Olivier Hermine

Summary

Country: France

Publications

  1. ncbi request reprint Adult T cell leukaemia: a review of established and new treatments
    O Hermine
    Department of Hematology and CNRS URA 1461, Necker University Hospital, Paris, France
    BioDrugs 10:447-62. 1998
  2. pmc Caspase activation is required for terminal erythroid differentiation
    Y Zermati
    Centre National de la Recherche Scientifique Unité Mixte de Recherche 8603, Universite Rene Descartes, Paris V, France
    J Exp Med 193:247-54. 2001
  3. pmc Case-control cohort study of patients' perceptions of disability in mastocytosis
    Olivier Hermine
    Service de Dermatologie, Centre de référence sur la mastocytose, Hopital Necker, Paris, France
    PLoS ONE 3:e2266. 2008
  4. ncbi request reprint Phase II trial of arsenic trioxide and alpha interferon in patients with relapsed/refractory adult T-cell leukemia/lymphoma
    Olivier Hermine
    Department of Hematology, Necker Hospital, Paris, France
    Hematol J 5:130-4. 2004
  5. ncbi request reprint A prospective phase II clinical trial with the use of zidovudine and interferon-alpha in the acute and lymphoma forms of adult T-cell leukemia/lymphoma
    Olivier Hermine
    Department of Hematology, Necker Hospital, AP HP, Paris, France
    Hematol J 3:276-82. 2002
  6. ncbi request reprint Regression of splenic lymphoma with villous lymphocytes after treatment of hepatitis C virus infection
    Olivier Hermine
    Department of Hematology and Centre National de la Recherche Scientifique Unité Mixte de Recherche 8603, Hopital Necker, Paris, France
    N Engl J Med 347:89-94. 2002
  7. doi request reprint Pediatric mastocytosis is a clonal disease associated with D816V and other activating c-KIT mutations
    Christine Bodemer
    Service de Dermatologie, Hopital Necker, CEREMAST, centre de référence des mastocytoses, Faculte Necker, Universite Rene Descartes Paris V, Paris, France
    J Invest Dermatol 130:804-15. 2010
  8. doi request reprint Early posttransplantation donor-derived invariant natural killer T-cell recovery predicts the occurrence of acute graft-versus-host disease and overall survival
    Marie Therese Rubio
    Hematology and Bone Marrow Transplantation Department, Saint Antoine Hospital, Assistance Publique des Hôpitaux de Paris AP HP 184, Paris, France
    Blood 120:2144-54. 2012
  9. doi request reprint Predictors of early relapse in patients with non-infectious mixed cryoglobulinemia vasculitis: results from the French nationwide CryoVas survey
    Benjamin Terrier
    Department of Internal Medicine, National Reference Center for Autoimmune Diseases, Hopital Cochin, Assistance Publique Hopitaux de Paris AP HP, Université Pierre Descartes, Paris 5, Paris, France
    Autoimmun Rev 13:630-4. 2014
  10. doi request reprint Anorectal Epstein-Barr virus infection mimicking Hodgkin lymphoma in an immunocompetent man
    Viorel Vasiliu
    Departments of Pathology, Necker Enfants Malades Hospital and Paris Descartes University, Paris, France
    Am J Surg Pathol 34:1715-9. 2010

Detail Information

Publications146 found, 100 shown here

  1. ncbi request reprint Adult T cell leukaemia: a review of established and new treatments
    O Hermine
    Department of Hematology and CNRS URA 1461, Necker University Hospital, Paris, France
    BioDrugs 10:447-62. 1998
    ..Since cross resistance between chemotherapy and zidovudine and IFNalpha does not seem to occur, a combination with best induction polychemotherapy is warranted...
  2. pmc Caspase activation is required for terminal erythroid differentiation
    Y Zermati
    Centre National de la Recherche Scientifique Unité Mixte de Recherche 8603, Universite Rene Descartes, Paris V, France
    J Exp Med 193:247-54. 2001
    ..These observations indicate a new function for caspases as key proteases in the process of erythroid differentiation...
  3. pmc Case-control cohort study of patients' perceptions of disability in mastocytosis
    Olivier Hermine
    Service de Dermatologie, Centre de référence sur la mastocytose, Hopital Necker, Paris, France
    PLoS ONE 3:e2266. 2008
    ..We therefore performed a case-control cohort study to examine self-reported disability and impact of symptoms on the quality of life in patients with mastocytosis...
  4. ncbi request reprint Phase II trial of arsenic trioxide and alpha interferon in patients with relapsed/refractory adult T-cell leukemia/lymphoma
    Olivier Hermine
    Department of Hematology, Necker Hospital, Paris, France
    Hematol J 5:130-4. 2004
    ..Future studies should assess the best timing for arsenic therapy: frontline with IFN/AZT or as maintenance after induction...
  5. ncbi request reprint A prospective phase II clinical trial with the use of zidovudine and interferon-alpha in the acute and lymphoma forms of adult T-cell leukemia/lymphoma
    Olivier Hermine
    Department of Hematology, Necker Hospital, AP HP, Paris, France
    Hematol J 3:276-82. 2002
    ..Despite impressive prolonged CR of more than three years, most of the patients relapse stressing the need for additional therapy after achieving CR with AZT/IFN...
  6. ncbi request reprint Regression of splenic lymphoma with villous lymphocytes after treatment of hepatitis C virus infection
    Olivier Hermine
    Department of Hematology and Centre National de la Recherche Scientifique Unité Mixte de Recherche 8603, Hopital Necker, Paris, France
    N Engl J Med 347:89-94. 2002
    ..We undertook this study after a patient with splenic lymphoma with villous lymphocytes had a hematologic response after antiviral treatment of HCV infection...
  7. doi request reprint Pediatric mastocytosis is a clonal disease associated with D816V and other activating c-KIT mutations
    Christine Bodemer
    Service de Dermatologie, Hopital Necker, CEREMAST, centre de référence des mastocytoses, Faculte Necker, Universite Rene Descartes Paris V, Paris, France
    J Invest Dermatol 130:804-15. 2010
    ..These findings strongly support the idea that, although pediatric mastocytosis can spontaneously regress, it is a clonal disease most commonly associated with activating mutations in c-KIT...
  8. doi request reprint Early posttransplantation donor-derived invariant natural killer T-cell recovery predicts the occurrence of acute graft-versus-host disease and overall survival
    Marie Therese Rubio
    Hematology and Bone Marrow Transplantation Department, Saint Antoine Hospital, Assistance Publique des Hôpitaux de Paris AP HP 184, Paris, France
    Blood 120:2144-54. 2012
    ..58 × 10(-3) was associated with a 94% risk reduction of aGVHD. These findings provide a proof of concept that early postallogeneic HSCT iNKT cell recovery can predict the occurrence of aGVHD and an improved overall survival...
