Nathalie Bernoud-Hubac

Summary

Affiliation: INSA de Lyon
Country: France

Publications

  1. ncbi request reprint Covalent binding of isoketals to ethanolamine phospholipids
    Nathalie Bernoud-Hubac
    INSERM U585, Physiopathologie des Lipides et Membranes, INSA Lyon, 69621 Villeurbanne, France
    Free Radic Biol Med 37:1604-11. 2004
  2. doi request reprint Low concentrations of reactive gamma-ketoaldehydes prime thromboxane-dependent human platelet aggregation via p38-MAPK activation
    Nathalie Bernoud-Hubac
    Universite de Lyon, F 69622, Lyon, France Univ Lyon 1, Villeurbanne, Insa Lyon F 69621 Villeurbanne, France
    Biochim Biophys Acta 1791:307-13. 2009
  3. ncbi request reprint Evidence for in situ ethanolamine phospholipid adducts with hydroxy-alkenals
    Sandrine Bacot
    Institut National de la Santé et de la Recherche Médicale U585, Institut National des Sciences Appliquees de Lyon, Lyon, France
    J Lipid Res 48:816-25. 2007
  4. pmc The eicosapentaenoic acid metabolite 15-deoxy-δ(12,14)-prostaglandin J3 increases adiponectin secretion by adipocytes partly via a PPARγ-dependent mechanism
    Jennifer Lefils-Lacourtablaise
    Universite de Lyon, Institut National de la Santé et de la Recherche Médicale Unité Mixte de Recherche 1060, Laboratoire de Recherche en Cardiovasculaire, Metabolisme, diabétologie et nutrition, Institut Multidisciplinaire de Biochimie des Lipides Institut National des Sciences Appliquées Lyon, Villeurbanne, France
    PLoS ONE 8:e63997. 2013
  5. doi request reprint Efficient Docosahexaenoic Acid Uptake by the Brain from a Structured Phospholipid
    Mayssa Hachem
    INSERM UMR 1060, CarMeN laboratory, IMBL INSA Lyon, Universite de Lyon, F 69621, Villeurbanne, France
    Mol Neurobiol 53:3205-15. 2016
  6. doi request reprint Dietary DHA: time course of tissue uptake and effects on cytokine secretion in mice
    Jennifer Lefils
    Universite de Lyon, UMR 870 Inserm, Insa Lyon RMND IMBL, Univ Lyon 1, INRA 1235, Hospices Civils de Lyon, F 69621 Villeurbanne, France
    Br J Nutr 104:1304-12. 2010
  7. ncbi request reprint Covalent binding of hydroxy-alkenals 4-HDDE, 4-HHE, and 4-HNE to ethanolamine phospholipid subclasses
    Sandrine Bacot
    Physiologie des lipides et membranes, INSERM U585, France
    J Lipid Res 44:917-26. 2003
  8. doi request reprint Omega-3 polyunsaturated fatty acids and oxygenated metabolism in atherothrombosis
    Michel Guichardant
    Universite de Lyon, UMR 1060 INSERM CarMeN, UMR 1397 INRA, INSA Lyon, IMBL, Villeurbanne, France Electronic address
    Biochim Biophys Acta 1851:485-95. 2015
  9. doi request reprint Lipidomics of essential fatty acids and oxygenated metabolites
    Michel Lagarde
    Universite de Lyon, UMR 1060 Inserm, IMBL, INSA Lyon, Villeurbanne, France
    Mol Nutr Food Res 57:1347-58. 2013
  10. doi request reprint The pleiotropic effects of omega-3 docosahexaenoic acid on the hallmarks of Alzheimer's disease
    Mounir Belkouch
    Universite de Lyon, UMR INSERM 1060, UMR Inra 1397, IMBL INSA Lyon, Cardiovasculaire, Metabolisme, Diabétologie et Nutrition Laboratory, Bat Louis Pasteur, INSA, Villeurbanne, France Electronic address
    J Nutr Biochem 38:1-11. 2016

