy sur Seine, Paris F 78290, France
    Cancer Lett 217:129-38. 2005
    ..By understanding how Cdks function during apoptosis it may be possible to optimise the use of these inhibitors in treating human tumours by blocking proliferation but permitting apoptosis...
  10. ncbi Quantification and pharmacological characterization of dialysate levels of noradrenaline in the striatum of freely-moving rats: release from adrenergic terminals and modulation by alpha2-autoreceptors
    Alain Gobert
    Psychopharmacology Department, Institut de Recherches Servier, Centre de Recherches de Croissy, 125 Chemin de Ronde, Croissy Seine 78290, France
    J Neurosci Methods 140:141-52. 2004
    ..A role of dopaminergic terminals in the reuptake of NA likely explains the elevation in its levels elicited by DA reuptake-inhibitors and D3/D2 receptor antagonists...
  11. ncbi Recent advances in cancer research
    Roy M Golsteyn
    Cancer Research Division, Institut de Recherches Servier, Croissy sur Seine, France
    Drug News Perspect 17:405-16. 2004
    ..A selection from the many excellent presentations and posters are described with an emphasis on new compounds, new methods to identify cancers, and recent discoveries that may change how we treat cancer...
  12. ncbi Current status of drug receptor nomenclature: receptor closure? The role of NC-IUPHAR
    Michael Spedding
    Institut de Recherches Internationales Servier, 29 31 rue du Pont, 92578 Neuilly Sur Seine Cedex, France
    Expert Opin Investig Drugs 13:461-4. 2004
    ..A major new effort is to functionally define relevant receptor polymorphisms. This initiative is open to all, and works only because of the freely given voluntary effort of scientists...
  13. ncbi [Communication between endothelial and smooth muscle cells]
    Michel Feletou
    Institut de Recherches Servier, 92150 Suresnes, France
    Med Sci (Paris) 19:1242-50. 2003
    ..The discovery of specific inhibitors of the endothelial cell hyperpolarization allows the assessment of the contribution of EDHF-mediated responses in the control of vascular tone...
  14. ncbi Protein tyrosine phosphatase 1B inhibitors for the treatment of type 2 diabetes and obesity: recent advances
    Elizabeth A Harley
    Institut de Recherches Servier, 11 rue des Moulineaux, 92150 Suresnes, France
    Curr Opin Investig Drugs 4:1179-89. 2003
    ..Furthermore, since selectivity and cell permeability are the two most important requirements for the development of successful PTP1B inhibitors, recent progress in finding compounds meeting these criteria are discussed...
  15. ncbi SFTG international collaborative study on in vitro micronucleus test I. General conditions and overall conclusions of the study
    Elisabeth Lorge
    Servier Group, Drug Safety Assessment, Orleans Gidy, France
    Mutat Res 607:13-36. 2006
    ....
  16. ncbi Generation of replication-dependent double-strand breaks by the novel N2-G-alkylator S23906-1
    Stephane Leonce
    Institut de Recherches Servier, Cancer Drug Discovery, Croissy sur Seine, France
    Cancer Res 66:7203-10. 2006
    ..These results suggest that secondary DNA lesions play an important role in the cytotoxicity of this compound and make histone H2AX phosphorylation an attractive marker for monitoring the efficacy of S23906-1...
  17. ncbi Discriminative stimulus properties of S32504, a novel D3/D2 receptor agonist and antiparkinson agent, in rats: attenuation by the antipsychotics, aripiprazole, bifeprunox, N-desmethylclozapine, and by selective antagonists at dopamine D2 but not D3 recept
    Mark J Millan
    Department of Neuropharmacology, Institut de Recherches Servier, Centre de Recherches de Croissy, 125 Chemin de Ronde, 78290, Croissy sur Seine, Paris, France
    Psychopharmacology (Berl) 191:767-82. 2007
    ..J Pharmacol Exp Ther 309:936-950, 2004a; Millan et al., J Pharmacol Exp Ther 309:903-920, 2004b; Millan et al., J Pharmacol Exp Ther 309:921-935, 2004c)...