  9. doi request reprint Predictors of early relapse in patients with non-infectious mixed cryoglobulinemia vasculitis: results from the French nationwide CryoVas survey
    Benjamin Terrier
    Department of Internal Medicine, National Reference Center for Autoimmune Diseases, Hopital Cochin, Assistance Publique Hopitaux de Paris AP HP, Université Pierre Descartes, Paris 5, Paris, France
    Autoimmun Rev 13:630-4. 2014
    ..We aimed to identify predictors of early relapses occurring within the first 12months of treatment in such patients...
  10. doi request reprint Anorectal Epstein-Barr virus infection mimicking Hodgkin lymphoma in an immunocompetent man
    Viorel Vasiliu
    Departments of Pathology, Necker Enfants Malades Hospital and Paris Descartes University, Paris, France
    Am J Surg Pathol 34:1715-9. 2010
    ..Eight years later, the complete resolution of the lesion without any treatment is a strong argument against a malignant lymphoid process and raises doubts as to the reality of isolated anorectal HL in immunocompetent participants...
  11. doi request reprint CHOP and DHAP plus rituximab followed by autologous stem cell transplantation in mantle cell lymphoma: a phase 2 study from the Groupe d'Etude des Lymphomes de l'Adulte
    Richard Delarue
    Service d Hematologie, Hopital Necker, Paris, France
    Blood 121:48-53. 2013
    ..This study confirms that induction with rituximab and cytarabine-based regimens is safe and effective in MCL patients. This regimen is currently compared with R-CHOP(21) induction in a multicentric European protocol...
  12. doi request reprint Macrophage, mast cell and T lymphocyte infiltrations are independent predictive biomarkers of primary refractoriness or early relapse in classical Hodgkin lymphoma
    Benedicte Deau
    Department of Hematology, Paris Descartes University, Hopital Necker, Paris, France
    Leuk Lymphoma 54:41-5. 2013
    ..276, 95% confidence interval 1.214-56.408). This study provides evidence that the marker CD68 might accurately predict early outcome of de novo cHL and could be used in combination with c-kit and TiA1 staining...
  13. doi request reprint Mast cell leukemia: identification of a new c-Kit mutation, dup(501-502), and response to masitinib, a c-Kit tyrosine kinase inhibitor
    Sophie Georgin-Lavialle
    centre de référence des mastocytoses, Faculté de Médecine et AP HP Necker Enfants Malades, Paris, France
    Eur J Haematol 89:47-52. 2012
    ..Our aim was to investigate c-Kit mutations associated with mast cell leukemia and find new treatment for this severe form of mastocytosis...
  14. doi request reprint Neuropilin-1 is not a marker of human Foxp3+ Treg
    Pierre Milpied
    CNRS UMR 8147, Universite Paris Descartes, Assistance Publique Hopitaux de Paris, Hopital Necker, Paris, France
    Eur J Immunol 39:1466-71. 2009
    ..We conclude that Nrp-1 cannot be used as a specific marker of human Treg, but might represent a novel activation marker of human T cells both in vitro and in vivo...
  15. doi request reprint Gastrointestinal manifestations in mastocytosis: a study of 83 patients
    Harry Sokol
    Service de Gastroenterologie et Nutrition, Hopital Saint Antoine, AP HP, Universite Pierre et Marie Curie Paris 6, Paris, France Equipe AVENIR, Laboratoire INSERM U1057 UMR CNRS 7203, Universite Pierre et Marie Curie 6, Paris, France Equipe Interactions des bactéries commensales et probiotiques avec l hôte, Micalis, INRA, Jouy en Josas, France Centre de Référence des Mastocytoses, Faculté de Médecine et AP HP Necker Enfants Malades, Paris, France
    J Allergy Clin Immunol 132:866-73.e1-3. 2013
    ..Gastrointestinal manifestations of systemic mastocytosis have been previously studied in small cohorts of patients, and no specific histologic description is available...
  16. pmc Phenotypic and genotypic characteristics of mastocytosis according to the age of onset
    Fanny Lanternier
    Universite Paris V, Service de Maladies Infectieuses et Tropicales, centre de référence des mastocytoses, Hopital Necker Enfants Malades, Centre d Infectiologie Necker Pasteur, Paris, France
    PLoS ONE 3:e1906. 2008
    ..001). In conclusion, pathogenesis of mastocytosis significantly differs according to the age of disease's onset. Our data may have major therapeutic relevance when considering c-kit-targeted therapy...
  17. doi request reprint In aggressive forms of mastocytosis, TET2 loss cooperates with c-KITD816V to transform mast cells
    Erinn Soucie
    Inserm U1068, Centre de Recherche en Cancerologie de Marseille, centre de référence des mastocytoses, Institut Paoli Calmettes, Universite de la Mediterranee, Marseille, France
    Blood 120:4846-9. 2012
    ..Taken together, these data demonstrate a oncogenic cooperation in mast cells and reveal TET2 mutation as a potential marker to diagnose and predict severe forms of mastocytosis...
  18. doi request reprint Enteropathy associated T cell lymphoma in celiac disease: a large retrospective study
    Georgia Malamut
    Universite Paris Descartes, Paris, France
    Dig Liver Dis 45:377-84. 2013
    ..How clinical presentation, pathological features and therapies influence outcome was evaluated in 37 thoroughly characterized patients with celiac disease and T-cell lymphoma...
  19. doi request reprint Tax unleashed: fulminant Tax-positive Adult T-cell Leukemia/Lymphoma after failed allogeneic stem cell transplantation
    David Ghez
    Service d Hématologie Adultes, Hopital Necker Enfants Malades, Paris, France
    J Clin Virol 46:378-80. 2009
    ..We report herein a unique case of CD4+ T-cell leukemia highly expressing Tax following rejection of an allogenic peripheral blood stem cell graft for an HTLV-1 associated lymphoma...
  20. doi request reprint Reduced expression of FOXP3 and regulatory T-cell function in severe forms of early-onset autoimmune enteropathy
    Nicolette Moes
    Universite Paris Descartes, Paris, France
    Gastroenterology 139:770-8. 2010
    ..We analyzed the molecular basis of neonatal or early postnatal AIE using clinical, genetic, and functional immunological studies...
  21. doi request reprint Rapamycin for refractory acute graft-versus-host disease
    David Ghez
    Adult Hematology Department, Hopital Necker Enfants Malades, Paris, France
    Transplantation 88:1081-7. 2009
    ..We retrospectively evaluated the role of rapamycin in this setting...
  22. pmc Autosomal dominant STAT3 deficiency and hyper-IgE syndrome: molecular, cellular, and clinical features from a French national survey
    Marie Olivia Chandesris
    Hematology Department, Necker Enfants Malades Hospital, Assistance Publique Hopitaux de Paris, Paris, France
    Medicine (Baltimore) 91:e1-19. 2012
    ..Overall, the prognosis of STAT3 deficiency may be considered good, provided that multiple prophylactic measures, including IgG infusions, are implemented...