Collaborators

  • Madeleine Picq
  • Sean S Davies
  • L J Roberts
  • Marie Caroline Michalski
  • Christophe O Soulage
  • Thomas Montine
  • Evelyne Vericel
  • Michel Lagarde
  • Michel Guichardant
  • Alain Geloen
  • Mayssa Hachem
  • Jennifer Lefils-Lacourtablaise
  • Hubert Vidal
  • Sandrine Bacot
  • Amanda Lo Van
  • Mounir Belkouch
  • Catherine Calzada
  • Emmanuelle Loizon
  • Patricia Daira
  • Cyrille Debard
  • Fabienne Laugerette
  • Jennifer Lefils
  • Christian Deshayes
  • Alain Doutheau
  • Bernard Chantegrel
  • Irene Zagol-Ikapitte
  • Gildas Breton
  • Baptiste Foumaux
  • Abdeljalil Elgot
  • Pedro Da Silva
  • Laurence Fenart
  • Fabien Gosselet
  • Mairobys Socorro
  • Zury Dominguez
  • Noel Peretti
  • Jacques Bodennec
  • Claire Simonet
  • Jean Pierre Furet
  • Gabriel Ponsin
  • Olivier Boutaud
  • John A Oates
  • Venkataraman Amarnath
  • Naima Baddas