  18. doi Signaling pathways leading to phosphorylation of Akt and GSK-3β by activation of cloned human and rat cerebral D₂and D₃ receptors
    Clotilde Mannoury La Cour
    Institut de Recherches Servier, Psychopharmacology Department, 125 Chemin de Ronde, 78290 Croissy sur Seine, France
    Mol Pharmacol 79:91-105. 2011
    ..However, significant differences were seen regarding the involvement of PLC, calmodulin, and ERK1/2...
  19. doi Vasoconstrictor prostanoids
    Michel Feletou
    Institut Recherches Servier, Suresnes, France
    Pflugers Arch 459:941-50. 2010
    ..TP receptor antagonists curtail endothelial dysfunction in diseases such as hypertension and diabetes, are potent antithrombotic agents, and prevent vascular inflammation...
  20. doi Modulations of the amide function of the preferential dopamine D3 agonist (R,R)-S32504: improvements of affinity and selectivity for D3 versus D2 receptors
    Jean Louis Peglion
    Institut de Recherches Servier, Chemistry B Departement, Suresnes, France
    Bioorg Med Chem Lett 19:2133-8. 2009
    ..Conversely, when the primary amide function was integrated in a lactam ring, an enhancement of affinity and selectivity was attained for the five-membered ring lactam but also for its five-membered ring lactone analogue...
  21. pmc Drug-drug interaction predictions with PBPK models and optimal multiresponse sampling time designs: application to midazolam and a phase I compound. Part 2: clinical trial results
    Marylore Chenel
    Institut de Recherches Internationales Servier, 6 place des Pleiades, 92415, Courbevoie Cedex, France
    J Pharmacokinet Pharmacodyn 35:661-81. 2008
    ..e. log(AUC) and log(C(max))) obtained either by a non-compartmental approach (NCA) using FD or from empirical Bayes estimates (EBE) obtained after fitting the model separately on each treatment group using either FD or MD...
  22. doi MT3/QR2 melatonin binding site does not use melatonin as a substrate or a co-substrate
    Jean A Boutin
    Pharmacologie Moléculaire et Cellulaire, Institut de Recherches Servier, Croissy sur Seine, France
    J Pineal Res 45:524-31. 2008
    ....
  23. doi Cognitive impairment in schizophrenia: a review of developmental and genetic models, and pro-cognitive profile of the optimised D(3) > D(2) antagonist, S33138
    Mark J Millan
    Institut de Recherches Servier, Croissy sur Seine, France
    Therapie 63:187-229. 2008
    ..It also reviews developmental and genetic risk factors for schizophrenia and their experimental modeling in rodents, with a particular emphasis on sensorimotor gating and cognitive deficits...
  24. doi Signaling at G-protein-coupled serotonin receptors: recent advances and future research directions
    Mark J Millan
    Institut de Recherche Servier, 125 Chemin de Ronde, 78290 Croissy sur Seine, Paris, France
    Trends Pharmacol Sci 29:454-64. 2008
    ..In view of the diversity of transduction mechanisms engaged by 5-HT, much of this discussion is relevant to other classes of G-protein-coupled receptors...
  25. doi [Oral bioavailability and drug/carrier particulate systems]
    Anne Wawrezinieck
    Technologie Servier, Orleans, France
    Med Sci (Paris) 24:659-64. 2008
    ..Producing highly effective particulate systems requiring low-complexity manufacturing processes is therefore an ongoing challenge...
  26. doi Consequences of ions and pH on the supramolecular organization of sphingomyelin and sphingomyelin/cholesterol bilayers
    Caroline Chemin
    Universite Paris Sud, UMR CNRS 8612, Chatenay Malabry, France
    Chem Phys Lipids 153:119-29. 2008
    ..Moreover, in the presence of salts, a weakening of van der Waals attraction forces was seen and led to a swelling of the water layer...
  27. ncbi Genetic toxicity assessment: employing the best science for human safety evaluation part IV: a strategy in genotoxicity testing in drug development: some examples
    Elisabeth Lorge
    Servier Group, Drug Safety Assessment, 45403 Orléans Gidy, France
    Toxicol Sci 98:39-42. 2007
    ..In this article, an example of an in-house decision tree is shown, with some options which can contribute to the current reflections. Additionally, tools built for early genotoxicity are presented...