  23. doi request reprint Morbidity and mortality from ataxia-telangiectasia are associated with ATM genotype
    Romain Micol
    CEREDIH, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, 75743 Paris Cedex 15, France
    J Allergy Clin Immunol 128:382-9.e1. 2011
    ..The course of the disease is characterized by neurologic manifestations, infections, and cancers...
  24. doi request reprint Enteropathy-associated T-cell lymphoma complicating an autoimmune enteropathy
    Georgia Malamut
    Universite Paris Descartes, Paris, France
    Gastroenterology 142:726-729.e3; quiz e13-4. 2012
    ..Emerging T-cell clones should be monitored in patients with AIE who receive long-term immunosuppressive therapy...
  25. doi request reprint Galectin-1 and semaphorin-3A are two soluble factors conferring T-cell immunosuppression to bone marrow mesenchymal stem cell
    Yves Lepelletier
    CNRS UMR 8147, Universite Paris Descartes, Hopital Necker, Paris, France
    Stem Cells Dev 19:1075-9. 2010
    ..Taken together, these results demonstrate the critical role of Galectin-1 and Sema-3A in MSCs functions and may open new perspectives in the understanding and treatment of various immune and neoplastic disorders...
  26. pmc Ineffective erythropoiesis with reduced red blood cell survival in serotonin-deficient mice
    Pascal Amireault
    Faculte de Medecine, Universite Paris Descartes, Centre National de la Recherche Scientifique Unité Mixte de Recherche 8147, Hopital Necker, 75743 Paris Cedex 15, France
    Proc Natl Acad Sci U S A 108:13141-6. 2011
    ..Our thorough analysis of TPH1(-/-) mice provides a unique model of morphological and functional aberrations of erythropoiesis and identifies 5-HT as a key factor for red blood cell production and survival...
  27. pmc Ineffective erythropoiesis in β -thalassemia
    Jean Antoine Ribeil
    Centre National de la Recherche Scientifique Unité Mixte de Recherche 8147, Universite Paris V, René Descartes, Hopital Necker, Paris, France
    ScientificWorldJournal 2013:394295. 2013
    ..In this paper, we will focus on the underlying mechanisms leading to premature death of thalassemic erythroid precursors in the bone marrow...
  28. ncbi request reprint Intravascular lymphoma associated with haemophagocytic syndrome: a very rare entity in western countries
    Benjamin Terrier
    Department of Adult Haematology, Necker Hospital, 149 161 Rue de Sèvres, 75743 Paris Cedex 15, France
    Eur J Haematol 75:341-5. 2005
    ..Early recognition of IVL-HS by performing bone marrow biopsy is critical to start rapidly appropriate treatment. The role of rituximab in the management of IVL-HS remains to be established...
  29. doi request reprint Defective nuclear localization of Hsp70 is associated with dyserythropoiesis and GATA-1 cleavage in myelodysplastic syndromes
    Emilie Frisan
    Département d Immuno Hématologie, Institut Cochin, 27 rue du Faubourg Saint Jacques, Paris, France
    Blood 119:1532-42. 2012
    ..Alteration of Hsp70 cytosolic-nuclear shuttling is a major feature of MDS that favors GATA-1 cleavage and differentiation impairment, but not apoptosis, in dysplastic erythroblasts...
  30. doi request reprint Blood CD34-c-Kit+ cell rate correlates with aggressive forms of systemic mastocytosis and behaves like a mast cell precursor
    Sophie Georgin-Lavialle
    Service d Hématologie Adultes et Centre de Référence sur les Mastocytoses, Hopital Necker Enfants Malades, Universite Paris Descartes, Assistance Publique Hopitaux de Paris, France
    Blood 118:5246-9. 2011
    ..Monitoring peripheral CD34(-)c-Kit(+) cells by flow cytometry could be a useful and low-invasive tool to determine the disease severity and the relapses and to assess treatment efficiency...
  31. doi request reprint Adult T cell leukemia aggressivenness correlates with loss of both 5-hydroxymethylcytosine and TET2 expression
    Ambroise Marçais
    Service d Hematologie, Hôpital Universitaire Necker Enfants Malades, APHP, Universite Paris Descartes, Institut Imagine, INSERM U1163 CNRS ERL8254, Sorbonne Paris Cité, Paris, France
    Oncotarget . 2016
    ..These findings demonstrate that ATLL progression coincides with loss of genomic 5-hmc and indicate that downregulation of TET2, rather than TET2 mutations, is the key mechanism involved in 5-hmc modulation during ATLL progression...
  32. doi request reprint Rapamycin combined with TGF-β converts human invariant NKT cells into suppressive Foxp3+ regulatory cells
    Lúcia Moreira-Teixeira
    Unité Mixte de Recherche 8147, Centre National de la Recherche Scientifique, Faculté de Médecine René Descartes, Paris V, Hopital Necker, 75015 Paris, France
    J Immunol 188:624-31. 2012
    ..Our findings demonstrate that human iNKT cells become suppressive in the presence of TGF-β plus rapamycin, thus adding a new facet to their complex functional properties...
  33. doi request reprint Therapeutic options for adult T-cell leukemia/lymphoma
    Ambroise Marçais
    Department of Hematology, Institut Imagine, Necker Hospital, Paris Descartes University, 149 rue de Sevres, 75473, Paris Cedex 15, France
    Curr Oncol Rep 15:457-64. 2013
    ..New drugs such as the new antibody anti-CXCR4 show promising results. Prospective trials testing maintenance therapy in order to avoid relapse are warranted when the patient cannot undergo allogeneic stem cell transplantation...
  34. ncbi request reprint Fas ligand-mediated lethal hepatitis after rapid lysis of a localized natural killer cell lymphoma
    David Ghez
    Service d Hematologie, Hopital Necker, Paris, France
    Clin Lymphoma Myeloma 6:417-9. 2006
    ..Immunohistochemistry revealed an intense staining for FasL. To our knowledge, this is the first description of the occurrence of FasL-mediated lethal hepatitis after lysis of a NK cell lymphoma...
  35. doi request reprint Autoimmune neutropenia after kidney transplantation: a disregarded entity of posttransplant neutropenia
    Olivier Aubert
    1 Department of Kidney Transplantation, Hopital Necker Enfants Malades, Universite Paris Descartes, AP HP, Paris, France 2 Department of Adult Haematology, Hopital Necker Enfants Malades, Universite Paris Descartes, AP HP, Paris, France 3 Department of Haematology, Hopital Saint Antoine, Universite Paris VI, AP HP, Paris, France 4 Address correspondence to Flore Sicre de Fontbrune, M D, M Sc, Hôpital Saint Louis Service d Hématologie, Greffe de Moelle, 1 avenue Claude Vellefaux, 75475 Paris Cedex 10, France
    Transplantation 97:725-9. 2014
    ..Drug toxicities are the main causes of posttransplant neutropenia (PTN), mainly related to immunosuppressive drugs as mycophenolic acid (MPA) and anti-infectious agents, but some PTN remain unexplained...
