F Peyron

Summary

Affiliation: Hospices Civils de Lyon
Country: France

Publications

  1. ncbi request reprint Congenital toxoplasmosis in twins: a report of fourteen consecutive cases and a comparison with published data
    Francois Peyron
    Service de Parasitologie, Hopital de la Croix Rousse, 103 Grande Rue de la Croix Rousse, 69004 Lyon, France
    Pediatr Infect Dis J 22:695-701. 2003
  2. ncbi request reprint Options for the pharmacotherapy of toxoplasmosis during pregnancy
    F Peyron
    Service de Parasitologie et de Pathologie Exotique, Hĵpital de la Croix Rousse, Lyon, France
    Expert Opin Pharmacother 2:1269-74. 2001
  3. ncbi request reprint Fitness of Toxoplasma gondii is not related to DHFR single-nucleotide polymorphism during congenital toxoplasmosis
    Francois Peyron
    E A 3732, Parasitology Unit, Faculty of Medicine, Claude Bernard University, Lyon, France
    Int J Parasitol 34:1169-75. 2004
  4. ncbi request reprint Serotyping of Toxoplasma gondii in chronically infected pregnant women: predominance of type II in Europe and types I and III in Colombia (South America)
    Francois Peyron
    Laboratoire de Parasitologie, Mycologie Medicale et Pathologie Exotique, Equipe d Accueil E A 3732, Faculté de médecine de Lyon, 8 avenue Rockefeller, 69373 Lyon, France
    Microbes Infect 8:2333-40. 2006
  5. ncbi request reprint When are we going to celebrate the centenary of the discovery of efficient treatment for congenital toxoplasmosis?
    F Peyron
    Laboratoire de Parasitologie et Pathologie Exotique, hôpital de Croix Rousse, Lyon, France
    Mem Inst Oswaldo Cruz 104:316-9. 2009
  6. ncbi request reprint Toxoplasma gondii: comparison of human CD34+ and monocyte-derived dendritic cells after parasite infection
    F Persat
    Laboratoire de Parasitologie, Mycologie Medicale et Pathologie Exotique, Universite Claude Bernard, Lyon 1, EA 37 32, 8 avenue Rockefeller, 69373 Lyon Cedex 08, France
    Exp Parasitol 115:103-6. 2007
  7. ncbi request reprint Value of cerebrospinal fluid cytochemical examination for the diagnosis of congenital toxoplasmosis at birth in France
    M Wallon
    Parasitology Department, Hopital de la Croix Rousse, Lyon, France
    Pediatr Infect Dis J 17:705-10. 1998
  8. pmc Heterogeneity in cellular and humoral immune responses against Toxoplasma gondii antigen in humans
    A F Fatoohi
    E A 3087 Parasitologie, Faculté de Médecine Lyon Nord, and Laboratoire d Immunologie, Hopital de la Croix Rousse, Lyon, France
    Clin Exp Immunol 136:535-41. 2004
  9. ncbi request reprint Cellular immunity to Toxoplasma gondii in congenitally infected newborns and immunocompetent infected hosts
    A F Fatoohi
    E A 3087 Parasitologie, Faculté de Médecine Lyon Nord, Laboratoire d Immunologie, Hopital de la Croix Rousse, Lyon, France
    Eur J Clin Microbiol Infect Dis 22:181-4. 2003
  10. pmc Congenital toxoplasmosis: systematic review of evidence of efficacy of treatment in pregnancy
    M Wallon
    Service de Parasitologie, Hopital de la Croix Rousse, 69004 Lyons, France
    BMJ 318:1511-4. 1999

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Congenital toxoplasmosis in twins: a report of fourteen consecutive cases and a comparison with published data
    Francois Peyron
    Service de Parasitologie, Hopital de la Croix Rousse, 103 Grande Rue de la Croix Rousse, 69004 Lyon, France
    Pediatr Infect Dis J 22:695-701. 2003
    ..Similarly little is known about the influence of genetic factors on the clinical course of this disease. The present study addresses these issues...
  2. ncbi request reprint Options for the pharmacotherapy of toxoplasmosis during pregnancy
    F Peyron
    Service de Parasitologie et de Pathologie Exotique, Hĵpital de la Croix Rousse, Lyon, France
    Expert Opin Pharmacother 2:1269-74. 2001
    ..Before making any change in preventative strategy, it is of utmost importance to increase our knowledge on treatment efficacy through proper randomised trials of existing drugs and of new potentially active compounds...