  28. ncbi S18986: a positive modulator of AMPA-receptors enhances (S)-AMPA-mediated BDNF mRNA and protein expression in rat primary cortical neuronal cultures
    Brian Paul Lockhart
    Servier Research Institute, Division of Molecular Pharmacology and Pathophysiology, 125, Chemin de Ronde, 78290 Croissy sur Seine, France
    Eur J Pharmacol 561:23-31. 2007
    ....
  29. ncbi Experimental models of thrombosis and atherosclerosis
    Tony J Verbeuren
    Division Angiology, Institut de Recherches Servier, Suresnes, France
    Therapie 61:379-87. 2006
    ..They have also been of great value to predict anti-thrombotic and/or anti-atherosclerotic properties of new substances such as terutroban, that may become novel treatments for this complex cardiovascular disease...
  30. ncbi Dopamine D1 receptor coupling to Gs/olf and Gq in rat striatum and cortex: a scintillation proximity assay (SPA)/antibody-capture characterization of benzazepine agonists
    C Mannoury la Cour
    Institut de Recherche Servier, Psychopharmacology Department, 125, Chemin de Ronde, 78290 Croissy sur Seine, France
    Neuropharmacology 52:1003-14. 2007
    ....
  31. ncbi The neurobiology and control of anxious states
    Mark J Millan
    Psychopharmacology Department, Centre de Rescherches de Croissy, Institut de Recherches IDR Servier, 125 Chemin de Ronde, 78290 Croissy sur Seine, Paris, France
    Prog Neurobiol 70:83-244. 2003
    ....
  32. ncbi Urinary collagen type II C-telopeptide fragments are sensitive markers of matrix metalloproteinase-dependent cartilage degradation in rat adjuvant-induced arthritis
    Frederic De Ceuninck
    Department of Rheumatology, Institut de Recherches Servier, Suresnes, France
    J Rheumatol 30:1561-4. 2003
    ..To assess the relevance of collagen type II C-telopeptide fragments (CTX-II) as markers of cartilage degradation during adjuvant-induced arthritis in rats...
  33. ncbi Complete bioavailability and lack of food-effect on pharmacokinetics of gliclazide 30 mg modified release in healthy volunteers
    P Delrat
    Servier Research and Development Ltd, Windmill Road, Fulmer, Slough, SL3 6HH, UK
    Biopharm Drug Dispos 23:151-7. 2002
    ..Diamicron 30 mg MR can be given without regards to meals i.e. before, during or after breakfast...
  34. ncbi Specific labelling of serotonin 5-HT(1B) receptors in rat frontal cortex with the novel, phenylpiperazine derivative, [3H]GR125,743. A pharmacological characterization
    M J Millan
    Psychopharmacology Department, Centre de Recherches de Croissy, Institut de Recherches Servier, 125 Chemin de Ronde, 78290 Croissy Seine, Paris, France
    Pharmacol Biochem Behav 71:589-98. 2002
    ..In conclusion, [3H]GR125,743 is an appropriate tool for the radiolabelling of native, rat 5-HT(1B) receptors and permitted determination of the affinities of an extensive series of ligands at these sites...
  35. ncbi Characterization of phospholipase C activity at h5-HT2C compared with h5-HT2B receptors: influence of novel ligands upon membrane-bound levels of [3H]phosphatidylinositols
    Didier Cussac
    Department of Psychopharmacology, Institut de Recherches Servier, 125 Chemin de Ronde, 78290 Croissy Sur Seine Paris, France
    Naunyn Schmiedebergs Arch Pharmacol 365:242-52. 2002
    ..Although several antagonists clearly differentiated h5-HT2C from h5-HT2B receptors under these conditions, highly selective agonists remain to be identified...
  36. ncbi Discriminative stimulus properties of the selective norepinephrine reuptake inhibitor, reboxetine, in rats
    A Dekeyne
    Institut de Recherches Servier, Centre de Recherches de Croissy, Psychopharmacology Department, 125 Chemin de Ronde, 78290 Croissy sur Seine, Paris, France
    Psychopharmacology (Berl) 158:213-8. 2001
    ..However, discriminative stimulus properties of selective norepinephrine (NE) reuptake inhibitors remain to be evaluated...