  36. pmc Masitinib (AB1010), a potent and selective tyrosine kinase inhibitor targeting KIT
    Patrice Dubreuil
    INSERM, U891, Centre de Recherche en Cancerologie de Marseille, Signalisation, Hematopoiesis and Mechanisms of Oncogenesis, centre de référence des mastocytoses, Marseille, France
    PLoS ONE 4:e7258. 2009
    ..Here, we characterise the in vitro and in vivo profiles of masitinib (AB1010), a novel phenylaminothiazole-type tyrosine kinase inhibitor that targets KIT...
  37. ncbi request reprint Diffuse large B-cell lymphoma in hyperimmunoglobulinemia E syndrome
    Nadège Wallet
    Service d Hématologie Adultes et Centre d Etudes et de Recherche sur les Déficits Immunitaires Héréditaires, Hopital Necker Enfants Malades, 149 163 rue de Sèvres, 75743 Paris, France
    Clin Lymphoma Myeloma 7:425-7. 2007
    ..Despite a theoretic risk of severe infectious complications, chemotherapy was well tolerated and resulted in a sustained complete remission...
  38. doi request reprint Long-term outcome of adults with systemic anaplastic large-cell lymphoma treated within the Groupe d'Etude des Lymphomes de l'Adulte trials
    David Sibon
    He matologie, Hopital Necker Enfants Malades, 149, rue de Sevres, 75015 Paris, France
    J Clin Oncol 30:3939-46. 2012
    ..Long-term outcomes of chemotherapy-treated adults are not definitively established and should be evaluated...
  39. pmc Control of human thymocyte migration by Neuropilin-1/Semaphorin-3A-mediated interactions
    Yves Lepelletier
    Centre National de la Recherche Scientifique Unité Mixte de Recherche 8147, Universite Rene Descartes Paris V, Hopital Necker, 75743 Paris, France
    Proc Natl Acad Sci U S A 104:5545-50. 2007
    ..In conclusion, we show here that NP-1/Sema-3A-mediated interactions participate in the control of human thymocyte development...
  40. doi request reprint Polymeric IgA1 controls erythroblast proliferation and accelerates erythropoiesis recovery in anemia
    Séverine Coulon
    Centre National de la Recherche Scientifique CNRS Unité Mixte Recherche UMR 8147, Universite Paris Descartes, Faculte de Medecine, Hopital Necker, Paris, France
    Nat Med 17:1456-65. 2011
    ..Targeting this pathway may provide alternate approaches to the treatment of ineffective erythropoiesis and anemia...
  41. doi request reprint Accessory spleen: differential diagnosis for lymphoma in autoimmune lymphoproliferative syndrome
    Sophie Georgin-Lavialle
    Department of Adult Hematology, Hopital Necker, Universite Paris Descartes, Faculte de Medecine, Assistance Publique Hopitaux de Paris, Paris, France
    Pediatr Blood Cancer 54:1020-2. 2010
    ..This observation highlights the lymphoma's differential diagnosis in this context...
  42. ncbi request reprint A neutralizing monoclonal antibody (mAb A24) directed against the transferrin receptor induces apoptosis of tumor T lymphocytes from ATL patients
    Ivan C Moura
    Institut National de la Santé et de la Recherche Médicale INSERM E 0225, Faculte de Medecine Xavier Bichat, Paris, France
    Blood 103:1838-45. 2004
    ..Therefore efficient therapeutic tools to treat acute forms of ATL might be derived from A24...
  43. doi request reprint Response to 5-azacytidine in a patient with TET2-mutated angioimmunoblastic T-cell lymphoma and chronic myelomonocytic leukaemia preceded by an EBV-positive large B-cell lymphoma
    Colombe Saillard
    Clinical Hematology, Imagine Institute, Paris Descartes Sorbonne Paris Cité University, Necker Hospital, AP HP, Paris, France
    Hematol Oncol . 2016
    ..Treatment with 5-azacytidine led to the complete remission of both diseases. Thus, targeting DNA methylation abnormalities in AITL may be an alternative strategy to chemotherapy. Copyright © 2016 John Wiley & Sons, Ltd...
  44. pmc Mastocytosis among elderly patients: A multicenter retrospective French study on 53 patients
    Audrey Rouet
    aService de Médecine Interne, Hopital Tenon, Universite Pierre et Marie Curie, Paris, France bService de Médecine Interne, CHU de Caen, Université Basse Normandie, Caen, France cInstitut d Hématologie de Basse Normandie, Centre Hospitalier Universitaire, Universite de Caen Basse Normandie, Caen, France dFaculté de Médecine et AP HP Necker Enfants Malades, centre de référence des mastocytoses, Paris Cedex 15, France eInserm, U1068, CRCM Signaling, Hematopoiesis and Mechanism of Oncogenesis, Institut Paoli Calmettes, Marseille, Aix Marseille Univ, CNRS, UMR7258, Marseille, France fMastocytosis Competence Center of Midi Pyrénées, Department of Dermatology, Toulouse University Hospital, Toulouse, France gService de Médecine Interne, Universite Claude Bernard Lyon1, Groupe Hospitalier Lyon Sud Chemin du Grand Revoyet, Pierre Benite, France hService de Dermatologie, Hopital Tenon, Universite Pierre et Marie Curie Paris 6, Paris, France iService d Hématologie Adultes, Kyushu University
    Medicine (Baltimore) 95:e3901. 2016
    ....
  45. pmc Serotonin is a key factor for mouse red blood cell survival
    Pascal Amireault
    Faculte de Medecine, Université Paris Descartes Sorbonne Paris Cité, Institut Imagine, CNRS UMR 8147, Hôpital Universitaire Necker Enfants Malades, Paris, France Laboratoire d Excellence GR Ex, Paris, France Inserm UMR_S665, Institut National de la Transfusion Sanguine, Paris, France
    PLoS ONE 8:e83010. 2013
    ..We further demonstrate a link between oxidation and the removal of damaged RBC following transfusion, as supplementation with 5-HT improves RBC post-transfusion survival in a mouse model of blood banking. ..
  46. doi request reprint Gastrointestinal involvement and manifestations in systemic mastocytosis
    Harry Sokol
    Department of Gastroenterology and Nutrition, Saint Antoine Hospital, Universite Paris VI, Faculte de Medecine, Assistance Publique Hopitaux de Paris, Paris, France
    Inflamm Bowel Dis 16:1247-53. 2010
    ..Diagnosis of mastocytosis GI manifestations should be evoked in the case of unexplained severe GI disorders...
  47. doi request reprint An activin receptor IIA ligand trap corrects ineffective erythropoiesis in β-thalassemia
    Michael Dussiot
    1 INSERM UMR 1163, Laboratory of Cellular and Molecular Mechanisms of Hematological Disorders and Therapeutic Implications, Paris, France 2 Paris Descartes Sorbonne Paris Cité University, Imagine Institute, Paris, France 3 CNRS ERL 8254, Paris, France 4 Laboratory of Excellence GR Ex, Paris, France 5 INSERM U1149, Center for Research on Inflammation, Paris, France 6
    Nat Med 20:398-407. 2014
    ....