  3. ncbi request reprint Fitness of Toxoplasma gondii is not related to DHFR single-nucleotide polymorphism during congenital toxoplasmosis
    Francois Peyron
    E A 3732, Parasitology Unit, Faculty of Medicine, Claude Bernard University, Lyon, France
    Int J Parasitol 34:1169-75. 2004
    ..We concluded that the DHFR gene mutations we investigated do not regulate T. gondii fitness in humans...
  4. ncbi request reprint Serotyping of Toxoplasma gondii in chronically infected pregnant women: predominance of type II in Europe and types I and III in Colombia (South America)
    Francois Peyron
    Laboratoire de Parasitologie, Mycologie Medicale et Pathologie Exotique, Equipe d Accueil E A 3732, Faculté de médecine de Lyon, 8 avenue Rockefeller, 69373 Lyon, France
    Microbes Infect 8:2333-40. 2006
    ..We demonstrated that, despite some limitation due to antigen and/or antibody specificity, serotyping is a promising assay to investigate the relationship between type of strain and severity of the disease...
  5. ncbi request reprint When are we going to celebrate the centenary of the discovery of efficient treatment for congenital toxoplasmosis?
    F Peyron
    Laboratoire de Parasitologie et Pathologie Exotique, hôpital de Croix Rousse, Lyon, France
    Mem Inst Oswaldo Cruz 104:316-9. 2009
    ..We must make progress in this field through well-designed collaborative studies and by drawing the attention of policy makers to this disastrous and unsustainable situation...
  6. ncbi request reprint Toxoplasma gondii: comparison of human CD34+ and monocyte-derived dendritic cells after parasite infection
    F Persat
    Laboratoire de Parasitologie, Mycologie Medicale et Pathologie Exotique, Universite Claude Bernard, Lyon 1, EA 37 32, 8 avenue Rockefeller, 69373 Lyon Cedex 08, France
    Exp Parasitol 115:103-6. 2007
    ..Under similar conditions, no significant difference was noticed between mature or immature mo-DC. These data indicated that CD34-DC represent an alternative model that allows migration assay of infected DC by T. gondii...
  7. ncbi request reprint Value of cerebrospinal fluid cytochemical examination for the diagnosis of congenital toxoplasmosis at birth in France
    M Wallon
    Parasitology Department, Hopital de la Croix Rousse, Lyon, France
    Pediatr Infect Dis J 17:705-10. 1998
    ..Our goal was to assess the value of cytochemical examination and to confirm whether using a portion of available CSF for this analysis is legitimate...
  8. pmc Heterogeneity in cellular and humoral immune responses against Toxoplasma gondii antigen in humans
    A F Fatoohi
    E A 3087 Parasitologie, Faculté de Médecine Lyon Nord, and Laboratoire d Immunologie, Hopital de la Croix Rousse, Lyon, France
    Clin Exp Immunol 136:535-41. 2004
    ..However, only two proteins in the 20-40 kD range induced a significant humoral response. Further studies are necessary to determine which proteins in the Fr 26-31.9 kD and 32-36.9 kD are superior immunogens for cellular responses...
  9. ncbi request reprint Cellular immunity to Toxoplasma gondii in congenitally infected newborns and immunocompetent infected hosts
    A F Fatoohi
    E A 3087 Parasitologie, Faculté de Médecine Lyon Nord, Laboratoire d Immunologie, Hopital de la Croix Rousse, Lyon, France
    Eur J Clin Microbiol Infect Dis 22:181-4. 2003
    ..Detection of CD25 constitutes a simple, sensitive and specific test for diagnosis of congenital toxoplasmosis...
  10. pmc Congenital toxoplasmosis: systematic review of evidence of efficacy of treatment in pregnancy
    M Wallon
    Service de Parasitologie, Hopital de la Croix Rousse, 69004 Lyons, France
    BMJ 318:1511-4. 1999
    ..To summarise the evidence that treating toxoplasmosis in pregnancy reduces the risk of congenital toxoplasma infection and improves infant outcomes...
  11. ncbi request reprint [Value of toxoplasma serology at delivery in women seronegative during pregnancy]
    M Wallon
    Service de Parasitologie et de Pathologie Exotique, Hopital de la Croix Rousse, 103, Grande rue de la Croix Rousse, 69004 Lyon
    J Gynecol Obstet Biol Reprod (Paris) 30:697-9. 2001
    ..As a consequence, late maternal infections resulting in a high risk of vertical transmission with potentially severe late sequelae are not detected...