  37. ncbi Agonist properties of pindolol at h5-HT1A receptors coupled to mitogen-activated protein kinase
    M J Millan
    Psychopharmacology Department, Centre de Recherches de Croissy, Institut de Recherches Servier, 125 Chemin de Ronde, 78290 Croissy sur Seine, Paris, France
    Eur J Pharmacol 424:13-7. 2001
    ..Thus, stimulation of MAPK provides an intracellular marker and signal for expression of the agonist actions of (-)-pindolol at h5-HT1A receptors...
  38. ncbi Potential antidepressants displayed combined alpha(2)-adrenoceptor antagonist and monoamine uptake inhibitor properties
    A A Cordi
    Institut de Recherches Servier, 11, rue des Moulineaux, F 92150 Suresnes, France
    J Med Chem 44:787-805. 2001
    ..Structure-activity relationships permitted the selection of 14c (4(5)-[(5-fluoroindan-2-yl)methyl]-4,5-dihydroimidazole) as a development candidate...
  39. ncbi Selective blockade of neurokinin (NK)(1) receptors facilitates the activity of adrenergic pathways projecting to frontal cortex and dorsal hippocampus in rats
    M J Millan
    Institut de Recherches Servier, Psychopharmacology Department, Croissy sur Seine, Paris, France
    J Neurochem 76:1949-54. 2001
    ..Adrenergic mechanisms may, thus, be involved in the potential antidepressant and other functional properties of NK(1) receptor antagonists...
  40. ncbi Improving the treatment of schizophrenia: focus on serotonin (5-HT)(1A) receptors
    M J Millan
    Psychopharmacology Department, Institut de Recherches Servier, Centre de Recherches de Croissy, Croissy Seine, Paris, France
    J Pharmacol Exp Ther 295:853-61. 2000
    ....
  41. ncbi High-capacity screening of arylalkylamine N-acetyltransferase inhibitors using a high-performance liquid chromatography system
    G Ferry
    Division de Pharmacologie Moleculaire et Cellulaire, Institut de Recherches Servier, Croissy sur Seine, France
    J Biomol Screen 5:361-8. 2000
    ..This enzymatic system was taken as an example, because the methodology can be extended to many other enzymes, particularly transferases, phosphatases, and kinases...
  42. ncbi Effects of S 18986-1, a novel cognitive enhancer, on memory performances in an object recognition task in rats
    C Lebrun
    Division of Cerebral Pathology, Institut de Recherches Servier, 125, Chemin de Ronde, 78290 Croissy sur Seine, France
    Eur J Pharmacol 401:205-12. 2000
    ..Furthermore, S 18986-1 was long-acting and demonstrated a good oral bioavailability. These data confer on S 18986-1, a potential role in improving episodic memory impaired in neurodegenerative diseases and during aging...
  43. ncbi Pharmacokinetics of sustained and immediate release formulations of indapamide after single and repeated oral administration in healthy volunteers
    P Schiavi
    Institut de Recherches Internationales Servier, Courbevoie, France
    Fundam Clin Pharmacol 14:139-46. 2000
    ..The SR formulation showed sustained release of indapamide with a reduction in peak concentration, while steady-state level was not affected by formulations. The two formulations have the same bioavailability...
  44. ncbi Food intake regulation in rodents: Y5 or Y1 NPY receptors or both?
    J Duhault
    Division of Diabetes and Metabolic Diseases, Institut de Recherches Servier, Suresnes, France
    Can J Physiol Pharmacol 78:173-85. 2000
    ....
  45. ncbi Effects of ceramide on apoptosis, proteoglycan degradation, and matrix metalloproteinase expression in rabbit articular cartilage
    M Sabatini
    Division of Rheumatology, Institut de Recherches Servier, Suresnes, France
    Biochem Biophys Res Commun 267:438-44. 2000
    ..This study supports the hypothesis that ceramide might play a mediatory role in both matrix degradation and apoptosis in processes of cartilage loss such as those observed in osteoarthritis...