  48. pmc Deferasirox and vitamin D improves overall survival in elderly patients with acute myeloid leukemia after demethylating agents failure
    Etienne Paubelle
    CNRS UMR 8147, Universite Paris Descartes, Faculte de Medecine, Hopital Necker, Paris, France
    PLoS ONE 8:e65998. 2013
    ..We conclude that DFX/VD treatment correlated with increased overall survival of AML patients in this retrospective cohort of elderly patients. ..
  49. ncbi request reprint Dramatic clinical efficacy of cladribine in Rosai-Dorfman disease and evolution of the cytokine profile: towards a new therapeutic approach
    Achille Aouba
    Department of Adult Hematology, Hopital Necker Enfants Malades, Paris V University, Assistance Publique Hopitaux de Paris AP HP, 49 161 rue de Sèvres, 75743 Paris Cedex 15, France
    Haematologica 91:ECR52. 2006
    ..Our findings show the promising efficacy of cladribine and suggest that therapies targeting specifically cytokines might be useful in some cases of active RDD...
  50. doi request reprint A Mendelian predisposition to B-cell lymphoma caused by IL-10R deficiency
    Benedicte Neven
    Unité d Immuno Hématologie Pédiatrique, Hopital Necker Enfant Malades, Assistance publique des Hôpitaux de Paris APHP, Paris, France
    Blood 122:3713-22. 2013
    ..Hence, IL-10R deficiency is associated with a high risk of developing B-cell lymphoma. Our results revealed an unexpected role of the IL-10R pathway in lymphomagenesis. ..
  51. pmc Lenalidomide as salvage treatment for multiple myeloma relapsing after allogeneic hematopoietic stem cell transplantation: a report from the French Society of Bone Marrow and Cellular Therapy
    Tereza Coman
    CNRS UMR, 8147, Hopital Necker Enfants Malades, Paris, France
    Haematologica 98:776-83. 2013
    ..Induced graft-versus-host disease has to be balanced against the potential benefit in terms of disease control. Further immunological studies would help us understand lenalidomide immunomodulatory activity in vivo...
  52. doi request reprint Leukocyte telomere length in mastocytosis: correlations with depression and perceived stress
    Sophie Georgin-Lavialle
    centre de référence des mastocytoses, Universite Paris Descartes, Sorbonne, Paris Cité, Hopital Necker Enfants Malades, Paris, France Institut Imagine Université Paris Descartes, Sorbonne, Paris Cité, Hopital Necker Enfants Malades, Paris, France CNRS UMR 8147, Hopital Necker Enfants Malades, 149 rue des Sèvres, 75743 Paris Cedex 15, France Electronic address
    Brain Behav Immun 35:51-7. 2014
    ..Taken together these observations led us to hypothesize that mast cells activity could be involved in both negative emotionality and telomere shortening in mastocytosis...
  53. doi request reprint EKLF-driven PIT1 expression is critical for mouse erythroid maturation in vivo and in vitro
    Anne Forand
    INSERM U845, Paris, France
    Blood 121:666-78. 2013
    ..This is the first demonstration of a physiologic involvement of PIT1 in erythroid maturation in vivo...
  54. doi request reprint Mast cell leukemia
    Sophie Georgin-Lavialle
    centre de référence des mastocytoses, Faculté de Médecine et Assistance Publique Hopitaux de Paris AP HP Necker Enfants Malades, Paris, France
    Blood 121:1285-95. 2013
    ..Therapy usually fails and the median survival time is < 6 months. The role of combination therapies and bone marrow transplantation needs further investigation...
  55. pmc The spectrum of type I cryoglobulinemia vasculitis: new insights based on 64 cases
    Benjamin Terrier
    Department of Internal Medicine, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie, Paris 6, Paris, France
    Medicine (Baltimore) 92:61-8. 2013
    ..Besides alkylating agents, the use of regimens based on rituximab, thalidomide or lenalinomide, and bortezomib are interesting alternative options, although the exact role of each strategy remains to be defined...
  56. pmc Evidence for cognitive impairment in mastocytosis: prevalence, features and correlations to depression
    Daniela Silva Moura
    centre de référence des mastocytoses, Hopital Necker Enfants Malades, Fondation Imagine Paris, Universite Paris Descartes, Sorbonne, Paris Cité, Paris, France
    PLoS ONE 7:e39468. 2012
    ..These results suggest differential effects of mast-cell activity in the brain, on systems involved in emotionality and in cognition...
  57. pmc Depression in patients with mastocytosis: prevalence, features and effects of masitinib therapy
    Daniela Silva Moura
    Universite Paris Descartes, Sorbonne, Paris Cité, Service d Hematologie, centre de référence des mastocytoses, Hopital Necker Enfants Malades, Paris, France
    PLoS ONE 6:e26375. 2011
    ..We conclude that depression in mastocytosis may originate from processes related to mast cells activation. Masitinib could therefore be a useful treatment for mastocytosis patients with depression and anxiety symptoms...
  58. doi request reprint Toll-like receptor control of glucocorticoid-induced apoptosis in human plasmacytoid predendritic cells (pDCs)
    Yves Lepelletier
    Universite Paris Descartes, Paris, France
    Blood 116:3389-97. 2010
    ..Our results demonstrate a novel property of the TLR pathway in regulating the interface between GC and innate immunity and reveal a previously undescribed mechanism of GC resistance...
  59. pmc Regulatory T-cell depletion in angioimmunoblastic T-cell lymphoma
    Julie Bruneau
    Department of Hematology, Necker Enfants Malades Hospital, Assistance Publique Hopitaux de Paris, Paris Descartes University, Paris, France
    Am J Pathol 177:570-4. 2010
    ..6% (6-48)]. Interestingly, Treg depletion was not observed in AITL peripheral blood at diagnosis. Altogether, these data suggest that Treg depletion could contribute to the nodal neoplastic T(FH) expansion and dysimmune symptoms in AITL...
  60. ncbi request reprint Hemophagocytic syndrome as a presenting sign of transformation of smoldering to acute adult T-cell leukemia/lymphoma: efficacy of anti-retroviral and interferon therapy
    Achille Aouba
    Department of Haematology, Hopital Necker Enfants Malades, Paris, France
    Am J Hematol 76:187-9. 2004
    ..Thus, we propose that adult T-cell leukemia/lymphoma must be added to the spectrum of etiologies of hemophagocytic syndrome...
  61. doi request reprint Mast cell sarcoma: new cases and literature review
    Jilliana Monnier
    Service de Medecine Interne, Hopital Tenon, Universite Paris VI, Assistance Publique Hopitaux de Paris AP HP, Paris, France
    Oncotarget . 2016
    ..Because conventional chemotherapies usually fail, the role of targeted therapies and bone marrow transplantation warrants further investigation in such aggressive neoplasms...