  12. ncbi request reprint Serological rebound in congenital toxoplasmosis: long-term follow-up of 133 children
    M Wallon
    Service de Parasitologie, Hĵpital de la Croix Rousse, Lyon, France
    Eur J Pediatr 160:534-40. 2001
    ..10; 95% CI: 0.47-2.58), and, among the 81 children who had one rebound diagnosed after initial treatment, in those who received an additional course of treatment and in those who did not (RR = 0.72; 95% CI: 0.30-1.72)...
  13. ncbi request reprint Delayed maturation of immunoglobulin G avidity: implication for the diagnosis of toxoplasmosis in pregnant women
    M Lefevre-Pettazzoni
    Departement de Parasitologie, Hopital de la Croix Rousse, 69317, Lyon Cedex 04, France
    Eur J Clin Microbiol Infect Dis 25:687-93. 2006
    ..Estimation of the time of infection remains difficult, especially in cases in which the samples are drawn late in pregnancy; the final estimate must be based on several tests repeated at intervals of weeks...
  14. pmc Effects of 2',3'-dideoxyinosine on Toxoplasma gondii cysts in mice
    M E Sarciron
    Department of Parasitology and Medical Mycology, Claude Bernard University, Lyon, France
    Antimicrob Agents Chemother 41:1531-6. 1997
    ..These cysts were not viable, as confirmed by immunofluorescence and reinfection experiments. These experiments suggest a possible role for ddI in the treatment of toxoplasmosis, and this possibility deserves further investigation...
  15. ncbi request reprint [Toxoplasma infections in early pregnancy: consequences and management]
    M Wallon
    Service de Parasitologie, Hospital de la Croix Rousse, 69317 Lyon Cedex 04, France
    J Gynecol Obstet Biol Reprod (Paris) 31:478-84. 2002
    ..To assess the consequences for the fetus of maternal toxoplasma infection acquired during the first 8 weeks of gestation and to set guidelines on how to manage these maternal infections...
  16. ncbi request reprint Diagnosis of congenital toxoplasmosis at birth: what is the value of testing for IgM and IgA?
    M Wallon
    Service de Parasitologie, Hopital de la Croix Rousse, Lyon, France
    Eur J Pediatr 158:645-9. 1999
    ..The influence of the date of maternal infection on the sensitivity and negative predictive value was also clearly demonstrated...
  17. ncbi request reprint Absence of nucleotide polymorphism in a Plasmodium vivax multidrug resistance gene after failure of mefloquine prophylaxis in French Guyana
    S Picot
    Laboratoire de Parasitologie, Mycologie Médicale et Maladies Tropicales, E A 3732, Universite Claude Bernard Lyon I, Lyon 69373, France
    Trans R Soc Trop Med Hyg 99:234-7. 2005
    ..vivax, when added to previously reported chloroquine and atovaquone-proguanil failure, strengthens the case for re-evaluating drug policies for vivax malaria and the need for continuous research on molecular markers of drug resistance...
  18. doi request reprint Seasonal variations in acute toxoplasmosis in pregnant women in the Rhône-Alpes region (France)
    L Morin
    Institut de Parasitologie et de Mycologie Médicale, Hopital de la Croix Rousse, Hospices Civils de Lyon, Lyon, France
    Clin Microbiol Infect 18:E401-3. 2012
    ..Further studies on individual risks and environmental and climatic factors are needed to understand what prevention message should be given to susceptible pregnant women...
  19. pmc Cellular immune responses to recombinant antigens in pregnant women chronically infected with Toxoplasma gondii
    A F Fatoohi
    E A 3087 Parasitologie, Faculté de Médecine Lyon Nord, Lyon, France
    Clin Diagn Lab Immunol 9:704-7. 2002
    ..Interleukin-4 was always absent from supernatants of cells stimulated with toxoplasma antigens. The heterogeneity of human responses to individual recombinant toxoplasma antigens should be considered in the design of potential vaccines...
  20. ncbi request reprint Comparative diagnostic performance of two commercial rapid tests for malaria in a non-endemic area
    F de Monbrison
    Service de parasitologie et mycologie médicale, 8 avenue Rockefeller, 69373 Lyon Cedex 08, France
    Eur J Clin Microbiol Infect Dis 23:784-6. 2004
    ..falciparum infections, and it generated seven false-positive results. The results suggest that these rapid diagnostic tests for malaria may be useful, but they cannot replace microscopic examination of blood films...