  46. ncbi Melanin-concentrating hormone and its receptors: state of the art
    Jean A Boutin
    Division de Pharmacologie Moleculaire et Cellulaire, Institut de Recherches Servier, Croissy sur Seine, France
    Can J Physiol Pharmacol 80:388-95. 2002
    ..The present review tentatively summarizes the knowledge on these two receptors and presents the first attempts to discover new classes of antagonists that might have major roles in the control of obesity and feeding behaviour...
  47. ncbi S 17092: a prolyl endopeptidase inhibitor as a potential therapeutic drug for memory impairment. Preclinical and clinical studies
    Philippe Morain
    Institut de Recherches Internationales Servier, 6 place des Pleiades, 92415 Courbevoie, France
    CNS Drug Rev 8:31-52. 2002
    ..Collectively, the preclinical and clinical effects of S 17092 have suggested a promising role for this compound as an agent for the treatment of cognitive disorders associated with cerebral aging...
  48. ncbi Ligand modulation of [35S]GTPgammaS binding at human alpha(2A), alpha(2B) and alpha(2C) adrenoceptors
    Valérie Audinot
    Département de Pharmacologie Moléculaire et Cellulaire, Institut de Recherches Servier, 125, Chemin de Ronde, 78290 Croissy sur Seine, France
    Cell Signal 14:829-37. 2002
    ..Moreover, they emphasize the continuing need for alpha(2)-AR subtype-selective antagonists in order to define further the roles and therapeutic relevance of halpha(2A)-, halpha(2B)-, and halpha(2C)-AR...
  49. ncbi Persistence of the nitric oxide pathway in the aorta of hypercholesterolemic apolipoprotein-E-deficient mice
    Nicole Villeneuve
    Division Pathologies Cardiovasculaires, Institut de Recherches Servier, Suresnes, France
    J Vasc Res 40:87-96. 2003
    ..However, these enzymes were less expressed in ApoE KO mice than in control mice. These results highlight that ApoE KO mice represent an atypical model of atherosclerosis...
  50. ncbi Quantitative assessment of articular cartilage and subchondral bone histology in the meniscectomized guinea pig model of osteoarthritis
    P Pastoureau
    Division of Rheumatology, Institut de Recherches Servier, Suresnes, France
    Osteoarthritis Cartilage 11:412-23. 2003
    ..A new image analysis system was employed to quantify the main histological parameters reflecting osteoarthritic features, at the cartilage and bone levels, in the meniscectomized guinea pig model of osteoarthritis (OA)...
  51. ncbi Decrease in survival threshold of quiescent colon carcinoma cells in the presence of a small molecule integrin antagonist
    Mike F Burbridge
    Cancer Research Division, Institut de Recherches Servier, 125 Chemin de Ronde, 78290 Croissy sur Seine, Paris, France
    Mol Pharmacol 63:1281-8. 2003
    ..Together, these observations could guide the use of combination therapy with integrin antagonists in the clinic...
  52. ncbi The novel melatonin agonist agomelatine (S20098) is an antagonist at 5-hydroxytryptamine2C receptors, blockade of which enhances the activity of frontocortical dopaminergic and adrenergic pathways
    M J Millan
    Department of Psychopharmacology, Institut de Recherches Servier, Croissy Seine, France
    J Pharmacol Exp Ther 306:954-64. 2003
    ..In conclusion, in contrast to melatonin, agomelatine behaves as an antagonist at 5-HT2B and 5-HT2C receptors: blockade of the latter reinforces frontocortical adrenergic and dopaminergic transmission...
  53. ncbi New fibrinolytic agents: benzothiophene derivatives as inhibitors of the t-PA-PAI-1 complex formation
    Guillaume de Nanteuil
    Division D of Medicinal Chemistry, Institut de Recherches Servier, 11 rue des Moulineaux, 92150 Suresnes, France
    Bioorg Med Chem Lett 13:1705-8. 2003
    ..This class of compounds potentially represents a new generation of antithrombotic-fibrinolytic agents...
  54. ncbi Generalization of clozapine as compared to other antipsychotic agents to a discriminative stimulus elicited by the serotonin (5-HT)2A antagonist, MDL100,907
    A Dekeyne
    Psychopharmacology Department, Institut de Recherches Servier, Centre de Recherches de Croissy, 125 Chemin de Ronde, Croissy sur Seine, Paris 78290, France
    Neuropharmacology 44:604-15. 2003
    ..These data underpin interest in MDL100,907 as a potential antipsychotic agent...