  62. doi request reprint Long-term efficacy and safety of cladribine (2-CdA) in adult patients with mastocytosis
    Stephane Barete
    Sorbonne Universités, UPMC Univ Paris VI, Assistance Publique Hopitaux de Paris, Département de dermatologie et allergologie, Hopital Tenon, centre de référence des mastocytoses, Paris, France
    Blood 126:1009-16; quiz 1050. 2015
    ..2-CdA appears to provide a significant efficacy with some toxicity in various M subtypes, mostly in indolent M, refractory to multiple symptomatic therapies. ..
  63. pmc Neuropilin-1 expression characterizes T follicular helper (Tfh) cells activated during B cell differentiation in human secondary lymphoid organs
    Amédée Renand
    CNRS, UMR 8147, Hopital Necker, Universite Paris Descartes, Sorbonne Paris Cité, Paris, France
    PLoS ONE 8:e85589. 2013
    ..Thus, Nrp1 is a specific marker of Tfh cells cognate activation in humans, which may prove useful as a prognostic factor and a therapeutic target in neoplastic diseases associated with Tfh cells activity. ..
  64. doi request reprint Lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease: a prospective observational cohort study
    Laurent Beaugerie
    Department of Gastroenterology, Assistance Publique Hopitaux de Paris AP HP, Hopital Saint Antoine, Universite Pierre et Marie Curie Paris VI, Paris, France
    Lancet 374:1617-25. 2009
    ..Reports of an increased risk of lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease are controversial. We assessed this risk in a prospective observational cohort study...
  65. doi request reprint Incidence, presentation, and prognosis of malignancies in ataxia-telangiectasia: a report from the French national registry of primary immune deficiencies
    Felipe Suarez
    Felipe Suarez, Nizar Mahlaoui, Danielle Canioni, Nicole Brousse, Jean Philippe Jais, Alain Fischer, and Olivier Hermine, Hôpital Universitaire Necker Enfants Malades, Assistance Publique Hôpitaux de Paris Felipe Suarez, Nizar Mahlaoui, Chantal Andriamanga, Alain Fischer, and Olivier Hermine, French National Reference Center for Primary Immune Deficiency Felipe Suarez, Nizar Mahlaoui, Jean Philippe Jais, Alain Fischer, and Olivier Hermine, Imagine Institute, Institut National de la Recherche Scientifique Unité Mixte de Recherche 1163, Sorbonne Paris Cité, Université Paris Descartes Felipe Suarez and Olivier Hermine, Centre National de la Recherche Scientifique Equipe de Recherche Labellisée 8254 Danielle Canioni, Nicole Brousse, and Dominique Stoppa Lyonnet, Université Paris Descartes Catherine Dubois d Enghien and Dominique Stoppa Lyonnet, Institut Curie and Alain Fischer, College de France, Paris, France
    J Clin Oncol 33:202-8. 2015
    ..Precise estimates of the risk, presentation, and outcomes of cancer in patients with AT need to be addressed in large series...
  66. ncbi request reprint Inhibition of TGF-beta signaling by IL-15: a new role for IL-15 in the loss of immune homeostasis in celiac disease
    Mélika Benahmed
    INSERM U793, Paris, France
    Gastroenterology 132:994-1008. 2007
    ..Our goal has been to investigate why the proinflammatory effects of IL-15 cannot be efficiently controlled by TGF-beta in celiac disease...
  67. doi request reprint Protective effect of IgM against colonization of the respiratory tract by nontypeable Haemophilus influenzae in patients with hypogammaglobulinemia
    Romain Micol
    CEREDIH network French National Reference Center for Primary Immunodeficiencies, Hopital Necker Enfants Malades, AP HP, Paris, France
    J Allergy Clin Immunol 129:770-7. 2012
    ..It is not known whether patients able to secrete IgM (eg, those with hyper-IgM [HIgM] syndrome) are as susceptible to these infections as patients who lack IgM production (eg, those with panhypogammaglobulinemia [PHG])...
  68. doi request reprint Inflammatory manifestations in a single-center cohort of patients with chronic granulomatous disease
    Alessandra Magnani
    Assistance Publique Hopitaux de Paris, Service d Immuno Hématologie et Rhumatologie Pédiatrique, Hôpital Universitaire Necker Enfants Malades, Paris, France Assistance Publique Hôpitaux de Paris, Centre de Référence des Déficits Immunitaires Héréditaires CEREDIH, Hôpital Universitaire Necker Enfants Malades, Paris, France University Paris Descartes, Sorbonne Paris Cité, Institut Imagine, Paris, France
    J Allergy Clin Immunol 134:655-662.e8. 2014
    ..Chronic granulomatous disease (CGD) is a rare phagocytic disorder that results in not only infections but also potentially severe inflammatory manifestations that can be difficult to diagnose and treat...
  69. pmc Iatrogenic Cushing's syndrome induced by posaconazole
    Benoit Pilmis
    Service de Maladies Infectieuses et Tropicales, Groupe Hospitalier Necker Enfants Malades, Centre d Infectiologie Necker Pasteur, Paris, France
    Antimicrob Agents Chemother 57:5727-8. 2013
    ..After a switch to posaconazole, the patient developed Cushingoid symptoms. ..
  70. ncbi request reprint Nodular regenerative hyperplasia: the main liver disease in patients with primary hypogammaglobulinemia and hepatic abnormalities
    Georgia Malamut
    Hepatology and Gastroenterology Department, Hopital Europeen Georges Pompidou, Paris, France
    J Hepatol 48:74-82. 2008
    ..Liver lesions associated with primary hypogammaglobulinemia have been poorly described. We aimed to assess the clinical, histological and immune features and outcome of hepatic injury in patients with primary hypogammaglobulinemia...
  71. doi request reprint Peripheral blood 8 colour flow cytometry monitoring of hairy cell leukaemia allows detection of high-risk patients
    Francine Garnache Ottou
    Laboratoire d Hématologie and CNRS UMR8147, Hopital Necker Enfants Malades, Universite Paris Descartes, 149 rue de Sevres, 75743, Paris Cedex 15, France INSERM UMR1098, Universite de Franche Comte, EFS B FC Plateforme de BioMonitoring, 1 bd Fleming, 25000, Besancon, France
    Br J Haematol 166:50-9. 2014
    ..003). These data demonstrate the clinical interest of a robust 8-FC HCL B/RD strategy that could become a surrogate biomarker for therapeutic stratification and new drug assessment, which should be evaluated prospectively...
  72. doi request reprint Characteristics of B-cell lymphomas in HIV/HCV-coinfected patients during the combined antiretroviral therapy era: an ANRS CO16 LYMPHOVIR cohort study
    Benjamin Terrier
    Department of Internal Medicine II, Université Paris 6 Pierre et Marie Curie UMR S 943, Paris, France
    J Acquir Immune Defic Syndr 63:249-53. 2013
    ..This supports the role of chronic antigenic stimulation by HCV on lymphomagenesis and further evaluation of HCV antiviral therapy in coinfected patients with NHL...