  21. ncbi request reprint [Real-time PCR for detection of molecular markers of resistance in Plasmodium falciparum]
    F de Monbrison
    Laboratoire de Parasitologie, Mycologie Medicale et Pathologie Exotique, E A 3087, Faculte de Medecine, Universite Claude Bernard, 8, avenue Rockefeller, 69373 Lyon cedex 03, France
    Pathol Biol (Paris) 51:528-33. 2003
    ..The aim of this study was not to provide definitive data concerning the rate of mutations in an endemic area, but to describe a powerful method allowing the detection of major pfmdr1 and pfcrt mutations...
  22. pmc Toxoplasma gondii regulates recruitment and migration of human dendritic cells via different soluble secreted factors
    J Diana
    Universite Claude Bernard Lyon 1, Laboratoire E A 37 32, Clinique Dermatologique, Hopital Edouard Herriot, Lyon, France
    Clin Exp Immunol 141:475-84. 2005
    ..Taken together, these results suggest that T. gondii controls recruitment and migration of immature DC by different soluble factors and may induce a dysfunction in the host-specific immune response...
  23. ncbi request reprint Flow cytometric application of the Sabin and Feldman dye test in the diagnosis of toxoplasmosis
    G J Cozon
    Unite d immunologie, Hopital de la Croix Rousse, Lyon, France
    J Microbiol Methods 38:131-6. 1999
    ..Correlation was good (r = 0.85) for positive sera. In conclusion, when easily available, flow cytometry is a very sensitive, specific and time-sparing method to detect specific antibodies to Toxoplasma gondii...
  24. ncbi request reprint Treatments for toxoplasmosis in pregnancy
    F Peyron
    Laboratoire de Parasitologie, Mycologie Medicale et Pathologie Exotique, Universite Claude Bernard Lyon 1, 8 avenue Rockefeller, 69373 Lyon, Cedex 08, France
    Cochrane Database Syst Rev . 2000
    ..Toxoplasmosis is a widespread parasitic disease and usually causes no symptoms. However, infection of pregnant women may cause congenital infection, resulting potentially in mental retardation and blindness in the infant...
  25. doi request reprint Congenital toxoplasma infection: monthly prenatal screening decreases transmission rate and improves clinical outcome at age 3 years
    M Wallon
    Hospices Civils de Lyon, Service de Parasitologie, et de Mycologie Médicale Hôpital de la Croix Rousse, 69004 Lyon, France
    Clin Infect Dis 56:1223-31. 2013
    ..Accurate risk estimates by GA are necessary to counsel parents and improve clinical decisions...
  26. ncbi request reprint Phenylalanine derivatives active against Toxoplasma gondii brain cysts in mice
    M E Sarciron
    Pharmaceutical Department of Parasitology and Medical Mycology, Lyon, France
    Parasite 5:359-64. 1998
    ..The present study provides evidence on the efficacy of phenylalanine derivatives and especially Boc-Phe 3, against T.gondii brain cysts in mice...
  27. ncbi request reprint [Side effects of chemoprophylaxis: real or imagined?]
    F Peyron
    Laboratoire de Parasitologie et Pathologie Exotique, 8 avenue Rockefeller, 69373 Lyon, France
    Bull Soc Pathol Exot 94:156-8. 2001
    ..We propose that the various scientific associations concerned by the issue draw together an information sheet on side effects so as to encourage practioners to investigate all cases of intolerance of antimalarial drugs...
  28. doi request reprint [Congenital toxoplasmosis: long-term ophthalmologic follow-up praised by patients]
    L Beraud
    Service de Parasitologie et Pathologie Exotique, Hopital de la Croix Rousse, 103, Grande rue de la Croix Rousse, 69317 Lyon Cedex 04, France
    J Fr Ophtalmol 36:494-8. 2013
    ..The goal of this study was to provide doctors with patient-reported information on how they perceived the long-term monitoring of their disease...
  29. ncbi request reprint Toxoplasma encephalitis: influence of the vehicle on the efficacy of different doses of 2',3'-dideoxyinosine in mice
    A Gherardi
    Département Pharmaceutique de Parasitologie et de Mycologie Médicale, Universite Claude Bernard, Lyon, France
    Parasite 7:39-42. 2000
    ..So ddI has an effect on the cerebral cysts of T. gondii even at a low dose. The galenic formulation influences its action since the doses prepared with Maalox were less efficient than those prepared from ground tablets...