  55. ncbi [In vivo exploration of cerebral ischemia: use of neuroprotective agents in animal studies]
    P Lestage
    Division de Pathologie, Cérébrale, Institut de Recherches Servier, Croissy sur Seine, France
    Therapie 57:554-63. 2002
    ..should be performed to eliminate confounding variables and to observe adverse systemic effects. The future of neuroprotection for stroke remains bright in spite of previous disappointments...
  56. ncbi The Vogel conflict test: procedural aspects, gamma-aminobutyric acid, glutamate and monoamines
    Mark J Millan
    Psychopharmacology Department, Institut de Recherches Servier, Centre de Recherches de Croissy, 125 Chemin de Ronde, 78290 Croissy Seine, Paris, France
    Eur J Pharmacol 463:67-96. 2003
    ..Indeed, in view of its clinical relevance, broader exploitation of the Vogel conflict test in the identification of novel classes of anxiolytic agents, and in the determination of their mechanisms of action, would prove instructive...
  57. ncbi Brain plasticity and pathology in psychiatric disease: sites of action for potential therapy
    Michael Spedding
    Institute de Recherches Internationales Servier, 192 Avenue Charles de Gaulle, 92200 Neuilly sur Seine, France
    Curr Opin Pharmacol 3:33-40. 2003
    ..Drugs acting on plasticity could affect the abnormal set point in psychiatric disease, resulting in treatment of the disease rather than just the symptoms...
  58. ncbi Characterization and regulation of a CHO cell line stably expressing human serotonin N-acetyltransferase (EC 2.3.1.87)
    G Ferry
    Pharmacologie Moléculaire et Cellulaire, Institut de Recherches Servier, Croissy sur Seine, France
    Cell Mol Life Sci 59:1395-405. 2002
    ..This cell line was used to screen libraries of compounds in a living system and led to the discovery of several potent specific and non-toxic AANAT inhibitors...
  59. ncbi Effects of agonists of peroxisome proliferator-activated receptor gamma on proteoglycan degradation and matrix metalloproteinase production in rat cartilage in vitro
    M Sabatini
    Division of Rheumatology, Institut de Recherches Servier IdRS, 11 rue des Moulineaux, 92150 Suresnes, France
    Osteoarthritis Cartilage 10:673-9. 2002
    ..To examine the effects of agonists of peroxisome proliferator-activated receptor (PPAR) gamma on proteoglycan degradation induced by interleukin (IL)-1beta or tumor necrosis factor (TNF)alpha in cartilage in vitro...
  60. ncbi Differential activation of Gq/11 and Gi(3) proteins at 5-hydroxytryptamine(2C) receptors revealed by antibody capture assays: influence of receptor reserve and relationship to agonist-directed trafficking
    Didier Cussac
    Institut de Recherches Servier, Psychopharmacology Department, Chemin de Ronde, Croissy Seine, Paris, France
    Mol Pharmacol 62:578-89. 2002
    ..In conclusion, h5-HT(2C) receptors couple to both Gq/11 and Gi(3) in CHO cells, and efficacy for G protein subtype activation is both ligand- and receptor reserve-dependent...
  61. ncbi Physiologically based model of acute ischemic stroke
    Vincent Duval
    Department of Clinical Pharmacology, EA643, School of Medicine, Universite Claude Bernard, Lyon, France
    J Cereb Blood Flow Metab 22:1010-8. 2002
    ..The model integrated different markers of acute ischemic stroke into a single entity in order to mimic acute ischemic stroke, and has been shown to have a reasonable degree of internal validity...
  62. ncbi Electrochemical detection of nitric oxide production in perfused pig coronary artery: comparison of the performances of two electrochemical sensors
    N Villeneuve
    Institut de Recherches Servier, Division Pathologies Cardiaques et Vasculaires, Suresnes, France
    J Pharmacol Toxicol Methods 40:95-100. 1998
    ..This study highlights the potential hazards and pitfalls that may be associated with the use of a Pt/Ir sensor calibrated with SNAP solutions for the detection of NO production in various biological systems...