  73. doi request reprint Small intestinal CD4+ T-cell lymphoma is a heterogenous entity with common pathology features
    Georgia Malamut
    Université Paris Descartes Sorbonne Paris Centre, Paris, France Gastroenterology Department, Hôpital Européen Georges Pompidou Assistance Publique des Hôpitaux de Paris, Paris, France Inserm U989, Paris, France Institute Imagine, Paris, France Electronic address
    Clin Gastroenterol Hepatol 12:599-608.e1. 2014
    ..Little is known about intestinal CD4+ T-cell lymphoma; this rare malignancy is misdiagnosed frequently. We evaluated diagnostic criteria and factors that might affect its development and outcome...
  74. doi request reprint Late-onset post-transplantation lymphoproliferative disorders after kidney transplantation: a monocentric study over three decades
    David Michonneau
    Service de Transplantation Rénale Adulte, Hopital Necker, Assistance Publique Hopitaux de Paris, Paris, France
    Nephrol Dial Transplant 28:471-8. 2013
    ..While early-onset PTLDs have a good prognosis following RI, this approach is generally inadequate for late-onset PTLDs. We assessed the specific outcome of late-onset PTLDs after kidney transplantation during the past three decades...
  75. doi request reprint Free HTLV-1 induces TLR7-dependent innate immune response and TRAIL relocalization in killer plasmacytoid dendritic cells
    Renaud Colisson
    Centre Nationale de la Recherche Scientifique CNRS Unite Mixte de Recherche UMR 8147, Universite Paris Descartes, Paris, France
    Blood 115:2177-85. 2010
    ..This is the first demonstration of an innate immune response induced by free HTLV-1...
  76. doi request reprint First experience of autologous peripheral blood stem cell mobilization with biosimilar granulocyte colony-stimulating factor
    Francois Lefrere
    Service de Biothérapie, Groupe Hospitalier Necker Enfants Malades, Paris, France
    Adv Ther 28:304-10. 2011
    ..Biosimilar versions of G-CSF are now available in Europe...
  77. doi request reprint Hodgkin lymphoma-associated hemophagocytic syndrome: a disorder strongly correlated with Epstein-Barr virus
    Fanny Menard
    Universite Paris Sud, F 94270, Paris, France
    Clin Infect Dis 47:531-4. 2008
    ..3:1), immunodeficiency-like histological features (lymphocyte depletion, 45% of cases; mixed cellularity Hodgkin lymphoma subtype, 40%), and strong association with Epstein-Barr virus (94%)...
  78. ncbi request reprint High-dose melphalan versus melphalan plus dexamethasone for AL amyloidosis
    Arnaud Jaccard
    Department of Hematology, Centre Hospitalier Universitaire, Université et Centre National de la Recherche Scientifique, UMR 6101, Limoges, France
    N Engl J Med 357:1083-93. 2007
    ....
  79. doi request reprint Large granular lymphocytic leukemia: a treatable form of refractory celiac disease
    Georgia Malamut
    Universite Paris Descartes, Paris, France
    Gastroenterology 143:1470-1472.e2. 2012
    ..Treatment with a combination of cyclosporine and methotrexate restored the patients' sensitivity to gluten-free diets. LGL therefore might be a cause of refractory celiac disease that is sensitive to immunosuppressive therapy...
  80. doi request reprint Highly active antiretroviral treatment against STLV-1 infection combining reverse transcriptase and HDAC inhibitors
    Philippe V Afonso
    Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, Centre National de la Recherche Scientifique CNRS URA 3015, Institut Pasteur, Paris, France
    Blood 116:3802-8. 2010
    ..Such treatments may be useful to reduce the risk of HAM/TSP in asymptomatic carriers with a high PVL...
  81. doi request reprint Presentation and long-term follow-up of refractory celiac disease: comparison of type I with type II
    Georgia Malamut
    Universite Paris Descartes, Paris, France
    Gastroenterology 136:81-90. 2009
    ..We compared the clinical and biological characteristics of RCD I and RCD II at diagnosis, the risk of developing an overt lymphoma, and the predictive factors of survival...
  82. doi request reprint IL-17-producing invariant NKT cells in lymphoid organs are recent thymic emigrants identified by neuropilin-1 expression
    Pierre Milpied
    Centre National de la Recherche Scientifique, Universite Paris Descartes, Paris, France
    Blood 118:2993-3002. 2011
    ..Our results establish an accurate marker of RTE iNKT cells and reveal that continuous thymic output is required for pro-inflammatory IL-17 secretion, a key function of adult iNKT cells...
  83. ncbi request reprint Characteristics and outcome of diffuse large B-cell lymphoma in hepatitis C virus-positive patients in LNH 93 and LNH 98 Groupe d'Etude des Lymphomes de l'Adulte programs
    Caroline Besson
    Service d hématologie adulte, Hopital Necker Enfants Malades, APHP, Paris, France
    J Clin Oncol 24:953-60. 2006
    ..Epidemiologic studies show an association between hepatitis C virus (HCV) and B-cell non-Hodgkin's lymphoma (NHL). Treatment and outcome of patients with diffuse large-cell lymphoma (DLCL) and HCV infection are still a matter of debate...
  84. pmc Masitinib combined with standard gemcitabine chemotherapy: in vitro and in vivo studies in human pancreatic tumour cell lines and ectopic mouse model
    Martine Humbert
    AB Science SA, Paris, France
    PLoS ONE 5:e9430. 2010
    ..This study evaluates the therapeutic potential of masitinib in pancreatic cancer, as a single agent and in combination with gemcitabine...
  85. ncbi request reprint Splenic lymphoma with villous lymphocytes, mixed cryoglobulinemia and HCV infection: deciphering the role of HCV in B-cell lymphomagenesis
    Felipe Suarez
    Service d Hématologie Adultes, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, Paris, France
    Dig Liver Dis 39:S32-7. 2007
    ..Antiviral therapy should be considered as first-line therapy in low-grade B-cell and possibly large-cell lymphomas associated with HCV, especially in the presence of MC...
  86. pmc Prognostic significance of new immunohistochemical markers in refractory classical Hodgkin lymphoma: a study of 59 cases
    Danielle Canioni
    Department of Pathology, Necker Hospital, Assistance Publique Hopitaux de Paris, University Paris Descartes, Faculte de Medecine, Paris, France
    PLoS ONE 4:e6341. 2009
    ..These novel cHL markers could be used in association with clinical parameters to identify newly diagnosed patients with favorable or unfavorable prognosis and to better tailor treatment for different risk groups...