Detail Information

Publications15

  1. ncbi request reprint Covalent binding of isoketals to ethanolamine phospholipids
    Nathalie Bernoud-Hubac
    INSERM U585, Physiopathologie des Lipides et Membranes, INSA Lyon, 69621 Villeurbanne, France
    Free Radic Biol Med 37:1604-11. 2004
    ..These studies identify in vitro novel isoketal adducts. This provides the basis to explore the formation of isoketal-aminophospholipid adducts in vivo and the biological consequences of the formation of these adducts...
  2. doi request reprint Low concentrations of reactive gamma-ketoaldehydes prime thromboxane-dependent human platelet aggregation via p38-MAPK activation
    Nathalie Bernoud-Hubac
    Universite de Lyon, F 69622, Lyon, France Univ Lyon 1, Villeurbanne, Insa Lyon F 69621 Villeurbanne, France
    Biochim Biophys Acta 1791:307-13. 2009
    ..These results indicate that isoketals could play an important role in platelet hyperfunction observed in pathological states such as atherosclerosis and thrombosis through the activation of the endogenous arachidonic acid cascade...
  3. ncbi request reprint Evidence for in situ ethanolamine phospholipid adducts with hydroxy-alkenals
    Sandrine Bacot
    Institut National de la Santé et de la Recherche Médicale U585, Institut National des Sciences Appliquees de Lyon, Lyon, France
    J Lipid Res 48:816-25. 2007
    ..These data suggest that these adducts could be used as specific markers of membrane disorders occurring in pathophysiological states with associated oxidative stress and might affect cell function...
  4. pmc The eicosapentaenoic acid metabolite 15-deoxy-δ(12,14)-prostaglandin J3 increases adiponectin secretion by adipocytes partly via a PPARγ-dependent mechanism
    Jennifer Lefils-Lacourtablaise
    Universite de Lyon, Institut National de la Santé et de la Recherche Médicale Unité Mixte de Recherche 1060, Laboratoire de Recherche en Cardiovasculaire, Metabolisme, diabétologie et nutrition, Institut Multidisciplinaire de Biochimie des Lipides Institut National des Sciences Appliquées Lyon, Villeurbanne, France
    PLoS ONE 8:e63997. 2013
    ..15d-PGJ3 was also detected in adipose tissue from EPA-fed mice. Thus, these studies provide a novel mechanism(s) for the therapeutic benefits of ω-3 polyunsaturated fatty acids dietary supplementation...
  5. doi request reprint Efficient Docosahexaenoic Acid Uptake by the Brain from a Structured Phospholipid
    Mayssa Hachem
    INSERM UMR 1060, CarMeN laboratory, IMBL INSA Lyon, Universite de Lyon, F 69621, Villeurbanne, France
    Mol Neurobiol 53:3205-15. 2016
    ..Our findings identify AceDoPC as an efficient way to specifically target DHA to the brain, which would allow potential preventive and therapeutic approaches for neurological diseases. ..
  6. doi request reprint Dietary DHA: time course of tissue uptake and effects on cytokine secretion in mice
    Jennifer Lefils
    Universite de Lyon, UMR 870 Inserm, Insa Lyon RMND IMBL, Univ Lyon 1, INRA 1235, Hospices Civils de Lyon, F 69621 Villeurbanne, France
    Br J Nutr 104:1304-12. 2010
    ..DHA mainly got incorporated at the expense of n-6 arachidonic acid. The present data show that DHA rapidly improved the profile of secreted adipokines, and that these protective effects were long lasting...
  7. ncbi request reprint Covalent binding of hydroxy-alkenals 4-HDDE, 4-HHE, and 4-HNE to ethanolamine phospholipid subclasses
    Sandrine Bacot
    Physiologie des lipides et membranes, INSERM U585, France
    J Lipid Res 44:917-26. 2003
    ..In addition to their antioxidant potential, alkenylacyl-GPEs may efficiently scavenge fatty aldehydes...
  8. doi request reprint Omega-3 polyunsaturated fatty acids and oxygenated metabolism in atherothrombosis
    Michel Guichardant
    Universite de Lyon, UMR 1060 INSERM CarMeN, UMR 1397 INRA, INSA Lyon, IMBL, Villeurbanne, France Electronic address
    Biochim Biophys Acta 1851:485-95. 2015
    ..This article is part of a Special Issue entitled "Oxygenated metabolism of PUFA: analysis and biological relevance". ..
  9. doi request reprint Lipidomics of essential fatty acids and oxygenated metabolites
    Michel Lagarde
    Universite de Lyon, UMR 1060 Inserm, IMBL, INSA Lyon, Villeurbanne, France
    Mol Nutr Food Res 57:1347-58. 2013
    ..Their biological function and life span are considered. Overall, this is a fluxolipidomics approach that is emerging. ..
  10. doi request reprint The pleiotropic effects of omega-3 docosahexaenoic acid on the hallmarks of Alzheimer's disease
    Mounir Belkouch
    Universite de Lyon, UMR INSERM 1060, UMR Inra 1397, IMBL INSA Lyon, Cardiovasculaire, Metabolisme, Diabétologie et Nutrition Laboratory, Bat Louis Pasteur, INSA, Villeurbanne, France Electronic address
    J Nutr Biochem 38:1-11. 2016
    ..Herein, our review investigates, from animal and cell culture studies, the molecular mechanisms involved in the neuroprotective potential of DHA with emphasis on AD...
  11. doi request reprint Oil composition of high-fat diet affects metabolic inflammation differently in connection with endotoxin receptors in mice
    Fabienne Laugerette
    Institut National de la Recherche Agronomique, CarMeN laboratory, Villeurbanne, France
    Am J Physiol Endocrinol Metab 302:E374-86. 2012
    ..This shows that dietary fat composition can contribute to modulate the onset of low-grade inflammation through the quality of endotoxin receptors...
  12. doi request reprint Expanding the horizons of lipidomics. Towards fluxolipidomics
    Michel Lagarde
    UMR 1060 INSERM CarMeN, IMBL, INSA Lyon, Villeurbanne 60621, France
    Mol Membr Biol 29:222-8. 2012
    ..The example of fluxolipidomics of essential fatty acids toward their enzyme-dependent oxygenated metabolites and further toward their degradation products is developed...
  13. ncbi request reprint Characterization of bis(levuglandinyl) urea derivatives as products of the reaction between prostaglandin H2 and arginine
    Irene Zagol-Ikapitte
    Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232 6602, USA
    Biochemistry 43:5503-10. 2004
    ..The soluble characteristic of these molecules provides a potential strategy for development of biological markers of lipid modification of proteins following cyclooxygenase activity or lipid peroxidation...
  14. ncbi request reprint Identification of oxidized derivatives of neuroketals
    Nathalie Bernoud-Hubac
    Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232 6602, USA
    Biochemistry 41:11466-71. 2002
    ....
  15. ncbi request reprint Effects of reactive gamma-ketoaldehydes formed by the isoprostane pathway (isoketals) and cyclooxygenase pathway (levuglandins) on proteasome function
    Sean S Davies
    Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 27232 6602, USA
    FASEB J 16:715-7. 2002
    ..These findings suggest that IsoKs/NeuroKs/LGs can inhibit proteasome activity and, if overproduced, may have relevance to the pathogenesis of neurodegenerative diseases...