  87. ncbi request reprint Prevention of mantle lymphoma tumor establishment by routing transferrin receptor toward lysosomal compartments
    Yves Lepelletier
    Centre National de la Recherche Scientifique UMR 8147, Universite Paris V, Hopital Necker, 161 rue de Sevres, 75015 Paris, France
    Cancer Res 67:1145-54. 2007
    ..Therefore, A24-based therapies alone or in association with classic chemotherapies could provide a new alternative strategy against MCL, particularly in relapsing cases...
  88. doi request reprint Management of noninfectious mixed cryoglobulinemia vasculitis: data from 242 cases included in the CryoVas survey
    Benjamin Terrier
    Department of Internal Medicine, Groupe Hospitalier Pitie Salpetriere, Assistance Publique des Hopitaux de Paris, Universite Pierre et Marie Curie, 47 83 boulevard de l Hopital, Paris, France
    Blood 119:5996-6004. 2012
    ..The role of each of these strategies remains to be defined in well-designed randomized controlled trials...
  89. doi request reprint A survey of 90 patients with autoimmune lymphoproliferative syndrome related to TNFRSF6 mutation
    Benedicte Neven
    Inserm U768, Hopital Necker Enfants Malades, Paris, France
    Blood 118:4798-807. 2011
    ..We also noted a significantly greater occurrence of disease-related symptoms in male than in female patients...
  90. doi request reprint The telomere/telomerase system in autoimmune and systemic immune-mediated diseases
    Sophie Georgin-Lavialle
    Department of Adult Haematology, Necker Enfants Malades Hospital, Mastocytosis Reference Center, Paris Descartes University, Paris, France
    Autoimmun Rev 9:646-51. 2010
    ..Studies on the telomere/telomerase system open new research avenues for the basic understanding and for therapeutic approaches of these pathologies...
  91. doi request reprint Clinical and biological features of t(4;14) multiple myeloma: a prospective study
    Lionel Karlin
    Immuno Hematology, Saint Louis Hospital, Paris, France
    Leuk Lymphoma 52:238-46. 2011
    ..Patients with t(4;14) MM have a high ORR after HDT, contrasting with a short PFS and aggressive relapses, and, despite novel agents, still have a poor prognosis...
  92. ncbi request reprint Human herpesvirus 8 (HHV-8)-associated peritoneal primary effusion lymphoma (PEL) in two HIV-negative elderly patients
    Emmanuelle Boulanger
    Unit of Epidemiology and Physiopathology of Oncogenic Viruses, Institut Pasteur, Paris, France
    Am J Hematol 76:88-91. 2004
    ..Compared to AIDS-related PEL, these two cases displayed distinct features in particular the advanced age of patients, as observed for Mediterranean KS, and the absence of EBV coinfection...
  93. doi request reprint Cutaneous findings in sporadic and familial autosomal dominant hyper-IgE syndrome: a retrospective, single-center study of 21 patients diagnosed using molecular analysis
    Amani Olaiwan
    Department of Dermatology, Necker Enfants Malades Hospital, Assistance Publique Hopitaux de Paris AP HP, Paris, France
    J Am Acad Dermatol 65:1167-72. 2011
    ..Recent identification of STAT3 mutations in autosomal dominant (AD) hyper-IgE syndrome (HIES) has improved the clinical, genetic, and molecular classification of the HIES...
  94. doi request reprint The LKB1/AMPK signaling pathway has tumor suppressor activity in acute myeloid leukemia through the repression of mTOR-dependent oncogenic mRNA translation
    Alexa S Green
    Institut Cochin, Universite Paris Descartes, CNRS UMR8104, Paris, France
    Blood 116:4262-73. 2010
    ..The induction of the LKB1/AMPK tumor-suppressor pathway thus represents a promising new strategy for AML therapy...
  95. pmc Neuropilin-1 is involved in human T-cell lymphotropic virus type 1 entry
    David Ghez
    CNRS UMR 8147, Universite Paris V, Assistance Publique Hopitaux de Paris, Hopital Necker, 161 rue de Sevres, 75743 Paris Cedex 15, France
    J Virol 80:6844-54. 2006
    ..These data show that NRP1 is involved in HTLV-1 and HTLV-2 entry, suggesting that the HTLV receptor has a multicomponent nature...
  96. ncbi request reprint Immunosuppressive role of semaphorin-3A on T cell proliferation is mediated by inhibition of actin cytoskeleton reorganization
    Yves Lepelletier
    CNRS UMR 8147, Faculte de Medecine, Universite Rene Descartes, Paris V, Hopital Necker, Assistance Publique Hopitaux de Paris, Paris, France
    Eur J Immunol 36:1782-93. 2006
    ..Therefore, we propose that Sema-3A secretion and the resulting NP-1/Sema-3A interaction are involved in a late negative feedback loop controlling DC-induced T cell proliferation...
  97. ncbi request reprint Differential expression and function of IgA receptors (CD89 and CD71) during maturation of dendritic cells
    Benoit Pasquier
    INSERM E0225, Bichat Medical School, Paris, France
    J Leukoc Biol 76:1134-41. 2004
    ..Our findings led us to propose that FcalphaRI expressed by interstitial-type DC could play a critical role to sample IgA-recognized antigens and also during DC activation...
  98. ncbi request reprint Combined treatment with arsenic trioxide and all-trans-retinoic acid in patients with relapsed acute promyelocytic leukemia
    Emmanuel Raffoux
    Department and Institute of Hematology, Hopital Saint Louis, Paris, France
    J Clin Oncol 21:2326-34. 2003
    ..Preclinical observations have indicated that all-trans-retinoic acid (ATRA) may strongly enhance the response to ATO...
  99. doi request reprint Rationale and efficacy of interleukin-1 targeting in Erdheim-Chester disease
    Achille Aouba
    Department of Internal Medicine, French National Referral Center for Langerhans Cell Histiocytosis, Hopital Cochin, Université de Paris Descartes, Assistance Publique Hopitaux de Paris AP HP, Paris, France
    Blood 116:4070-6. 2010
    ..Therefore, our results support a central role of the IL-1 network, which seemed to be overstimulated in ECD. Its specific blockade using anakinra thereby opens new pathophysiology and therapeutic perspectives in ECD...
  100. ncbi request reprint Rapamycin inhibits growth and survival of D816V-mutated c-kit mast cells
    Marion Gabillot-Carré
    CNRS UMR 8147, Universite Rene Descartes Paris V, Hopital Necker, 161 rue de Sevres, 75743 Paris Cedex 15, France
    Blood 108:1065-72. 2006
    ..The data presented here provide a rationale to test whether rapamycin could be a possible treatment for SM and other hematologic malignancies with the D816V mutation...
  101. doi request reprint Fanconi syndrome in lymphoma patients: report of the first case series
    Jill Vanmassenhove
    Nephrology Department, Universite Paris Descartes, AP HP, Hopital Necker, Paris, France
    Nephrol Dial Transplant 25:2516-20. 2010
    ..It is caused by inherited or acquired disorders including low mass or high mass multiple myeloma...